Reviewed,
UniProtKB/Swiss-Prot Q04800 (FRP1_SCHPO)
Last modified
June 16, 2009.
Version 74.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ferric reductase transmembrane component 1 EC=1.16.1.7 Alternative name(s): Ferric-chelate reductase 1 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 564 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Is required for the uptake of Fe3+ ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe3+ ion) via FAD and heme intermediates. |
| Catalytic activity | 2 Fe2+ + NAD+ = 2 Fe3+ + NADH. |
| Cofactor | FAD Probable. |
| Subcellular location | |
| Sequence similarities | Belongs to the ferric reductase (FRE) family. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 564 | 564 | Ferric reductase transmembrane component 1 | PRO_0000210152 | |||||
Regions | |||||||||
| Transmembrane | 10 – 30 | 21 | Potential | ||||||
| Transmembrane | 73 – 93 | 21 | Potential | ||||||
| Transmembrane | 117 – 137 | 21 | Potential | ||||||
| Transmembrane | 160 – 180 | 21 | Potential | ||||||
| Transmembrane | 193 – 213 | 21 | Potential | ||||||
| Transmembrane | 417 – 437 | 21 | Potential | ||||||
| Domain | 121 – 254 | 134 | Ferric oxidoreductase | ||||||
| Domain | 255 – 410 | 156 | FAD-binding FR-type | ||||||
| Nucleotide binding | 317 – 323 | 7 | FAD Potential | ||||||
| Nucleotide binding | 419 – 427 | 9 | NAD Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 362 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 381 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 383 | 1 | Phosphoserine Ref.3 | ||||||
| Glycosylation | 4 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 111 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 268 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 360 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 501 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase." Roman D.G., Dancis A., Anderson G.J., Klausner R.D. Mol. Cell. Biol. 13:4342-4350(1993) [PubMed: 8321236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-381 AND SER-383, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| L07749 Genomic DNA. Translation: AAA68045.1. CU329671 Genomic DNA. Translation: CAB91171.1. | |
| PIR | A48141. |
| RefSeq | NP_595065.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2539711. |
| KEGG | spo:SPBC1683.09c. |
| NMPDR | fig|4896.1.peg.931. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC1683.09c. |
Phylogenomic databases | |
| OMA | Q04800. TEMNINI. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003170-MON. |
| BRENDA | 1.16.1.7. 653. |
Gene expression databases | |
| ArrayExpress | Q04800. |
Family and domain databases | |
| InterPro | IPR013112. FAD_bd_8. IPR017927. Fd_Rdtase_FAD-bd. IPR013130. Fe3_reduct_TM_N. IPR013121. Fe_red_NAD_bd_6. [Graphical view] |
| Pfam | PF08022. FAD_binding_8. 1 hit. PF01794. Ferric_reduct. 1 hit. PF08030. NAD_binding_6. 1 hit. [Graphical view] |
| PROSITE | PS51384. FAD_FR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FRP1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q04800 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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