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Protein

Homeobox protein EMX2

Gene

Emx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • brain development Source: MGI
  • cell proliferation in forebrain Source: MGI
  • cerebral cortex development Source: MGI
  • cerebral cortex regionalization Source: MGI
  • dentate gyrus development Source: MGI
  • forebrain cell migration Source: MGI
  • forebrain development Source: MGI
  • neuron differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • renal system development Source: MGI
  • response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX2
Alternative name(s):
Empty spiracles homolog 2
Empty spiracles-like protein 2
Gene namesi
Name:Emx2
Synonyms:Emx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95388. Emx2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Homeobox protein EMX2PRO_0000048869Add
BLAST

Proteomic databases

PRIDEiQ04744.

PTM databases

PhosphoSiteiQ04744.

Expressioni

Tissue specificityi

Cerebral cortex.1 Publication

Gene expression databases

CleanExiMM_EMX2.

Interactioni

Protein-protein interaction databases

BioGridi199443. 4 interactions.
STRINGi10090.ENSMUSP00000053361.

Structurei

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG264928.
GeneTreeiENSGT00790000122946.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiGQMNPFL.
OrthoDBiEOG7XDBJW.
TreeFamiTF317015.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG
60 70 80 90 100
FHSAAAAAAA GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL
110 120 130 140 150
PSSHSPHPLF ASQQRDPSTF YPWLIHRYRY LGHRFQGNDT SPESFLLHNA
160 170 180 190 200
LARKPKRIRT AFSPSQLLRL EHAFEKNHYV VGAERKQLAH SLSLTETQVK
210 220 230 240 250
VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK QASPEEIDVT

SDD
Length:253
Mass (Da):28,374
Last modified:October 3, 2012 - v3
Checksum:i4AE978446786B204
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031S → L in AAM94018 (PubMed:12573261).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117415 mRNA. Translation: AAM94018.1.
AC098733 Genomic DNA. No translation available.
CH466585 Genomic DNA. Translation: EDL01826.1.
X68882 mRNA. Translation: CAA48753.1.
CCDSiCCDS29937.1.
PIRiS29086.
RefSeqiNP_034262.2. NM_010132.2.
UniGeneiMm.245394.

3D structure databases

ProteinModelPortaliQ04744.
SMRiQ04744. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199443. 4 interactions.
STRINGi10090.ENSMUSP00000053361.

PTM databases

PhosphoSiteiQ04744.

Proteomic databases

PRIDEiQ04744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
GeneIDi13797.
KEGGimmu:13797.
UCSCiuc008ibl.1. mouse.

Organism-specific databases

CTDi2018.
MGIiMGI:95388. Emx2.

Phylogenomic databases

eggNOGiNOG264928.
GeneTreeiENSGT00790000122946.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04744.
KOiK09317.
OMAiGQMNPFL.
OrthoDBiEOG7XDBJW.
TreeFamiTF317015.

Miscellaneous databases

NextBioi284546.
PROiQ04744.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EMX2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Antisense transcripts at the EMX2 locus in human and mouse."
    Noonan F.C., Goodfellow P.J., Staloch L.J., Mutch D.G., Simon T.C.
    Genomics 81:58-66(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
    Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
    EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220, FUNCTION, TISSUE SPECIFICITY.
  5. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220.
    Tissue: Brain.
  6. "Emx1 and Emx2 cooperate in initial phase of archipallium development."
    Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
    Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEMX2_MOUSE
AccessioniPrimary (citable) accession number: Q04744
Secondary accession number(s): G3X9A6, Q80UE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: June 24, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.