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Q04742 (EMX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein EMX1
Alternative name(s):
Empty spiracles homolog 1
Empty spiracles-like protein 1
Gene names
Name:Emx1
Synonyms:Emx-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Ref.3 Ref.4

Subunit structure

Intercts with WRD11 By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

Cerebral cortex. Expressed in the olfactory bulbs. Ref.3 Ref.5

Developmental stage

Detectable from E9.5 of gestation. Ref.5

Sequence similarities

Belongs to the EMX homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Homeobox protein EMX1
PRO_0000048867

Regions

DNA binding159 – 21860Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q04742 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: EC0051BC674430DF

FASTA25728,173
        10         20         30         40         50         60 
MFQPAAKRGF TIESLVAKDG GTGGSPGSGG AGSHPLAVAA SEEPLRPTAL NYPHPSAAET 

        70         80         90        100        110        120 
AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGSSSLQP PHSFFSAQHR 

       130        140        150        160        170        180 
DPLHFYPWVL RNRFFGHRFQ ASDVPQDGLL LHGPFARKPK RIRTAFSPSQ LLRLERAFEK 

       190        200        210        220        230        240 
NHYVVGAERK QLAGSLSLSE TQVKVWFQNR RTKYKRQKLE EEGPESEQKK KGSHHINRWR 

       250 
IATKQANGED IDVTSND 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex."
Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E.
EMBO J. 11:2541-2550(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
[3]"Nested expression domains of four homeobox genes in developing rostral brain."
Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224, FUNCTION, TISSUE SPECIFICITY.
Tissue: Brain.
[4]"Emx1 and Emx2 cooperate in initial phase of archipallium development."
Shinozaki K., Yoshida M., Nakamura M., Aizawa S., Suda Y.
Mech. Dev. 121:475-489(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome."
Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A., Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G., Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H. expand/collapse author list , Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y., Layman L.C.
Am. J. Hum. Genet. 87:465-479(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC104322 mRNA. No translation available.
BC104323 mRNA. No translation available.
X68881 mRNA. Translation: CAA48752.1.
CCDSCCDS20290.1.
PIRS29085.
RefSeqNP_034261.1. NM_010131.2.
UniGeneMm.391473.

3D structure databases

ProteinModelPortalQ04742.
SMRQ04742. Positions 157-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199442. 16 interactions.
STRING10090.ENSMUSP00000046026.

Proteomic databases

PRIDEQ04742.

Protocols and materials databases

DNASU13796.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045942; ENSMUSP00000046026; ENSMUSG00000033726.
GeneID13796.
KEGGmmu:13796.
UCSCuc009cpi.1. mouse.

Organism-specific databases

CTD2016.
MGIMGI:95387. Emx1.

Phylogenomic databases

eggNOGNOG266219.
GeneTreeENSGT00750000117439.
HOGENOMHOG000247032.
HOVERGENHBG005024.
InParanoidQ04742.
KOK09317.
OMANHHINRW.
OrthoDBEOG7XDBJW.
PhylomeDBQ04742.
TreeFamTF317015.

Gene expression databases

BgeeQ04742.
CleanExMM_EMX1.
GenevestigatorQ04742.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284542.
PROQ04742.
SOURCESearch...

Entry information

Entry nameEMX1_MOUSE
AccessionPrimary (citable) accession number: Q04742
Secondary accession number(s): Q3SXG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot