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Q04751 (NAT4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-specific N-acetyltransferase NAT4

EC=2.3.1.-
Gene names
Name:NAT4
Ordered Locus Names:YMR069W
ORF Names:YM9916.08
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the acetylation of the N-terminal residues of histones H4 and H2A. Ref.4

Subcellular location

Nucleus. Cytoplasm Ref.5.

Sequence similarities

Belongs to the acetyltransferase family. GNAT subfamily.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistone acetylation

Inferred from direct assay Ref.4. Source: SGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone acetyltransferase activity

Inferred from direct assay Ref.4. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Histone-specific N-acetyltransferase NAT4
PRO_0000074636

Regions

Domain88 – 274187N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q04751 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 20127B782E1F5F1A

FASTA28532,334
        10         20         30         40         50         60 
MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH KDTDGNGNFT 

        70         80         90        100        110        120 
TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV LDACVQLIDK HLGAKYRRAS 

       130        140        150        160        170        180 
RIMYGNRKPW KANKLAEMKS AGLVYVCYWD NGVLGAFTSF MLTEETGLVE GDALHEVSVP 

       190        200        210        220        230        240 
VIYLYEVHVA SAHRGHGIGR RLLEHALCDG VARHTRRMCD NFFGVALTVF SDNTRARRLY 

       250        260        270        280 
EALGFYRAPG SPAPASPTIR HTRHGGGRVV VPCDPLYYVY CLHMP 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A."
Song O.-K., Wang X., Waterborg J.H., Sternglanz R.
J. Biol. Chem. 278:38109-38112(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48952 Genomic DNA. Translation: CAA88794.1.
AY557984 Genomic DNA. Translation: AAS56310.1.
BK006946 Genomic DNA. Translation: DAA09967.1.
PIRS52829.
RefSeqNP_013785.1. NM_001182567.1.

3D structure databases

ProteinModelPortalQ04751.
SMRQ04751. Positions 141-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35244. 41 interactions.
DIPDIP-2745N.
IntActQ04751. 2 interactions.
MINTMINT-575427.
STRING4932.YMR069W.

Proteomic databases

PaxDbQ04751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR069W; YMR069W; YMR069W.
GeneID855091.
KEGGsce:YMR069W.

Organism-specific databases

CYGDYMR069w.
SGDS000004673. NAT4.

Phylogenomic databases

eggNOGCOG0454.
OrthoDBEOG7DNP74.

Enzyme and pathway databases

BioCycYEAST:G3O-32771-MONOMER.
BRENDA2.3.1.48. 984.

Gene expression databases

GenevestigatorQ04751.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978396.

Entry information

Entry nameNAT4_YEAST
AccessionPrimary (citable) accession number: Q04751
Secondary accession number(s): D6VZP3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families