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Q04767

- TVP18_YEAST

UniProt

Q04767 - TVP18_YEAST

Protein

Golgi apparatus membrane protein TVP18

Gene

TVP18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Golgi membrane protein involved in vesicular trafficking.1 Publication

    GO - Biological processi

    1. vesicle-mediated transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32773-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi apparatus membrane protein TVP18
    Alternative name(s):
    TLG2 compartment vesicle protein of 18 kDa
    Gene namesi
    Name:TVP18
    Ordered Locus Names:YMR071C
    ORF Names:YM9916.10C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR071c.
    SGDiS000004675. TVP18.

    Subcellular locationi

    Golgi apparatus membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Golgi apparatus membrane protein TVP18PRO_0000203281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Modified residuei146 – 1461Phosphothreonine1 Publication
    Modified residuei153 – 1531Phosphothreonine2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ04767.
    PaxDbiQ04767.
    PeptideAtlasiQ04767.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04767.

    Interactioni

    Subunit structurei

    Interacts with TVP15 and YIP4.1 Publication

    Protein-protein interaction databases

    BioGridi35246. 42 interactions.
    DIPiDIP-1731N.
    IntActiQ04767. 14 interactions.
    MINTiMINT-386645.
    STRINGi4932.YMR071C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04767.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11417HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 13717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TVP18 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82114.
    HOGENOMiHOG000066042.
    OMAiSIYGQWT.
    OrthoDBiEOG72NS2V.

    Family and domain databases

    InterProiIPR019365. TVP18/Ca-channel_flower.
    [Graphical view]
    PfamiPF10233. Cg6151-P. 1 hit.
    [Graphical view]
    SMARTiSM01077. Cg6151-P. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04767-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSLGQFIN VGGMVKDLKS FNFSVYGRWF GYINIILCIA LGIANLFHVS    50
    GVIAFGIISI IQGLVILFIE IPFLLKICPL SDNFIEFIKR FETNGWRCLF 100
    YLAMAIIQYI SIAVMATSLI VVAVGLTISS ISYAVAYTKH QEFQNTNIIK 150
    NPTDDDFPHE AVVREML 167
    Length:167
    Mass (Da):18,693
    Last modified:November 1, 1997 - v1
    Checksum:i46698DC0400D3097
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88796.1.
    AY558402 Genomic DNA. Translation: AAS56728.1.
    BK006946 Genomic DNA. Translation: DAA09969.1.
    PIRiS52831.
    RefSeqiNP_013787.1. NM_001182569.1.

    Genome annotation databases

    EnsemblFungiiYMR071C; YMR071C; YMR071C.
    GeneIDi855093.
    KEGGisce:YMR071C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88796.1 .
    AY558402 Genomic DNA. Translation: AAS56728.1 .
    BK006946 Genomic DNA. Translation: DAA09969.1 .
    PIRi S52831.
    RefSeqi NP_013787.1. NM_001182569.1.

    3D structure databases

    ProteinModelPortali Q04767.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35246. 42 interactions.
    DIPi DIP-1731N.
    IntActi Q04767. 14 interactions.
    MINTi MINT-386645.
    STRINGi 4932.YMR071C.

    Proteomic databases

    MaxQBi Q04767.
    PaxDbi Q04767.
    PeptideAtlasi Q04767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR071C ; YMR071C ; YMR071C .
    GeneIDi 855093.
    KEGGi sce:YMR071C.

    Organism-specific databases

    CYGDi YMR071c.
    SGDi S000004675. TVP18.

    Phylogenomic databases

    eggNOGi NOG82114.
    HOGENOMi HOG000066042.
    OMAi SIYGQWT.
    OrthoDBi EOG72NS2V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32773-MONOMER.

    Miscellaneous databases

    NextBioi 978402.

    Gene expression databases

    Genevestigatori Q04767.

    Family and domain databases

    InterProi IPR019365. TVP18/Ca-channel_flower.
    [Graphical view ]
    Pfami PF10233. Cg6151-P. 1 hit.
    [Graphical view ]
    SMARTi SM01077. Cg6151-P. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
      Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
      Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP15 AND YIP4.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTVP18_YEAST
    AccessioniPrimary (citable) accession number: Q04767
    Secondary accession number(s): D6VZP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3