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Protein

Homeobox protein EMX1

Gene

EMX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi159 – 218HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein EMX1
Alternative name(s):
Empty spiracles homolog 1
Empty spiracles-like protein 1
Gene namesi
Name:EMX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135638.13
HGNCiHGNC:3340 EMX1
MIMi600034 gene
neXtProtiNX_Q04741

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2016
PharmGKBiPA27777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488661 – 257Homeobox protein EMX1Add BLAST257

Proteomic databases

EPDiQ04741
PaxDbiQ04741
PeptideAtlasiQ04741
PRIDEiQ04741
ProteomicsDBi58275
58276 [Q04741-2]

Expressioni

Tissue specificityi

Cerebral cortex.

Gene expression databases

BgeeiENSG00000135638
CleanExiHS_EMX1
ExpressionAtlasiQ04741 baseline and differential
GenevisibleiQ04741 HS

Organism-specific databases

HPAiHPA006230
HPA006421

Interactioni

Protein-protein interaction databases

BioGridi108331, 7 interactors
STRINGi9606.ENSP00000258106

Structurei

3D structure databases

ProteinModelPortaliQ04741
SMRiQ04741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843 Eukaryota
ENOG4111SRW LUCA
HOGENOMiHOG000247032
HOVERGENiHBG005024
InParanoidiQ04741
KOiK09317
OrthoDBiEOG091G0P41
PhylomeDBiQ04741
TreeFamiTF317015

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q04741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQPAAKRGF TIESLVAKDG GTGGGTGGGG AGSHLLAAAA SEEPLRPTAL
60 70 80 90 100
NYPHPSAAEA AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA
110 120 130 140 150
HQLGASPLQP PHSFFGAQHR DPLHFYPWVL RNRFFGHRFQ ASDVPQDGLL
160 170 180 190 200
LHGPFARKPK RIRTAFSPSQ LLRLERAFEK NHYVVGAERK QLAGSLSLSE
210 220 230 240 250
TQVKVWFQNR RTKYKRQKLE EEGPESEQKK KGSHHINRWR IATKQANGED

IDVTSND
Length:257
Mass (Da):28,039
Last modified:January 4, 2005 - v2
Checksum:i127B0BE676F14B46
GO
Isoform 2 (identifier: Q04741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-140: FQ → MV

Note: No experimental confirmation available.
Show »
Length:119
Mass (Da):13,725
Checksum:i38BE4315E2F30532
GO

Sequence cautioni

The sequence AAH45762 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0221451 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_022146139 – 140FQ → MV in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012366 Genomic DNA Translation: AAY14744.1
BC037242 mRNA Translation: AAH37242.1
BC045762 mRNA Translation: AAH45762.2 Different initiation.
X68879 mRNA Translation: CAA48750.1
PIRiS22721
RefSeqiNP_004088.2, NM_004097.2
XP_011530999.1, XM_011532697.2 [Q04741-2]
UniGeneiHs.516090

Genome annotation databases

EnsembliENST00000258106; ENSP00000258106; ENSG00000135638
GeneIDi2016
KEGGihsa:2016
UCSCiuc002sin.1 human [Q04741-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEMX1_HUMAN
AccessioniPrimary (citable) accession number: Q04741
Secondary accession number(s): Q0D2P0, Q53T30, Q86XB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 4, 2005
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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