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Q04726

- TLE3_HUMAN

UniProt

Q04726 - TLE3_HUMAN

Protein

Transducin-like enhancer protein 3

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. Notch signaling pathway Source: Reactome
    2. organ morphogenesis Source: ProtInc
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. signal transduction Source: ProtInc
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_200731. deactivation of the beta-catenin transactivating complex.
    REACT_200753. formation of the beta-catenin:TCF transactivating complex.
    SignaLinkiQ04726.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transducin-like enhancer protein 3
    Alternative name(s):
    Enhancer of split groucho-like protein 3
    Short name:
    ESG3
    Gene namesi
    Name:TLE3
    Synonyms:KIAA1547
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:11839. TLE3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36541.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 772772Transducin-like enhancer protein 3PRO_0000051280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei203 – 2031Phosphoserine5 Publications
    Modified residuei207 – 2071Phosphoserine1 Publication
    Modified residuei217 – 2171Phosphoserine1 Publication
    Modified residuei240 – 2401Phosphoserine1 Publication
    Modified residuei245 – 2451Phosphoserine1 Publication
    Modified residuei259 – 2591Phosphothreonine4 Publications
    Modified residuei263 – 2631Phosphoserine3 Publications
    Modified residuei267 – 2671Phosphoserine3 Publications
    Modified residuei286 – 2861Phosphoserine4 Publications
    Modified residuei312 – 3121Phosphothreonine1 Publication
    Modified residuei317 – 3171Phosphoserine1 Publication
    Modified residuei319 – 3191Phosphothreonine1 Publication
    Modified residuei321 – 3211Phosphothreonine1 Publication
    Modified residuei328 – 3281Phosphothreonine3 Publications
    Modified residuei334 – 3341Phosphothreonine4 Publications
    Modified residuei413 – 4131Phosphoserine1 Publication

    Post-translational modificationi

    Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ04726.
    PaxDbiQ04726.
    PRIDEiQ04726.

    PTM databases

    PhosphoSiteiQ04726.

    Expressioni

    Tissue specificityi

    Placenta and lung.

    Gene expression databases

    ArrayExpressiQ04726.
    BgeeiQ04726.
    CleanExiHS_TLE3.
    GenevestigatoriQ04726.

    Organism-specific databases

    HPAiHPA054116.

    Interactioni

    Subunit structurei

    Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 By similarity. Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi112945. 27 interactions.
    IntActiQ04726. 9 interactions.
    MINTiMINT-2805536.
    STRINGi9606.ENSP00000319233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04726.
    SMRiQ04726. Positions 443-772.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati484 – 52239WD 1Add
    BLAST
    Repeati530 – 56940WD 2Add
    BLAST
    Repeati574 – 61340WD 3Add
    BLAST
    Repeati616 – 65540WD 4Add
    BLAST
    Repeati657 – 69640WD 5Add
    BLAST
    Repeati698 – 73740WD 6Add
    BLAST
    Repeati739 – 77133WD 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 26870CCN domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi225 – 2284Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 131131Gln-richAdd
    BLAST
    Compositional biasi132 – 19867Gly/Pro-richAdd
    BLAST
    Compositional biasi269 – 451183Pro/Ser-richAdd
    BLAST
    Compositional biasi401 – 4099Poly-Ala

    Sequence similaritiesi

    Belongs to the WD repeat Groucho/TLE family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000293211.
    HOVERGENiHBG004689.
    InParanoidiQ04726.
    OrthoDBiEOG7HQNC3.
    PhylomeDBiQ04726.
    TreeFamiTF314167.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR005617. Groucho/TLE_N.
    IPR009146. Groucho_enhance.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF03920. TLE_N. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR01850. GROUCHOFAMLY.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q04726-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL    50
    ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH 100
    QQQVAQAVER AKQVTMTELN AIIGQQQLQA QHLSHATHGP PVQLPPHPSG 150
    LQPPGIPPVT GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN 200
    SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS DGDKSDDLVV 250
    DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 300
    TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI 350
    GIMASALRTP ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS 400
    AAAAAAAAAY GRSPMVSFGA VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF 450
    HVSADGQMQP VPFPHDALAG PGIPRHARQI NTLSHGEVVC AVTISNPTRH 500
    VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL LPDGRTLIVG 550
    GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 600
    AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG 650
    RQLQQHDFTS QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE 700
    SCVLSLKFAY CGKWFVSTGK DNLLNAWRTP YGASIFQSKE SSSVLSCDIS 750
    ADDKYIVTGS GDKKATVYEV IY 772
    Length:772
    Mass (Da):83,417
    Last modified:May 10, 2002 - v2
    Checksum:iA2A469D73BF04A43
    GO
    Isoform 2 (identifier: Q04726-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         342-353: Missing.

    Show »
    Length:760
    Mass (Da):82,222
    Checksum:i5CA1DDAE26C00E19
    GO
    Isoform 3 (identifier: Q04726-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-353: Missing.
         417-421: Missing.

    Note: Contains a N6-acetyllysine at position 343.

    Show »
    Length:764
    Mass (Da):82,654
    Checksum:iEF5606A1D9C7C2BA
    GO
    Isoform 4 (identifier: Q04726-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MYPQGRHP → MPPPPPLSCLRGLQ
         127-127: Missing.
         417-421: Missing.

    Show »
    Length:772
    Mass (Da):83,348
    Checksum:iF10C1C00DE38D280
    GO
    Isoform 5 (identifier: Q04726-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-353: Missing.

    Note: No experimental confirmation available. Contains a N6-acetyllysine at position 343.

    Show »
    Length:769
    Mass (Da):83,115
    Checksum:i9E7895DE647F9D9E
    GO
    Isoform 6 (identifier: Q04726-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-420: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:767
    Mass (Da):82,955
    Checksum:i7081DB8CE8BF2EAD
    GO
    Isoform 7 (identifier: Q04726-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MYPQGRHP → M
         351-353: Missing.

    Show »
    Length:762
    Mass (Da):82,279
    Checksum:iE82ECE78C54894E1
    GO

    Sequence cautioni

    The sequence BAB13373.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti358 – 3581R → C in BAG60692. (PubMed:14702039)Curated
    Sequence conflicti365 – 3651S → G in BAG60692. (PubMed:14702039)Curated
    Sequence conflicti409 – 4091A → T in AAH41831. (PubMed:15489334)Curated
    Sequence conflicti487 – 4871E → G in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti498 – 4981T → S in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti535 – 5351I → M in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti541 – 5411L → H in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti549 – 5491V → E in BAG60692. (PubMed:14702039)Curated
    Sequence conflicti553 – 5531A → G in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti692 – 6921D → H in AAA61194. (PubMed:1303260)Curated
    Sequence conflicti736 – 7361F → S in AAA61194. (PubMed:1303260)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti229 – 2291A → V.1 Publication
    Corresponds to variant rs1057864 [ dbSNP | Ensembl ].
    VAR_053421

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 88MYPQGRHP → MPPPPPLSCLRGLQ in isoform 4. 1 PublicationVSP_007023
    Alternative sequencei1 – 88MYPQGRHP → M in isoform 7. 1 PublicationVSP_055168
    Alternative sequencei127 – 1271Missing in isoform 4. 1 PublicationVSP_007024
    Alternative sequencei342 – 35312Missing in isoform 2. 1 PublicationVSP_006788Add
    BLAST
    Alternative sequencei351 – 3533Missing in isoform 3, isoform 5 and isoform 7. 2 PublicationsVSP_006789
    Alternative sequencei416 – 4205Missing in isoform 6. 1 PublicationVSP_054598
    Alternative sequencei417 – 4215Missing in isoform 3 and isoform 4. 1 PublicationVSP_006790

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99438 mRNA. Translation: AAA61194.1.
    AB046767 mRNA. Translation: BAB13373.1. Different initiation.
    AK315058 mRNA. No translation available.
    AK298482 mRNA. Translation: BAG60692.1.
    AC026583 Genomic DNA. No translation available.
    AC068327 Genomic DNA. No translation available.
    BC015729 mRNA. No translation available.
    BC041831 mRNA. Translation: AAH41831.1.
    BC043247 mRNA. Translation: AAH43247.1.
    CCDSiCCDS45293.1. [Q04726-1]
    CCDS45294.1. [Q04726-5]
    CCDS58375.1. [Q04726-2]
    CCDS61689.1. [Q04726-7]
    CCDS61691.1. [Q04726-6]
    CCDS61692.1. [Q04726-3]
    PIRiD56695.
    RefSeqiNP_001098662.1. NM_001105192.2. [Q04726-5]
    NP_001269908.1. NM_001282979.1. [Q04726-3]
    NP_001269909.1. NM_001282980.1. [Q04726-6]
    NP_001269910.1. NM_001282981.1.
    NP_001269911.1. NM_001282982.1.
    NP_005069.2. NM_005078.3. [Q04726-1]
    NP_065959.1. NM_020908.2. [Q04726-2]
    UniGeneiHs.287362.

