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Q04779

- RCO1_YEAST

UniProt

Q04779 - RCO1_YEAST

Protein

Transcriptional regulatory protein RCO1

Gene

RCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri260 – 30950PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 47259PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone deacetylation Source: SGD
    2. negative regulation of antisense RNA transcription Source: SGD
    3. regulation of DNA-dependent DNA replication initiation Source: SGD
    4. transcription elongation from RNA polymerase II promoter Source: SGD
    5. transfer RNA gene-mediated silencing Source: SGD

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32777-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein RCO1
    Gene namesi
    Name:RCO1
    Ordered Locus Names:YMR075W
    ORF Names:YM9916.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR075w.
    SGDiS000004680. RCO1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. histone deacetylase complex Source: SGD
    2. Rpd3S complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Transcriptional regulatory protein RCO1PRO_0000203282Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei68 – 681Phosphoserine1 Publication
    Modified residuei683 – 6831Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ04779.
    PaxDbiQ04779.
    PeptideAtlasiQ04779.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04779.

    Interactioni

    Subunit structurei

    Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1.1 Publication

    Protein-protein interaction databases

    BioGridi35250. 237 interactions.
    DIPiDIP-1959N.
    IntActiQ04779. 50 interactions.
    MINTiMINT-497703.
    STRINGi4932.YMR075W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04779.
    SMRiQ04779. Positions 259-307, 437-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 3016Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri260 – 30950PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 47259PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG145066.
    GeneTreeiENSGT00530000063984.
    HOGENOMiHOG000066043.
    OMAiFLCCDTC.
    OrthoDBiEOG72C57X.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 2 hits.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSKKDTTR SPSHSNSSSP SSSSLSSSSS KEKKRPKRLS SQNVNYDLKR    50
    RKIITSEGIE RSFKNEHSNL AVEDNIPEEE PKELLEKDSK GNIIKLNEPS 100
    TISEDSKVSV TGLPLNKGPS EKIKRESLWN YRKNLGGQSN NSEMTLVPSK 150
    RFTQVPKNFQ DLNRNDLKTF LTENMTEESN IRSTIGWNGD IINRTRDREP 200
    ESDRDNKKLS NIRTKIILST NATYDSKSKL FGQNSIKSTS NASEKIFRDK 250
    NNSTIDFENE DFCSACNQSG SFLCCDTCPK SFHFLCLDPP IDPNNLPKGD 300
    WHCNECKFKI FINNSMATLK KIESNFIKQN NNVKIFAKLL FNIDSHNPKQ 350
    FQLPNYIKET FPAVKTGSRG QYSDENDKIP LTDRQLFNTS YGQSITKLDS 400
    YNPDTHIDSN SGKFLICYKC NQTRLGSWSH PENSRLIMTC DYCQTPWHLD 450
    CVPRASFKNL GSKWKCPLHS PTKVYKKIHH CQEDNSVNYK VWKKQRLINK 500
    KNQLYYEPLQ KIGYQNNGNI QIIPTTSHTD YDFNQDFKIT QIDENSIKYD 550
    FFDKIYKSKM VQKRKLFQFQ ESLIDKLVSN GSQNGNSEDN MVKDIASLIY 600
    FQVSNNDKSS NNKSASKSNN LRKLWDLKEL TNVVVPNELD SIQFNDFSSD 650
    EIKHLLYLKK IIESKPKEEL LKFLNIENPE NQSE 684
    Length:684
    Mass (Da):78,836
    Last modified:November 1, 1997 - v1
    Checksum:iCFC282DC9A782E5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88800.1.
    BK006946 Genomic DNA. Translation: DAA09973.1.
    PIRiS52835.
    RefSeqiNP_013791.1. NM_001182574.1.

    Genome annotation databases

    EnsemblFungiiYMR075W; YMR075W; YMR075W.
    GeneIDi855097.
    KEGGisce:YMR075W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88800.1 .
    BK006946 Genomic DNA. Translation: DAA09973.1 .
    PIRi S52835.
    RefSeqi NP_013791.1. NM_001182574.1.

    3D structure databases

    ProteinModelPortali Q04779.
    SMRi Q04779. Positions 259-307, 437-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35250. 237 interactions.
    DIPi DIP-1959N.
    IntActi Q04779. 50 interactions.
    MINTi MINT-497703.
    STRINGi 4932.YMR075W.

    Proteomic databases

    MaxQBi Q04779.
    PaxDbi Q04779.
    PeptideAtlasi Q04779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR075W ; YMR075W ; YMR075W .
    GeneIDi 855097.
    KEGGi sce:YMR075W.

    Organism-specific databases

    CYGDi YMR075w.
    SGDi S000004680. RCO1.

    Phylogenomic databases

    eggNOGi NOG145066.
    GeneTreei ENSGT00530000063984.
    HOGENOMi HOG000066043.
    OMAi FLCCDTC.
    OrthoDBi EOG72C57X.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32777-MONOMER.

    Miscellaneous databases

    NextBioi 978414.

    Gene expression databases

    Genevestigatori Q04779.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 2 hits.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION IN THE RPD3C(S) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION OF THE RPD3C(S) COMPLEX.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68 AND SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRCO1_YEAST
    AccessioniPrimary (citable) accession number: Q04779
    Secondary accession number(s): D6VZP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 486 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3