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Protein

Penicillin-binding protein 1A

Gene

ponA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei370Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 1A
Short name:
PBP-1A
Gene namesi
Name:ponA
Ordered Locus Names:SP_0369
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1255141.
DrugBankiDB01150. Cefprozil.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000831821 – 719Penicillin-binding protein 1AAdd BLAST719

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000612.

Structurei

Secondary structure

1719
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi54 – 56Combined sources3
Beta strandi62 – 65Combined sources4
Helixi270 – 272Combined sources3
Helixi273 – 287Combined sources15
Turni291 – 293Combined sources3
Beta strandi296 – 300Combined sources5
Helixi304 – 315Combined sources12
Beta strandi316 – 319Combined sources4
Beta strandi328 – 335Combined sources8
Turni336 – 338Combined sources3
Beta strandi340 – 345Combined sources6
Turni360 – 362Combined sources3
Helixi369 – 371Combined sources3
Helixi372 – 376Combined sources5
Helixi378 – 383Combined sources6
Beta strandi393 – 398Combined sources6
Beta strandi417 – 420Combined sources4
Helixi421 – 427Combined sources7
Helixi431 – 440Combined sources10
Helixi442 – 450Combined sources9
Turni451 – 453Combined sources3
Helixi461 – 464Combined sources4
Beta strandi473 – 477Combined sources5
Helixi480 – 491Combined sources12
Beta strandi494 – 496Combined sources3
Beta strandi502 – 507Combined sources6
Beta strandi512 – 514Combined sources3
Beta strandi519 – 521Combined sources3
Helixi525 – 540Combined sources16
Turni543 – 546Combined sources4
Beta strandi555 – 560Combined sources6
Helixi565 – 570Combined sources6
Beta strandi578 – 587Combined sources10
Beta strandi589 – 598Combined sources10
Helixi608 – 612Combined sources5
Helixi613 – 626Combined sources14
Beta strandi640 – 643Combined sources4
Beta strandi646 – 649Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZC5X-ray3.00A/C47-70[»]
B/D264-653[»]
2ZC6X-ray2.70A/C47-70[»]
B/D264-653[»]
ProteinModelPortaliQ04707.
SMRiQ04707.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04707.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi658 – 683Ser-richAdd BLAST26

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 51 family.Curated
In the C-terminal section; belongs to the transpeptidase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000041140.
KOiK05366.
OMAiGINQAVE.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

Q04707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPTILRLI KYLSISFLSL VIAAIVLGGG VFFYYVSKAP SLSESKLVAT
60 70 80 90 100
TSSKIYDNKN QLIADLGSER RVNAQANDIP TDLVKAIVSI EDHRFFDHRG
110 120 130 140 150
IDTIRILGAF LRNLQSNSLQ GGSTLTQQLI KLTYFSTSTS DQTISRKAQE
160 170 180 190 200
AWLAIQLEQK ATKQEILTYY INKVYMSNGN YGMQTAAQNY YGKDLNNLSL
210 220 230 240 250
PQLALLAGMP QAPNQYDPYS HPEAAQDRRN LVLSEMKNQG YISAEQYEKA
260 270 280 290 300
VNTPITDGLQ SLKSASNYPA YMDNYLKEVI NQVEEETGYN LLTTGMDVYT
310 320 330 340 350
NVDQEAQKHL WDIYNTDEYV AYPDDELQVA STIVDVSNGK VIAQLGARHQ
360 370 380 390 400
SSNVSFGINQ AVETNRDWGS TMKPITDYAP ALEYGVYDST ATIVHDEPYN
410 420 430 440 450
YPGTNTPVYN WDRGYFGNIT LQYALQQSRN VPAVETLNKV GLNRAKTFLN
460 470 480 490 500
GLGIDYPSIH YSNAISSNTT ESDKKYGASS EKMAAAYAAF ANGGTYYKPM
510 520 530 540 550
YIHKVVFSDG SEKEFSNVGT RAMKETTAYM MTDMMKTVLT YGTGRNAYLA
560 570 580 590 600
WLPQAGKTGT SNYTDEEIEN HIKTSQFVAP DELFAGYTRK YSMAVWTGYS
610 620 630 640 650
NRLTPLVGNG LTVAAKVYRS MMTYLSEGSN PEDWNIPEGL YRNGEFVFKN
660 670 680 690 700
GARSTWNSPA PQQPPSTESS SSSSDSSTSQ SSSTTPSTNN STTTNPNNNT
710
QQSNTTPDQQ NQNPQPAQP
Length:719
Mass (Da):79,759
Last modified:September 26, 2001 - v2
Checksum:i5BD397E83B4B3AA6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti386V → I in strain: 63915. 1
Natural varianti397E → K in strain: 63915. 1
Natural varianti523M → I in strain: 63915. 1
Natural varianti533D → E in strain: 45607. 1
Natural varianti540T → S in strain: 63915. 1
Natural varianti657N → S in strain: 45607. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67873 Genomic DNA. Translation: CAA48073.1.
X67872 Genomic DNA. Translation: CAA48072.1.
AE005672 Genomic DNA. Translation: AAK74536.1.
PIRiG95042.
S28037.
S28038.
RefSeqiWP_001040013.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74536; AAK74536; SP_0369.
KEGGispn:SP_0369.
PATRICi19705079. VBIStrPne105772_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67873 Genomic DNA. Translation: CAA48073.1.
X67872 Genomic DNA. Translation: CAA48072.1.
AE005672 Genomic DNA. Translation: AAK74536.1.
PIRiG95042.
S28037.
S28038.
RefSeqiWP_001040013.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZC5X-ray3.00A/C47-70[»]
B/D264-653[»]
2ZC6X-ray2.70A/C47-70[»]
B/D264-653[»]
ProteinModelPortaliQ04707.
SMRiQ04707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000612.

Chemistry databases

ChEMBLiCHEMBL1255141.
DrugBankiDB01150. Cefprozil.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74536; AAK74536; SP_0369.
KEGGispn:SP_0369.
PATRICi19705079. VBIStrPne105772_0385.

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000041140.
KOiK05366.
OMAiGINQAVE.

Enzyme and pathway databases

UniPathwayiUPA00219.

Miscellaneous databases

EvolutionaryTraceiQ04707.
PROiQ04707.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPBPA_STRPN
AccessioniPrimary (citable) accession number: Q04707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

These strains are penicillin-sensitive.

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.