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Q04695 (K1C17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
39.1
Cytokeratin-17
Short name=CK-17
Keratin-17
Short name=K17
Gene names
Name:KRT17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity. Ref.10 Ref.11 Ref.14

Subunit structure

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD and SFN By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). Ref.1 Ref.8 Ref.9 Ref.10

Induction

Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and transforming growth factor-alpha (TGF-alpha), and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib. Ref.2 Ref.11 Ref.12 Ref.14

Post-translational modification

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Involvement in disease

Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.6 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28

Steatocystoma multiplex (SM) [MIM:184500]: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20 Ref.21 Ref.28

KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence AAH72018.1 differs from that shown. Reason: Frameshift at position 109.

Ontologies

Keywords
   Cellular componentCytoplasm
Intermediate filament
Keratin
   DiseaseDisease mutation
Ectodermal dysplasia
Palmoplantar keratoderma
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processepidermis development

Traceable author statement Ref.6. Source: ProtInc

intermediate filament organization

Inferred from electronic annotation. Source: Ensembl

keratinization

Inferred from electronic annotation. Source: Ensembl

morphogenesis of an epithelium

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of hair follicle development

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

signal transduction

Inferred from mutant phenotype Ref.11. Source: UniProtKB

   Cellular_componentcell periphery

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular vesicular exosome

Inferred from direct assay PubMed 19199708. Source: UniProt

intermediate filament

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionMHC class II protein binding

Inferred from physical interaction Ref.11. Source: UniProtKB

MHC class II receptor activity

Inferred from direct assay Ref.11. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 16189514. Source: IntAct

structural constituent of cytoskeleton

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CCDC85BQ158342EBI-297873,EBI-739674

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Keratin, type I cytoskeletal 17
PRO_0000063664

Regions

Region1 – 8383Head
Region84 – 392309Rod
Region84 – 12037Coil 1A
Region102 – 11615Peptide epitope S1; induces T-cell and keratinocyte proliferation and IFN-gamma production
Region121 – 13818Linker 1
Region139 – 23092Coil 1B
Region153 – 16715Peptide epitope S2; induces T-cell proliferation and IFN-gamma production
Region231 – 25020Linker 12
Region251 – 392142Coil 2
Region332 – 34615Peptide epitope S4; induces T-cell and keratinocyte proliferation and IFN-gamma production
Region393 – 43240Tail

Amino acid modifications

Modified residue131Phosphoserine Ref.16
Modified residue321Phosphoserine Ref.15 Ref.16 Ref.17
Modified residue391Phosphoserine Ref.16
Modified residue441Phosphoserine; by RPS6KA1 Ref.19

Natural variations

Natural variant881M → T in PC2 and SM. Ref.22 Ref.28
VAR_010512
Natural variant921N → D in PC2. Ref.6
VAR_003847
Natural variant921N → H in SM. Ref.20
VAR_003848
Natural variant921N → S in PC2. Ref.20 Ref.21
VAR_003849
Natural variant94 – 985Missing in PC2.
VAR_017069
Natural variant941R → C in PC2 and SM. Ref.21
VAR_010513
Natural variant941R → H in SM. Ref.20
VAR_003850
Natural variant941R → P in PC2. Ref.23
VAR_017068
Natural variant951L → P in PC2. Ref.24
VAR_017071
Natural variant951L → Q in PC2. Ref.23
VAR_017070
Natural variant971Missing in PC2. Ref.24
VAR_017072
Natural variant981Y → D in PC2. Ref.20
VAR_003851
Natural variant991L → P in PC2. Ref.24
VAR_017073
Natural variant1021V → M in PC2. Ref.25 Ref.27
VAR_017074
Natural variant1091N → D in PC2. Ref.4 Ref.26
VAR_037083

