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Q04786 (HEX_VIBVL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
Gene names
Name:hex
OrganismVibrio vulnificus
Taxonomic identifier672 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length847 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolysis of terminal, non-reducing N-acetyl-beta-D-glucosamine residues in chitobiose and higher analogs, and in glycoproteins.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Pathway

Glycan degradation; chitin degradation.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 847847Beta-hexosaminidase
PRO_0000215378

Sites

Active site5191Proton donor By similarity

Amino acid modifications

Disulfide bond31 ↔ 40 By similarity
Disulfide bond377 ↔ 385 By similarity
Disulfide bond484 ↔ 530 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04786 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3C4405EFA34F3D14

FASTA84794,277
        10         20         30         40         50         60 
MASDIDQKDV DYAAKNLKLT TSLVANKPKD CPPEAPWGAC YRVEINLENT GSKSLNENVE 

        70         80         90        100        110        120 
IYFSSIHRTL GSKSEEFKVE HINGDLHKIT TTEKFKGLKG GKTKSFQVDF MNWIVSNSDF 

       130        140        150        160        170        180 
MPNYYVASEH LEGRNILNTV PIDAVHITEE VSGFTTGIKH TPNQLKRTAN DLLPAATATT 

       190        200        210        220        230        240 
RYEQYSKVKD LGADAVSAHI LPTPLETSVH EGSLNIAQGI NIVSDALPAD QVEALNFRFE 

       250        260        270        280        290        300 
TLGVNTGTGV PVNVTIKADS SKKSGSYTLD VTSSGIRIVG VDKAGAFYGV QSLAGLVTVG 

       310        320        330        340        350        360 
KDTINQVSIN DEPRLDYRGM HMDVSRNFHS KELVFRFLDQ MAAYKMNKFH FHLADDEGWR 

       370        380        390        400        410        420 
LEINGLPELT QVGAHRCHDV EQNKCMMPQL GSGAELPNNG SGYYTREDYK EILAYASARN 

       430        440        450        460        470        480 
IQVIPSMDMP GHSLAAVKSM EARYRKFMAE GDVVKAEMYL LSDPNDTTQY YSIQHYQDNT 

       490        500        510        520        530        540 
INPCMESSFV FMDKVIDEIN KLHKEGGQPL TDYHIGADET AGAWGDSPEC RKMFVAPESG 

       550        560        570        580        590        600 
VKNAKDINGY FINRISHILD AKGLTLGAWN DGLSHKALDA SSLAGNPPKA WVWGTMFWGG 

       610        620        630        640        650        660 
VDQYNSFANK GYDVVVTPPD AYYFDMPYEN DPEERGYYWA TRFNDTKKVF SFMPENVPAN 

       670        680        690        700        710        720 
VEWMTDRMGA KISATTGEKT HDFLGVQGAL WSETIRTDAQ VEYMVLPRMI AVAERGWHKA 

       730        740        750        760        770        780 
SWEEEHKEGI TYTSNVDGHE GTTHLNDNIA TRDADWAHFS NILGYKEMPK LDKAGITYRL 

       790        800        810        820        830        840 
PVLGAVIKNN ILDVVTEFHG VAIQYSLDGK TWHKYDDTKK PQVSTKALVR SVSTNGRTGR 


AVEVLAK 

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References

[1]"Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases."
Somerville C.C., Colwell R.R.
Proc. Natl. Acad. Sci. U.S.A. 90:6751-6755(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 27562 / DSM 10143 / JCM 3725 / LMG 13545 / NBRC 15645 / NCIMB 2046.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04544 Genomic DNA. Translation: AAA27527.1.
PIRA48228.

3D structure databases

ProteinModelPortalQ04786.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00349.

Family and domain databases

Gene3D2.60.40.290. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR014756. Ig_E-set.
[Graphical view]
PfamPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PRINTSPR00738. GLHYDRLASE20.
SMARTSM01081. CHB_HEX. 1 hit.
[Graphical view]
SUPFAMSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEX_VIBVL
AccessionPrimary (citable) accession number: Q04786
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries