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Protein

Histone-specific N-acetyltransferase NAT4

Gene

NAT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.1 Publication

GO - Molecular functioni

  • histone acetyltransferase activity Source: SGD

GO - Biological processi

  • histone acetylation Source: SGD
  • regulation of chromatin silencing at rDNA Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-32771-MONOMER.
BRENDAi2.3.1.48. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-specific N-acetyltransferase NAT4 (EC:2.3.1.-)
Gene namesi
Name:NAT4
Ordered Locus Names:YMR069W
ORF Names:YM9916.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR069w.
EuPathDBiFungiDB:YMR069W.
SGDiS000004673. NAT4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Histone-specific N-acetyltransferase NAT4PRO_0000074636Add
BLAST

Proteomic databases

PaxDbiQ04751.

Interactioni

Protein-protein interaction databases

BioGridi35244. 42 interactions.
DIPiDIP-2745N.
IntActiQ04751. 2 interactions.
MINTiMINT-575427.

Structurei

3D structure databases

ProteinModelPortaliQ04751.
SMRiQ04751. Positions 66-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 274187N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0454.
InParanoidiQ04751.
OrthoDBiEOG7DNP74.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH
60 70 80 90 100
KDTDGNGNFT TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV
110 120 130 140 150
LDACVQLIDK HLGAKYRRAS RIMYGNRKPW KANKLAEMKS AGLVYVCYWD
160 170 180 190 200
NGVLGAFTSF MLTEETGLVE GDALHEVSVP VIYLYEVHVA SAHRGHGIGR
210 220 230 240 250
RLLEHALCDG VARHTRRMCD NFFGVALTVF SDNTRARRLY EALGFYRAPG
260 270 280
SPAPASPTIR HTRHGGGRVV VPCDPLYYVY CLHMP
Length:285
Mass (Da):32,334
Last modified:November 1, 1997 - v1
Checksum:i20127B782E1F5F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88794.1.
AY557984 Genomic DNA. Translation: AAS56310.1.
BK006946 Genomic DNA. Translation: DAA09967.1.
PIRiS52829.
RefSeqiNP_013785.1. NM_001182567.1.

Genome annotation databases

EnsemblFungiiYMR069W; YMR069W; YMR069W.
GeneIDi855091.
KEGGisce:YMR069W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88794.1.
AY557984 Genomic DNA. Translation: AAS56310.1.
BK006946 Genomic DNA. Translation: DAA09967.1.
PIRiS52829.
RefSeqiNP_013785.1. NM_001182567.1.

3D structure databases

ProteinModelPortaliQ04751.
SMRiQ04751. Positions 66-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35244. 42 interactions.
DIPiDIP-2745N.
IntActiQ04751. 2 interactions.
MINTiMINT-575427.

Proteomic databases

PaxDbiQ04751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR069W; YMR069W; YMR069W.
GeneIDi855091.
KEGGisce:YMR069W.

Organism-specific databases

CYGDiYMR069w.
EuPathDBiFungiDB:YMR069W.
SGDiS000004673. NAT4.

Phylogenomic databases

eggNOGiCOG0454.
InParanoidiQ04751.
OrthoDBiEOG7DNP74.

Enzyme and pathway databases

BioCyciYEAST:G3O-32771-MONOMER.
BRENDAi2.3.1.48. 984.

Miscellaneous databases

NextBioi978396.
PROiQ04751.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A."
    Song O.-K., Wang X., Waterborg J.H., Sternglanz R.
    J. Biol. Chem. 278:38109-38112(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNAT4_YEAST
AccessioniPrimary (citable) accession number: Q04751
Secondary accession number(s): D6VZP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.