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Protein

N-alpha-acetyltransferase 40

Gene

NAT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A.1 Publication

Catalytic activityi

Acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-N(alpha)-acetyl-L-seryl-[histone H4] + CoA.1 Publication
Acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-N(alpha)-acetyl-L-seryl-[histone H2A] + CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1
Sitei186Essential for catalytic activityBy similarity1
Binding sitei228SubstrateBy similarity1
Binding sitei233Acetyl-CoABy similarity1

GO - Molecular functioni

  • histone acetyltransferase activity Source: SGD

GO - Biological processi

  • histone acetylation Source: SGD
  • regulation of chromatin silencing at rDNA Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-32771-MONOMER
BRENDAi2.3.1.48 984

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 40By similarity (EC:2.3.1.2571 Publication)
Alternative name(s):
Histone-specific N-acetyltransferase NAT4Curated
Gene namesi
Name:NAT4Imported
Ordered Locus Names:YMR069W
ORF Names:YM9916.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR069W
SGDiS000004673 NAT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746361 – 285N-alpha-acetyltransferase 40Add BLAST285

Proteomic databases

PaxDbiQ04751
PRIDEiQ04751

PTM databases

iPTMnetiQ04751

Interactioni

Protein-protein interaction databases

BioGridi35244, 92 interactors
DIPiDIP-2745N
IntActiQ04751, 2 interactors
MINTiQ04751
STRINGi4932.YMR069W

Structurei

3D structure databases

ProteinModelPortaliQ04751
SMRiQ04751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 274N-acetyltransferasePROSITE-ProRule annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 165Substrate bindingBy similarity3
Regioni187 – 189Acetyl-CoA bindingBy similarity3
Regioni195 – 200Acetyl-CoA bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ04751
KOiK20794
OrthoDBiEOG092C55DH

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q04751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH
60 70 80 90 100
KDTDGNGNFT TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV
110 120 130 140 150
LDACVQLIDK HLGAKYRRAS RIMYGNRKPW KANKLAEMKS AGLVYVCYWD
160 170 180 190 200
NGVLGAFTSF MLTEETGLVE GDALHEVSVP VIYLYEVHVA SAHRGHGIGR
210 220 230 240 250
RLLEHALCDG VARHTRRMCD NFFGVALTVF SDNTRARRLY EALGFYRAPG
260 270 280
SPAPASPTIR HTRHGGGRVV VPCDPLYYVY CLHMP
Length:285
Mass (Da):32,334
Last modified:November 1, 1997 - v1
Checksum:i20127B782E1F5F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA Translation: CAA88794.1
AY557984 Genomic DNA Translation: AAS56310.1
BK006946 Genomic DNA Translation: DAA09967.1
PIRiS52829
RefSeqiNP_013785.1, NM_001182567.1

Genome annotation databases

EnsemblFungiiYMR069W; YMR069W; YMR069W
GeneIDi855091
KEGGisce:YMR069W

Similar proteinsi

Entry informationi

Entry nameiNAA40_YEAST
AccessioniPrimary (citable) accession number: Q04751
Secondary accession number(s): D6VZP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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