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Protein

Golgi apparatus membrane protein TVP18

Gene

TVP18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Golgi membrane protein involved in vesicular trafficking.1 Publication

GO - Biological processi

  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP18
Alternative name(s):
TLG2 compartment vesicle protein of 18 kDa
Gene namesi
Name:TVP18
Ordered Locus Names:YMR071C
ORF Names:YM9916.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR071c.
EuPathDBiFungiDB:YMR071C.
SGDiS000004675. TVP18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei98 – 11417HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 13717HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Golgi apparatus membrane protein TVP18PRO_0000203281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Modified residuei146 – 1461Phosphothreonine1 Publication
Modified residuei153 – 1531Phosphothreonine2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ04767.
PaxDbiQ04767.
PeptideAtlasiQ04767.

Interactioni

Subunit structurei

Interacts with TVP15 and YIP4.1 Publication

Protein-protein interaction databases

BioGridi35246. 42 interactions.
DIPiDIP-1731N.
IntActiQ04767. 14 interactions.
MINTiMINT-386645.

Structurei

3D structure databases

ProteinModelPortaliQ04767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP18 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82114.
HOGENOMiHOG000066042.
InParanoidiQ04767.
OMAiSIYGQWT.
OrthoDBiEOG72NS2V.

Family and domain databases

InterProiIPR019365. TVP18/Ca-channel_flower.
[Graphical view]
PfamiPF10233. Cg6151-P. 1 hit.
[Graphical view]
SMARTiSM01077. Cg6151-P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLGQFIN VGGMVKDLKS FNFSVYGRWF GYINIILCIA LGIANLFHVS
60 70 80 90 100
GVIAFGIISI IQGLVILFIE IPFLLKICPL SDNFIEFIKR FETNGWRCLF
110 120 130 140 150
YLAMAIIQYI SIAVMATSLI VVAVGLTISS ISYAVAYTKH QEFQNTNIIK
160
NPTDDDFPHE AVVREML
Length:167
Mass (Da):18,693
Last modified:November 1, 1997 - v1
Checksum:i46698DC0400D3097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88796.1.
AY558402 Genomic DNA. Translation: AAS56728.1.
BK006946 Genomic DNA. Translation: DAA09969.1.
PIRiS52831.
RefSeqiNP_013787.1. NM_001182569.1.

Genome annotation databases

EnsemblFungiiYMR071C; YMR071C; YMR071C.
GeneIDi855093.
KEGGisce:YMR071C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88796.1.
AY558402 Genomic DNA. Translation: AAS56728.1.
BK006946 Genomic DNA. Translation: DAA09969.1.
PIRiS52831.
RefSeqiNP_013787.1. NM_001182569.1.

3D structure databases

ProteinModelPortaliQ04767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35246. 42 interactions.
DIPiDIP-1731N.
IntActiQ04767. 14 interactions.
MINTiMINT-386645.

Proteomic databases

MaxQBiQ04767.
PaxDbiQ04767.
PeptideAtlasiQ04767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR071C; YMR071C; YMR071C.
GeneIDi855093.
KEGGisce:YMR071C.

Organism-specific databases

CYGDiYMR071c.
EuPathDBiFungiDB:YMR071C.
SGDiS000004675. TVP18.

Phylogenomic databases

eggNOGiNOG82114.
HOGENOMiHOG000066042.
InParanoidiQ04767.
OMAiSIYGQWT.
OrthoDBiEOG72NS2V.

Enzyme and pathway databases

BioCyciYEAST:G3O-32773-MONOMER.

Miscellaneous databases

NextBioi978402.
PROiQ04767.

Family and domain databases

InterProiIPR019365. TVP18/Ca-channel_flower.
[Graphical view]
PfamiPF10233. Cg6151-P. 1 hit.
[Graphical view]
SMARTiSM01077. Cg6151-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
    Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
    Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP15 AND YIP4.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTVP18_YEAST
AccessioniPrimary (citable) accession number: Q04767
Secondary accession number(s): D6VZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.