Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04792

- DCE_YEAST

UniProt

Q04792 - DCE_YEAST

Protein

Glutamate decarboxylase

Gene

GAD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: SGD
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular response to oxidative stress Source: SGD
    2. glutamate catabolic process Source: SGD

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciYEAST:YMR250W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase (EC:4.1.1.15)
    Short name:
    GAD
    Gene namesi
    Name:GAD1
    Ordered Locus Names:YMR250W
    ORF Names:YM9920.04
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR250w.
    SGDiS000004862. GAD1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Glutamate decarboxylasePRO_0000146977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei318 – 3181N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    MaxQBiQ04792.
    PeptideAtlasiQ04792.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04792.

    Interactioni

    Protein-protein interaction databases

    BioGridi35428. 25 interactions.
    DIPiDIP-2552N.
    IntActiQ04792. 3 interactions.
    MINTiMINT-423058.
    STRINGi4932.YMR250W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04792.
    SMRiQ04792. Positions 48-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiEYPHVQQ.
    OrthoDBiEOG7P2Z22.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04792-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHRHGSKQK NFENIAGKVV HDLAGLQLLS NDVQKSAVQS GHQGSNNMRD    50
    TSSQGMANKY SVPKKGLPAD LSYQLIHNEL TLDGNPHLNL ASFVNTFTTD 100
    QARKLIDENL TKNLADNDEY PQLIELTQRC ISMLAQLWHA NPDEEPIGCA 150
    TTGSSEAIML GGLAMKKRWE HRMKNAGKDA SKPNIIMSSA CQVALEKFTR 200
    YFEVECRLVP VSHRSHHMLD PESLWDYVDE NTIGCFVILG TTYTGHLENV 250
    EKVADVLSQI EAKHPDWSNT DIPIHADGAS GGFIIPFGFE KEHMKAYGME 300
    RWGFNHPRVV SMNTSGHKFG LTTPGLGWVL WRDESLLADE LRFKLKYLGG 350
    VEETFGLNFS RPGFQVVHQY FNFVSLGHSG YRTQFQNSLF VARAFSFELL 400
    NSSKLPGCFE IVSSIHESIE NDSAPKSVKD YWEHPQAYKP GVPLVAFKLS 450
    KKFHEEYPEV PQAILSSLLR GRGWIIPNYP LPKATDGSDE KEVLRVVFRS 500
    EMKLDLAQLL IVDIESILTK LIHSYEKVCH HIELASEQTP ERKSSFIYEM 550
    LLALASPQDD IPTPDEIEKK NKLKETTTRN YRGTC 585
    Length:585
    Mass (Da):65,990
    Last modified:November 1, 1997 - v1
    Checksum:iDDD22868CEB7B955
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48639 Genomic DNA. Translation: CAA88577.1.
    BK006946 Genomic DNA. Translation: DAA10150.1.
    PIRiS53072.
    RefSeqiNP_013976.1. NM_001182756.1.

    Genome annotation databases

    EnsemblFungiiYMR250W; YMR250W; YMR250W.
    GeneIDi855291.
    KEGGisce:YMR250W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48639 Genomic DNA. Translation: CAA88577.1 .
    BK006946 Genomic DNA. Translation: DAA10150.1 .
    PIRi S53072.
    RefSeqi NP_013976.1. NM_001182756.1.

    3D structure databases

    ProteinModelPortali Q04792.
    SMRi Q04792. Positions 48-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35428. 25 interactions.
    DIPi DIP-2552N.
    IntActi Q04792. 3 interactions.
    MINTi MINT-423058.
    STRINGi 4932.YMR250W.

    Proteomic databases

    MaxQBi Q04792.
    PeptideAtlasi Q04792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR250W ; YMR250W ; YMR250W .
    GeneIDi 855291.
    KEGGi sce:YMR250W.

    Organism-specific databases

    CYGDi YMR250w.
    SGDi S000004862. GAD1.

    Phylogenomic databases

    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi EYPHVQQ.
    OrthoDBi EOG7P2Z22.

    Enzyme and pathway databases

    BioCyci YEAST:YMR250W-MONOMER.

    Miscellaneous databases

    NextBioi 978940.

    Gene expression databases

    Genevestigatori Q04792.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCE_YEAST
    AccessioniPrimary (citable) accession number: Q04792
    Secondary accession number(s): D6W076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3