Q047K9 (DLTC_LACDB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 2
EC=6.1.1.13

Alternative name(s):
D-alanyl carrier protein
Short name=DCP

Gene names

Name:	dltC
Ordered Locus Names:	LBUL_1983

Organism

Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [Complete proteome] [HAMAP]

Taxonomic identifier

321956 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA By similarity. HAMAP MF_00565
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00565
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00565
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP By similarity. HAMAP MF_00565
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation
Ligand	ATP-binding Nucleotide-binding Phosphopantetheine
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: EC acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 80	80	D-alanine--poly(phosphoribitol) ligase subunit 2 HAMAP MF_00565		PRO_1000024916
Amino acid modifications
	Modified residue	35	1	O-(pantetheine 4'-phosphoryl)serine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q047K9 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 7E04797CBF27A4FF	FASTA	80	9,259
	10 20 30 40 50 60 MDIQKQIVDI LAEATGEDFS DNMDQELYES GIMDSMTTVQ MLLTLQETFD ITVPVSEFNR 70 80 DDWNTPNKLV EQVKKLQDEE

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-365.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000412 Genomic DNA. Translation: ABJ59363.1.
RefSeq	YP_813801.1. NC_008529.1.
3D structure databases
ProteinModelPortal	Q047K9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q047K9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4434733.
GenomeReviews	Gene locus LBUL_1983 in contig CP000412_GR.
KEGG	lbu:LBUL_1983.
PATRIC	22223833. VBILacDel70259_1888.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0236.
HOGENOM	HBG516530.
OMA	QMDENIF.
ProtClustDB	PRK05087.
Enzyme and pathway databases
BioCyc	LDEL321956:LBUL_1983-MONOMER.
Family and domain databases
HAMAP	MF_00565. DltC. [Tree]
InterPro	IPR009081. Acyl_carrier_prot-like. IPR003230. D-ala_carrier. IPR006163. Phsphopanteth-bd. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
KO	K14188.
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR01688. DltC. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTC_LACDB

Accession

Primary (citable) accession number: Q047K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program