Reviewed, UniProtKB/Swiss-Prot Q04708 (P5CR_PEA)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:

PROC

Organism

Pisum sativum (Garden pea)

Taxonomic identifier

3888 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Pyrroline-5-carboxylate reductase		PRO_0000187324

Sequences

	Sequence		Length	Mass (Da)
	Q04708-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: D719F52935966588	FASTA	273	28,238
	10 20 30 40 50 60 MEILPILSDS YTLGFIGAGK MAESIAKGAS RSGVLPSSRI VTAHSNPSRR AAFESIGITV 70 80 90 100 110 120 LSSNDDVVRA SNVVVFSVKP QLVKDVVLKL KPLLTKDKLL VSVAAGIKLK DLQEWAGHER 130 140 150 160 170 180 FIRVMPNTPA AVGQAASVMS LGGAATEEDA NLISQLFGSI GKIWKADDKF FDAITGLSGS 190 200 210 220 230 240 GPAYIYLAIE ALADGGVAAG LPRDLALSLA SQTVLGAASM ATLSGKHPGQ LKDDVTSPGG 250 260 270 TTIAGVHELE KGGFRGTLMN AVVAAAKRSR ELS

References

[1]	"Molecular cloning and evidence for osmoregulation of the delta 1-pyrroline-5-carboxylate reductase (proC) gene in pea (Pisum sativum L.)." Williamson C.L., Slocum R.D. Plant Physiol. 100:1464-1470(1992) [PubMed: 11537868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62842 mRNA. Translation: CAA44646.1.
PIR	T06477.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.5.1.2. 287.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_PEA

Accession

Primary (citable) accession number: Q04708

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)