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Q04712

- RRN11_YEAST

UniProt

Q04712 - RRN11_YEAST

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Protein
RNA polymerase I-specific transcription initiation factor RRN11
Gene
RRN11, YML043C, YM9827.09C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.1 Publication

GO - Molecular functioni

  1. RNA polymerase I CORE element sequence-specific DNA binding Source: SGD
  2. RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: SGD
  3. TBP-class protein binding Source: SGD
  4. protein binding Source: IntAct

GO - Biological processi

  1. RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript Source: GOC
  2. transcription initiation from RNA polymerase I promoter Source: SGD
  3. transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN11
Gene namesi
Name:RRN11
Ordered Locus Names:YML043C
ORF Names:YM9827.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML043c.
SGDiS000004507. RRN11.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. RNA polymerase I core factor complex Source: SGD
  2. nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507RNA polymerase I-specific transcription initiation factor RRN11
PRO_0000203257Add
BLAST

Proteomic databases

PaxDbiQ04712.
PeptideAtlasiQ04712.

Expressioni

Gene expression databases

GenevestigatoriQ04712.

Interactioni

Subunit structurei

Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RRN6P327862EBI-27790,EBI-15986
RRN7P409922EBI-27790,EBI-15990
SPT15P133932EBI-27790,EBI-19129

Protein-protein interaction databases

BioGridi35126. 11 interactions.
DIPiDIP-4542N.
IntActiQ04712. 8 interactions.
MINTiMINT-526952.
STRINGi4932.YML043C.

Structurei

3D structure databases

ProteinModelPortaliQ04712.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG75014.
HOGENOMiHOG000141986.
KOiK15222.
OMAiMFEVPIT.
OrthoDBiEOG7MSN0R.

Family and domain databases

InterProiIPR007224. TIF_Rrn11.
IPR016850. TIF_Rrn11_budding_yeast.
[Graphical view]
PfamiPF04090. RNA_pol_I_TF. 1 hit.
[Graphical view]
PIRSFiPIRSF027133. Rrn11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04712-1 [UniParc]FASTAAdd to Basket

« Hide

MFEVPITLTN RKFAQRRKLK YQYINYISRR FDRISKKSTT TDSLPTPENS    50
AAENNDEEEG QNSEAGTYRR SVLQQKKRRR ERHWRSVVGE IYSTTESETD 100
SQEEETEEGG EHDTGIDKED SDEERKFWKK YEKPEKSFEI WRTVSSQNKQ 150
PINKQKMTYH NFKKIEKIPL RKMEIPLLHC TKENKLYFQS ISRGLEPLKT 200
STSEVRNYRT RHIVTLTDLL HLNVSRHNWS LAYKIFATLI RIPGVQIKSL 250
WGIGVEILDN LSNSSSGLDF LQWMCQIYSS KSRFVQNINY RSIVPPFQTG 300
SRTHTAKFAI TYLWSSLINC QKSMEPSSNI IDKPFDTEND LLQELIDKIS 350
EWVLTPPFME DAEVWFIYAS CHLLKADTLS RQFVNDNKNN DLIGLDRDIK 400
INQVIKHIHY VRTFLKICLD KGGFAVPSRL IENQLKSFES RLYGEAQDIQ 450
ERDVANVYDS IDNSSVENSF GDVYETNAEF LDTQLMDLSP EDNGLDEMHY 500
SDEDSSE 507
Length:507
Mass (Da):59,254
Last modified:November 1, 1997 - v1
Checksum:i726B0963F0E79783
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47816 Genomic DNA. Translation: CAA87831.1.
AY692808 Genomic DNA. Translation: AAT92827.1.
BK006946 Genomic DNA. Translation: DAA09856.1.
PIRiS50949.
RefSeqiNP_013669.1. NM_001182401.1.

Genome annotation databases

EnsemblFungiiYML043C; YML043C; YML043C.
GeneIDi854964.
KEGGisce:YML043C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47816 Genomic DNA. Translation: CAA87831.1 .
AY692808 Genomic DNA. Translation: AAT92827.1 .
BK006946 Genomic DNA. Translation: DAA09856.1 .
PIRi S50949.
RefSeqi NP_013669.1. NM_001182401.1.

3D structure databases

ProteinModelPortali Q04712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35126. 11 interactions.
DIPi DIP-4542N.
IntActi Q04712. 8 interactions.
MINTi MINT-526952.
STRINGi 4932.YML043C.

Proteomic databases

PaxDbi Q04712.
PeptideAtlasi Q04712.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML043C ; YML043C ; YML043C .
GeneIDi 854964.
KEGGi sce:YML043C.

Organism-specific databases

CYGDi YML043c.
SGDi S000004507. RRN11.

Phylogenomic databases

eggNOGi NOG75014.
HOGENOMi HOG000141986.
KOi K15222.
OMAi MFEVPIT.
OrthoDBi EOG7MSN0R.

Enzyme and pathway databases

BioCyci YEAST:G3O-32641-MONOMER.

Miscellaneous databases

NextBioi 978053.

Gene expression databases

Genevestigatori Q04712.

Family and domain databases

InterProi IPR007224. TIF_Rrn11.
IPR016850. TIF_Rrn11_budding_yeast.
[Graphical view ]
Pfami PF04090. RNA_pol_I_TF. 1 hit.
[Graphical view ]
PIRSFi PIRSF027133. Rrn11. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae."
    Keys D.A., Vu L., Steffan J.S., Dodd J.A., Yamamoto R.T., Nogi Y., Nomura M.
    Genes Dev. 8:2349-2362(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CF COMPLEX.
  5. "RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I."
    Lalo D., Steffan J.S., Dodd J.A., Nomura M.
    J. Biol. Chem. 271:21062-21067(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CF COMPLEX, INTERACTION WITH RRN6; RRN7 AND SPT15.
  6. "A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae."
    Lin C.W., Moorefield B., Payne J., Aprikian P., Mitomo K., Reeder R.H.
    Mol. Cell. Biol. 16:6436-6443(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE CF COMPLEX.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRN11_YEAST
AccessioniPrimary (citable) accession number: Q04712
Secondary accession number(s): D6VZD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 476 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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