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Q04744 (EMX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein EMX2
Alternative name(s):
Empty spiracles homolog 2
Empty spiracles-like protein 2
Gene names
Name:Emx2
Synonyms:Emx-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Ref.4 Ref.6

Subcellular location

Nucleus Probable.

Tissue specificity

Cerebral cortex. Ref.4

Sequence similarities

Belongs to the EMX homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 12196586. Source: MGI

brain development

Inferred from mutant phenotype PubMed 12091317PubMed 12196586PubMed 12209834PubMed 12561075. Source: MGI

cell proliferation in forebrain

Inferred from mutant phenotype PubMed 10729342. Source: MGI

cerebral cortex development

Inferred from genetic interaction PubMed 12764040. Source: MGI

cerebral cortex regionalization

Inferred from mutant phenotype PubMed 12764040. Source: MGI

dentate gyrus development

Inferred from mutant phenotype PubMed 10729342. Source: MGI

forebrain cell migration

Inferred from mutant phenotype PubMed 10729342. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 15294144. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 12561075. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 12764040PubMed 16919471. Source: MGI

renal system development

Inferred from genetic interaction PubMed 21731775. Source: MGI

response to drug

Inferred from direct assay PubMed 9098922. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Homeobox protein EMX2
PRO_0000048869

Regions

DNA binding155 – 21460Homeobox

Experimental info

Sequence conflict1031S → L in AAM94018. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04744 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: 4AE978446786B204

FASTA25328,374
        10         20         30         40         50         60 
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA 

        70         80         90        100        110        120 
GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSSHSPHPLF ASQQRDPSTF 

       130        140        150        160        170        180 
YPWLIHRYRY LGHRFQGNDT SPESFLLHNA LARKPKRIRT AFSPSQLLRL EHAFEKNHYV 

       190        200        210        220        230        240 
VGAERKQLAH SLSLTETQVK VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK 

       250 
QASPEEIDVT SDD 

« Hide

References

« Hide 'large scale' references
[1]"Antisense transcripts at the EMX2 locus in human and mouse."
Noonan F.C., Goodfellow P.J., Staloch L.J., Mutch D.G., Simon T.C.
Genomics 81:58-66(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220, FUNCTION, TISSUE SPECIFICITY.
[5]"Nested expression domains of four homeobox genes in developing rostral brain."
Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220.
Tissue: Brain.
[6]"Emx1 and Emx2 cooperate in initial phase of archipallium development."
Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSCCDS29937.1.
PIRS29086.
RefSeqNP_034262.2. NM_010132.2.
UniGeneMm.245394.

3D structure databases

ProteinModelPortalQ04744.
SMRQ04744. Positions 129-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000053361.

PTM databases

PhosphoSiteQ04744.

Proteomic databases

PRIDEQ04744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneID13797.
KEGGmmu:13797.
UCSCuc008ibl.1. mouse.

Organism-specific databases

CTD2018.
MGIMGI:95388. Emx2.

Phylogenomic databases

eggNOGNOG264928.
GeneTreeENSGT00750000117439.
HOGENOMHOG000247032.
HOVERGENHBG005024.
InParanoidQ04744.
KOK09317.
OMAGQMNPFL.
OrthoDBEOG7XDBJW.
TreeFamTF317015.

Gene expression databases

CleanExMM_EMX2.
GenevestigatorQ04744.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284546.
PROQ04744.
SOURCESearch...

Entry information

Entry nameEMX2_MOUSE
AccessionPrimary (citable) accession number: Q04744
Secondary accession number(s): G3X9A6, Q80UE7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot