Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q046V3 (DDL_LACGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:LGAS_0107
OrganismLactobacillus gasseri (strain ATCC 33323 / DSM 20243) [Complete proteome] [HAMAP]
Taxonomic identifier324831 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence caution

The sequence ABJ59519.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341119

Regions

Domain134 – 344211ATP-grasp
Nucleotide binding169 – 22456ATP By similarity

Sites

Metal binding2971Magnesium or manganese 1 By similarity
Metal binding3111Magnesium or manganese 1 By similarity
Metal binding3111Magnesium or manganese 2 By similarity
Metal binding3131Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q046V3 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: 853607C36FC0F34B

FASTA36140,401
        10         20         30         40         50         60 
MTDKIKVGLI FGGNSSEYEV SIMSAHNIYE EIDTNKFDVY PMWITNDGYL ANDADSRKVL 

        70         80         90        100        110        120 
DNPKMEVANP HKVANISNIV ELKDRPEIDV FFPIVHGNLG EDGCLQGLFR VLDKPFVGDD 

       130        140        150        160        170        180 
VLAAAVTMDK EMTKILAQRA GVPVAKWIAV KRFEYNDPDN NKLDYEYVAS QLGSDLFVKP 

       190        200        210        220        230        240 
SNQGSSVGVS HVTNEKEYKV ALAEAFKYDD KVLVEETVHG TEVETAVLGN DKPIVAGVGQ 

       250        260        270        280        290        300 
IINAKDSFYT YENKYDDNST STLEIPAKLP EGIVEKVRKN ALKVFQATEC SGLARIDSML 

       310        320        330        340        350        360 
RTEDKEVVLT EVNALPGFTN ISMYPKLFEE VGIPYTDLIT KLIDYAMERY DHKKTLLHKH 


D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000413 Genomic DNA. Translation: ABJ59519.1. Different initiation.
RefSeqYP_813957.1. NC_008530.1.

3D structure databases

ProteinModelPortalQ046V3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324831.LGAS_0107.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ59519; ABJ59519; LGAS_0107.
GeneID4440479.
KEGGlga:LGAS_0107.
PATRIC22228359. VBILacGas62225_0106.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycLGAS324831:GHTY-107-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_LACGA
AccessionPrimary (citable) accession number: Q046V3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways