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Protein

Interleukin-4

Gene

IL4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • myeloid dendritic cell differentiation Source: Ensembl
  • negative regulation of complement-dependent cytotoxicity Source: AgBase
  • negative regulation of endothelial cell apoptotic process Source: AgBase
  • negative regulation of epithelial cell migration Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • positive regulation of establishment of endothelial barrier Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • positive regulation of interleukin-13 production Source: Ensembl
  • positive regulation of JAK-STAT cascade Source: AgBase
  • positive regulation of protein phosphorylation Source: AgBase
  • positive regulation of T cell differentiation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of protein export from nucleus Source: AgBase
  • T cell activation Source: Ensembl
  • T-helper 2 cell cytokine production Source: Ensembl

Keywordsi

Molecular functionCytokine, Growth factor
Biological processB-cell activation

Enzyme and pathway databases

ReactomeiR-SSC-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Lymphocyte stimulatory factor 1
Gene namesi
Name:IL4
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001554125 – 133Interleukin-4Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 133By similarity
Disulfide bondi48 ↔ 85By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 105By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ04745
PRIDEiQ04745

Expressioni

Gene expression databases

ExpressionAtlasiQ04745 baseline
GenevisibleiQ04745 SS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015193

Structurei

3D structure databases

ProteinModelPortaliQ04745
SMRiQ04745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiQ04745
KOiK05430
OMAiLACTSNF
OrthoDBiEOG091G0WDE
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTSQLIPT LVCLLACTSN FVHGHKCDIT LQEIIKTLNI LTARKNSCME
60 70 80 90 100
LPVTDVFAAP ENTTEKETFC RASTVLRHIY RHHTCMKSLL SGLDRNLSSM
110 120 130
ANMTCSVHEA KKSTLKDFLE RLKTIMKEKY SKC
Length:133
Mass (Da):15,023
Last modified:February 1, 1994 - v1
Checksum:i333033EF515D084F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45K → E in AAM27191 (Ref. 3) Curated1
Sequence conflicti53 – 54VT → GD in AAA31055 (Ref. 2) Curated2
Sequence conflicti64T → R in AAA31055 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68330 mRNA Translation: CAA48407.1
L12991 mRNA Translation: AAA31055.1
AF493991 mRNA Translation: AAM27191.1
PIRiS28187
RefSeqiNP_999288.1, NM_214123.1
UniGeneiSsc.15837

Genome annotation databases

EnsembliENSSSCT00000015605; ENSSSCP00000015193; ENSSSCG00000014282
GeneIDi397225
KEGGissc:397225

Similar proteinsi

Entry informationi

Entry nameiIL4_PIG
AccessioniPrimary (citable) accession number: Q04745
Secondary accession number(s): Q29054, Q8MKE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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