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Q04744

- EMX2_MOUSE

UniProt

Q04744 - EMX2_MOUSE

Protein

Homeobox protein EMX2

Gene

Emx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. brain development Source: MGI
    3. cell proliferation in forebrain Source: MGI
    4. cerebral cortex development Source: MGI
    5. cerebral cortex regionalization Source: MGI
    6. dentate gyrus development Source: MGI
    7. forebrain cell migration Source: MGI
    8. forebrain development Source: MGI
    9. neuron differentiation Source: MGI
    10. regulation of gene expression Source: MGI
    11. renal system development Source: MGI
    12. response to drug Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein EMX2
    Alternative name(s):
    Empty spiracles homolog 2
    Empty spiracles-like protein 2
    Gene namesi
    Name:Emx2
    Synonyms:Emx-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:95388. Emx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Homeobox protein EMX2PRO_0000048869Add
    BLAST

    Proteomic databases

    PRIDEiQ04744.

    PTM databases

    PhosphoSiteiQ04744.

    Expressioni

    Tissue specificityi

    Cerebral cortex.1 Publication

    Gene expression databases

    CleanExiMM_EMX2.
    GenevestigatoriQ04744.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000053361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04744.
    SMRiQ04744. Positions 129-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EMX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG264928.
    GeneTreeiENSGT00750000117439.
    HOGENOMiHOG000247032.
    HOVERGENiHBG005024.
    InParanoidiQ04744.
    KOiK09317.
    OMAiGQMNPFL.
    OrthoDBiEOG7XDBJW.
    TreeFamiTF317015.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04744-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG    50
    FHSAAAAAAA GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL 100
    PSSHSPHPLF ASQQRDPSTF YPWLIHRYRY LGHRFQGNDT SPESFLLHNA 150
    LARKPKRIRT AFSPSQLLRL EHAFEKNHYV VGAERKQLAH SLSLTETQVK 200
    VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK QASPEEIDVT 250
    SDD 253
    Length:253
    Mass (Da):28,374
    Last modified:October 3, 2012 - v3
    Checksum:i4AE978446786B204
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031S → L in AAM94018. (PubMed:12573261)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY117415 mRNA. Translation: AAM94018.1.
    AC098733 Genomic DNA. No translation available.
    CH466585 Genomic DNA. Translation: EDL01826.1.
    X68882 mRNA. Translation: CAA48753.1.
    CCDSiCCDS29937.1.
    PIRiS29086.
    RefSeqiNP_034262.2. NM_010132.2.
    UniGeneiMm.245394.

    Genome annotation databases

    EnsembliENSMUST00000062216; ENSMUSP00000053361; ENSMUSG00000043969.
    GeneIDi13797.
    KEGGimmu:13797.
    UCSCiuc008ibl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY117415 mRNA. Translation: AAM94018.1 .
    AC098733 Genomic DNA. No translation available.
    CH466585 Genomic DNA. Translation: EDL01826.1 .
    X68882 mRNA. Translation: CAA48753.1 .
    CCDSi CCDS29937.1.
    PIRi S29086.
    RefSeqi NP_034262.2. NM_010132.2.
    UniGenei Mm.245394.

    3D structure databases

    ProteinModelPortali Q04744.
    SMRi Q04744. Positions 129-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000053361.

    PTM databases

    PhosphoSitei Q04744.

    Proteomic databases

    PRIDEi Q04744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062216 ; ENSMUSP00000053361 ; ENSMUSG00000043969 .
    GeneIDi 13797.
    KEGGi mmu:13797.
    UCSCi uc008ibl.1. mouse.

    Organism-specific databases

    CTDi 2018.
    MGIi MGI:95388. Emx2.

    Phylogenomic databases

    eggNOGi NOG264928.
    GeneTreei ENSGT00750000117439.
    HOGENOMi HOG000247032.
    HOVERGENi HBG005024.
    InParanoidi Q04744.
    KOi K09317.
    OMAi GQMNPFL.
    OrthoDBi EOG7XDBJW.
    TreeFami TF317015.

    Miscellaneous databases

    NextBioi 284546.
    PROi Q04744.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_EMX2.
    Genevestigatori Q04744.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Antisense transcripts at the EMX2 locus in human and mouse."
      Noonan F.C., Goodfellow P.J., Staloch L.J., Mutch D.G., Simon T.C.
      Genomics 81:58-66(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
      Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
      EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220, FUNCTION, TISSUE SPECIFICITY.
    5. "Nested expression domains of four homeobox genes in developing rostral brain."
      Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
      Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-220.
      Tissue: Brain.
    6. "Emx1 and Emx2 cooperate in initial phase of archipallium development."
      Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
      Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiEMX2_MOUSE
    AccessioniPrimary (citable) accession number: Q04744
    Secondary accession number(s): G3X9A6, Q80UE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3