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Q04718

- FUMA_GEOSE

UniProt

Q04718 - FUMA_GEOSE

Protein

Fumarate hydratase class I, aerobic

Gene

fumA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate = fumarate + H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Iron-sulfurSequence Analysis
    Metal bindingi187 – 1871Iron-sulfurSequence Analysis
    Metal bindingi274 – 2741Iron-sulfurSequence Analysis
    Active sitei358 – 3581Sequence Analysis
    Binding sitei422 – 4221SubstrateSequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. fumarate hydratase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fumarate hydratase class I, aerobic (EC:4.2.1.2)
    Short name:
    Fumarase
    Gene namesi
    Name:fumA
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Fumarate hydratase class I, aerobicPRO_0000195655Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04718.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I fumarase family.Curated

    Family and domain databases

    Gene3Di3.20.130.10. 1 hit.
    InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
    IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
    IPR011167. Fe_dep_fumarate_hydratase.
    [Graphical view]
    PfamiPF05681. Fumerase. 1 hit.
    PF05683. Fumerase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
    SUPFAMiSSF117457. SSF117457. 1 hit.
    TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
    TIGR00723. ttdB_fumA_fumB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04718-1 [UniParc]FASTAAdd to Basket

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    MEKLYESMYQ LIVETSTKLP KDVRRAILKA KQRENAGTRA AMSLATITEN    50
    IKMADENVSP ICQDTGLPTF KIKVPVGINQ IQIKETIKKA IAQATKDGKL 100
    RPNSVDSLTG ENSGDNLGEG LPVVKFEQWE KDYMDVRLIL KGGGCENKNI 150
    QYSLPCELEG LGRAGRDLDG IRKCILHAVY QAQGQGCSAG FIGVGIGGDR 200
    SAGYDLAKEQ LFREVDDVNP NEELRQLEEY IMENANKLGI GTMGFGGETT 250
    LLGCKVGAMH RIPASFFVSV AYNCWAFRRL GVHIDPNTGE IIKWLYQDGE 300
    DVDFQENAAQ EEHLASTDSE RRVITLQAPI TEEQIRELKV GDVVRINGII 350
    YTGRDAIHKY LMDHDAPVDL NGQIIYHCGP VMLKDENGNW EVKAAGPTTS 400
    IREEPYQGDI MKKFGIRAVM GKGGMGQKTL QALKEHGGVY LNAIGGAAQY 450
    YADCIEAVEG VDLLEFGIPE AMWHLRVKDF TAVVTMDSHG NSLHEDIEKS 500
    SLEKLSQFKE PVFS 514
    Length:514
    Mass (Da):56,792
    Last modified:October 1, 1993 - v1
    Checksum:i238F2890E8CC54E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05611 Genomic DNA. Translation: AAA72317.1.
    PIRiA47692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05611 Genomic DNA. Translation: AAA72317.1 .
    PIRi A47692.

    3D structure databases

    ProteinModelPortali Q04718.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01007 .

    Family and domain databases

    Gene3Di 3.20.130.10. 1 hit.
    InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
    IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
    IPR011167. Fe_dep_fumarate_hydratase.
    [Graphical view ]
    Pfami PF05681. Fumerase. 1 hit.
    PF05683. Fumerase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
    SUPFAMi SSF117457. SSF117457. 1 hit.
    TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
    TIGR00723. ttdB_fumA_fumB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and enzymological evidence for two classes of fumarase in Bacillus stearothermophilus (var. non-diastaticus)."
      Reaney S.K., Bungard S.J., Guest J.R.
      J. Gen. Microbiol. 139:403-416(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 2334 / Var. Non-diastaticus.

    Entry informationi

    Entry nameiFUMA_GEOSE
    AccessioniPrimary (citable) accession number: Q04718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3