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Protein

Lanosterol synthase

Gene

ERG7

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

Pathwayi: lanosterol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Squalene monooxygenase (ERG1)
  3. Lanosterol synthase (ERG7)
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Proton acceptorBy similarity
Active sitei450 – 4501Proton donorBy similarity

GO - Molecular functioni

  • lanosterol synthase activity Source: CGD

GO - Biological processi

  • ergosterol biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00767; UER00753.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol synthase (EC:5.4.99.7)
Alternative name(s):
2,3-epoxysqualene--lanosterol cyclase
Oxidosqualene--lanosterol cyclase
Short name:
OSC
Gene namesi
Name:ERG7
ORF Names:CaO19.1570
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000184383. ERG7.

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075056.
DrugBankiDB00239. Oxiconazole.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Lanosterol synthasePRO_0000072654Add
BLAST

Interactioni

Chemistry

BindingDBiQ04782.

Structurei

3D structure databases

ProteinModelPortaliQ04782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati117 – 15943PFTB 1Add
BLAST
Repeati561 – 60242PFTB 2Add
BLAST
Repeati611 – 65747PFTB 3Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ04782.
KOiK01852.
OrthoDBiEOG70610B.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYSEEIGLP KTDISRWRLR SDALGRETWH YLSQSECESE PQSTFVQWLL
60 70 80 90 100
ESPDFPSPPS SDIHTSGEAA RKGADFLKLL QLDNGIFPCQ YKGPMFMTIG
110 120 130 140 150
YVTANYYSKT EIPEPYRVEM IRYIVNTAHP VDGGWGLHSV DKSTCFGTTM
160 170 180 190 200
NYVCLRLLGM EKDHPVLVKA RKTLHRLGGA IKNPHWGKAW LSILNLYEWE
210 220 230 240 250
GVNPAPPELW RLPYWLPIHP AKWWVHTRAI YLPLGYTSAN RVQCELDPLL
260 270 280 290 300
KEIRNEIYVP SQLPYESIKF GNQRNNVCGV DLYYPHTKIL DFANSILSKW
310 320 330 340 350
EAVRPKWLLN WVNKKVYDLI VKEYQNTEYL CIAPVSFAFN MVVTCHYEGS
360 370 380 390 400
ESENFKKLQN RMNDVLFHGP QGMTVMGTNG VQVWDAAFMV QYFFMTGLVD
410 420 430 440 450
DPKYHDMIRK SYLFLVRSQF TENCVDGSFR DRRKGAWPFS TKEQGYTVSD
460 470 480 490 500
CTAEAMKAII MVRNHASFAD IRDEIKDENL FDAVEVLLQI QNVGEWEYGS
510 520 530 540 550
FSTYEGIKAP LLLEKLNPAE VFNNIMVEYP YVECTDSSVL GLTYFAKYYP
560 570 580 590 600
DYKPELIQKT ISSAIQYILD SQDNIDGSWY GCWGICYTYA SMFALEALHT
610 620 630 640 650
VGLDYESSSA VKKGCDFLIS KQLPDGGWSE SMKGCETHSY VNGENSLVVQ
660 670 680 690 700
SAWALIGLIL GNYPDEEPIK RGIQFLMKRQ LPTGEWKYED IEGVFNHSCA
710 720
IEYPSYRFLF PIKALGLYKN KYGDKVLV
Length:728
Mass (Da):83,715
Last modified:October 1, 1993 - v1
Checksum:i98A6289237A074B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04305 Genomic DNA. Translation: AAA34342.1.
AACQ01000007 Genomic DNA. Translation: EAL03873.1.
PIRiJN0664.
RefSeqiXP_722612.1. XM_717519.1.

Genome annotation databases

EnsemblFungiiEAL03873; EAL03873; CaO19.1570.
GeneIDi3635761.
KEGGical:CaO19.1570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04305 Genomic DNA. Translation: AAA34342.1.
AACQ01000007 Genomic DNA. Translation: EAL03873.1.
PIRiJN0664.
RefSeqiXP_722612.1. XM_717519.1.

3D structure databases

ProteinModelPortaliQ04782.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ04782.
ChEMBLiCHEMBL1075056.
DrugBankiDB00239. Oxiconazole.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL03873; EAL03873; CaO19.1570.
GeneIDi3635761.
KEGGical:CaO19.1570.

Organism-specific databases

CGDiCAL0000184383. ERG7.

Phylogenomic databases

InParanoidiQ04782.
KOiK01852.
OrthoDBiEOG70610B.

Enzyme and pathway databases

UniPathwayiUPA00767; UER00753.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiERG7_CANAL
AccessioniPrimary (citable) accession number: Q04782
Secondary accession number(s): Q5AM05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 20, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.