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Protein

HLA class I histocompatibility antigen, B-40 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-40 alpha chain
Alternative name(s):
Bw-60
MHC class I antigen B*40
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi416557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-40 alpha chainPRO_0000018844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiQ04826.
PeptideAtlasiQ04826.
PRIDEiQ04826.

PTM databases

SwissPalmiQ04826.

Expressioni

Gene expression databases

BgeeiENSG00000206450.
CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ04826.
SMRiQ04826. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,505
Last modified:October 1, 1993 - v1
Checksum:i7D66503ACD865152
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671Missing AA sequence (PubMed:6193808).Curated

Polymorphismi

The following alleles of B-40 are known: B*40:01, B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2), B*40:05 (BN21), B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown is that of B*40:02.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91L → V in allele B*40:01.
VAR_016435
Natural varianti14 – 152WG → SA in allele B*40:01.
VAR_016436
Natural varianti17 – 171V → L in allele B*40:01.
VAR_016437
Natural varianti35 – 362SV → AM in allele B*40:01 and allele B*40:16.
VAR_016438
Natural varianti87 – 871E → N in allele B*40:08; requires 2 nucleotide substitutions.
VAR_016439
Natural varianti91 – 911S → F in allele B*40:08.
VAR_016440
Natural varianti101 – 1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_056363
Natural varianti118 – 1192TL → II in allele B*40:03.
VAR_016441
Natural varianti119 – 1191L → W in allele B*40:06.
VAR_016442
Natural varianti121 – 1211S → R in allele B*40:01 and allele B*40:03.
VAR_016443
Natural varianti121 – 1211S → T in allele B*40:06.
VAR_016444
Natural varianti127 – 1271V → L in allele B*40:03.
VAR_016445
Natural varianti137 – 1371H → Y in allele B*40:09.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_016658
Natural varianti138 – 1381N → D in allele B*40:04 and allele B*40:09. Combined sources
VAR_016446
Natural varianti140 – 1401Y → N in allele B*40:27.
VAR_016447
Natural varianti140 – 1401Y → S in allele B*40:04.
VAR_016448
Natural varianti155 – 1551R → S.Combined sources
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056364
Natural varianti167 – 1671T → S in allele B*40:01.
VAR_016449
Natural varianti171 – 1711W → L in allele B*40:01.
VAR_016450
Natural varianti176 – 1761V → E in allele B*40:05 and allele B*40:16.
VAR_016451
Natural varianti180 – 1801L → R in allele B*40:16.
VAR_016655
Natural varianti187 – 1871E → L in allele B*40:05; requires 2 nucleotide substitutions.
VAR_016452
Natural varianti201 – 2022ET → DK in allele B*40:01 and allele B*40:16.
VAR_016453
Natural varianti204 – 2041Q → E in allele B*40:01 and allele B*40:16.
VAR_016454
Natural varianti306 – 3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056365
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056366
Natural varianti349 – 3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061413
Natural varianti349 – 3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061414

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03698 mRNA. Translation: AAA03719.1.
L41628 Genomic DNA. Translation: AAA65040.1.
L09736 mRNA. Translation: AAA36224.1.
D14343 mRNA. Translation: BAA03277.1.
M84383 mRNA. Translation: AAA59633.1.
M84384 mRNA. Translation: AAA59634.1.
M84694 mRNA. Translation: AAA03661.1.
X84725 mRNA. Translation: CAA59215.1.
AJ300180 Genomic DNA. Translation: CAC15501.1.
AJ292253 Genomic DNA. Translation: CAC29021.1.
L41353 Genomic DNA. Translation: AAC41923.1.
L76934 mRNA. Translation: AAA96270.1.
AH005563 Genomic DNA. Translation: AAB70252.1.
AH008232 Genomic DNA. Translation: AAD56943.1.
PIRiI38437. HLHU40.
I56149.
I59655.
I61905.
I61906.
S52486.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03698 mRNA. Translation: AAA03719.1.
L41628 Genomic DNA. Translation: AAA65040.1.
L09736 mRNA. Translation: AAA36224.1.
D14343 mRNA. Translation: BAA03277.1.
M84383 mRNA. Translation: AAA59633.1.
M84384 mRNA. Translation: AAA59634.1.
M84694 mRNA. Translation: AAA03661.1.
X84725 mRNA. Translation: CAA59215.1.
AJ300180 Genomic DNA. Translation: CAC15501.1.
AJ292253 Genomic DNA. Translation: CAC29021.1.
L41353 Genomic DNA. Translation: AAC41923.1.
L76934 mRNA. Translation: AAA96270.1.
AH005563 Genomic DNA. Translation: AAB70252.1.
AH008232 Genomic DNA. Translation: AAD56943.1.
PIRiI38437. HLHU40.
I56149.
I59655.
I61905.
I61906.
S52486.
UniGeneiHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortaliQ04826.
SMRiQ04826. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiQ04826.

Polymorphism and mutation databases

DMDMi416557.

Proteomic databases

EPDiQ04826.
PeptideAtlasiQ04826.
PRIDEiQ04826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_Q04826.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206450.
CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B40_HUMAN
AccessioniPrimary (citable) accession number: Q04826
Secondary accession number(s): O19556
, O19651, P01890, P30477, P30478, Q29762, Q29842, Q29855, Q30173, Q31603, Q9TPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.