Experimental info

Mutagenesis1031R → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S1. Ref.14
Mutagenesis1061E → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S1. Ref.14
Mutagenesis1091N → A: No significant effect on T-cell proliferation or IFN-gamma production when part of the altered peptide epitope S1. Ref.14
Mutagenesis1541N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. Ref.14
Mutagenesis1551I → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. Ref.14
Mutagenesis1571L → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S2. Ref.14
Mutagenesis1601D → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. Ref.14
Mutagenesis3331N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. Ref.14
Mutagenesis3341R → A: No significant effect on T-cell proliferation but can induce IFN-gamma production when part of the altered peptide epitope S2. Ref.14
Mutagenesis3361C → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. Ref.14
Mutagenesis3391L → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S4. Ref.14
Sequence conflict301R → Q in AL353997. Ref.4
Sequence conflict301R → Q in AC022596. Ref.4
Sequence conflict421L → P in AL353997. Ref.4
Sequence conflict421L → P in AC022596. Ref.4
Sequence conflict51 – 566Missing in BAC04534. Ref.3
Sequence conflict511T → A in AL353997. Ref.4
Sequence conflict511T → A in AC022596. Ref.4
Sequence conflict721S → SS in AL353997. Ref.4
Sequence conflict73 – 742FG → SFE in AC022596. Ref.4
Sequence conflict741G → E in AL353997. Ref.4
Sequence conflict811A → V in AL353997. Ref.4
Sequence conflict811A → V in AC022596. Ref.4
Sequence conflict94 – 10815Missing in AAH72018. Ref.5
Sequence conflict1371T → I in AL353997. Ref.4
Sequence conflict1371T → I in AC022596. Ref.4
Sequence conflict145 – 1473ILT → VGPA in AL353997. Ref.4
Sequence conflict1581Q → H in AC022596. Ref.4
Sequence conflict1591I → N in AL353997. Ref.4
Sequence conflict1631R → H in AL353997. Ref.4
Sequence conflict1631R → H in AC022596. Ref.4
Sequence conflict1671D → A in AL353997. Ref.4
Sequence conflict1671D → A in AC022596. Ref.4
Sequence conflict1801R → C in AL353997. Ref.4
Sequence conflict1801R → C in AC022596. Ref.4
Sequence conflict190 – 1912LR → PC in AL353997. Ref.4
Sequence conflict190 – 1912LR → PC in AC022596. Ref.4
Sequence conflict2041L → P in AL353997. Ref.4
Sequence conflict2071Q → H in AL353997. Ref.4
Sequence conflict2071Q → H in AC022596. Ref.4
Sequence conflict2251Missing in AL353997. Ref.4
Sequence conflict2251Missing in AC022596. Ref.4
Sequence conflict2291L → P in AL353997. Ref.4
Sequence conflict2291L → P in AC022596. Ref.4
Sequence conflict2421D → G in AL353997. Ref.4
Sequence conflict2421D → G in AC022596. Ref.4
Sequence conflict2581D → E in AL353997. Ref.4
Sequence conflict2581D → E in AC022596. Ref.4
Sequence conflict3051R → C in AL353997. Ref.4
Sequence conflict3051R → C in AC022596. Ref.4
Sequence conflict3371V → M in AL353997. Ref.4
Sequence conflict3371V → M in AC022596. Ref.4
Sequence conflict3521Q → R in AL353997. Ref.4
Sequence conflict3521Q → R in AC022596. Ref.4
Sequence conflict3571R → L in AL353997. Ref.4
Sequence conflict3571R → L in AC022596. Ref.4
Sequence conflict373 – 3753VKT → MKM in AL353997. Ref.4
Sequence conflict373 – 3753VKT → MKM in AC022596. Ref.4
Sequence conflict3791Q → L in AL353997. Ref.4
Sequence conflict3791Q → L in AC022596. Ref.4
Sequence conflict3821A → T in AL353997. Ref.4
Sequence conflict3821A → T in AC022596. Ref.4
Sequence conflict3851R → H in AL353997. Ref.4
Sequence conflict3851R → H in AC022596. Ref.4
Sequence conflict395 – 40410LTQYKKEPVT → FRMSESSPVS in AC022596. Ref.4
Sequence conflict4061R → C in AL353997. Ref.4
Sequence conflict4091R → P in AL353997. Ref.4
Sequence conflict4281H → R in AL353997. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q04695 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 35B429243F47EB5C

FASTA43248,106
        10         20         30         40         50         60 
MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC 

        70         80         90        100        110        120 
YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY 

