Q04773 (YMW4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein YMR074C

Gene names

Ordered Locus Names:	YMR074C
ORF Names:	YM9916.13C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 2550 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the PDCD5 family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from mutant phenotype PubMed 19469552. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 145

145

Uncharacterized protein YMR074C

PRO_0000121548

Amino acid modifications

Modified residue

121

1

Phosphoserine Ref.5

Modified residue

126

1

Phosphoserine Ref.4 Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

145

Helix Strand Turn

Details...

Helix

3 – 15

13

Helix

44 – 47

4

Helix

52 – 64

13

Helix

66 – 82

17

Helix

91 – 104

14

Sequences

	Sequence		Length	Mass (Da)
	Q04773 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 36EEA1AFA3F6135D	FASTA	145	15,977
	10 20 30 40 50 60 MDPELQAIRE ARLAQLKNNS GGTNGDRNSG ANNGGGENSA PVGAAIANFL EPQALERLSR 70 80 90 100 110 120 VALVRRDRAQ AVETYLKKLI ATNNVTHKIT EAEIVSILNG IAKQQNSQNN SKIIFERKDF 130 140 SEDLNSFDKQ NAKNDDDEDD DDFFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, MASS SPECTROMETRY.
[5]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121 AND SER-126, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z48952 Genomic DNA. Translation: CAA88799.1.
BK006946 Genomic DNA. Translation: DAA09972.1.

PIR

S52834.

RefSeq

NP_013790.1. NM_001182572.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FH0	NMR	-	A	36-116	[»]
2JXN	NMR	-	A	1-116	[»]

ProteinModelPortal

Q04773.

SMR

Q04773. Positions 1-116.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5242N.

MINT

MINT-536983.

STRING

4932.YMR074C.

Proteomic databases

PaxDb

Q04773.

PeptideAtlas

Q04773.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YMR074C; YMR074C; YMR074C.

GeneID

855096.

KEGG

sce:YMR074C.

Organism-specific databases

CYGD

YMR074c.

SGD

S000004678. YMR074C.

Phylogenomic databases

eggNOG

COG2118.

GeneTree

ENSGT00390000011085.

HOGENOM

HOG000194121.

KO

K06875.

OMA

IIFDRRE.

OrthoDB

EOG4XSQ0Q.

Gene expression databases

Genevestigator

Q04773.

GermOnline

YMR074C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

1.10.8.140. 1 hit.

InterPro

IPR002836. TFAR19_DNA-bd.
[Graphical view]

PANTHER

PTHR10840. PTHR10840. 1 hit.

Pfam

PF01984. dsDNA_bind. 1 hit.
[Graphical view]

PIRSF

PIRSF015730. TFAR19. 1 hit.

SUPFAM

SSF46950. TFAR19-related. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q04773.

NextBio

978411.

Entry information

Entry name

YMW4_YEAST

Accession

Primary (citable) accession number: Q04773
Secondary accession number(s): D6VZP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program