Q04761 (RECA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein RecA

Alternative name(s):
Recombinase A

Gene names

Name:	recA
Ordered Locus Names:	BruAb1_1207

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. HAMAP-Rule MF_00268
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the RecA family.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair SOS response
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repair Inferred from electronic annotation. Source: HAMAP SOS response Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA-dependent ATPase activity Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: HAMAP single-stranded DNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Protein RecA HAMAP-Rule MF_00268		PRO_0000122670
Regions
	Nucleotide binding	77 – 84	8	ATP By similarity
Experimental info
	Sequence conflict	121	1	D → H in AAA22999. Ref.1
	Sequence conflict	131	1	D → I in AAA22999. Ref.1
	Sequence conflict	174 – 175	2	LP → H in AAA22999. Ref.1
	Sequence conflict	186	1	L → V in AAA22999. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q04761 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 6E15766D33E5756E	FASTA	361	38,735
	10 20 30 40 50 60 MSQNSLRLVE DNSVDKTKAL DAALSQIERA FGKGSIMRLG QNDQVVEIET VSTGSLSLDI 70 80 90 100 110 120 ALGVGGLPKG RIVEIYGPES SGKTTLALHT IAEAQKKGGI CAFVDAEHAL DPVYARKLGV 130 140 150 160 170 180 DLENLLISQP DTGEQALEIT DTLVRSGAID VLVVDSVAAL TPRAEIEGEM GDSLPGLQAR 190 200 210 220 230 240 LMSQALRKLT GSISRSNCMV IFINQIRMKI GVMFGSPETT TGGNALKFYA SVRLDIRRIG 250 260 270 280 290 300 SIKERDEVVG NQTRVKVVKN KLAPPFKQVE FDIMYGAGVS KVGELVDLGV KAGVVEKSGA 310 320 330 340 350 360 WFSYNSQRLG QGRENAKQYL KDNPEVAREI ETTLRQNAGL IAEQFLDDGG PEEDAAGAAE M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Construction of a Brucella abortus RecA mutant and its survival in mice." Tatum F.M. Microb. Pathog. 14:177-185(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00679 Genomic DNA. Translation: AAA22999.1. AE017223 Genomic DNA. Translation: AAX74545.1.
PIR	I40347.
RefSeq	YP_221906.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q04761.
SMR	Q04761. Positions 15-336.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1207.
Proteomic databases
PRIDE	Q04761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX74545; AAX74545; BruAb1_1207.
GeneID	3340715.
KEGG	bmb:BruAb1_1207.
PATRIC	17824104. VBIBruAbo15061_1274.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0468.
HOGENOM	HOG000264120.
KO	K03553.
OMA	TRKGAWY.
ProtClustDB	PRK09354.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1229-MONOMER.
Family and domain databases
Gene3D	3.30.250.10. 1 hit.
HAMAP	MF_00268. RecA.
InterPro	IPR003593. AAA+_ATPase. IPR013765. DNA_recomb/repair_RecA. IPR020584. DNA_recomb/repair_RecA_CS. IPR020588. DNA_recomb_RecA/RadB_ATP-bd. IPR023400. RecA_C. IPR020587. RecA_monomer-monomer_interface. [Graphical view]
PANTHER	PTHR22942:SF1. PTHR22942:SF1. 1 hit.
Pfam	PF00154. RecA. 1 hit. [Graphical view]
PRINTS	PR00142. RECA.
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF54752. SSF54752. 1 hit.
TIGRFAMs	TIGR02012. tigrfam_recA. 1 hit.
PROSITE	PS00321. RECA_1. 1 hit. PS50162. RECA_2. 1 hit. PS50163. RECA_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RECA_BRUAB

Accession

Primary (citable) accession number: Q04761
Secondary accession number(s): Q57CT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program