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Protein

Homeobox protein EMX2

Gene

Emx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • brain development Source: MGI
  • cell proliferation in forebrain Source: MGI
  • cerebral cortex development Source: MGI
  • cerebral cortex regionalization Source: MGI
  • dentate gyrus development Source: MGI
  • forebrain cell migration Source: MGI
  • forebrain development Source: MGI
  • neuron differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • renal system development Source: MGI
  • response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX2
Alternative name(s):
Empty spiracles homolog 2
Empty spiracles-like protein 2
Gene namesi
Name:Emx2
Synonyms:Emx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95388. Emx2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Homeobox protein EMX2PRO_0000048869Add
BLAST

Proteomic databases

PaxDbiQ04744.
PeptideAtlasiQ04744.
PRIDEiQ04744.

PTM databases

iPTMnetiQ04744.
PhosphoSiteiQ04744.

Expressioni

Tissue specificityi

Cerebral cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000043969.
CleanExiMM_EMX2.
ExpressionAtlasiQ04744. baseline and differential.
GenevisibleiQ04744. MM.

Interactioni

Protein-protein interaction databases

BioGridi199443. 4 interactions.
STRINGi10090.ENSMUSP00000053361.

Structurei

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
GeneTreeiENSGT00840000129733.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiYANSGQM.
OrthoDBiEOG091G0P41.
TreeFamiTF317015.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG
60 70 80 90 100
FHSAAAAAAA GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL
110 120 130 140 150
PSSHSPHPLF ASQQRDPSTF YPWLIHRYRY LGHRFQGNDT SPESFLLHNA
160 170 180 190 200
LARKPKRIRT AFSPSQLLRL EHAFEKNHYV VGAERKQLAH SLSLTETQVK
210 220 230 240 250
VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK QASPEEIDVT

SDD
Length:253
Mass (Da):28,374
Last modified:October 3, 2012 - v3
Checksum:i4AE978446786B204
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031S → L in AAM94018 (PubMed:12573261).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199443. 4 interactions.
STRINGi10090.ENSMUSP00000053361.

PTM databases

iPTMnetiQ04744.
PhosphoSiteiQ04744.

Proteomic databases

PaxDbiQ04744.
PeptideAtlasiQ04744.
PRIDEiQ04744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Organism-specific databases

CTDi2018.
MGIiMGI:95388. Emx2.

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
GeneTreeiENSGT00840000129733.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiYANSGQM.
OrthoDBiEOG091G0P41.
TreeFamiTF317015.

Miscellaneous databases

PROiQ04744.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043969.
CleanExiMM_EMX2.
ExpressionAtlasiQ04744. baseline and differential.
GenevisibleiQ04744. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMX2_MOUSE
AccessioniPrimary (citable) accession number: Q04744
Secondary accession number(s): G3X9A6, Q80UE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.