ID   ALDC_BACSU              Reviewed;         255 AA.
AC   Q04777;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   16-JUN-2009, entry version 70.
DE   RecName: Full=Alpha-acetolactate decarboxylase;
DE            EC=4.1.1.5;
GN   Name=alsD; OrderedLocusNames=BSU36000;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93286000; PubMed=7685336;
RA   Renna M.C., Najimudin N., Winik L.R., Zahler S.A.;
RT   "Regulation of the Bacillus subtilis alsS, alsD, and alsR genes
RT   involved in post-exponential-phase production of acetoin.";
RL   J. Bacteriol. 175:3863-3875(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98015417; PubMed=9353933;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H.,
RA   Villani G., Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   REGULATION.
RX   MEDLINE=20270134; PubMed=10809684;
RX   DOI=10.1128/JB.182.11.3072-3080.2000;
RA   Cruz Ramos H., Hoffmann T., Marino M., Nedjari H., Presecan-Siedel E.,
RA   Dreesen O., Glaser P., Jahn D.;
RT   "Fermentative metabolism of Bacillus subtilis: physiology and
RT   regulation of gene expression.";
RL   J. Bacteriol. 182:3072-3080(2000).
CC   -!- FUNCTION: Converts acetolactate into acetoin, which can be
CC       excreted by the cells. This may be a mechanism for controlling the
CC       internal pH of cells in the stationary stage.
CC   -!- CATALYTIC ACTIVITY: (2S)-2-hydroxy-2-methyl-3-oxobutanoate = (3R)-
CC       3-hydroxybutan-2-one + CO(2).
CC   -!- PATHWAY: Polyol metabolism; 2,3-butanediol biosynthesis; (R,R)-
CC       2,3-butanediol from pyruvate: step 2/3.
CC   -!- INDUCTION: Strongly induced under anaerobic conditions. Activated
CC       by resDE, fnr and arfM.
CC   -!- SIMILARITY: Belongs to the alpha-acetolactate decarboxylase
CC       family.
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DR   EMBL; L04470; AAA22223.1; -; Genomic_DNA.
DR   EMBL; Z93767; CAB07786.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15617.1; -; Genomic_DNA.
DR   PIR; B47126; B47126.
DR   RefSeq; NP_391481.1; -.
DR   GeneID; 936857; -.
DR   GenomeReviews; AL009126_GR; BSU36000.
DR   KEGG; bsu:BSU36000; -.
DR   NMPDR; fig|224308.1.peg.3607; -.
DR   SubtiList; BG10472; alsD.
DR   HOGENOM; Q04777; -.
DR   OMA; Q04777; DGEMIAF.
DR   BioCyc; BSUB224308:BSU3598-MON; -.
DR   BRENDA; 4.1.1.5; 150.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0047605; F:acetolactate decarboxylase activity; IEA:EC.
DR   GO; GO:0045151; P:acetoin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0019751; P:polyol metabolic process; IEA:InterPro.
DR   InterPro; IPR005128; Acetolactate_a_deCO2ase.
DR   Pfam; PF03306; AAL_decarboxy; 1.
DR   PIRSF; PIRSF001332; Acetolac_decarb; 1.
DR   ProDom; PD006931; Acetolac_decarb; 1.
DR   TIGRFAMs; TIGR01252; acetolac_decarb; 1.
PE   2: Evidence at transcript level;
KW   Acetoin biosynthesis; Complete proteome; Decarboxylase; Lyase.
FT   CHAIN         1    255       Alpha-acetolactate decarboxylase.
FT                                /FTId=PRO_0000218438.
SQ   SEQUENCE   255 AA;  28799 MW;  1B90C69424D39B10 CRC64;
     MKRESNIQVL SRGQKDQPVS QIYQVSTMTS LLDGVYDGDF ELSEIPKYGD FGIGTFNKLD
     GELIGFDGEF YRLRSDGTAT PVQNGDRSPF CSFTFFTPDM THKIDAKMTR EDFEKEINSM
     LPSRNLFYAI RIDGLFKKVQ TRTVELQEKP YVPMVEAVKT QPIFNFDNVR GTIVGFLTPA
     YANGIAVSGY HLHFIDEGRN SGGHVFDYVL EDCTVTISQK MNMNLRLPNT ADFFNANLDN
     PDFAKDIETT EGSPE
//