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Protein

HLA class I histocompatibility antigen, B-40 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-40 alpha chain
Alternative name(s):
Bw-60
MHC class I antigen B*40
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi416557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001884425 – 362HLA class I histocompatibility antigen, B-40 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)1
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiQ04826.
MaxQBiQ04826.
PeptideAtlasiQ04826.
PRIDEiQ04826.

PTM databases

SwissPalmiQ04826.

Expressioni

Gene expression databases

BgeeiENSG00000206450.
CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ04826.
SMRiQ04826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,505
Last modified:October 1, 1993 - v1
Checksum:i7D66503ACD865152
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167Missing AA sequence (PubMed:6193808).Curated1

Polymorphismi

The following alleles of B-40 are known: B*40:01, B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2), B*40:05 (BN21), B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown is that of B*40:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0164359L → V in allele B*40:01. 1
Natural variantiVAR_01643614 – 15WG → SA in allele B*40:01. 2
Natural variantiVAR_01643717V → L in allele B*40:01. 1
Natural variantiVAR_01643835 – 36SV → AM in allele B*40:01 and allele B*40:16. 2
Natural variantiVAR_01643987E → N in allele B*40:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01644091S → F in allele B*40:08. 1
Natural variantiVAR_056363101S → N.Corresponds to variant rs1050388dbSNPEnsembl.1
Natural variantiVAR_016441118 – 119TL → II in allele B*40:03. 2
Natural variantiVAR_016442119L → W in allele B*40:06. 1
Natural variantiVAR_016443121S → R in allele B*40:01 and allele B*40:03. 1
Natural variantiVAR_016444121S → T in allele B*40:06. 1
Natural variantiVAR_016445127V → L in allele B*40:03. 1
Natural variantiVAR_016658137H → Y in allele B*40:09. Corresponds to variant rs1050379dbSNPEnsembl.1
Natural variantiVAR_016446138N → D in allele B*40:04 and allele B*40:09. Combined sources1
Natural variantiVAR_016447140Y → N in allele B*40:27. 1
Natural variantiVAR_016448140Y → S in allele B*40:04. 1
Natural variantiVAR_056364155R → S.Combined sourcesCorresponds to variant rs1050654dbSNPEnsembl.1
Natural variantiVAR_016449167T → S in allele B*40:01. 1
Natural variantiVAR_016450171W → L in allele B*40:01. 1
Natural variantiVAR_016451176V → E in allele B*40:05 and allele B*40:16. 1
Natural variantiVAR_016655180L → R in allele B*40:16. 1
Natural variantiVAR_016452187E → L in allele B*40:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016453201 – 202ET → DK in allele B*40:01 and allele B*40:16. 2
Natural variantiVAR_016454204Q → E in allele B*40:01 and allele B*40:16. 1
Natural variantiVAR_056365306V → I.Corresponds to variant rs1131500dbSNPEnsembl.1
Natural variantiVAR_056366329A → T.Corresponds to variant rs1051488dbSNPEnsembl.1
Natural variantiVAR_061413349C → S.Corresponds to variant rs2308655dbSNPEnsembl.1
Natural variantiVAR_061414349C → Y.Corresponds to variant rs2308655dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03698 mRNA. Translation: AAA03719.1.
L41628 Genomic DNA. Translation: AAA65040.1.
L09736 mRNA. Translation: AAA36224.1.
D14343 mRNA. Translation: BAA03277.1.
M84383 mRNA. Translation: AAA59633.1.
M84384 mRNA. Translation: AAA59634.1.
M84694 mRNA. Translation: AAA03661.1.
X84725 mRNA. Translation: CAA59215.1.
AJ300180 Genomic DNA. Translation: CAC15501.1.
AJ292253 Genomic DNA. Translation: CAC29021.1.
L41353 Genomic DNA. Translation: AAC41923.1.
L76934 mRNA. Translation: AAA96270.1.
AH005563 Genomic DNA. Translation: AAB70252.1.
AH008232 Genomic DNA. Translation: AAD56943.1.
PIRiI38437. HLHU40.
I56149.
I59655.
I61905.
I61906.
S52486.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03698 mRNA. Translation: AAA03719.1.
L41628 Genomic DNA. Translation: AAA65040.1.
L09736 mRNA. Translation: AAA36224.1.
D14343 mRNA. Translation: BAA03277.1.
M84383 mRNA. Translation: AAA59633.1.
M84384 mRNA. Translation: AAA59634.1.
M84694 mRNA. Translation: AAA03661.1.
X84725 mRNA. Translation: CAA59215.1.
AJ300180 Genomic DNA. Translation: CAC15501.1.
AJ292253 Genomic DNA. Translation: CAC29021.1.
L41353 Genomic DNA. Translation: AAC41923.1.
L76934 mRNA. Translation: AAA96270.1.
AH005563 Genomic DNA. Translation: AAB70252.1.
AH008232 Genomic DNA. Translation: AAD56943.1.
PIRiI38437. HLHU40.
I56149.
I59655.
I61905.
I61906.
S52486.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

ProteinModelPortaliQ04826.
SMRiQ04826.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiQ04826.

Polymorphism and mutation databases

DMDMi416557.

Proteomic databases

EPDiQ04826.
MaxQBiQ04826.
PeptideAtlasiQ04826.
PRIDEiQ04826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_Q04826.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206450.
CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B40_HUMAN
AccessioniPrimary (citable) accession number: Q04826
Secondary accession number(s): O19556
, O19651, P01890, P30477, P30478, Q29762, Q29842, Q29855, Q30173, Q31603, Q9TPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.