Reviewed,
UniProtKB/Swiss-Prot Q04795 (AK1_BACSU)
Last modified
November 3, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aspartokinase 1 EC=2.7.2.4 Alternative name(s): Aspartokinase I Aspartate kinase 1 | ||||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 404 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-aspartate = ADP + 4-phospho-L-aspartate. |
| Enzyme regulation | Diaminopimelate-sensitive. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. |
| Subunit structure | Tetramer consisting of 2 isoforms Alpha (catalytic) and 2 isoforms Beta (function not known) By similarity. |
| Sequence similarities | Belongs to the aspartokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis |
| Coding sequence diversity | Alternative initiation |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform Alpha (identifier: Q04795-1) Also known as: Aspartokinase 1 subunit alpha; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Beta (identifier: Q04795-2) Also known as: Aspartokinase 1 subunit beta; The sequence of this isoform differs from the canonical sequence as follows: 1-244: Missing. 245-245: V → M | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase." Chen N.-Y., Jiang S.-Q., Klein D.A., Paulus H. J. Biol. Chem. 268:9448-9465(1993) [PubMed: 8098035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 399. |
Cross-references
Sequence databases | |
|---|---|
| L08471 Genomic DNA. Translation: AAA22384.1. AL009126 Genomic DNA. Translation: CAB13549.2. | |
| PIR | C46665. |
| RefSeq | NP_389558.2. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 936710. |
| GenomeReviews | Gene locus BSU16760 in contig AL009126_GR. |
| KEGG | bsu:BSU16760. |
| NMPDR | fig|224308.1.peg.1679. |
Organism-specific databases | |
| SubtiList | BG10784. dapG. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q04795. |
| OMA | PMRIRST. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU1677-MON. |
| BRENDA | 2.7.2.4. 150. |
Family and domain databases | |
| InterPro | IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kin_reg. IPR018042. Aspartate_kinase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1160.10. Aa_kinase. 1 hit. |
| Pfam | PF00696. AA_kinase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00656. asp_kin_monofn. 1 hit. TIGR00657. asp_kinases. 1 hit. |
| PROSITE | PS00324. ASPARTOKINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AK1_BACSU | ||||||||
| Accession | Primary (citable) accession number: Q04795 Secondary accession number(s): O31759 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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