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Protein

Homeobox protein EMX1

Gene

Emx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi159 – 21860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. brain development Source: MGI
  2. brain morphogenesis Source: MGI
  3. cerebral cortex development Source: MGI
  4. cerebral cortex neuron differentiation Source: MGI
  5. cerebral cortex regionalization Source: MGI
  6. in utero embryonic development Source: MGI
  7. neuron differentiation Source: MGI
  8. neuron projection extension Source: MGI
  9. post-embryonic development Source: MGI
  10. regulation of transcription, DNA-templated Source: InterPro
  11. response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX1
Alternative name(s):
Empty spiracles homolog 1
Empty spiracles-like protein 1
Gene namesi
Name:Emx1
Synonyms:Emx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95387. Emx1.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Homeobox protein EMX1PRO_0000048867Add
BLAST

Proteomic databases

PRIDEiQ04742.

Expressioni

Tissue specificityi

Cerebral cortex. Expressed in the olfactory bulbs.2 Publications

Developmental stagei

Detectable from E9.5 of gestation.1 Publication

Gene expression databases

BgeeiQ04742.
CleanExiMM_EMX1.
GenevestigatoriQ04742.

Interactioni

Subunit structurei

Intercts with WRD11.By similarity

Protein-protein interaction databases

BioGridi199442. 16 interactions.
STRINGi10090.ENSMUSP00000046026.

Structurei

3D structure databases

ProteinModelPortaliQ04742.
SMRiQ04742. Positions 157-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG266219.
GeneTreeiENSGT00760000119254.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04742.
KOiK09317.
OMAiNHHINRW.
OrthoDBiEOG7XDBJW.
PhylomeDBiQ04742.
TreeFamiTF317015.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQPAAKRGF TIESLVAKDG GTGGSPGSGG AGSHPLAVAA SEEPLRPTAL
60 70 80 90 100
NYPHPSAAET AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA
110 120 130 140 150
HQLGSSSLQP PHSFFSAQHR DPLHFYPWVL RNRFFGHRFQ ASDVPQDGLL
160 170 180 190 200
LHGPFARKPK RIRTAFSPSQ LLRLERAFEK NHYVVGAERK QLAGSLSLSE
210 220 230 240 250
TQVKVWFQNR RTKYKRQKLE EEGPESEQKK KGSHHINRWR IATKQANGED

IDVTSND
Length:257
Mass (Da):28,173
Last modified:January 9, 2007 - v2
Checksum:iEC0051BC674430DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104322 mRNA. No translation available.
BC104323 mRNA. No translation available.
X68881 mRNA. Translation: CAA48752.1.
CCDSiCCDS20290.1.
PIRiS29085.
RefSeqiNP_034261.1. NM_010131.2.
UniGeneiMm.391473.

Genome annotation databases

EnsembliENSMUST00000045942; ENSMUSP00000046026; ENSMUSG00000033726.
GeneIDi13796.
KEGGimmu:13796.
UCSCiuc009cpi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104322 mRNA. No translation available.
BC104323 mRNA. No translation available.
X68881 mRNA. Translation: CAA48752.1.
CCDSiCCDS20290.1.
PIRiS29085.
RefSeqiNP_034261.1. NM_010131.2.
UniGeneiMm.391473.

3D structure databases

ProteinModelPortaliQ04742.
SMRiQ04742. Positions 157-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199442. 16 interactions.
STRINGi10090.ENSMUSP00000046026.

Proteomic databases

PRIDEiQ04742.

Protocols and materials databases

DNASUi13796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045942; ENSMUSP00000046026; ENSMUSG00000033726.
GeneIDi13796.
KEGGimmu:13796.
UCSCiuc009cpi.1. mouse.

Organism-specific databases

CTDi2016.
MGIiMGI:95387. Emx1.

Phylogenomic databases

eggNOGiNOG266219.
GeneTreeiENSGT00760000119254.
HOGENOMiHOG000247032.
HOVERGENiHBG005024.
InParanoidiQ04742.
KOiK09317.
OMAiNHHINRW.
OrthoDBiEOG7XDBJW.
PhylomeDBiQ04742.
TreeFamiTF317015.

Miscellaneous databases

NextBioi284542.
PROiQ04742.
SOURCEiSearch...

Gene expression databases

BgeeiQ04742.
CleanExiMM_EMX1.
GenevestigatoriQ04742.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
    Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
    EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
  3. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  4. "Emx1 and Emx2 cooperate in initial phase of archipallium development."
    Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
    Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome."
    Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A., Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G., Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H.
    , Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y., Layman L.C.
    Am. J. Hum. Genet. 87:465-479(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiEMX1_MOUSE
AccessioniPrimary (citable) accession number: Q04742
Secondary accession number(s): Q3SXG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: January 7, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.