Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q04786

- HEX_VIBVL

UniProt

Q04786 - HEX_VIBVL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-hexosaminidase

Gene

hex

Organism
Vibrio vulnificus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolysis of terminal, non-reducing N-acetyl-beta-D-glucosamine residues in chitobiose and higher analogs, and in glycoproteins.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei519 – 5191Proton donorBy similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. chitin catabolic process Source: UniProtKB-UniPathway
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00349.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:hex
OrganismiVibrio vulnificus
Taxonomic identifieri672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Beta-hexosaminidasePRO_0000215378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 40By similarity
Disulfide bondi377 ↔ 385By similarity
Disulfide bondi484 ↔ 530By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ04786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SMARTiSM01081. CHB_HEX. 1 hit.
[Graphical view]
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04786-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASDIDQKDV DYAAKNLKLT TSLVANKPKD CPPEAPWGAC YRVEINLENT
60 70 80 90 100
GSKSLNENVE IYFSSIHRTL GSKSEEFKVE HINGDLHKIT TTEKFKGLKG
110 120 130 140 150
GKTKSFQVDF MNWIVSNSDF MPNYYVASEH LEGRNILNTV PIDAVHITEE
160 170 180 190 200
VSGFTTGIKH TPNQLKRTAN DLLPAATATT RYEQYSKVKD LGADAVSAHI
210 220 230 240 250
LPTPLETSVH EGSLNIAQGI NIVSDALPAD QVEALNFRFE TLGVNTGTGV
260 270 280 290 300
PVNVTIKADS SKKSGSYTLD VTSSGIRIVG VDKAGAFYGV QSLAGLVTVG
310 320 330 340 350
KDTINQVSIN DEPRLDYRGM HMDVSRNFHS KELVFRFLDQ MAAYKMNKFH
360 370 380 390 400
FHLADDEGWR LEINGLPELT QVGAHRCHDV EQNKCMMPQL GSGAELPNNG
410 420 430 440 450
SGYYTREDYK EILAYASARN IQVIPSMDMP GHSLAAVKSM EARYRKFMAE
460 470 480 490 500
GDVVKAEMYL LSDPNDTTQY YSIQHYQDNT INPCMESSFV FMDKVIDEIN
510 520 530 540 550
KLHKEGGQPL TDYHIGADET AGAWGDSPEC RKMFVAPESG VKNAKDINGY
560 570 580 590 600
FINRISHILD AKGLTLGAWN DGLSHKALDA SSLAGNPPKA WVWGTMFWGG
610 620 630 640 650
VDQYNSFANK GYDVVVTPPD AYYFDMPYEN DPEERGYYWA TRFNDTKKVF
660 670 680 690 700
SFMPENVPAN VEWMTDRMGA KISATTGEKT HDFLGVQGAL WSETIRTDAQ
710 720 730 740 750
VEYMVLPRMI AVAERGWHKA SWEEEHKEGI TYTSNVDGHE GTTHLNDNIA
760 770 780 790 800
TRDADWAHFS NILGYKEMPK LDKAGITYRL PVLGAVIKNN ILDVVTEFHG
810 820 830 840
VAIQYSLDGK TWHKYDDTKK PQVSTKALVR SVSTNGRTGR AVEVLAK
Length:847
Mass (Da):94,277
Last modified:November 1, 1995 - v1
Checksum:i3C4405EFA34F3D14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04544 Genomic DNA. Translation: AAA27527.1.
PIRiA48228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04544 Genomic DNA. Translation: AAA27527.1 .
PIRi A48228.

3D structure databases

ProteinModelPortali Q04786.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00349 .

Family and domain databases

Gene3Di 2.60.40.290. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR014756. Ig_E-set.
[Graphical view ]
Pfami PF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SMARTi SM01081. CHB_HEX. 1 hit.
[Graphical view ]
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases."
    Somerville C.C., Colwell R.R.
    Proc. Natl. Acad. Sci. U.S.A. 90:6751-6755(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 27562 / DSM 10143 / JCM 3725 / LMG 13545 / NBRC 15645 / NCIMB 2046.

Entry informationi

Entry nameiHEX_VIBVL
AccessioniPrimary (citable) accession number: Q04786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3