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Protein

Keratin, type I cytoskeletal 17

Gene

KRT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.By similarity3 Publications

GO - Molecular functioni

  • MHC class II protein binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
39.1
Cytokeratin-17
Short name:
CK-17
Keratin-17
Short name:
K17
Gene namesi
Name:KRT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6427. KRT17.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cell periphery Source: Ensembl
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Pachyonychia congenita 2 (PC2)18 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
See also OMIM:167210
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07244188M → K in PC2. 1 PublicationCorresponds to variant rs28928898dbSNPEnsembl.1
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant rs28928898dbSNPEnsembl.1
Natural variantiVAR_07244291L → P in PC2. 1 Publication1
Natural variantiVAR_07244392 – 99Missing in PC2. 1 Publication8
Natural variantiVAR_00384792N → D in PC2. 1 PublicationCorresponds to variant rs28928896dbSNPEnsembl.1
Natural variantiVAR_00384992N → S in PC2. 6 PublicationsCorresponds to variant rs59151893dbSNPEnsembl.1
Natural variantiVAR_01706994 – 98Missing in PC2. 5
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant rs58730926dbSNPEnsembl.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant rs28928897dbSNPEnsembl.1
Natural variantiVAR_01706894R → P in PC2. 1 PublicationCorresponds to variant rs28928897dbSNPEnsembl.1
Natural variantiVAR_01707195L → P in PC2. 1 PublicationCorresponds to variant rs28928899dbSNPEnsembl.1
Natural variantiVAR_01707095L → Q in PC2. 1 PublicationCorresponds to variant rs28928899dbSNPEnsembl.1
Natural variantiVAR_01707297Missing in PC2. 1 Publication1
Natural variantiVAR_00385198Y → D in PC2. 1 PublicationCorresponds to variant rs28933088dbSNPEnsembl.1
Natural variantiVAR_01707399L → P in PC2. 1 PublicationCorresponds to variant rs28933089dbSNPEnsembl.1
Natural variantiVAR_017074102V → M in PC2. 2 PublicationsCorresponds to variant rs59977263dbSNPEnsembl.1
Natural variantiVAR_037083109N → D in PC2. 2 PublicationsCorresponds to variant rs267607412dbSNPEnsembl.1
Natural variantiVAR_072444388L → P in PC2. 1 PublicationCorresponds to variant rs56690581dbSNPEnsembl.1
Natural variantiVAR_072445388L → R in PC2. 1 Publication1
Steatocystoma multiplex (SM)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
See also OMIM:184500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant rs28928898dbSNPEnsembl.1
Natural variantiVAR_00384892N → H in SM. 1 PublicationCorresponds to variant rs28928896dbSNPEnsembl.1
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant rs58730926dbSNPEnsembl.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant rs28928897dbSNPEnsembl.1

KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103R → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi106E → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi109N → A: No significant effect on T-cell proliferation or IFN-gamma production when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi154N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi155I → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi157L → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi160D → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. 1 Publication1
Mutagenesisi333N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. 1 Publication1
Mutagenesisi334R → A: No significant effect on T-cell proliferation but can induce IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi336C → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi339L → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S4. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi3872.
MalaCardsiKRT17.
MIMi167210. phenotype.
184500. phenotype.
OpenTargetsiENSG00000128422.
Orphaneti2309. Pachyonychia congenita.
841. Sebocystomatosis.
PharmGKBiPA30214.

Polymorphism and mutation databases

BioMutaiKRT17.
DMDMi547751.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636641 – 432Keratin, type I cytoskeletal 17Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei32PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei44Phosphoserine; by RPS6KA11 Publication1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ04695.
PaxDbiQ04695.
PeptideAtlasiQ04695.
PRIDEiQ04695.
TopDownProteomicsiQ04695.

2D gel databases

SWISS-2DPAGEQ04695.

PTM databases

iPTMnetiQ04695.
PhosphoSitePlusiQ04695.
SwissPalmiQ04695.

Miscellaneous databases

PMAP-CutDBQ04695.

Expressioni

Tissue specificityi

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).4 Publications

Inductioni

Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and transforming growth factor-alpha (TGF-alpha), and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib.4 Publications

Gene expression databases

BgeeiENSG00000128422.
ExpressionAtlasiQ04695. baseline and differential.
GenevisibleiQ04695. HS.

