Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04751

- NAT4_YEAST

UniProt

Q04751 - NAT4_YEAST

Protein

Histone-specific N-acetyltransferase NAT4

Gene

NAT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.1 Publication

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: SGD

    GO - Biological processi

    1. histone acetylation Source: SGD
    2. regulation of chromatin silencing at rDNA Source: SGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32771-MONOMER.
    BRENDAi2.3.1.48. 984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-specific N-acetyltransferase NAT4 (EC:2.3.1.-)
    Gene namesi
    Name:NAT4
    Ordered Locus Names:YMR069W
    ORF Names:YM9916.08
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR069w.
    SGDiS000004673. NAT4.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Histone-specific N-acetyltransferase NAT4PRO_0000074636Add
    BLAST

    Proteomic databases

    PaxDbiQ04751.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04751.

    Interactioni

    Protein-protein interaction databases

    BioGridi35244. 41 interactions.
    DIPiDIP-2745N.
    IntActiQ04751. 2 interactions.
    MINTiMINT-575427.
    STRINGi4932.YMR069W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04751.
    SMRiQ04751. Positions 137-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 274187N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0454.
    OrthoDBiEOG7DNP74.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH    50
    KDTDGNGNFT TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV 100
    LDACVQLIDK HLGAKYRRAS RIMYGNRKPW KANKLAEMKS AGLVYVCYWD 150
    NGVLGAFTSF MLTEETGLVE GDALHEVSVP VIYLYEVHVA SAHRGHGIGR 200
    RLLEHALCDG VARHTRRMCD NFFGVALTVF SDNTRARRLY EALGFYRAPG 250
    SPAPASPTIR HTRHGGGRVV VPCDPLYYVY CLHMP 285
    Length:285
    Mass (Da):32,334
    Last modified:November 1, 1997 - v1
    Checksum:i20127B782E1F5F1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88794.1.
    AY557984 Genomic DNA. Translation: AAS56310.1.
    BK006946 Genomic DNA. Translation: DAA09967.1.
    PIRiS52829.
    RefSeqiNP_013785.1. NM_001182567.1.

    Genome annotation databases

    EnsemblFungiiYMR069W; YMR069W; YMR069W.
    GeneIDi855091.
    KEGGisce:YMR069W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48952 Genomic DNA. Translation: CAA88794.1 .
    AY557984 Genomic DNA. Translation: AAS56310.1 .
    BK006946 Genomic DNA. Translation: DAA09967.1 .
    PIRi S52829.
    RefSeqi NP_013785.1. NM_001182567.1.

    3D structure databases

    ProteinModelPortali Q04751.
    SMRi Q04751. Positions 137-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35244. 41 interactions.
    DIPi DIP-2745N.
    IntActi Q04751. 2 interactions.
    MINTi MINT-575427.
    STRINGi 4932.YMR069W.

    Proteomic databases

    PaxDbi Q04751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR069W ; YMR069W ; YMR069W .
    GeneIDi 855091.
    KEGGi sce:YMR069W.

    Organism-specific databases

    CYGDi YMR069w.
    SGDi S000004673. NAT4.

    Phylogenomic databases

    eggNOGi COG0454.
    OrthoDBi EOG7DNP74.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32771-MONOMER.
    BRENDAi 2.3.1.48. 984.

    Miscellaneous databases

    NextBioi 978396.

    Gene expression databases

    Genevestigatori Q04751.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A."
      Song O.-K., Wang X., Waterborg J.H., Sternglanz R.
      J. Biol. Chem. 278:38109-38112(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNAT4_YEAST
    AccessioniPrimary (citable) accession number: Q04751
    Secondary accession number(s): D6VZP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3