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Q04786

- HEX_VIBVL

UniProt

Q04786 - HEX_VIBVL

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Protein

Beta-hexosaminidase

Gene
hex
Organism
Vibrio vulnificus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolysis of terminal, non-reducing N-acetyl-beta-D-glucosamine residues in chitobiose and higher analogs, and in glycoproteins.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei519 – 5191Proton donor By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. chitin catabolic process Source: UniProtKB-UniPathway
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00349.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:hex
OrganismiVibrio vulnificus
Taxonomic identifieri672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Beta-hexosaminidasePRO_0000215378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 40 By similarity
Disulfide bondi377 ↔ 385 By similarity
Disulfide bondi484 ↔ 530 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ04786.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SMARTiSM01081. CHB_HEX. 1 hit.
[Graphical view]
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04786-1 [UniParc]FASTAAdd to Basket

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MASDIDQKDV DYAAKNLKLT TSLVANKPKD CPPEAPWGAC YRVEINLENT    50
GSKSLNENVE IYFSSIHRTL GSKSEEFKVE HINGDLHKIT TTEKFKGLKG 100
GKTKSFQVDF MNWIVSNSDF MPNYYVASEH LEGRNILNTV PIDAVHITEE 150
VSGFTTGIKH TPNQLKRTAN DLLPAATATT RYEQYSKVKD LGADAVSAHI 200
LPTPLETSVH EGSLNIAQGI NIVSDALPAD QVEALNFRFE TLGVNTGTGV 250
PVNVTIKADS SKKSGSYTLD VTSSGIRIVG VDKAGAFYGV QSLAGLVTVG 300
KDTINQVSIN DEPRLDYRGM HMDVSRNFHS KELVFRFLDQ MAAYKMNKFH 350
FHLADDEGWR LEINGLPELT QVGAHRCHDV EQNKCMMPQL GSGAELPNNG 400
SGYYTREDYK EILAYASARN IQVIPSMDMP GHSLAAVKSM EARYRKFMAE 450
GDVVKAEMYL LSDPNDTTQY YSIQHYQDNT INPCMESSFV FMDKVIDEIN 500
KLHKEGGQPL TDYHIGADET AGAWGDSPEC RKMFVAPESG VKNAKDINGY 550
FINRISHILD AKGLTLGAWN DGLSHKALDA SSLAGNPPKA WVWGTMFWGG 600
VDQYNSFANK GYDVVVTPPD AYYFDMPYEN DPEERGYYWA TRFNDTKKVF 650
SFMPENVPAN VEWMTDRMGA KISATTGEKT HDFLGVQGAL WSETIRTDAQ 700
VEYMVLPRMI AVAERGWHKA SWEEEHKEGI TYTSNVDGHE GTTHLNDNIA 750
TRDADWAHFS NILGYKEMPK LDKAGITYRL PVLGAVIKNN ILDVVTEFHG 800
VAIQYSLDGK TWHKYDDTKK PQVSTKALVR SVSTNGRTGR AVEVLAK 847
Length:847
Mass (Da):94,277
Last modified:November 1, 1995 - v1
Checksum:i3C4405EFA34F3D14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04544 Genomic DNA. Translation: AAA27527.1.
PIRiA48228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04544 Genomic DNA. Translation: AAA27527.1 .
PIRi A48228.

3D structure databases

ProteinModelPortali Q04786.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00349 .

Family and domain databases

Gene3Di 2.60.40.290. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR014756. Ig_E-set.
[Graphical view ]
Pfami PF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SMARTi SM01081. CHB_HEX. 1 hit.
[Graphical view ]
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases."
    Somerville C.C., Colwell R.R.
    Proc. Natl. Acad. Sci. U.S.A. 90:6751-6755(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 27562 / DSM 10143 / JCM 3725 / LMG 13545 / NBRC 15645 / NCIMB 2046.

Entry informationi

Entry nameiHEX_VIBVL
AccessioniPrimary (citable) accession number: Q04786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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