Organism-specific databases

HPAiCAB000029.
HPA000452.
HPA000453.
HPA045062.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC85BQ158342EBI-297873,EBI-739674

GO - Molecular functioni

  • MHC class II protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110070. 35 interactors.
DIPiDIP-33093N.
IntActiQ04695. 14 interactors.
MINTiMINT-256746.
STRINGi9606.ENSP00000308452.

Structurei

3D structure databases

ProteinModelPortaliQ04695.
SMRiQ04695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 83HeadAdd BLAST83
Regioni84 – 392RodAdd BLAST309
Regioni84 – 120Coil 1AAdd BLAST37
Regioni102 – 116Peptide epitope S1; induces T-cell and keratinocyte proliferation and IFN-gamma productionAdd BLAST15
Regioni121 – 138Linker 1Add BLAST18
Regioni139 – 230Coil 1BAdd BLAST92
Regioni153 – 167Peptide epitope S2; induces T-cell proliferation and IFN-gamma productionAdd BLAST15
Regioni231 – 250Linker 12Add BLAST20
Regioni251 – 392Coil 2Add BLAST142
Regioni332 – 346Peptide epitope S4; induces T-cell and keratinocyte proliferation and IFN-gamma productionAdd BLAST15
Regioni393 – 432TailAdd BLAST40

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiQ04695.
KOiK07604.
OMAiQYHRTIE.
OrthoDBiEOG091G087I.
PhylomeDBiQ04695.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS
60 70 80 90 100
TLGGSSYSSC YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD
110 120 130 140 150
KVRALEEANT ELEVKIRDWY QRQAPGPARD YSQYYRTIEE LQNKILTATV
160 170 180 190 200
DNANILLQID NARLAADDFR TKFETEQALR LSVEADINGL RRVLDELTLA
210 220 230 240 250
RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS
260 270 280 290 300
RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
310 320 330 340 350
SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE
360 370 380 390 400
EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK
410 420 430
EPVTTRQVRT IVEEVQDGKV ISSREQVHQT TR
Length:432
Mass (Da):48,106
Last modified:January 23, 2007 - v2
Checksum:i35B429243F47EB5C
GO

