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Q04718

- FUMA_GEOSE

UniProt

Q04718 - FUMA_GEOSE

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Protein
Fumarate hydratase class I, aerobic
Gene
fumA
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate = fumarate + H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron-sulfur Reviewed prediction
Metal bindingi187 – 1871Iron-sulfur Reviewed prediction
Metal bindingi274 – 2741Iron-sulfur Reviewed prediction
Active sitei358 – 3581 Reviewed prediction
Binding sitei422 – 4221Substrate Reviewed prediction

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. fumarate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class I, aerobic (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fumA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Fumarate hydratase class I, aerobic
PRO_0000195655Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ04718.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
[Graphical view]
PfamiPF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04718-1 [UniParc]FASTAAdd to Basket

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MEKLYESMYQ LIVETSTKLP KDVRRAILKA KQRENAGTRA AMSLATITEN    50
IKMADENVSP ICQDTGLPTF KIKVPVGINQ IQIKETIKKA IAQATKDGKL 100
RPNSVDSLTG ENSGDNLGEG LPVVKFEQWE KDYMDVRLIL KGGGCENKNI 150
QYSLPCELEG LGRAGRDLDG IRKCILHAVY QAQGQGCSAG FIGVGIGGDR 200
SAGYDLAKEQ LFREVDDVNP NEELRQLEEY IMENANKLGI GTMGFGGETT 250
LLGCKVGAMH RIPASFFVSV AYNCWAFRRL GVHIDPNTGE IIKWLYQDGE 300
DVDFQENAAQ EEHLASTDSE RRVITLQAPI TEEQIRELKV GDVVRINGII 350
YTGRDAIHKY LMDHDAPVDL NGQIIYHCGP VMLKDENGNW EVKAAGPTTS 400
IREEPYQGDI MKKFGIRAVM GKGGMGQKTL QALKEHGGVY LNAIGGAAQY 450
YADCIEAVEG VDLLEFGIPE AMWHLRVKDF TAVVTMDSHG NSLHEDIEKS 500
SLEKLSQFKE PVFS 514
Length:514
Mass (Da):56,792
Last modified:October 1, 1993 - v1
Checksum:i238F2890E8CC54E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05611 Genomic DNA. Translation: AAA72317.1.
PIRiA47692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05611 Genomic DNA. Translation: AAA72317.1 .
PIRi A47692.

3D structure databases

ProteinModelPortali Q04718.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .

Family and domain databases

Gene3Di 3.20.130.10. 1 hit.
InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
[Graphical view ]
Pfami PF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMi SSF117457. SSF117457. 1 hit.
TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular and enzymological evidence for two classes of fumarase in Bacillus stearothermophilus (var. non-diastaticus)."
    Reaney S.K., Bungard S.J., Guest J.R.
    J. Gen. Microbiol. 139:403-416(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 2334 / Var. Non-diastaticus.

Entry informationi

Entry nameiFUMA_GEOSE
AccessioniPrimary (citable) accession number: Q04718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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