       130        140        150        160        170        180 
QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR 

       190        200        210        220        230        240 
LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE 

       250        260        270        280        290        300 
MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI 

       310        320        330        340        350        360 
SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM 

       370        380        390        400        410        420 
EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV 

       430 
ISSREQVHQT TR 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human gene encoding cytokeratin 17 and its expression pattern."
Troyanovsky S.M., Leube R.E., Franke W.W.
Eur. J. Cell Biol. 59:127-137(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"Interferon-gamma regulates expression of a novel keratin class I gene."
Flohr T., Buwitt U., Bonnekoh B., Decker T., Boettger E.C.
Eur. J. Immunol. 22:975-979(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PC2 ASP-109.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Cervix and Muscle.
[6]"Keratin 16 and keratin 17 mutations cause pachyonychia congenita."
McLean W.H.I., Rugg E.L., Lunny D.P., Morley S.M., Lane E.B., Swensson O., Dopping-Hepenstal P.J.C., Griffiths W.A.D., Eady R.A.J., Higgins C., Navsaria H.A., Leigh I.M., Strachan T., Kunkeler L., Munro C.S.
Nat. Genet. 9:273-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-101, VARIANT PC2 ASP-92.
[7]Shen Z., Chen L., Wang G., Liu Y.-F.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-117; 152-168; 306-322 AND 331-347.
[8]"Patterns of expression of keratin 17 in human epithelia: dependency on cell position."
Troyanovsky S.M., Guelstein V.I., Tchipysheva T.A., Krutovskikh V.A., Bannikov G.A.
J. Cell Sci. 93:419-426(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Keratin expression in the normal nail unit: markers of regional differentiation."
De Berker D., Wojnarowska F., Sviland L., Westgate G.E., Dawber R.P., Leigh I.M.
Br. J. Dermatol. 142:89-96(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[10]"Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype."
McGowan K.M., Coulombe P.A.
J. Invest. Dermatol. 114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[11]"HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."
Shen Z., Wang G., Fan J.-Y., Li W., Liu Y.-F.
J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[12]"Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects."
Bockelmann R., Horn T., Gollnick H., Bonnekoh B.
Skin Pharmacol. Physiol. 18:42-54(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[13]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis."
Shen Z., Chen L., Liu Y.-F., Gao T.-W., Wang G., Fan X.-L., Fan J.-Y., Fan P.-S., Li C.-Y., Liu B., Dang Y.-P., Li C.-X.
J. Am. Acad. Dermatol. 54:992-1002(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, MUTAGENESIS OF ARG-103; GLU-106; ASN-109; ASN-154; ILE-155; LEU-157; ASP-160; ASN-333; ARG-334; CYS-336 AND LEU-339.
[15]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-32 AND SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[18]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion."
Pan X., Kane L.A., Van Eyk J.E., Coulombe P.A.
J. Biol. Chem. 286:42403-42413(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-44.
[20]"Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex."
Smith F.J.D., Corden L.D., Rugg E.L., Ratnavel R., Leigh I.M., Moss C., Tidman M.J., Hohl D., Huber M., Kunkeler L., Munro C.S., Lane E.B., McLean W.H.I.
J. Invest. Dermatol. 108:220-223(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PC2 SER-92 AND ASP-98, VARIANTS SM HIS-92 AND HIS-94.
[21]"Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2."
Covello S.P., Smith F.J.D., Sillevis Smitt J.H., Paller A.S., Munro C.S., Jonkman M.F., Uitto J., McLean W.H.I.
Br. J. Dermatol. 139:475-480(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PC2 SER-92 AND CYS-94, VARIANT SM CYS-94.
[22]"Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2."
Celebi J.T., Tanzi E.L., Yao Y.J., Michael E.J., Peacocke M.
J. Invest. Dermatol. 113:848-850(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PC2 THR-88.
[23]"Novel keratin 17 mutations in pachyonychia congenita type 2."
Smith F.J.D., Coleman C.M., Bayoumy N.M., Tenconi R., Nelson J., David A., McLean W.H.I.
J. Invest. Dermatol. 116:806-808(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PC2 94-PRO--TYR-98 DEL; PRO-94 AND GLN-95.
[24]"Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."
Terrinoni A., Smith F.J.D., Didona B., Canzona F., Paradisi M., Huber M., Hohl D., David A., Verloes A., Leigh I.M., Munro C.S., Melino G., McLean W.H.I.
J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PC2 PRO-95; SER-97 DEL AND PRO-99.
[25]"A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2."
Hashiguchi T., Yotsumoto S., Shimada H., Terasaki K., Setoyama M., Kobayashi K., Saheki T., Kanzaki T.
J. Invest. Dermatol. 118:545-547(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PC2 MET-102.
[26]"A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2."
Xiao S.-X., Feng Y.-G., Ren X.-R., Tan S.-S., Li L., Wang J.-M., Shi Y.-Z.
J. Invest. Dermatol. 122:892-895(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PC2 ASP-109.
[27]"Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2."
Uchida T., Inaoki M., Makino E., Fujimoto W.
J. Dermatol. Sci. 38:60-63(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PC2 MET-102.
[28]"Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity."
Oh S.-W., Kim M.Y., Lee J.S., Kim S.-C.
J. Dermatol. 33:161-164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PC2 THR-88, VARIANT SM THR-88.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z19574 Genomic DNA. Translation: CAA79626.1.
X62571 mRNA. Translation: CAA44451.1.
AK095342 mRNA. Translation: BAC04534.1.
AC022596 Genomic DNA. No translation available.
AL353997 Genomic DNA. No translation available.
BC000159 mRNA. Translation: AAH00159.2.
BC011901 mRNA. Translation: AAH11901.1.
BC056421 mRNA. Translation: AAH56421.1.
BC072018 mRNA. Translation: AAH72018.1. Frameshift.
BC072019 mRNA. Translation: AAH72019.1.
S78515 Genomic DNA. Translation: AAB34565.1.
EF608068 mRNA. Translation: ABQ96595.1.
EF608069 mRNA. Translation: ABQ96596.1.
EF608070 mRNA. Translation: ABQ96597.1.
EF608071 mRNA. Translation: ABQ96598.1.
CCDSCCDS11402.1.
PIRS30433.
RefSeqNP_000413.1. NM_000422.2.
UniGeneHs.2785.

