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Protein

Transcriptional regulatory protein RCO1

Gene

RCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 309PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri414 – 472PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

  • histone deacetylation Source: SGD
  • negative regulation of antisense RNA transcription Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
  • transfer RNA gene-mediated silencing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32777-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RCO1
Gene namesi
Name:RCO1
Ordered Locus Names:YMR075W
ORF Names:YM9916.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR075W.
SGDiS000004680. RCO1.

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: SGD
  • Rpd3S complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032821 – 684Transcriptional regulatory protein RCO1Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04779.
PRIDEiQ04779.

PTM databases

iPTMnetiQ04779.

Interactioni

Subunit structurei

Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35250. 240 interactors.
DIPiDIP-1959N.
IntActiQ04779. 50 interactors.
MINTiMINT-497703.

Structurei

3D structure databases

ProteinModelPortaliQ04779.
SMRiQ04779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 30Poly-SerAdd BLAST16

Sequence similaritiesi

Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 309PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri414 – 472PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00440000033777.
HOGENOMiHOG000066043.
InParanoidiQ04779.
OMAiFLCCDTC.
OrthoDBiEOG092C2VA1.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSKKDTTR SPSHSNSSSP SSSSLSSSSS KEKKRPKRLS SQNVNYDLKR
60 70 80 90 100
RKIITSEGIE RSFKNEHSNL AVEDNIPEEE PKELLEKDSK GNIIKLNEPS
110 120 130 140 150
TISEDSKVSV TGLPLNKGPS EKIKRESLWN YRKNLGGQSN NSEMTLVPSK
160 170 180 190 200
RFTQVPKNFQ DLNRNDLKTF LTENMTEESN IRSTIGWNGD IINRTRDREP
210 220 230 240 250
ESDRDNKKLS NIRTKIILST NATYDSKSKL FGQNSIKSTS NASEKIFRDK
260 270 280 290 300
NNSTIDFENE DFCSACNQSG SFLCCDTCPK SFHFLCLDPP IDPNNLPKGD
310 320 330 340 350
WHCNECKFKI FINNSMATLK KIESNFIKQN NNVKIFAKLL FNIDSHNPKQ
360 370 380 390 400
FQLPNYIKET FPAVKTGSRG QYSDENDKIP LTDRQLFNTS YGQSITKLDS
410 420 430 440 450
YNPDTHIDSN SGKFLICYKC NQTRLGSWSH PENSRLIMTC DYCQTPWHLD
460 470 480 490 500
CVPRASFKNL GSKWKCPLHS PTKVYKKIHH CQEDNSVNYK VWKKQRLINK
510 520 530 540 550
KNQLYYEPLQ KIGYQNNGNI QIIPTTSHTD YDFNQDFKIT QIDENSIKYD
560 570 580 590 600
FFDKIYKSKM VQKRKLFQFQ ESLIDKLVSN GSQNGNSEDN MVKDIASLIY
610 620 630 640 650
FQVSNNDKSS NNKSASKSNN LRKLWDLKEL TNVVVPNELD SIQFNDFSSD
660 670 680
EIKHLLYLKK IIESKPKEEL LKFLNIENPE NQSE
Length:684
Mass (Da):78,836
Last modified:November 1, 1997 - v1
Checksum:iCFC282DC9A782E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88800.1.
BK006946 Genomic DNA. Translation: DAA09973.1.
PIRiS52835.
RefSeqiNP_013791.1. NM_001182574.1.

Genome annotation databases

EnsemblFungiiYMR075W; YMR075W; YMR075W.
GeneIDi855097.
KEGGisce:YMR075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88800.1.
BK006946 Genomic DNA. Translation: DAA09973.1.
PIRiS52835.
RefSeqiNP_013791.1. NM_001182574.1.

3D structure databases

ProteinModelPortaliQ04779.
SMRiQ04779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35250. 240 interactors.
DIPiDIP-1959N.
IntActiQ04779. 50 interactors.
MINTiMINT-497703.

PTM databases

iPTMnetiQ04779.

Proteomic databases

MaxQBiQ04779.
PRIDEiQ04779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR075W; YMR075W; YMR075W.
GeneIDi855097.
KEGGisce:YMR075W.

Organism-specific databases

EuPathDBiFungiDB:YMR075W.
SGDiS000004680. RCO1.

Phylogenomic databases

GeneTreeiENSGT00440000033777.
HOGENOMiHOG000066043.
InParanoidiQ04779.
OMAiFLCCDTC.
OrthoDBiEOG092C2VA1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32777-MONOMER.

Miscellaneous databases

PROiQ04779.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCO1_YEAST
AccessioniPrimary (citable) accession number: Q04779
Secondary accession number(s): D6VZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 486 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.