Q04726 (TLE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transducin-like enhancer protein 3

Alternative name(s):
Enhancer of split groucho-like protein 3
Short name=ESG3

Gene names

Name:	TLE3
Synonyms:	KIAA1547

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	772 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES By similarity.
Subunit structure	Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 By similarity. Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Ref.6 Ref.17
Subcellular location	Nucleus.
Tissue specificity	Placenta and lung.
Post-translational modification	Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ref.17
Sequence similarities	Belongs to the WD repeat Groucho/TLE family. Contains 7 WD repeats.
Sequence caution	The sequence BAB13373.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Molecular function	Repressor
PTM	Acetylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Traceable author statement. Source: Reactome Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW organ morphogenesis Traceable author statement PubMed 8808280. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q04726-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q04726-2)

The sequence of this isoform differs from the canonical sequence as follows:
     342-353: Missing.

Isoform 3 (identifier: Q04726-3)

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.
     417-421: Missing.

Note: Contains a N6-acetyllysine at position 343.

Isoform 4 (identifier: Q04726-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MYPQGRHP → MPPPPPLSCLRGLQ
     127-127: Missing.
     417-421: Missing.

Isoform 5 (identifier: Q04726-5)

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.

Note: No experimental confirmation available. Contains a N6-acetyllysine at position 343.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 772	772	Transducin-like enhancer protein 3		PRO_0000051280
Regions
	Repeat	484 – 522	39	WD 1
	Repeat	530 – 569	40	WD 2
	Repeat	574 – 613	40	WD 3
	Repeat	616 – 655	40	WD 4
	Repeat	657 – 696	40	WD 5
	Repeat	698 – 737	40	WD 6
	Repeat	739 – 771	33	WD 7
	Region	199 – 268	70	CCN domain
	Motif	225 – 228	4	Nuclear localization signal Potential
	Compositional bias	1 – 131	131	Gln-rich
	Compositional bias	132 – 198	67	Gly/Pro-rich
	Compositional bias	269 – 451	183	Pro/Ser-rich
	Compositional bias	401 – 409	9	Poly-Ala
Amino acid modifications
	Modified residue	203	1	Phosphoserine Ref.8 Ref.10 Ref.12 Ref.14 Ref.16
	Modified residue	207	1	Phosphoserine Ref.10
	Modified residue	217	1	Phosphoserine Ref.7
	Modified residue	240	1	Phosphoserine Ref.16
	Modified residue	245	1	Phosphoserine Ref.16
	Modified residue	259	1	Phosphothreonine Ref.10 Ref.12 Ref.14 Ref.16
	Modified residue	263	1	Phosphoserine Ref.10 Ref.14 Ref.16
	Modified residue	267	1	Phosphoserine Ref.10 Ref.14 Ref.16
	Modified residue	286	1	Phosphoserine Ref.8 Ref.10 Ref.12 Ref.16
	Modified residue	312	1	Phosphothreonine Ref.10
	Modified residue	317	1	Phosphoserine Ref.10
	Modified residue	319	1	Phosphothreonine Ref.10
	Modified residue	321	1	Phosphothreonine Ref.10
	Modified residue	328	1	Phosphothreonine Ref.10 Ref.12 Ref.14
	Modified residue	334	1	Phosphothreonine Ref.8 Ref.10 Ref.12 Ref.14
	Modified residue	413	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 8	8	MYPQGRHP → MPPPPPLSCLRGLQ in isoform 4.		VSP_007023
	Alternative sequence	127	1	Missing in isoform 4.		VSP_007024
	Alternative sequence	342 – 353	12	Missing in isoform 2.		VSP_006788
	Alternative sequence	351 – 353	3	Missing in isoform 3 and isoform 5.		VSP_006789
	Alternative sequence	417 – 421	5	Missing in isoform 3 and isoform 4.		VSP_006790
	Natural variant	229	1	A → V. Ref.1 Corresponds to variant rs1057864 [ dbSNP | Ensembl ].		VAR_053421
Experimental info
	Sequence conflict	409	1	A → T in AAH41831. Ref.5
	Sequence conflict	487	1	E → G in AAA61194. Ref.1
	Sequence conflict	498	1	T → S in AAA61194. Ref.1
	Sequence conflict	535	1	I → M in AAA61194. Ref.1
	Sequence conflict	541	1	L → H in AAA61194. Ref.1
	Sequence conflict	553	1	A → G in AAA61194. Ref.1
	Sequence conflict	692	1	D → H in AAA61194. Ref.1
	Sequence conflict	736	1	F → S in AAA61194. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: A2A469D73BF04A43	FASTA	772	83,417
	10 20 30 40 50 60 MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 190 200 210 220 230 240 KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 250 260 270 280 290 300 DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 310 320 330 340 350 360 TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI GIMASALRTP 370 380 390 400 410 420 ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY GRSPMVSFGA 430 440 450 460 470 480 VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI 490 500 510 520 530 540 NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL 550 560 570 580 590 600 LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 610 620 630 640 650 660 AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS 670 680 690 700 710 720 QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK 730 740 750 760 770 DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY
	Isoform 2 [UniParc]. Checksum: 5CA1DDAE26C00E19	FASTA	760	82,222
	10 20 30 40 50 60 MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 190 200 210 220 230 240 KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 250 260 270 280 290 300 DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 310 320 330 340 350 360 TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PASALRTPIS ITSSYAAPFA 370 380 390 400 410 420 MMSHHEMNGS LTSPGAYAGL HNIPPQMSAA AAAAAAAYGR SPMVSFGAVG FDPHPPMRAT 430 440 450 460 470 480 GLPSSLASIP GGKPAYSFHV SADGQMQPVP FPHDALAGPG IPRHARQINT LSHGEVVCAV 490 500 510 520 530 540 TISNPTRHVY TGGKGCVKIW DISQPGSKSP ISQLDCLNRD NYIRSCKLLP DGRTLIVGGE 550 560 570 580 590 600 ASTLTIWDLA SPTPRIKAEL TSSAPACYAL AISPDAKVCF SCCSDGNIAV WDLHNQTLVR 610 620 630 640 650 660 QFQGHTDGAS CIDISHDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE 670 680 690 700 710 720 WLAVGMESSN VEVLHHTKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG 730 740 750 760 ASIFQSKESS SVLSCDISAD DKYIVTGSGD KKATVYEVIY
	Isoform 3 [UniParc]. Checksum: EF5606A1D9C7C2BA	FASTA	764	82,654
	10 20 30 40 50 60 MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 190 200 210 220 230 240 KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 250 260 270 280 290 300 DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 310 320 330 340 350 360 TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 370 380 390 400 410 420 TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVGFDPHPP 430 440 450 460 470 480 MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 490 500 510 520 530 540 VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 550 560 570 580 590 600 VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ 610 620 630 640 650 660 TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 670 680 690 700 710 720 PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 730 740 750 760 TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY
	Isoform 4 [UniParc]. Checksum: F10C1C00DE38D280	FASTA	772	83,348
	10 20 30 40 50 60 MPPPPPLSCL RGLQAPHQPG QPGFKFTVAE SCDRIKDEFQ FLQAQYHSLK VEYDKLANEK 70 80 90 100 110 120 TEMQRHYVMY YEMSYGLNIE MHKQTEIAKR LNTILAQIMP FLSQEHQQQV AQAVERAKQV 130 140 150 160 170 180 TMTELNAIIG QQLQAQHLSH ATHGPPVQLP PHPSGLQPPG IPPVTGSSSG LLALGALGSQ 190 200 210 220 230 240 AHLTVKDEKN HHELDHRERE SSANNSVSPS ESLRASEKHR GSADYSMEAK KRKAEEKDSL 250 260 270 280 290 300 SRYDSDGDKS DDLVVDVSNE DPATPRVSPA HSPPENGLDK ARSLKKDAPT SPASVASSSS 310 320 330 340 350 360 TPSSKTKDLG HNDKSSTPGL KSNTPTPRND APTPGTSTTP GLRSMPGKPP GMDPIGIMAS 370 380 390 400 410 420 ALRTPISITS SYAAPFAMMS HHEMNGSLTS PGAYAGLHNI PPQMSAAAAA AAAAYGRSPM 430 440 450 460 470 480 VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI 490 500 510 520 530 540 NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL 550 560 570 580 590 600 LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 610 620 630 640 650 660 AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS 670 680 690 700 710 720 QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK 730 740 750 760 770 DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY
	Isoform 5 [UniParc]. Checksum: 9E7895DE647F9D9E	FASTA	769	83,115
