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Q04788

- PIT1_PIG

UniProt

Q04788 - PIT1_PIG

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Protein

Pituitary-specific positive transcription factor 1

Gene

POU1F1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi214 – 27360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary-specific positive transcription factor 1
Short name:
PIT-1
Alternative name(s):
Growth hormone factor 1
Short name:
GHF-1
Gene namesi
Name:POU1F1
Synonyms:PIT-1, PIT1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Pituitary-specific positive transcription factor 1PRO_0000100700Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ04788.
SMRiQ04788. Positions 129-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19875POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241031.
HOGENOMiHOG000116302.
HOVERGENiHBG053120.
InParanoidiQ04788.
KOiK09363.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04788-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCQPFTSAD TFIPLNSESS ATLPLIMHHS AAECLPASNH ATNVMSTATG
60 70 80 90 100
LHYSVPSCHY GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPMYQPLLPE
110 120 130 140 150
DPTAADFKQE LRRKSKLVEE PIDMDSPEIR ELEKFPNEFK VRRIKLGYTQ
160 170 180 190 200
TNVGEALAAV HGSEFSQTTI CRFENLQLSF KNACKLKAIL SKWLEEAEQV
210 220 230 240 250
GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS SQEILRMAEE
260 270 280 290
LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FTISKEHLEC R
Length:291
Mass (Da):33,033
Last modified:April 27, 2001 - v3
Checksum:iC13EB6634697F8EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641P → S in AAB65789. 1 PublicationCurated
Sequence conflicti94 – 941Y → H in AAB65789. 1 PublicationCurated
Sequence conflicti136 – 1361P → A in AAB65789. 1 PublicationCurated
Sequence conflicti141 – 1411V → A in CAA73939. 1 PublicationCurated
Sequence conflicti144 – 1441I → M in AAA31108. (PubMed:8098921)Curated
Sequence conflicti155 – 1617EALAAVH → QVAAAWT in CAA73939. 1 PublicationCurated
Sequence conflicti183 – 1831A → R in CAA73939. 1 PublicationCurated
Sequence conflicti196 – 1961E → V in CAA73939. 1 PublicationCurated
Sequence conflicti259 – 2591R → S in AAA31108. (PubMed:8098921)Curated
Sequence conflicti260 – 2601V → F in CAA73939. 1 PublicationCurated
Sequence conflicti265 – 2651R → H(PubMed:8098921)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13617 mRNA. Translation: CAA73939.1.
AF016251 mRNA. Translation: AAB65789.2.
L03841 mRNA. Translation: AAA31108.1.
RefSeqiNP_999328.1. NM_214163.1.
UniGeneiSsc.16019.

Genome annotation databases

GeneIDi397325.
KEGGissc:397325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13617 mRNA. Translation: CAA73939.1 .
AF016251 mRNA. Translation: AAB65789.2 .
L03841 mRNA. Translation: AAA31108.1 .
RefSeqi NP_999328.1. NM_214163.1.
UniGenei Ssc.16019.

3D structure databases

ProteinModelPortali Q04788.
SMRi Q04788. Positions 129-273.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397325.
KEGGi ssc:397325.

Organism-specific databases

CTDi 5449.

Phylogenomic databases

eggNOGi NOG241031.
HOGENOMi HOG000116302.
HOVERGENi HBG053120.
InParanoidi Q04788.
KOi K09363.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of pig (Sus scrofa) pituitary transcription factor GHF-1/Pit-1."
    Vila V., Sanchez M.P., Malagon M.M., Gracia F., Castrillo J.-L.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "Cloning of the full length pig PIT-1 cDNA and its alternative transcripts, and functional studies of their encoded proteins."
    Yu T.-P., Sun H.S., Rothschild M.F., Tuggle C.K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1, a gene controlling growth hormone expression."
    Tuggle C.K., Yu T.-P., Helm J., Rothschild M.F.
    Anim. Genet. 24:17-21(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-267.
    Strain: Duroc.
    Tissue: Brain cortex and Pituitary.

Entry informationi

Entry nameiPIT1_PIG
AccessioniPrimary (citable) accession number: Q04788
Secondary accession number(s): O18807, O46410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3