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Q04742

- EMX1_MOUSE

UniProt

Q04742 - EMX1_MOUSE

Protein

Homeobox protein EMX1

Gene

Emx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi159 – 21860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: MGI
    2. brain morphogenesis Source: MGI
    3. cerebral cortex development Source: MGI
    4. cerebral cortex neuron differentiation Source: MGI
    5. cerebral cortex regionalization Source: MGI
    6. in utero embryonic development Source: MGI
    7. neuron differentiation Source: MGI
    8. neuron projection extension Source: MGI
    9. post-embryonic development Source: MGI
    10. response to drug Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein EMX1
    Alternative name(s):
    Empty spiracles homolog 1
    Empty spiracles-like protein 1
    Gene namesi
    Name:Emx1
    Synonyms:Emx-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:95387. Emx1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Homeobox protein EMX1PRO_0000048867Add
    BLAST

    Proteomic databases

    PRIDEiQ04742.

    Expressioni

    Tissue specificityi

    Cerebral cortex. Expressed in the olfactory bulbs.2 Publications

    Developmental stagei

    Detectable from E9.5 of gestation.1 Publication

    Gene expression databases

    BgeeiQ04742.
    CleanExiMM_EMX1.
    GenevestigatoriQ04742.

    Interactioni

    Subunit structurei

    Intercts with WRD11.By similarity

    Protein-protein interaction databases

    BioGridi199442. 16 interactions.
    STRINGi10090.ENSMUSP00000046026.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04742.
    SMRiQ04742. Positions 157-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EMX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG266219.
    GeneTreeiENSGT00750000117439.
    HOGENOMiHOG000247032.
    HOVERGENiHBG005024.
    InParanoidiQ04742.
    KOiK09317.
    OMAiNHHINRW.
    OrthoDBiEOG7XDBJW.
    PhylomeDBiQ04742.
    TreeFamiTF317015.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04742-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQPAAKRGF TIESLVAKDG GTGGSPGSGG AGSHPLAVAA SEEPLRPTAL    50
    NYPHPSAAET AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA 100
    HQLGSSSLQP PHSFFSAQHR DPLHFYPWVL RNRFFGHRFQ ASDVPQDGLL 150
    LHGPFARKPK RIRTAFSPSQ LLRLERAFEK NHYVVGAERK QLAGSLSLSE 200
    TQVKVWFQNR RTKYKRQKLE EEGPESEQKK KGSHHINRWR IATKQANGED 250
    IDVTSND 257
    Length:257
    Mass (Da):28,173
    Last modified:January 9, 2007 - v2
    Checksum:iEC0051BC674430DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104322 mRNA. No translation available.
    BC104323 mRNA. No translation available.
    X68881 mRNA. Translation: CAA48752.1.
    CCDSiCCDS20290.1.
    PIRiS29085.
    RefSeqiNP_034261.1. NM_010131.2.
    UniGeneiMm.391473.

    Genome annotation databases

    EnsembliENSMUST00000045942; ENSMUSP00000046026; ENSMUSG00000033726.
    GeneIDi13796.
    KEGGimmu:13796.
    UCSCiuc009cpi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104322 mRNA. No translation available.
    BC104323 mRNA. No translation available.
    X68881 mRNA. Translation: CAA48752.1 .
    CCDSi CCDS20290.1.
    PIRi S29085.
    RefSeqi NP_034261.1. NM_010131.2.
    UniGenei Mm.391473.

    3D structure databases

    ProteinModelPortali Q04742.
    SMRi Q04742. Positions 157-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199442. 16 interactions.
    STRINGi 10090.ENSMUSP00000046026.

    Proteomic databases

    PRIDEi Q04742.

    Protocols and materials databases

    DNASUi 13796.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045942 ; ENSMUSP00000046026 ; ENSMUSG00000033726 .
    GeneIDi 13796.
    KEGGi mmu:13796.
    UCSCi uc009cpi.1. mouse.

    Organism-specific databases

    CTDi 2016.
    MGIi MGI:95387. Emx1.

    Phylogenomic databases

    eggNOGi NOG266219.
    GeneTreei ENSGT00750000117439.
    HOGENOMi HOG000247032.
    HOVERGENi HBG005024.
    InParanoidi Q04742.
    KOi K09317.
    OMAi NHHINRW.
    OrthoDBi EOG7XDBJW.
    PhylomeDBi Q04742.
    TreeFami TF317015.

    Miscellaneous databases

    NextBioi 284542.
    PROi Q04742.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04742.
    CleanExi MM_EMX1.
    Genevestigatori Q04742.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
      Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
      EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
    3. "Nested expression domains of four homeobox genes in developing rostral brain."
      Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
      Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    4. "Emx1 and Emx2 cooperate in initial phase of archipallium development."
      Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
      Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome."
      Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A., Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G., Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H.
      , Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y., Layman L.C.
      Am. J. Hum. Genet. 87:465-479(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiEMX1_MOUSE
    AccessioniPrimary (citable) accession number: Q04742
    Secondary accession number(s): Q3SXG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3