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Q04770 (CDK2_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division protein kinase 2 homolog

EC=2.7.11.22
Gene names
Name:CDC2
OrganismEntamoeba histolytica
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Cell division protein kinase 2 homolog
PRO_0000085775

Regions

Domain4 – 283280Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1251Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1581Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04770 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 205A078246E153B7

FASTA29133,845
        10         20         30         40         50         60 
MTRYEKKQQL GEGTYGVVCK AWDTVCNRYV ALKKIKQERE DDGIPVTSVR EIAVLLELKH 

        70         80         90        100        110        120 
PNVVDLYDIY LEDKFLYLVF EFCDEDLYQF MSRSSKIPIN ETRSIVYQIL QGLAFCHYHQ 

       130        140        150        160        170        180 
ILHRDMKPQN ILINKNGTIK LGEFGLARLT TINDRKYTSE VVTLWYRAPE ILLGATQYGG 

       190        200        210        220        230        240 
AIDIWSTAAI FGELINKEEL FKGRCKIDQL FKIFSQLGTP TEDIWNGVTK LPFYLSTFPK 

       250        260        270        280        290 
WKAKDLHTIF HTDERAVDLL QKMFIYTPEK RISAADALKH PFFDPLNKPN N 

« Hide

References

[1]"Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34cdc2 homologue."
Lohia A., Samuelson J.
Gene 127:203-207(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L03810 Genomic DNA. Translation: AAA51480.1.
PIRJN0631.

3D structure databases

ProteinModelPortalQ04770.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.

Enzyme and pathway databases

BRENDA2.7.11.22. 2080.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK2_ENTHI
AccessionPrimary (citable) accession number: Q04770
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families