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Q04744

- EMX2_MOUSE

UniProt

Q04744 - EMX2_MOUSE

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Protein

Homeobox protein EMX2

Gene

Emx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. brain development Source: MGI
  3. cell proliferation in forebrain Source: MGI
  4. cerebral cortex development Source: MGI
  5. cerebral cortex regionalization Source: MGI
  6. dentate gyrus development Source: MGI
  7. forebrain cell migration Source: MGI
  8. forebrain development Source: MGI
  9. neuron differentiation Source: MGI
  10. regulation of gene expression Source: MGI
  11. regulation of transcription, DNA-templated Source: InterPro
  12. renal system development Source: MGI
  13. response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX2
Alternative name(s):
Empty spiracles homolog 2
Empty spiracles-like protein 2
Gene namesi
Name:Emx2
Synonyms:Emx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95388. Emx2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Homeobox protein EMX2PRO_0000048869Add
BLAST

Proteomic databases

PRIDEiQ04744.

PTM databases

PhosphoSiteiQ04744.

Expressioni

Tissue specificityi

Cerebral cortex.1 Publication

Gene expression databases

CleanExiMM_EMX2.
GenevestigatoriQ04744.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053361.

Structurei

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744. Positions 129-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG264928.
GeneTreeiENSGT00760000119254.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiGQMNPFL.
OrthoDBiEOG7XDBJW.
TreeFamiTF317015.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04744-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG
60 70 80 90 100
FHSAAAAAAA GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL
110 120 130 140 150
PSSHSPHPLF ASQQRDPSTF YPWLIHRYRY LGHRFQGNDT SPESFLLHNA
160 170 180 190 200
LARKPKRIRT AFSPSQLLRL EHAFEKNHYV VGAERKQLAH SLSLTETQVK
210 220 230 240 250
VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK QASPEEIDVT

SDD
Length:253
Mass (Da):28,374
Last modified:October 3, 2012 - v3
Checksum:i4AE978446786B204
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031S → L in AAM94018. (PubMed:12573261)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1 .
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1 .
X68882 mRNA. Translation: CAA48753.1 .
CCDSi CCDS29937.1.
PIRi S29086.
RefSeqi NP_034262.2. NM_010132.2.
UniGenei Mm.245394.

3D structure databases

ProteinModelPortali Q04744.
SMRi Q04744. Positions 129-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000053361.

PTM databases

PhosphoSitei Q04744.

Proteomic databases

PRIDEi Q04744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062216 ; ENSMUSP00000053361 ; ENSMUSG00000043969 .
GeneIDi 13797.
KEGGi mmu:13797.
UCSCi uc008ibl.1. mouse.

Organism-specific databases

CTDi 2018.
MGIi MGI:95388. Emx2.

Phylogenomic databases

eggNOGi NOG264928.
GeneTreei ENSGT00760000119254.
HOGENOMi HOG000247032.
HOVERGENi HBG005024.
InParanoidi Q04744.
KOi K09317.
OMAi GQMNPFL.
OrthoDBi EOG7XDBJW.
TreeFami TF317015.

Miscellaneous databases

NextBioi 284546.
PROi Q04744.
SOURCEi Search...

Gene expression databases

CleanExi MM_EMX2.
Genevestigatori Q04744.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Antisense transcripts at the EMX2 locus in human and mouse."
    Noonan F.C., Goodfellow P.J., Staloch L.J., Mutch D.G., Simon T.C.
    Genomics 81:58-66(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
    Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
    EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220, FUNCTION, TISSUE SPECIFICITY.
  5. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220.
    Tissue: Brain.
  6. "Emx1 and Emx2 cooperate in initial phase of archipallium development."
    Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
    Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEMX2_MOUSE
AccessioniPrimary (citable) accession number: Q04744
Secondary accession number(s): G3X9A6, Q80UE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3