Reviewed, UniProtKB/Swiss-Prot Q04770 (CDK2_ENTHI)

Names and origin

Protein names

Recommended name:
    Cell division protein kinase 2 homolog
    EC=2.7.11.22

Gene names

Name:

CDC2

Organism

Entamoeba histolytica

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.
Subunit structure	Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Cell division protein kinase 2 homolog		PRO_0000085775
Regions
	Domain	4 – 283	280	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	125	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Amino acid modifications
	Modified residue	14	1	Phosphothreonine By similarity
	Modified residue	15	1	Phosphotyrosine By similarity
	Modified residue	158	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04770-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 205A078246E153B7	FASTA	291	33,845
	10 20 30 40 50 60 MTRYEKKQQL GEGTYGVVCK AWDTVCNRYV ALKKIKQERE DDGIPVTSVR EIAVLLELKH 70 80 90 100 110 120 PNVVDLYDIY LEDKFLYLVF EFCDEDLYQF MSRSSKIPIN ETRSIVYQIL QGLAFCHYHQ 130 140 150 160 170 180 ILHRDMKPQN ILINKNGTIK LGEFGLARLT TINDRKYTSE VVTLWYRAPE ILLGATQYGG 190 200 210 220 230 240 AIDIWSTAAI FGELINKEEL FKGRCKIDQL FKIFSQLGTP TEDIWNGVTK LPFYLSTFPK 250 260 270 280 290 WKAKDLHTIF HTDERAVDLL QKMFIYTPEK RISAADALKH PFFDPLNKPN N

References

[1]	"Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34cdc2 homologue." Lohia A., Samuelson J. Gene 127:203-207(1993) [PubMed: 8500762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L03810 Genomic DNA. Translation: AAA51480.1.
PIR	JN0631.
3D structure databases
HSSP	HSSP built from PDB template 1DI8 based on UniProtKB P24941.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 323.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK2_ENTHI

Accession

Primary (citable) accession number: Q04770

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)