Q04779 (RCO1_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Transcriptional regulatory protein RCO1 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 684 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Ref.5 |
| Subunit structure | Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1. |
| Subcellular location | |
| Miscellaneous | Present with 486 molecules/cell in log phase SD medium. Ref.4 |
| Sequence similarities | Contains 2 PHD-type zinc fingers. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Chromatin regulator Repressor |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | histone deacetylation Inferred from mutant phenotype. Source: SGD negative regulation of antisense RNA transcriptionInferred from mutant phenotype. Source: SGD regulation of DNA-dependent DNA replication initiationInferred from mutant phenotype. Source: SGD transcription elongation from RNA polymerase II promoterInferred from genetic interaction. Source: SGD |
| Cellular component | Rpd3L complex Inferred from direct assay. Source: SGD Rpd3S complexInferred from direct assay Ref.5. Source: SGD |
| Molecular function | zinc ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 684 | 684 | Transcriptional regulatory protein RCO1 | PRO_0000203282 | |||||
Regions | |||||||||
| Zinc finger | 260 – 309 | 50 | PHD-type 1 | ||||||
| Zinc finger | 414 – 472 | 59 | PHD-type 2; atypical | ||||||
| Compositional bias | 15 – 30 | 16 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 68 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 368 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 394 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 683 | 1 | Phosphoserine Ref.6 Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G.Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [3] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [5] | "Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex." Keogh M.-C., Kurdistani S.K., Morris S.A., Ahn S.H., Podolny V., Collins S.R., Schuldiner M., Chin K., Punna T., Thompson N.J., Boone C., Emili A., Weissman J.S., Hughes T.R., Strahl B.D., Grunstein M., Greenblatt J.F., Buratowski S., Krogan N.J. Cell 123:593-605(2005) [PubMed: 16286008] [Abstract] Cited for: IDENTIFICATION IN THE RPD3C(S) COMPLEX, MASS SPECTROMETRY, FUNCTION OF THE RPD3C(S) COMPLEX. |
| [6] | "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, MASS SPECTROMETRY. Strain: YAL6B. |
| [7] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-368; SER-394 AND SER-683, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z48952 Genomic DNA. Translation: CAA88800.1. BK006946 Genomic DNA. Translation: DAA09973.1. |
| PIR | S52835. |
| RefSeq | NP_013791.1. NM_001182574.1. |
3D structure databases | |
| ProteinModelPortal | Q04779. |
| SMR | Q04779. Positions 257-309, 329-365, 415-471. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1959N. |
| IntAct | Q04779. 53 interactions. |
| MINT | MINT-497703. |
| STRING | Q04779. |
Proteomic databases | |
| PeptideAtlas | Q04779. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YMR075W; YMR075W; YMR075W. |
| GeneID | 855097. |
| KEGG | sce:YMR075W. |
| NMPDR | fig|4932.3.peg.4838. |
Organism-specific databases | |
| CYGD | YMR075w. |
| SGD | S000004680. RCO1. |
Phylogenomic databases | |
| eggNOG | fuNOG04705. |
| GeneTree | EFGT00050000000952. |
| HOGENOM | HBG203412. |
| OMA | FLCCDTC. |
| OrthoDB | EOG4TQQJV. |
Gene expression databases | |
| ArrayExpress | Q04779. |
| Genevestigator | Q04779. |
| GermOnline | YMR075W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] |
| Gene3D | G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 2 hits. |
| Pfam | PF00628. PHD. 1 hit. [Graphical view] |
| SMART | SM00249. PHD. 2 hits. [Graphical view] |
| SUPFAM | SSF57903. FYVE_PHD_ZnF. 2 hits. |
| PROSITE | PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 978414. |
Entry information
| Entry name | RCO1_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q04779 Secondary accession number(s): D6VZP9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIII Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with