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Q04718

- FUMA_GEOSE

UniProt

Q04718 - FUMA_GEOSE

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Protein

Putative fumarate hydratase class I

Gene

fumA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible hydration of fumarate to (S)-malate.By similarity

Catalytic activityi

(S)-malate = fumarate + H2O.By similarity

Cofactori

Binds 1 4Fe-4S cluster per subunit.By similarity

Pathwayi

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. fumarate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fumarate hydratase class I (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fumA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Putative fumarate hydratase class IPRO_0000195655Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ04718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.Curated

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
[Graphical view]
PfamiPF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLYESMYQ LIVETSTKLP KDVRRAILKA KQRENAGTRA AMSLATITEN
60 70 80 90 100
IKMADENVSP ICQDTGLPTF KIKVPVGINQ IQIKETIKKA IAQATKDGKL
110 120 130 140 150
RPNSVDSLTG ENSGDNLGEG LPVVKFEQWE KDYMDVRLIL KGGGCENKNI
160 170 180 190 200
QYSLPCELEG LGRAGRDLDG IRKCILHAVY QAQGQGCSAG FIGVGIGGDR
210 220 230 240 250
SAGYDLAKEQ LFREVDDVNP NEELRQLEEY IMENANKLGI GTMGFGGETT
260 270 280 290 300
LLGCKVGAMH RIPASFFVSV AYNCWAFRRL GVHIDPNTGE IIKWLYQDGE
310 320 330 340 350
DVDFQENAAQ EEHLASTDSE RRVITLQAPI TEEQIRELKV GDVVRINGII
360 370 380 390 400
YTGRDAIHKY LMDHDAPVDL NGQIIYHCGP VMLKDENGNW EVKAAGPTTS
410 420 430 440 450
IREEPYQGDI MKKFGIRAVM GKGGMGQKTL QALKEHGGVY LNAIGGAAQY
460 470 480 490 500
YADCIEAVEG VDLLEFGIPE AMWHLRVKDF TAVVTMDSHG NSLHEDIEKS
510
SLEKLSQFKE PVFS
Length:514
Mass (Da):56,792
Last modified:October 1, 1993 - v1
Checksum:i238F2890E8CC54E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05611 Genomic DNA. Translation: AAA72317.1.
PIRiA47692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05611 Genomic DNA. Translation: AAA72317.1 .
PIRi A47692.

3D structure databases

ProteinModelPortali Q04718.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .

Family and domain databases

Gene3Di 3.20.130.10. 1 hit.
InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
[Graphical view ]
Pfami PF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMi SSF117457. SSF117457. 1 hit.
TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular and enzymological evidence for two classes of fumarase in Bacillus stearothermophilus (var. non-diastaticus)."
    Reaney S.K., Bungard S.J., Guest J.R.
    J. Gen. Microbiol. 139:403-416(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 2334 / Var. Non-diastaticus.

Entry informationi

Entry nameiFUMA_GEOSE
AccessioniPrimary (citable) accession number: Q04718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3