3D structure databases

ProteinModelPortalQ04695.
SMRQ04695. Positions 86-120, 134-232, 248-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110070. 31 interactions.
DIPDIP-33093N.
IntActQ04695. 13 interactions.
MINTMINT-256746.

PTM databases

PhosphoSiteQ04695.

Polymorphism databases

DMDM547751.

2D gel databases

SWISS-2DPAGEQ04695.

Proteomic databases

MaxQBQ04695.
PaxDbQ04695.
PRIDEQ04695.

Protocols and materials databases

DNASU3872.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311208; ENSP00000308452; ENSG00000128422.
GeneID3872.
KEGGhsa:3872.
UCSCuc002hxh.2. human.

Organism-specific databases

CTD3872.
GeneCardsGC17M039775.
GeneReviewsKRT17.
H-InvDBHIX0059686.
HGNCHGNC:6427. KRT17.
HPACAB000029.
HPA000452.
HPA000453.
MIM148069. gene.
167210. phenotype.
184500. phenotype.
neXtProtNX_Q04695.
Orphanet2309. Pachyonychia congenita.
841. Sebocystomatosis.
PharmGKBPA30214.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148784.
HOVERGENHBG013015.
InParanoidQ04695.
KOK07604.
OMAGCYSFGS.
OrthoDBEOG7FV3Q8.
PhylomeDBQ04695.
TreeFamTF332742.

Gene expression databases

BgeeQ04695.
GenevestigatorQ04695.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKeratin_17.
GenomeRNAi3872.
NextBio15209.
PMAP-CutDBQ04695.
PROQ04695.
SOURCESearch...

Entry information

Entry nameK1C17_HUMAN
AccessionPrimary (citable) accession number: Q04695
Secondary accession number(s): A5Z1M9 expand/collapse secondary AC list , A5Z1N0, A5Z1N1, A5Z1N2, A6NDV6, A6NKQ2, Q6IP98, Q8N1P6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM