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Protein

Fat-body protein 1

Gene

Fbp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein transporter activity Source: FlyBase

GO - Biological processi

  • storage protein import into fat body Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fat-body protein 1
Short name:
P1 protein
Gene namesi
Name:Fbp1
Synonyms:P1
ORF Names:CG17285
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000639. Fbp1.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 10291012Fat-body protein 1PRO_0000021232Add
BLAST

Proteomic databases

PaxDbiQ04691.

Expressioni

Tissue specificityi

Fat body.

Developmental stagei

Expressed during the late third larval stage.

Inductioni

By ecdysone.

Gene expression databases

BgeeiQ04691.
ExpressionAtlasiQ04691. differential.
GenevisibleiQ04691. DM.

Interactioni

Protein-protein interaction databases

BioGridi64902. 2 interactions.
IntActiQ04691. 3 interactions.
STRINGi7227.FBpp0075491.

Structurei

3D structure databases

ProteinModelPortaliQ04691.
SMRiQ04691. Positions 609-1028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 711489Gln-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KBI1. Eukaryota.
ENOG4110N8A. LUCA.
GeneTreeiENSGT00530000063973.
InParanoidiQ04691.
OMAiVHINRRR.
OrthoDBiEOG7CVPWX.
PhylomeDBiQ04691.

Family and domain databases

Gene3Di1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProiIPR013788. Hemocyanin/hexamerin.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11511. PTHR11511. 3 hits.
PfamiPF03723. Hemocyanin_C. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view]
SUPFAMiSSF48050. SSF48050. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q04691-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRIMLLVAF AAGVVAAGRI TTNQDRVQGI DRMSLEDLQL QKFILDIVQN
60 70 80 90 100
IRQPLQQSEL INLDVGLIAD SQRYRGGIDK VMHNVIDLDR QRRLLDEHQV
110 120 130 140 150
YSVGRLEHVQ QLRGIYRLLA RAQDFDTLRR NVVYLRRNIN PVLLVNALAL
160 170 180 190 200
AIRDREDTQA LIVPAVQELL PELYLDEEVI QQVRSVLREQ TQRPSLMDIV
210 220 230 240 250
GMRQRAMNPV MSILMPWREI HMQMALRKQQ NIQNVLGQKR VVVRAENQGQ
260 270 280 290 300
VEGTSLLTDD IELQNFVQNL IQELALLEDV TQLEQSQLIN NDQREEQWVG
310 320 330 340 350
RQRVQYQDNN QERDLGQDVD TGRLLRVSRR RLLEQQDEYQ GQNIYGNQKD
360 370 380 390 400
RFQRLLRRDD DNDDNDDDDD QDIRMGRVQL QRGISQGGLR IGGAHNLPTV
410 420 430 440 450
SVNSDRLLHV SRRRLNAIQQ DQQQDQLNGR QRFMGLVRGD RLSEGRRVGQ
460 470 480 490 500
LDDVRQERQN NWQKQDYILT QGRTFGVQQE RQNYADQLES VSRDDERLVH
510 520 530 540 550
INRRRLNQDN QDIQQQQMHF PRRINSIGEG RRVMGERPIQ DEDILKLIRG
560 570 580 590 600
ENRLKLMTDD EILEMLQRNR QQRLQKHQND DDDDVNDDDV NVVHRQGLRS
610 620 630 640 650
RRSLPNLRQQ NNRLSEIVLH NLRQLVARLN QESIAQGQLI EEQQQLINNP
660 670 680 690 700
RLTQSERYAL RLNQIRINSQ RSRQVLAQIG QIEQRIQEVI GQVLNQVNVN
710 720 730 740 750
SLRGQVIDQR QVESLIADVL LGRLGQVGIM TIIRQVVQDN NIEQIDRTGL
760 770 780 790 800
GIRLSDPVVQ YTLRRIVRIV DEQREQILGG YRQEQLQMRG VSINDVRVDK
810 820 830 840 850
LRTRIEEHEL DLSNLVEQQV QGIQQEIVGR QRRLNNKAFT IDMDITSDQD
860 870 880 890 900
QDAIIRIFLG PAEDQQGRQG ASLDERRRDF VLLDAIQVQL ENGRNRIHRR
910 920 930 940 950
SIDIPWTTSD VTPLVEIYRQ VMLQLKGQQA QQVVGIQQLV GENGRFPQHL
960 970 980 990 1000
LLPRGRPEGL PMQLLVVVSP LVELQVQDVV PAITIGIGSA SLRDARPLGY
1010 1020
PLDRPIHNEQ ELLQLTNVLL QDVVIIQEN
Length:1,029
Mass (Da):119,663
Last modified:June 21, 2005 - v2
Checksum:i555168D01768B8CC
GO
Isoform B (identifier: Q04691-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:997
Mass (Da):116,223
Checksum:i27C37C2E8747A8BF
GO

Sequence cautioni

The sequence AAO24985.1 differs from that shown. Reason: Frameshift at several positions. The frameshift is due to large deletion.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831H → Q (PubMed:1696317).Curated
Sequence conflicti83 – 831H → Q (PubMed:8293980).Curated
Sequence conflicti125 – 1251F → L (PubMed:1696317).Curated
Sequence conflicti125 – 1251F → L (PubMed:8293980).Curated
Sequence conflicti160 – 1601A → T (PubMed:1696317).Curated
Sequence conflicti160 – 1601A → T (PubMed:8293980).Curated
Sequence conflicti217 – 2171W → Q (PubMed:1696317).Curated
Sequence conflicti217 – 2171W → Q (PubMed:8293980).Curated
Sequence conflicti311 – 3111Q → R (PubMed:1696317).Curated
Sequence conflicti311 – 3111Q → R (PubMed:8293980).Curated
Sequence conflicti317 – 3171Q → N (PubMed:1696317).Curated
Sequence conflicti317 – 3171Q → N (PubMed:8293980).Curated
Sequence conflicti324 – 3318LLRVSRRR → PTPCESAAG (PubMed:1696317).Curated
Sequence conflicti324 – 3318LLRVSRRR → PTPCESAAG (PubMed:8293980).Curated
Sequence conflicti395 – 3951H → R (PubMed:1696317).Curated
Sequence conflicti395 – 3951H → R (PubMed:8293980).Curated
Sequence conflicti519 – 5191H → N (PubMed:1696317).Curated
Sequence conflicti519 – 5191H → N (PubMed:8293980).Curated
Sequence conflicti533 – 5375VMGER → RHGRA (PubMed:1696317).Curated
Sequence conflicti533 – 5375VMGER → RHGRA (PubMed:8293980).Curated
Sequence conflicti581 – 5811D → Y (Ref. 6) Curated
Sequence conflicti585 – 5851V → D (PubMed:1696317).Curated
Sequence conflicti585 – 5851V → D (PubMed:8293980).Curated
Sequence conflicti695 – 6951N → S (PubMed:1696317).Curated
Sequence conflicti695 – 6951N → S (PubMed:8293980).Curated
Sequence conflicti742 – 7421I → S (PubMed:1696317).Curated
Sequence conflicti742 – 7421I → S (PubMed:8293980).Curated
Sequence conflicti748 – 7481T → N (PubMed:1696317).Curated
Sequence conflicti748 – 7481T → N (PubMed:8293980).Curated
Sequence conflicti898 – 8981H → Q (PubMed:1696317).Curated
Sequence conflicti898 – 8981H → Q (PubMed:8293980).Curated
Sequence conflicti979 – 9791V → I (PubMed:1696317).Curated
Sequence conflicti979 – 9791V → I (PubMed:8293980).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform B. CuratedVSP_014264Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54997 Genomic DNA. Translation: CAA38744.1.
X69965 Genomic DNA. Translation: CAA49588.1.
AE014296 Genomic DNA. Translation: AAF49757.2.
AE014296 Genomic DNA. Translation: AAN11802.1.
AY119088 mRNA. Translation: AAM50948.1.
BT003568 mRNA. Translation: AAO39572.1.
BT003230 mRNA. Translation: AAO24985.1. Sequence problems.
PIRiS11034.
RefSeqiNP_524065.1. NM_079341.2. [Q04691-1]
NP_729959.1. NM_168578.2. [Q04691-2]
UniGeneiDm.7260.

Genome annotation databases

EnsemblMetazoaiFBtr0075749; FBpp0075491; FBgn0000639. [Q04691-1]
GeneIDi39566.
KEGGidme:Dmel_CG17285.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54997 Genomic DNA. Translation: CAA38744.1.
X69965 Genomic DNA. Translation: CAA49588.1.
AE014296 Genomic DNA. Translation: AAF49757.2.
AE014296 Genomic DNA. Translation: AAN11802.1.
AY119088 mRNA. Translation: AAM50948.1.
BT003568 mRNA. Translation: AAO39572.1.
BT003230 mRNA. Translation: AAO24985.1. Sequence problems.
PIRiS11034.
RefSeqiNP_524065.1. NM_079341.2. [Q04691-1]
NP_729959.1. NM_168578.2. [Q04691-2]
UniGeneiDm.7260.

3D structure databases

ProteinModelPortaliQ04691.
SMRiQ04691. Positions 609-1028.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64902. 2 interactions.
IntActiQ04691. 3 interactions.
STRINGi7227.FBpp0075491.

Proteomic databases

PaxDbiQ04691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075749; FBpp0075491; FBgn0000639. [Q04691-1]
GeneIDi39566.
KEGGidme:Dmel_CG17285.

Organism-specific databases

CTDi2203.
FlyBaseiFBgn0000639. Fbp1.

Phylogenomic databases

eggNOGiENOG410KBI1. Eukaryota.
ENOG4110N8A. LUCA.
GeneTreeiENSGT00530000063973.
InParanoidiQ04691.
OMAiVHINRRR.
OrthoDBiEOG7CVPWX.
PhylomeDBiQ04691.

Miscellaneous databases

ChiTaRSiFbp1. fly.
GenomeRNAii39566.
PROiQ04691.

Gene expression databases

BgeeiQ04691.
ExpressionAtlasiQ04691. differential.
GenevisibleiQ04691. DM.

Family and domain databases

Gene3Di1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProiIPR013788. Hemocyanin/hexamerin.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11511. PTHR11511. 3 hits.
PfamiPF03723. Hemocyanin_C. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view]
SUPFAMiSSF48050. SSF48050. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the ecdysone-inducible P1 gene of Drosophila melanogaster."
    Maschat F., Dubertret M.-L., Therond P., Claverie J.-M., Lepesant J.-A.
    J. Mol. Biol. 214:359-372(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
    Tissue: Fat body.
  2. "Deletion scanning of the regulatory sequences of the Fbp1 gene of Drosophila melanogaster using P transposase-induced deficiencies."
    Lapie P., Nasr F., Lepesant J.-A., Deutsch J.
    Genetics 135:801-816(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Larva and Pupae.

Entry informationi

Entry nameiFBP1_DROME
AccessioniPrimary (citable) accession number: Q04691
Secondary accession number(s): Q86PB6, Q8IQL4, Q9VUD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 21, 2005
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.