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Q04712 (RRN11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase I-specific transcription initiation factor RRN11
Gene names
Name:RRN11
Ordered Locus Names:YML043C
ORF Names:YM9827.09C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex. Ref.6

Subunit structure

Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15. Ref.4 Ref.5

Subcellular location

Nucleusnucleolus Ref.7.

Miscellaneous

Present with 476 molecules/cell in log phase SD medium.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507RNA polymerase I-specific transcription initiation factor RRN11
PRO_0000203257

Sequences

Sequence LengthMass (Da)Tools
Q04712 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 726B0963F0E79783

FASTA50759,254
        10         20         30         40         50         60 
MFEVPITLTN RKFAQRRKLK YQYINYISRR FDRISKKSTT TDSLPTPENS AAENNDEEEG 

        70         80         90        100        110        120 
QNSEAGTYRR SVLQQKKRRR ERHWRSVVGE IYSTTESETD SQEEETEEGG EHDTGIDKED 

       130        140        150        160        170        180 
SDEERKFWKK YEKPEKSFEI WRTVSSQNKQ PINKQKMTYH NFKKIEKIPL RKMEIPLLHC 

       190        200        210        220        230        240 
TKENKLYFQS ISRGLEPLKT STSEVRNYRT RHIVTLTDLL HLNVSRHNWS LAYKIFATLI 

       250        260        270        280        290        300 
RIPGVQIKSL WGIGVEILDN LSNSSSGLDF LQWMCQIYSS KSRFVQNINY RSIVPPFQTG 

       310        320        330        340        350        360 
SRTHTAKFAI TYLWSSLINC QKSMEPSSNI IDKPFDTEND LLQELIDKIS EWVLTPPFME 

       370        380        390        400        410        420 
DAEVWFIYAS CHLLKADTLS RQFVNDNKNN DLIGLDRDIK INQVIKHIHY VRTFLKICLD 

       430        440        450        460        470        480 
KGGFAVPSRL IENQLKSFES RLYGEAQDIQ ERDVANVYDS IDNSSVENSF GDVYETNAEF 

       490        500 
LDTQLMDLSP EDNGLDEMHY SDEDSSE 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae."
Keys D.A., Vu L., Steffan J.S., Dodd J.A., Yamamoto R.T., Nogi Y., Nomura M.
Genes Dev. 8:2349-2362(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CF COMPLEX.
[5]"RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I."
Lalo D., Steffan J.S., Dodd J.A., Nomura M.
J. Biol. Chem. 271:21062-21067(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CF COMPLEX, INTERACTION WITH RRN6; RRN7 AND SPT15.
[6]"A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae."
Lin C.W., Moorefield B., Payne J., Aprikian P., Mitomo K., Reeder R.H.
Mol. Cell. Biol. 16:6436-6443(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE CF COMPLEX.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47816 Genomic DNA. Translation: CAA87831.1.
AY692808 Genomic DNA. Translation: AAT92827.1.
BK006946 Genomic DNA. Translation: DAA09856.1.
PIRS50949.
RefSeqNP_013669.1. NM_001182401.1.

3D structure databases

ProteinModelPortalQ04712.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35126. 11 interactions.
DIPDIP-4542N.
IntActQ04712. 8 interactions.
MINTMINT-526952.
STRING4932.YML043C.

Proteomic databases

PaxDbQ04712.
PeptideAtlasQ04712.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML043C; YML043C; YML043C.
GeneID854964.
KEGGsce:YML043C.

Organism-specific databases

CYGDYML043c.
SGDS000004507. RRN11.

Phylogenomic databases

eggNOGNOG75014.
HOGENOMHOG000141986.
KOK15222.
OMAMFEVPIT.
OrthoDBEOG7MSN0R.

Enzyme and pathway databases

BioCycYEAST:G3O-32641-MONOMER.

Gene expression databases

GenevestigatorQ04712.

Family and domain databases

InterProIPR007224. TIF_Rrn11.
IPR016850. TIF_Rrn11_budding_yeast.
[Graphical view]
PfamPF04090. RNA_pol_I_TF. 1 hit.
[Graphical view]
PIRSFPIRSF027133. Rrn11. 1 hit.
ProtoNetSearch...

Other

NextBio978053.

Entry information

Entry nameRRN11_YEAST
AccessionPrimary (citable) accession number: Q04712
Secondary accession number(s): D6VZD2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD