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Protein

RNA polymerase I-specific transcription initiation factor RRN11

Gene

RRN11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.1 Publication

Miscellaneous

Present with 476 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • transcription initiation from RNA polymerase I promoter Source: SGD
  • transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: SGD

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN11
Gene namesi
Name:RRN11
Ordered Locus Names:YML043C
ORF Names:YM9827.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML043C.
SGDiS000004507. RRN11.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • RNA polymerase I core factor complex Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032571 – 507RNA polymerase I-specific transcription initiation factor RRN11Add BLAST507

Proteomic databases

PRIDEiQ04712.

PTM databases

iPTMnetiQ04712.

Interactioni

Subunit structurei

Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • TBP-class protein binding Source: SGD

Protein-protein interaction databases

BioGridi35126. 69 interactors.
DIPiDIP-4542N.
IntActiQ04712. 9 interactors.
MINTiMINT-526952.
STRINGi4932.YML043C.

Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 35Combined sources25
Helixi75 – 83Combined sources9
Beta strandi146 – 148Combined sources3
Helixi159 – 167Combined sources9
Helixi169 – 174Combined sources6
Helixi176 – 178Combined sources3
Helixi182 – 193Combined sources12
Beta strandi196 – 199Combined sources4
Helixi202 – 204Combined sources3
Helixi208 – 225Combined sources18
Helixi229 – 241Combined sources13
Helixi250 – 260Combined sources11
Beta strandi262 – 265Combined sources4
Helixi267 – 277Combined sources11
Beta strandi278 – 280Combined sources3
Beta strandi296 – 298Combined sources3
Beta strandi301 – 303Combined sources3
Helixi307 – 321Combined sources15
Helixi346 – 352Combined sources7
Beta strandi353 – 355Combined sources3
Helixi362 – 375Combined sources14
Helixi402 – 416Combined sources15
Turni418 – 420Combined sources3
Helixi429 – 439Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5N5XX-ray3.20C/F/I/L/O/R1-507[»]
5N5Yelectron microscopy7.70R1-507[»]
5N5Zelectron microscopy7.70R1-507[»]
5N60electron microscopy7.70R1-507[»]
5N61electron microscopy3.40R1-507[»]
ProteinModelPortaliQ04712.
SMRiQ04712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000141986.
InParanoidiQ04712.
KOiK15222.
OMAiCFALLIR.
OrthoDBiEOG092C4GJ2.

Family and domain databases

InterProiView protein in InterPro
IPR007224. TIF_Rrn11.
IPR016850. TIF_Rrn11_budding_yeast.
PfamiView protein in Pfam
PF04090. RNA_pol_I_TF. 1 hit.
PIRSFiPIRSF027133. Rrn11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEVPITLTN RKFAQRRKLK YQYINYISRR FDRISKKSTT TDSLPTPENS
60 70 80 90 100
AAENNDEEEG QNSEAGTYRR SVLQQKKRRR ERHWRSVVGE IYSTTESETD
110 120 130 140 150
SQEEETEEGG EHDTGIDKED SDEERKFWKK YEKPEKSFEI WRTVSSQNKQ
160 170 180 190 200
PINKQKMTYH NFKKIEKIPL RKMEIPLLHC TKENKLYFQS ISRGLEPLKT
210 220 230 240 250
STSEVRNYRT RHIVTLTDLL HLNVSRHNWS LAYKIFATLI RIPGVQIKSL
260 270 280 290 300
WGIGVEILDN LSNSSSGLDF LQWMCQIYSS KSRFVQNINY RSIVPPFQTG
310 320 330 340 350
SRTHTAKFAI TYLWSSLINC QKSMEPSSNI IDKPFDTEND LLQELIDKIS
360 370 380 390 400
EWVLTPPFME DAEVWFIYAS CHLLKADTLS RQFVNDNKNN DLIGLDRDIK
410 420 430 440 450
INQVIKHIHY VRTFLKICLD KGGFAVPSRL IENQLKSFES RLYGEAQDIQ
460 470 480 490 500
ERDVANVYDS IDNSSVENSF GDVYETNAEF LDTQLMDLSP EDNGLDEMHY

SDEDSSE
Length:507
Mass (Da):59,254
Last modified:November 1, 1997 - v1
Checksum:i726B0963F0E79783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47816 Genomic DNA. Translation: CAA87831.1.
AY692808 Genomic DNA. Translation: AAT92827.1.
BK006946 Genomic DNA. Translation: DAA09856.1.
PIRiS50949.
RefSeqiNP_013669.1. NM_001182401.1.

Genome annotation databases

EnsemblFungiiYML043C; YML043C; YML043C.
GeneIDi854964.
KEGGisce:YML043C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRRN11_YEAST
AccessioniPrimary (citable) accession number: Q04712
Secondary accession number(s): D6VZD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names