	10 20 30 40 50 60 MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 190 200 210 220 230 240 KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 250 260 270 280 290 300 DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 310 320 330 340 350 360 TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 370 380 390 400 410 420 TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVSFGAVGF 430 440 450 460 470 480 DPHPPMRATG LPSSLASIPG GKPAYSFHVS ADGQMQPVPF PHDALAGPGI PRHARQINTL 490 500 510 520 530 540 SHGEVVCAVT ISNPTRHVYT GGKGCVKIWD ISQPGSKSPI SQLDCLNRDN YIRSCKLLPD 550 560 570 580 590 600 GRTLIVGGEA STLTIWDLAS PTPRIKAELT SSAPACYALA ISPDAKVCFS CCSDGNIAVW 610 620 630 640 650 660 DLHNQTLVRQ FQGHTDGASC IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF 670 680 690 700 710 720 SLGYCPTGEW LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL 730 740 750 760 LNAWRTPYGA SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins." Stifani S., Blaumueller C.M., Redhead N.J., Hill R.E., Artavanis-Tsakonas S. Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-229. Tissue: Fetal brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Trachea.
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Pancreas and Testis.
[6]	"Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta." Wang J.-C., Waltner-Law M., Yamada K., Osawa H., Stifani S., Granner D.K. J. Biol. Chem. 275:18418-18423(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 324-338 AND 521-531, INTERACTION WITH FOXA2.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-286 AND THR-334, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-207; THR-259; SER-263; SER-267; SER-286; THR-312; SER-317; THR-319; THR-321; THR-328; THR-334 AND SER-413, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; THR-259; SER-286; THR-328 AND THR-334, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-343 (ISOFORMS 3 AND 5), MASS SPECTROMETRY.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; THR-259; SER-263; SER-267; THR-328 AND THR-334, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-240; SER-245; THR-259; SER-263; SER-267 AND SER-286, MASS SPECTROMETRY.
[17]	"XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling." Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E. Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, UBIQUITINATION BY XIAP/BIRC4, INTERACTION WITH XIAP/BIRC4 AND TCF7L2/TCF4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M99438 mRNA. Translation: AAA61194.1. AB046767 mRNA. Translation: BAB13373.1. Different initiation. AK315058 mRNA. No translation available. AC026583 Genomic DNA. No translation available. AC068327 Genomic DNA. No translation available. BC015729 mRNA. No translation available. BC041831 mRNA. Translation: AAH41831.1.
IPI	IPI00177938. IPI00182478. IPI00219368. IPI00221206. IPI00867718.
PIR	D56695.
RefSeq	NP_001098662.1. NM_001105192.1. NP_005069.2. NM_005078.2. NP_065959.1. NM_020908.1.
UniGene	Hs.287362.
3D structure databases
ProteinModelPortal	Q04726.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q04726. 4 interactions.
STRING	9606.ENSP00000319233.
PTM databases
PhosphoSite	Q04726.
Polymorphism databases
DMDM	20532417.
Proteomic databases
PaxDb	Q04726.
PRIDE	Q04726.
Protocols and materials databases
DNASU	7090.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317509; ENSP00000319233; ENSG00000140332. ENST00000451782; ENSP00000394717; ENSG00000140332. ENST00000557907; ENSP00000453107; ENSG00000140332. ENST00000557997; ENSP00000453083; ENSG00000140332. ENST00000558939; ENSP00000452871; ENSG00000140332. ENST00000559048; ENSP00000453760; ENSG00000140332.
GeneID	7090.
KEGG	hsa:7090.
UCSC	uc002asl.2. human. uc002asm.2. human. uc002asn.2. human. uc002asp.2. human.
Organism-specific databases
CTD	7090.
GeneCards	GC15M070341.
HGNC	HGNC:11839. TLE3.
HPA	HPA054116.
MIM	600190. gene.
neXtProt	NX_Q04726.
PharmGKB	PA36541.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000293211.
HOVERGEN	HBG004689.
InParanoid	Q04726.
OMA	SQAHLAV.
OrthoDB	EOG4MGS6V.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q04726.
Bgee	Q04726.
CleanEx	HS_TLE3.
Genevestigator	Q04726.
GermOnline	ENSG00000140332. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR005617. Groucho/TLE_N. IPR009146. Groucho_enhance. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF03920. TLE_N. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
PRINTS	PR01850. GROUCHOFAMLY.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7090.
NextBio	27731.
SOURCE	Search...

Entry information

Entry name

TLE3_HUMAN

Accession

Primary (citable) accession number: Q04726
Secondary accession number(s): E9PD64 , Q8IVV6, Q8WVR2, Q9HCM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	May 10, 2002
Last modified:	May 1, 2013
This is version 137 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.