Sequence cautioni

The sequence AAH72018 differs from that shown. Reason: Frameshift at position 109.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30R → Q in AL353997 (PubMed:16625196).Curated1
Sequence conflicti30R → Q in AC022596 (PubMed:16625196).Curated1
Sequence conflicti42L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti42L → P in AC022596 (PubMed:16625196).Curated1
Sequence conflicti51 – 56Missing in BAC04534 (PubMed:14702039).Curated6
Sequence conflicti51T → A in AL353997 (PubMed:16625196).Curated1
Sequence conflicti51T → A in AC022596 (PubMed:16625196).Curated1
Sequence conflicti72S → SS in AL353997 (PubMed:16625196).Curated1
Sequence conflicti73 – 74FG → SFE in AC022596 (PubMed:16625196).Curated2
Sequence conflicti74G → E in AL353997 (PubMed:16625196).Curated1
Sequence conflicti81A → V in AL353997 (PubMed:16625196).Curated1
Sequence conflicti81A → V in AC022596 (PubMed:16625196).Curated1
Sequence conflicti94 – 108Missing in AAH72018 (PubMed:15489334).CuratedAdd BLAST15
Sequence conflicti137T → I in AL353997 (PubMed:16625196).Curated1
Sequence conflicti137T → I in AC022596 (PubMed:16625196).Curated1
Sequence conflicti145 – 147ILT → VGPA in AL353997 (PubMed:16625196).Curated3
Sequence conflicti158Q → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti159I → N in AL353997 (PubMed:16625196).Curated1
Sequence conflicti163R → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti163R → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti167D → A in AL353997 (PubMed:16625196).Curated1
Sequence conflicti167D → A in AC022596 (PubMed:16625196).Curated1
Sequence conflicti180R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti180R → C in AC022596 (PubMed:16625196).Curated1
Sequence conflicti190 – 191LR → PC in AL353997 (PubMed:16625196).Curated2
Sequence conflicti190 – 191LR → PC in AC022596 (PubMed:16625196).Curated2
Sequence conflicti204L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti207Q → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti207Q → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti225Missing in AL353997 (PubMed:16625196).Curated1
Sequence conflicti225Missing in AC022596 (PubMed:16625196).Curated1
Sequence conflicti229L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti229L → P in AC022596 (PubMed:16625196).Curated1
Sequence conflicti242D → G in AL353997 (PubMed:16625196).Curated1
Sequence conflicti242D → G in AC022596 (PubMed:16625196).Curated1
Sequence conflicti258D → E in AL353997 (PubMed:16625196).Curated1
Sequence conflicti258D → E in AC022596 (PubMed:16625196).Curated1
Sequence conflicti305R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti305R → C in AC022596 (PubMed:16625196).Curated1
Sequence conflicti337V → M in AL353997 (PubMed:16625196).Curated1
Sequence conflicti337V → M in AC022596 (PubMed:16625196).Curated1
Sequence conflicti352Q → R in AL353997 (PubMed:16625196).Curated1
Sequence conflicti352Q → R in AC022596 (PubMed:16625196).Curated1
Sequence conflicti357R → L in AL353997 (PubMed:16625196).Curated1
Sequence conflicti357R → L in AC022596 (PubMed:16625196).Curated1
Sequence conflicti373 – 375VKT → MKM in AL353997 (PubMed:16625196).Curated3
Sequence conflicti373 – 375VKT → MKM in AC022596 (PubMed:16625196).Curated3
Sequence conflicti379Q → L in AL353997 (PubMed:16625196).Curated1
Sequence conflicti379Q → L in AC022596 (PubMed:16625196).Curated1
Sequence conflicti382A → T in AL353997 (PubMed:16625196).Curated1
Sequence conflicti382A → T in AC022596 (PubMed:16625196).Curated1
Sequence conflicti385R → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti385R → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti395 – 404LTQYKKEPVT → FRMSESSPVS in AC022596 (PubMed:16625196).Curated10
Sequence conflicti406R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti409R → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti428H → R in AL353997 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07244188M → K in PC2. 1 PublicationCorresponds to variant rs28928898dbSNPEnsembl.1
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant rs28928898dbSNPEnsembl.1
Natural variantiVAR_07244291L → P in PC2. 1 Publication1
Natural variantiVAR_07244392 – 99Missing in PC2. 1 Publication8
Natural variantiVAR_00384792N → D in PC2. 1 PublicationCorresponds to variant rs28928896dbSNPEnsembl.1
Natural variantiVAR_00384892N → H in SM. 1 PublicationCorresponds to variant rs28928896dbSNPEnsembl.1
Natural variantiVAR_00384992N → S in PC2. 6 PublicationsCorresponds to variant rs59151893dbSNPEnsembl.1
Natural variantiVAR_01706994 – 98Missing in PC2. 5
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant rs58730926dbSNPEnsembl.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant rs28928897dbSNPEnsembl.1
Natural variantiVAR_01706894R → P in PC2. 1 PublicationCorresponds to variant rs28928897dbSNPEnsembl.1
Natural variantiVAR_01707195L → P in PC2. 1 PublicationCorresponds to variant rs28928899dbSNPEnsembl.1
Natural variantiVAR_01707095L → Q in PC2. 1 PublicationCorresponds to variant rs28928899dbSNPEnsembl.1
Natural variantiVAR_01707297Missing in PC2. 1 Publication1
Natural variantiVAR_00385198Y → D in PC2. 1 PublicationCorresponds to variant rs28933088dbSNPEnsembl.1
Natural variantiVAR_01707399L → P in PC2. 1 PublicationCorresponds to variant rs28933089dbSNPEnsembl.1
Natural variantiVAR_017074102V → M in PC2. 2 PublicationsCorresponds to variant rs59977263dbSNPEnsembl.1
Natural variantiVAR_037083109N → D in PC2. 2 PublicationsCorresponds to variant rs267607412dbSNPEnsembl.1
Natural variantiVAR_072444388L → P in PC2. 1 PublicationCorresponds to variant rs56690581dbSNPEnsembl.1
Natural variantiVAR_072445388L → R in PC2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19574 Genomic DNA. Translation: CAA79626.1.
X62571 mRNA. Translation: CAA44451.1.
AK095342 mRNA. Translation: BAC04534.1.
AC022596 Genomic DNA. No translation available.
AL353997 Genomic DNA. No translation available.
BC000159 mRNA. Translation: AAH00159.2.
BC011901 mRNA. Translation: AAH11901.1.
BC056421 mRNA. Translation: AAH56421.1.
BC072018 mRNA. Translation: AAH72018.1. Frameshift.
BC072019 mRNA. Translation: AAH72019.1.
S78515 Genomic DNA. Translation: AAB34565.1.
EF608068 mRNA. Translation: ABQ96595.1.
EF608069 mRNA. Translation: ABQ96596.1.
EF608070 mRNA. Translation: ABQ96597.1.
EF608071 mRNA. Translation: ABQ96598.1.
CCDSiCCDS11402.1.
PIRiS30433.
RefSeqiNP_000413.1. NM_000422.2.
UniGeneiHs.2785.

