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Q04767 (TVP18_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi apparatus membrane protein TVP18
Alternative name(s):
TLG2 compartment vesicle protein of 18 kDa
Gene names
Name:TVP18
Ordered Locus Names:YMR071C
ORF Names:YM9916.10C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Golgi membrane protein involved in vesicular trafficking. Ref.6

Subunit structure

Interacts with TVP15 and YIP4. Ref.6

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.4 Ref.5 Ref.6.

Sequence similarities

Belongs to the TVP18 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Golgi apparatus membrane protein TVP18
PRO_0000203281

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane98 – 11417Helical; Potential
Transmembrane121 – 13717Helical; Potential

Amino acid modifications

Modified residue1461Phosphothreonine Ref.8
Modified residue1531Phosphothreonine Ref.7 Ref.8
Glycosylation221N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q04767 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 46698DC0400D3097

FASTA16718,693
        10         20         30         40         50         60 
MALSLGQFIN VGGMVKDLKS FNFSVYGRWF GYINIILCIA LGIANLFHVS GVIAFGIISI 

        70         80         90        100        110        120 
IQGLVILFIE IPFLLKICPL SDNFIEFIKR FETNGWRCLF YLAMAIIQYI SIAVMATSLI 

       130        140        150        160 
VVAVGLTISS ISYAVAYTKH QEFQNTNIIK NPTDDDFPHE AVVREML 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP15 AND YIP4.
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48952 Genomic DNA. Translation: CAA88796.1.
AY558402 Genomic DNA. Translation: AAS56728.1.
BK006946 Genomic DNA. Translation: DAA09969.1.
PIRS52831.
RefSeqNP_013787.1. NM_001182569.1.

3D structure databases

ProteinModelPortalQ04767.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35246. 42 interactions.
DIPDIP-1731N.
IntActQ04767. 14 interactions.
MINTMINT-386645.
STRING4932.YMR071C.

Proteomic databases

MaxQBQ04767.
PaxDbQ04767.
PeptideAtlasQ04767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR071C; YMR071C; YMR071C.
GeneID855093.
KEGGsce:YMR071C.

Organism-specific databases

CYGDYMR071c.
SGDS000004675. TVP18.

Phylogenomic databases

eggNOGNOG82114.
HOGENOMHOG000066042.
OMASIYGQWT.
OrthoDBEOG72NS2V.

Enzyme and pathway databases

BioCycYEAST:G3O-32773-MONOMER.

Gene expression databases

GenevestigatorQ04767.

Family and domain databases

InterProIPR019365. TVP18/Ca-channel_flower.
[Graphical view]
PfamPF10233. Cg6151-P. 1 hit.
[Graphical view]
SMARTSM01077. Cg6151-P. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978402.

Entry information

Entry nameTVP18_YEAST
AccessionPrimary (citable) accession number: Q04767
Secondary accession number(s): D6VZP5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families