ID   CDK2_ENTHI              Reviewed;         291 AA.
AC   Q04770;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Cell division protein kinase 2 homolog;
DE            EC=2.7.11.22;
GN   Name=CDC2;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Archamoebae; Entamoebidae; Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93273232; PubMed=8500762; DOI=10.1016/0378-1119(93)90720-N;
RA   Lohia A., Samuelson J.;
RT   "Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a
RT   protein kinase p34cdc2 homologue.";
RL   Gene 127:203-207(1993).
CC   -!- FUNCTION: Probably involved in the control of the cell cycle.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates
CC       the enzyme, while phosphorylation at Thr-158 activates it (By
CC       similarity).
CC   -!- SUBUNIT: Forms a stable but non-covalent complex with a regulatory
CC       subunit and with a cyclin (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; L03810; AAA51480.1; -; Genomic_DNA.
DR   PIR; JN0631; JN0631.
DR   HSSP; P24941; 1DI8.
DR   BRENDA; 2.7.11.22; 323.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Kinase; Mitosis;
KW   Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase;
KW   Transferase.
FT   CHAIN         1    291       Cell division protein kinase 2 homolog.
FT                                /FTId=PRO_0000085775.
FT   DOMAIN        4    283       Protein kinase.
FT   NP_BIND      10     18       ATP (By similarity).
FT   ACT_SITE    125    125       Proton acceptor (By similarity).
FT   BINDING      33     33       ATP (By similarity).
FT   MOD_RES      14     14       Phosphothreonine (By similarity).
FT   MOD_RES      15     15       Phosphotyrosine (By similarity).
FT   MOD_RES     158    158       Phosphothreonine; by CAK (By similarity).
SQ   SEQUENCE   291 AA;  33845 MW;  205A078246E153B7 CRC64;
     MTRYEKKQQL GEGTYGVVCK AWDTVCNRYV ALKKIKQERE DDGIPVTSVR EIAVLLELKH
     PNVVDLYDIY LEDKFLYLVF EFCDEDLYQF MSRSSKIPIN ETRSIVYQIL QGLAFCHYHQ
     ILHRDMKPQN ILINKNGTIK LGEFGLARLT TINDRKYTSE VVTLWYRAPE ILLGATQYGG
     AIDIWSTAAI FGELINKEEL FKGRCKIDQL FKIFSQLGTP TEDIWNGVTK LPFYLSTFPK
     WKAKDLHTIF HTDERAVDLL QKMFIYTPEK RISAADALKH PFFDPLNKPN N
//