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Protein

Homeobox protein EMX2

Gene

Emx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • brain development Source: MGI
  • cell proliferation in forebrain Source: MGI
  • cerebral cortex development Source: MGI
  • cerebral cortex regionalization Source: MGI
  • dentate gyrus development Source: MGI
  • forebrain cell migration Source: MGI
  • forebrain development Source: MGI
  • neuron differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • renal system development Source: MGI
  • response to drug Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX2
Alternative name(s):
Empty spiracles homolog 2
Empty spiracles-like protein 2
Gene namesi
Name:Emx2
Synonyms:Emx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95388. Emx2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488691 – 253Homeobox protein EMX2Add BLAST253

Proteomic databases

PaxDbiQ04744.
PeptideAtlasiQ04744.
PRIDEiQ04744.

PTM databases

iPTMnetiQ04744.
PhosphoSitePlusiQ04744.

Expressioni

Tissue specificityi

Cerebral cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000043969.
CleanExiMM_EMX2.
ExpressionAtlasiQ04744. baseline and differential.
GenevisibleiQ04744. MM.

Interactioni

Protein-protein interaction databases

BioGridi199443. 4 interactors.
STRINGi10090.ENSMUSP00000053361.

Structurei

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
GeneTreeiENSGT00900000140795.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiFQPTPKR.
OrthoDBiEOG091G0P41.
TreeFamiTF317015.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG
60 70 80 90 100
FHSAAAAAAA GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL
110 120 130 140 150
PSSHSPHPLF ASQQRDPSTF YPWLIHRYRY LGHRFQGNDT SPESFLLHNA
160 170 180 190 200
LARKPKRIRT AFSPSQLLRL EHAFEKNHYV VGAERKQLAH SLSLTETQVK
210 220 230 240 250
VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK QASPEEIDVT

SDD
Length:253
Mass (Da):28,374
Last modified:October 3, 2012 - v3
Checksum:i4AE978446786B204
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103S → L in AAM94018 (PubMed:12573261).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiEMX2_MOUSE
AccessioniPrimary (citable) accession number: Q04744
Secondary accession number(s): G3X9A6, Q80UE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: November 22, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families