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Q04712

- RRN11_YEAST

UniProt

Q04712 - RRN11_YEAST

Protein

RNA polymerase I-specific transcription initiation factor RRN11

Gene

RRN11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase I CORE element sequence-specific DNA binding Source: SGD
    3. RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: SGD
    4. TBP-class protein binding Source: SGD

    GO - Biological processi

    1. RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript Source: GOC
    2. transcription initiation from RNA polymerase I promoter Source: SGD
    3. transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: SGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32641-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase I-specific transcription initiation factor RRN11
    Gene namesi
    Name:RRN11
    Ordered Locus Names:YML043C
    ORF Names:YM9827.09C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML043c.
    SGDiS000004507. RRN11.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. RNA polymerase I core factor complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507RNA polymerase I-specific transcription initiation factor RRN11PRO_0000203257Add
    BLAST

    Proteomic databases

    PaxDbiQ04712.
    PeptideAtlasiQ04712.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04712.

    Interactioni

    Subunit structurei

    Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RRN6P327862EBI-27790,EBI-15986
    RRN7P409922EBI-27790,EBI-15990
    SPT15P133932EBI-27790,EBI-19129

    Protein-protein interaction databases

    BioGridi35126. 11 interactions.
    DIPiDIP-4542N.
    IntActiQ04712. 8 interactions.
    MINTiMINT-526952.
    STRINGi4932.YML043C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG75014.
    HOGENOMiHOG000141986.
    KOiK15222.
    OMAiMFEVPIT.
    OrthoDBiEOG7MSN0R.

    Family and domain databases

    InterProiIPR007224. TIF_Rrn11.
    IPR016850. TIF_Rrn11_budding_yeast.
    [Graphical view]
    PfamiPF04090. RNA_pol_I_TF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027133. Rrn11. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04712-1 [UniParc]FASTAAdd to Basket

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    MFEVPITLTN RKFAQRRKLK YQYINYISRR FDRISKKSTT TDSLPTPENS    50
    AAENNDEEEG QNSEAGTYRR SVLQQKKRRR ERHWRSVVGE IYSTTESETD 100
    SQEEETEEGG EHDTGIDKED SDEERKFWKK YEKPEKSFEI WRTVSSQNKQ 150
    PINKQKMTYH NFKKIEKIPL RKMEIPLLHC TKENKLYFQS ISRGLEPLKT 200
    STSEVRNYRT RHIVTLTDLL HLNVSRHNWS LAYKIFATLI RIPGVQIKSL 250
    WGIGVEILDN LSNSSSGLDF LQWMCQIYSS KSRFVQNINY RSIVPPFQTG 300
    SRTHTAKFAI TYLWSSLINC QKSMEPSSNI IDKPFDTEND LLQELIDKIS 350
    EWVLTPPFME DAEVWFIYAS CHLLKADTLS RQFVNDNKNN DLIGLDRDIK 400
    INQVIKHIHY VRTFLKICLD KGGFAVPSRL IENQLKSFES RLYGEAQDIQ 450
    ERDVANVYDS IDNSSVENSF GDVYETNAEF LDTQLMDLSP EDNGLDEMHY 500
    SDEDSSE 507
    Length:507
    Mass (Da):59,254
    Last modified:November 1, 1997 - v1
    Checksum:i726B0963F0E79783
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47816 Genomic DNA. Translation: CAA87831.1.
    AY692808 Genomic DNA. Translation: AAT92827.1.
    BK006946 Genomic DNA. Translation: DAA09856.1.
    PIRiS50949.
    RefSeqiNP_013669.1. NM_001182401.1.

    Genome annotation databases

    EnsemblFungiiYML043C; YML043C; YML043C.
    GeneIDi854964.
    KEGGisce:YML043C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47816 Genomic DNA. Translation: CAA87831.1 .
    AY692808 Genomic DNA. Translation: AAT92827.1 .
    BK006946 Genomic DNA. Translation: DAA09856.1 .
    PIRi S50949.
    RefSeqi NP_013669.1. NM_001182401.1.

    3D structure databases

    ProteinModelPortali Q04712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35126. 11 interactions.
    DIPi DIP-4542N.
    IntActi Q04712. 8 interactions.
    MINTi MINT-526952.
    STRINGi 4932.YML043C.

    Proteomic databases

    PaxDbi Q04712.
    PeptideAtlasi Q04712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML043C ; YML043C ; YML043C .
    GeneIDi 854964.
    KEGGi sce:YML043C.

    Organism-specific databases

    CYGDi YML043c.
    SGDi S000004507. RRN11.

    Phylogenomic databases

    eggNOGi NOG75014.
    HOGENOMi HOG000141986.
    KOi K15222.
    OMAi MFEVPIT.
    OrthoDBi EOG7MSN0R.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32641-MONOMER.

    Miscellaneous databases

    NextBioi 978053.

    Gene expression databases

    Genevestigatori Q04712.

    Family and domain databases

    InterProi IPR007224. TIF_Rrn11.
    IPR016850. TIF_Rrn11_budding_yeast.
    [Graphical view ]
    Pfami PF04090. RNA_pol_I_TF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027133. Rrn11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae."
      Keys D.A., Vu L., Steffan J.S., Dodd J.A., Yamamoto R.T., Nogi Y., Nomura M.
      Genes Dev. 8:2349-2362(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CF COMPLEX.
    5. "RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I."
      Lalo D., Steffan J.S., Dodd J.A., Nomura M.
      J. Biol. Chem. 271:21062-21067(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CF COMPLEX, INTERACTION WITH RRN6; RRN7 AND SPT15.
    6. "A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae."
      Lin C.W., Moorefield B., Payne J., Aprikian P., Mitomo K., Reeder R.H.
      Mol. Cell. Biol. 16:6436-6443(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE CF COMPLEX.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRRN11_YEAST
    AccessioniPrimary (citable) accession number: Q04712
    Secondary accession number(s): D6VZD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 476 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3