Genome annotation databases

EnsembliENST00000311208; ENSP00000308452; ENSG00000128422.
GeneIDi3872.
KEGGihsa:3872.
UCSCiuc002hxh.3. human.

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19574 Genomic DNA. Translation: CAA79626.1.
X62571 mRNA. Translation: CAA44451.1.
AK095342 mRNA. Translation: BAC04534.1.
AC022596 Genomic DNA. No translation available.
AL353997 Genomic DNA. No translation available.
BC000159 mRNA. Translation: AAH00159.2.
BC011901 mRNA. Translation: AAH11901.1.
BC056421 mRNA. Translation: AAH56421.1.
BC072018 mRNA. Translation: AAH72018.1. Frameshift.
BC072019 mRNA. Translation: AAH72019.1.
S78515 Genomic DNA. Translation: AAB34565.1.
EF608068 mRNA. Translation: ABQ96595.1.
EF608069 mRNA. Translation: ABQ96596.1.
EF608070 mRNA. Translation: ABQ96597.1.
EF608071 mRNA. Translation: ABQ96598.1.
CCDSiCCDS11402.1.
PIRiS30433.
RefSeqiNP_000413.1. NM_000422.2.
UniGeneiHs.2785.

3D structure databases

ProteinModelPortaliQ04695.
SMRiQ04695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110070. 35 interactors.
DIPiDIP-33093N.
IntActiQ04695. 14 interactors.
MINTiMINT-256746.
STRINGi9606.ENSP00000308452.

PTM databases

iPTMnetiQ04695.
PhosphoSitePlusiQ04695.
SwissPalmiQ04695.

Polymorphism and mutation databases

BioMutaiKRT17.
DMDMi547751.

2D gel databases

SWISS-2DPAGEQ04695.

Proteomic databases

EPDiQ04695.
PaxDbiQ04695.
PeptideAtlasiQ04695.
PRIDEiQ04695.
TopDownProteomicsiQ04695.

Protocols and materials databases

DNASUi3872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311208; ENSP00000308452; ENSG00000128422.
GeneIDi3872.
KEGGihsa:3872.
UCSCiuc002hxh.3. human.

Organism-specific databases

CTDi3872.
DisGeNETi3872.
GeneCardsiKRT17.
GeneReviewsiKRT17.
H-InvDBHIX0059686.
HGNCiHGNC:6427. KRT17.
HPAiCAB000029.
HPA000452.
HPA000453.
HPA045062.
MalaCardsiKRT17.
MIMi148069. gene.
167210. phenotype.
184500. phenotype.
neXtProtiNX_Q04695.
OpenTargetsiENSG00000128422.
Orphaneti2309. Pachyonychia congenita.
841. Sebocystomatosis.
PharmGKBiPA30214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiQ04695.
KOiK07604.
OMAiQYHRTIE.
OrthoDBiEOG091G087I.
PhylomeDBiQ04695.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiKeratin_17.
GenomeRNAii3872.
PMAP-CutDBQ04695.
PROiQ04695.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128422.
ExpressionAtlasiQ04695. baseline and differential.
GenevisibleiQ04695. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C17_HUMAN
AccessioniPrimary (citable) accession number: Q04695
Secondary accession number(s): A5Z1M9
, A5Z1N0, A5Z1N1, A5Z1N2, A6NDV6, A6NKQ2, Q6IP98, Q8N1P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.