Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional regulatory protein RCO1

Gene

RCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.1 Publication

Miscellaneous

Present with 486 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 309PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri414 – 472PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

  • histone deacetylation Source: SGD
  • negative regulation of antisense RNA transcription Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
  • transfer RNA gene-mediated silencing Source: SGD

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32777-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RCO1
Gene namesi
Name:RCO1
Ordered Locus Names:YMR075W
ORF Names:YM9916.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR075W
SGDiS000004680 RCO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032821 – 684Transcriptional regulatory protein RCO1Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04779
PaxDbiQ04779
PRIDEiQ04779

PTM databases

iPTMnetiQ04779

Interactioni

Subunit structurei

Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35250, 372 interactors
DIPiDIP-1959N
IntActiQ04779, 70 interactors
MINTiQ04779
STRINGi4932.YMR075W

Structurei

3D structure databases

ProteinModelPortaliQ04779
SMRiQ04779
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 30Poly-SerAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 309PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri414 – 472PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00440000033777
HOGENOMiHOG000066043
InParanoidiQ04779
OMAiFLCCDTC
OrthoDBiEOG092C2VA1

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSKKDTTR SPSHSNSSSP SSSSLSSSSS KEKKRPKRLS SQNVNYDLKR
60 70 80 90 100
RKIITSEGIE RSFKNEHSNL AVEDNIPEEE PKELLEKDSK GNIIKLNEPS
110 120 130 140 150
TISEDSKVSV TGLPLNKGPS EKIKRESLWN YRKNLGGQSN NSEMTLVPSK
160 170 180 190 200
RFTQVPKNFQ DLNRNDLKTF LTENMTEESN IRSTIGWNGD IINRTRDREP
210 220 230 240 250
ESDRDNKKLS NIRTKIILST NATYDSKSKL FGQNSIKSTS NASEKIFRDK
260 270 280 290 300
NNSTIDFENE DFCSACNQSG SFLCCDTCPK SFHFLCLDPP IDPNNLPKGD
310 320 330 340 350
WHCNECKFKI FINNSMATLK KIESNFIKQN NNVKIFAKLL FNIDSHNPKQ
360 370 380 390 400
FQLPNYIKET FPAVKTGSRG QYSDENDKIP LTDRQLFNTS YGQSITKLDS
410 420 430 440 450
YNPDTHIDSN SGKFLICYKC NQTRLGSWSH PENSRLIMTC DYCQTPWHLD
460 470 480 490 500
CVPRASFKNL GSKWKCPLHS PTKVYKKIHH CQEDNSVNYK VWKKQRLINK
510 520 530 540 550
KNQLYYEPLQ KIGYQNNGNI QIIPTTSHTD YDFNQDFKIT QIDENSIKYD
560 570 580 590 600
FFDKIYKSKM VQKRKLFQFQ ESLIDKLVSN GSQNGNSEDN MVKDIASLIY
610 620 630 640 650
FQVSNNDKSS NNKSASKSNN LRKLWDLKEL TNVVVPNELD SIQFNDFSSD
660 670 680
EIKHLLYLKK IIESKPKEEL LKFLNIENPE NQSE
Length:684
Mass (Da):78,836
Last modified:November 1, 1997 - v1
Checksum:iCFC282DC9A782E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA Translation: CAA88800.1
BK006946 Genomic DNA Translation: DAA09973.1
PIRiS52835
RefSeqiNP_013791.1, NM_001182574.1

Genome annotation databases

EnsemblFungiiYMR075W; YMR075W; YMR075W
GeneIDi855097
KEGGisce:YMR075W

Similar proteinsi

Entry informationi

Entry nameiRCO1_YEAST
AccessioniPrimary (citable) accession number: Q04779
Secondary accession number(s): D6VZP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health