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Q04786

- HEX_VIBVL

UniProt

Q04786 - HEX_VIBVL

Protein

Beta-hexosaminidase

Gene

hex

Organism
Vibrio vulnificus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Hydrolysis of terminal, non-reducing N-acetyl-beta-D-glucosamine residues in chitobiose and higher analogs, and in glycoproteins.

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei519 – 5191Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
    2. polysaccharide binding Source: InterPro

    GO - Biological processi

    1. chitin catabolic process Source: UniProtKB-UniPathway
    2. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00349.

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase
    Chitobiase
    N-acetyl-beta-glucosaminidase
    Gene namesi
    Name:hex
    OrganismiVibrio vulnificus
    Taxonomic identifieri672 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 847847Beta-hexosaminidasePRO_0000215378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 40By similarity
    Disulfide bondi377 ↔ 385By similarity
    Disulfide bondi484 ↔ 530By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ04786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Family and domain databases

    Gene3Di2.60.40.290. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR008965. Carb-bd_dom.
    IPR012291. CBD_carb-bd_dom.
    IPR004866. CHB/HEX_N_dom.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR015882. HEX_bac_N.
    IPR014756. Ig_E-set.
    [Graphical view]
    PfamiPF03173. CHB_HEX. 1 hit.
    PF00728. Glyco_hydro_20. 1 hit.
    PF02838. Glyco_hydro_20b. 1 hit.
    [Graphical view]
    PRINTSiPR00738. GLHYDRLASE20.
    SMARTiSM01081. CHB_HEX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49384. SSF49384. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04786-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASDIDQKDV DYAAKNLKLT TSLVANKPKD CPPEAPWGAC YRVEINLENT    50
    GSKSLNENVE IYFSSIHRTL GSKSEEFKVE HINGDLHKIT TTEKFKGLKG 100
    GKTKSFQVDF MNWIVSNSDF MPNYYVASEH LEGRNILNTV PIDAVHITEE 150
    VSGFTTGIKH TPNQLKRTAN DLLPAATATT RYEQYSKVKD LGADAVSAHI 200
    LPTPLETSVH EGSLNIAQGI NIVSDALPAD QVEALNFRFE TLGVNTGTGV 250
    PVNVTIKADS SKKSGSYTLD VTSSGIRIVG VDKAGAFYGV QSLAGLVTVG 300
    KDTINQVSIN DEPRLDYRGM HMDVSRNFHS KELVFRFLDQ MAAYKMNKFH 350
    FHLADDEGWR LEINGLPELT QVGAHRCHDV EQNKCMMPQL GSGAELPNNG 400
    SGYYTREDYK EILAYASARN IQVIPSMDMP GHSLAAVKSM EARYRKFMAE 450
    GDVVKAEMYL LSDPNDTTQY YSIQHYQDNT INPCMESSFV FMDKVIDEIN 500
    KLHKEGGQPL TDYHIGADET AGAWGDSPEC RKMFVAPESG VKNAKDINGY 550
    FINRISHILD AKGLTLGAWN DGLSHKALDA SSLAGNPPKA WVWGTMFWGG 600
    VDQYNSFANK GYDVVVTPPD AYYFDMPYEN DPEERGYYWA TRFNDTKKVF 650
    SFMPENVPAN VEWMTDRMGA KISATTGEKT HDFLGVQGAL WSETIRTDAQ 700
    VEYMVLPRMI AVAERGWHKA SWEEEHKEGI TYTSNVDGHE GTTHLNDNIA 750
    TRDADWAHFS NILGYKEMPK LDKAGITYRL PVLGAVIKNN ILDVVTEFHG 800
    VAIQYSLDGK TWHKYDDTKK PQVSTKALVR SVSTNGRTGR AVEVLAK 847
    Length:847
    Mass (Da):94,277
    Last modified:November 1, 1995 - v1
    Checksum:i3C4405EFA34F3D14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04544 Genomic DNA. Translation: AAA27527.1.
    PIRiA48228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04544 Genomic DNA. Translation: AAA27527.1 .
    PIRi A48228.

    3D structure databases

    ProteinModelPortali Q04786.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00349 .

    Family and domain databases

    Gene3Di 2.60.40.290. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR008965. Carb-bd_dom.
    IPR012291. CBD_carb-bd_dom.
    IPR004866. CHB/HEX_N_dom.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR015882. HEX_bac_N.
    IPR014756. Ig_E-set.
    [Graphical view ]
    Pfami PF03173. CHB_HEX. 1 hit.
    PF00728. Glyco_hydro_20. 1 hit.
    PF02838. Glyco_hydro_20b. 1 hit.
    [Graphical view ]
    PRINTSi PR00738. GLHYDRLASE20.
    SMARTi SM01081. CHB_HEX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49384. SSF49384. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases."
      Somerville C.C., Colwell R.R.
      Proc. Natl. Acad. Sci. U.S.A. 90:6751-6755(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 27562 / DSM 10143 / JCM 3725 / LMG 13545 / NBRC 15645 / NCIMB 2046.

    Entry informationi

    Entry nameiHEX_VIBVL
    AccessioniPrimary (citable) accession number: Q04786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3