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Q04788

- PIT1_PIG

UniProt

Q04788 - PIT1_PIG

Protein

Pituitary-specific positive transcription factor 1

Gene

POU1F1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi214 – 27360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary-specific positive transcription factor 1
    Short name:
    PIT-1
    Alternative name(s):
    Growth hormone factor 1
    Short name:
    GHF-1
    Gene namesi
    Name:POU1F1
    Synonyms:PIT-1, PIT1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Pituitary-specific positive transcription factor 1PRO_0000100700Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ04788.
    SMRiQ04788. Positions 129-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 19875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241031.
    HOGENOMiHOG000116302.
    HOVERGENiHBG053120.
    KOiK09363.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04788-1 [UniParc]FASTAAdd to Basket

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    MSCQPFTSAD TFIPLNSESS ATLPLIMHHS AAECLPASNH ATNVMSTATG    50
    LHYSVPSCHY GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPMYQPLLPE 100
    DPTAADFKQE LRRKSKLVEE PIDMDSPEIR ELEKFPNEFK VRRIKLGYTQ 150
    TNVGEALAAV HGSEFSQTTI CRFENLQLSF KNACKLKAIL SKWLEEAEQV 200
    GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS SQEILRMAEE 250
    LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FTISKEHLEC R 291
    Length:291
    Mass (Da):33,033
    Last modified:April 27, 2001 - v3
    Checksum:iC13EB6634697F8EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641P → S in AAB65789. 1 PublicationCurated
    Sequence conflicti94 – 941Y → H in AAB65789. 1 PublicationCurated
    Sequence conflicti136 – 1361P → A in AAB65789. 1 PublicationCurated
    Sequence conflicti141 – 1411V → A in CAA73939. 1 PublicationCurated
    Sequence conflicti144 – 1441I → M in AAA31108. (PubMed:8098921)Curated
    Sequence conflicti155 – 1617EALAAVH → QVAAAWT in CAA73939. 1 PublicationCurated
    Sequence conflicti183 – 1831A → R in CAA73939. 1 PublicationCurated
    Sequence conflicti196 – 1961E → V in CAA73939. 1 PublicationCurated
    Sequence conflicti259 – 2591R → S in AAA31108. (PubMed:8098921)Curated
    Sequence conflicti260 – 2601V → F in CAA73939. 1 PublicationCurated
    Sequence conflicti265 – 2651R → H(PubMed:8098921)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13617 mRNA. Translation: CAA73939.1.
    AF016251 mRNA. Translation: AAB65789.2.
    L03841 mRNA. Translation: AAA31108.1.
    RefSeqiNP_999328.1. NM_214163.1.
    UniGeneiSsc.16019.

    Genome annotation databases

    GeneIDi397325.
    KEGGissc:397325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13617 mRNA. Translation: CAA73939.1 .
    AF016251 mRNA. Translation: AAB65789.2 .
    L03841 mRNA. Translation: AAA31108.1 .
    RefSeqi NP_999328.1. NM_214163.1.
    UniGenei Ssc.16019.

    3D structure databases

    ProteinModelPortali Q04788.
    SMRi Q04788. Positions 129-273.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397325.
    KEGGi ssc:397325.

    Organism-specific databases

    CTDi 5449.

    Phylogenomic databases

    eggNOGi NOG241031.
    HOGENOMi HOG000116302.
    HOVERGENi HBG053120.
    KOi K09363.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of pig (Sus scrofa) pituitary transcription factor GHF-1/Pit-1."
      Vila V., Sanchez M.P., Malagon M.M., Gracia F., Castrillo J.-L.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "Cloning of the full length pig PIT-1 cDNA and its alternative transcripts, and functional studies of their encoded proteins."
      Yu T.-P., Sun H.S., Rothschild M.F., Tuggle C.K.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1, a gene controlling growth hormone expression."
      Tuggle C.K., Yu T.-P., Helm J., Rothschild M.F.
      Anim. Genet. 24:17-21(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-267.
      Strain: Duroc.
      Tissue: Brain cortex and Pituitary.

    Entry informationi

    Entry nameiPIT1_PIG
    AccessioniPrimary (citable) accession number: Q04788
    Secondary accession number(s): O18807, O46410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3