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Q04767

- TVP18_YEAST

UniProt

Q04767 - TVP18_YEAST

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Protein
Golgi apparatus membrane protein TVP18
Gene
TVP18, YMR071C, YM9916.10C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Golgi membrane protein involved in vesicular trafficking.1 Publication

GO - Biological processi

  1. vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP18
Alternative name(s):
TLG2 compartment vesicle protein of 18 kDa
Gene namesi
Name:TVP18
Ordered Locus Names:YMR071C
ORF Names:YM9916.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR071c.
SGDiS000004675. TVP18.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321Helical; Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Transmembranei98 – 11417Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 13717Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Golgi apparatus membrane protein TVP18
PRO_0000203281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Modified residuei146 – 1461Phosphothreonine1 Publication
Modified residuei153 – 1531Phosphothreonine2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ04767.
PaxDbiQ04767.
PeptideAtlasiQ04767.

Expressioni

Gene expression databases

GenevestigatoriQ04767.

Interactioni

Subunit structurei

Interacts with TVP15 and YIP4.1 Publication

Protein-protein interaction databases

BioGridi35246. 42 interactions.
DIPiDIP-1731N.
IntActiQ04767. 14 interactions.
MINTiMINT-386645.
STRINGi4932.YMR071C.

Structurei

3D structure databases

ProteinModelPortaliQ04767.

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP18 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82114.
HOGENOMiHOG000066042.
OMAiSIYGQWT.
OrthoDBiEOG72NS2V.

Family and domain databases

InterProiIPR019365. TVP18/Ca-channel_flower.
[Graphical view]
PfamiPF10233. Cg6151-P. 1 hit.
[Graphical view]
SMARTiSM01077. Cg6151-P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04767-1 [UniParc]FASTAAdd to Basket

« Hide

MALSLGQFIN VGGMVKDLKS FNFSVYGRWF GYINIILCIA LGIANLFHVS    50
GVIAFGIISI IQGLVILFIE IPFLLKICPL SDNFIEFIKR FETNGWRCLF 100
YLAMAIIQYI SIAVMATSLI VVAVGLTISS ISYAVAYTKH QEFQNTNIIK 150
NPTDDDFPHE AVVREML 167
Length:167
Mass (Da):18,693
Last modified:November 1, 1997 - v1
Checksum:i46698DC0400D3097
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48952 Genomic DNA. Translation: CAA88796.1.
AY558402 Genomic DNA. Translation: AAS56728.1.
BK006946 Genomic DNA. Translation: DAA09969.1.
PIRiS52831.
RefSeqiNP_013787.1. NM_001182569.1.

Genome annotation databases

EnsemblFungiiYMR071C; YMR071C; YMR071C.
GeneIDi855093.
KEGGisce:YMR071C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48952 Genomic DNA. Translation: CAA88796.1 .
AY558402 Genomic DNA. Translation: AAS56728.1 .
BK006946 Genomic DNA. Translation: DAA09969.1 .
PIRi S52831.
RefSeqi NP_013787.1. NM_001182569.1.

3D structure databases

ProteinModelPortali Q04767.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35246. 42 interactions.
DIPi DIP-1731N.
IntActi Q04767. 14 interactions.
MINTi MINT-386645.
STRINGi 4932.YMR071C.

Proteomic databases

MaxQBi Q04767.
PaxDbi Q04767.
PeptideAtlasi Q04767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR071C ; YMR071C ; YMR071C .
GeneIDi 855093.
KEGGi sce:YMR071C.

Organism-specific databases

CYGDi YMR071c.
SGDi S000004675. TVP18.

Phylogenomic databases

eggNOGi NOG82114.
HOGENOMi HOG000066042.
OMAi SIYGQWT.
OrthoDBi EOG72NS2V.

Enzyme and pathway databases

BioCyci YEAST:G3O-32773-MONOMER.

Miscellaneous databases

NextBioi 978402.

Gene expression databases

Genevestigatori Q04767.

Family and domain databases

InterProi IPR019365. TVP18/Ca-channel_flower.
[Graphical view ]
Pfami PF10233. Cg6151-P. 1 hit.
[Graphical view ]
SMARTi SM01077. Cg6151-P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
    Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
    Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP15 AND YIP4.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTVP18_YEAST
AccessioniPrimary (citable) accession number: Q04767
Secondary accession number(s): D6VZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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