    Genome annotation databases

    GeneIDi7090.
    KEGGihsa:7090.
    UCSCiuc002asl.2. human. [Q04726-4]
    uc002asm.2. human. [Q04726-1]
    uc002asn.2. human. [Q04726-2]
    uc002asp.2. human. [Q04726-3]

    Polymorphism databases

    DMDMi20532417.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99438 mRNA. Translation: AAA61194.1 .
    AB046767 mRNA. Translation: BAB13373.1 . Different initiation.
    AK315058 mRNA. No translation available.
    AK298482 mRNA. Translation: BAG60692.1 .
    AC026583 Genomic DNA. No translation available.
    AC068327 Genomic DNA. No translation available.
    BC015729 mRNA. No translation available.
    BC041831 mRNA. Translation: AAH41831.1 .
    BC043247 mRNA. Translation: AAH43247.1 .
    CCDSi CCDS45293.1. [Q04726-1 ]
    CCDS45294.1. [Q04726-5 ]
    CCDS58375.1. [Q04726-2 ]
    CCDS61689.1. [Q04726-7 ]
    CCDS61691.1. [Q04726-6 ]
    CCDS61692.1. [Q04726-3 ]
    PIRi D56695.
    RefSeqi NP_001098662.1. NM_001105192.2. [Q04726-5 ]
    NP_001269908.1. NM_001282979.1. [Q04726-3 ]
    NP_001269909.1. NM_001282980.1. [Q04726-6 ]
    NP_001269910.1. NM_001282981.1.
    NP_001269911.1. NM_001282982.1.
    NP_005069.2. NM_005078.3. [Q04726-1 ]
    NP_065959.1. NM_020908.2. [Q04726-2 ]
    UniGenei Hs.287362.

    3D structure databases

    ProteinModelPortali Q04726.
    SMRi Q04726. Positions 443-772.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112945. 27 interactions.
    IntActi Q04726. 9 interactions.
    MINTi MINT-2805536.
    STRINGi 9606.ENSP00000319233.

    PTM databases

    PhosphoSitei Q04726.

    Polymorphism databases

    DMDMi 20532417.

    Proteomic databases

    MaxQBi Q04726.
    PaxDbi Q04726.
    PRIDEi Q04726.

    Protocols and materials databases

    DNASUi 7090.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7090.
    KEGGi hsa:7090.
    UCSCi uc002asl.2. human. [Q04726-4 ]
    uc002asm.2. human. [Q04726-1 ]
    uc002asn.2. human. [Q04726-2 ]
    uc002asp.2. human. [Q04726-3 ]

    Organism-specific databases

    CTDi 7090.
    GeneCardsi GC15M070341.
    HGNCi HGNC:11839. TLE3.
    HPAi HPA054116.
    MIMi 600190. gene.
    neXtProti NX_Q04726.
    PharmGKBi PA36541.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000293211.
    HOVERGENi HBG004689.
    InParanoidi Q04726.
    OrthoDBi EOG7HQNC3.
    PhylomeDBi Q04726.
    TreeFami TF314167.

    Enzyme and pathway databases

    Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_200731. deactivation of the beta-catenin transactivating complex.
    REACT_200753. formation of the beta-catenin:TCF transactivating complex.
    SignaLinki Q04726.

    Miscellaneous databases

    GeneWikii TLE3.
    GenomeRNAii 7090.
    NextBioi 27731.
    PROi Q04726.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04726.
    Bgeei Q04726.
    CleanExi HS_TLE3.
    Genevestigatori Q04726.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR005617. Groucho/TLE_N.
    IPR009146. Groucho_enhance.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF03920. TLE_N. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR01850. GROUCHOFAMLY.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."
      Stifani S., Blaumueller C.M., Redhead N.J., Hill R.E., Artavanis-Tsakonas S.
      Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-229.
      Tissue: Fetal brain.
    2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7).
      Tissue: Trachea.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6).
      Tissue: Pancreas and Testis.
    6. "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta."
      Wang J.-C., Waltner-Law M., Yamada K., Osawa H., Stifani S., Granner D.K.
      J. Biol. Chem. 275:18418-18423(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 324-338 AND 521-531, INTERACTION WITH FOXA2.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-286 AND THR-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-207; THR-259; SER-263; SER-267; SER-286; THR-312; SER-317; THR-319; THR-321; THR-328; THR-334 AND SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; THR-259; SER-286; THR-328 AND THR-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-343 (ISOFORMS 3 AND 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; THR-259; SER-263; SER-267; THR-328 AND THR-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-240; SER-245; THR-259; SER-263; SER-267 AND SER-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
      Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.
      Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, UBIQUITINATION BY XIAP/BIRC4, INTERACTION WITH XIAP/BIRC4 AND TCF7L2/TCF4.

    Entry informationi

    Entry nameiTLE3_HUMAN
    AccessioniPrimary (citable) accession number: Q04726
    Secondary accession number(s): B4DPT0
    , E9PD64, F8W964, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 153 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3