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Q04690

- NF1_MOUSE

UniProt

Q04690 - NF1_MOUSE

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Protein

Neurofibromin

Gene
Nf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

GO - Molecular functioni

  1. GTPase activator activity Source: MGI
  2. phosphatidylcholine binding Source: UniProtKB
  3. phosphatidylethanolamine binding Source: UniProtKB
  4. protein binding Source: MGI
  5. Ras GTPase activator activity Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. adrenal gland development Source: MGI
  3. artery morphogenesis Source: MGI
  4. brain development Source: MGI
  5. camera-type eye morphogenesis Source: MGI
  6. cell communication Source: MGI
  7. cerebral cortex development Source: MGI
  8. collagen fibril organization Source: MGI
  9. extracellular matrix organization Source: MGI
  10. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  11. forebrain astrocyte development Source: MGI
  12. forebrain morphogenesis Source: MGI
  13. heart development Source: MGI
  14. liver development Source: MGI
  15. MAPK cascade Source: MGI
  16. metanephros development Source: MGI
  17. myelination in peripheral nervous system Source: MGI
  18. negative regulation of angiogenesis Source: MGI
  19. negative regulation of astrocyte differentiation Source: MGI
  20. negative regulation of cell-matrix adhesion Source: MGI
  21. negative regulation of cell migration Source: MGI
  22. negative regulation of cell proliferation Source: MGI
  23. negative regulation of endothelial cell proliferation Source: MGI
  24. negative regulation of fibroblast proliferation Source: BHF-UCL
  25. negative regulation of MAPK cascade Source: MGI
  26. negative regulation of MAP kinase activity Source: MGI
  27. negative regulation of neuroblast proliferation Source: MGI
  28. negative regulation of neurotransmitter secretion Source: MGI
  29. negative regulation of oligodendrocyte differentiation Source: MGI
  30. negative regulation of osteoclast differentiation Source: MGI
  31. negative regulation of protein kinase activity Source: MGI
  32. negative regulation of Rac protein signal transduction Source: MGI
  33. negative regulation of Ras protein signal transduction Source: MGI
  34. negative regulation of transcription factor import into nucleus Source: MGI
  35. neural tube development Source: MGI
  36. osteoblast differentiation Source: MGI
  37. peripheral nervous system development Source: MGI
  38. phosphatidylinositol 3-kinase signaling Source: MGI
  39. pigmentation Source: MGI
  40. positive regulation of adenylate cyclase activity Source: MGI
  41. positive regulation of apoptotic process Source: MGI
  42. positive regulation of endothelial cell proliferation Source: MGI
  43. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  44. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  45. positive regulation of neuron apoptotic process Source: MGI
  46. positive regulation of Ras GTPase activity Source: MGI
  47. Ras protein signal transduction Source: MGI
  48. regulation of angiogenesis Source: MGI
  49. regulation of blood vessel endothelial cell migration Source: Ensembl
  50. regulation of bone resorption Source: MGI
  51. regulation of cell-matrix adhesion Source: MGI
  52. regulation of cell proliferation Source: MGI
  53. regulation of glial cell differentiation Source: MGI
  54. regulation of long-term neuronal synaptic plasticity Source: MGI
  55. regulation of synaptic transmission, GABAergic Source: MGI
  56. response to hypoxia Source: MGI
  57. Schwann cell development Source: MGI
  58. skeletal muscle tissue development Source: MGI
  59. smooth muscle tissue development Source: MGI
  60. spinal cord development Source: MGI
  61. sympathetic nervous system development Source: MGI
  62. visual learning Source: MGI
  63. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofibromin
Alternative name(s):
Neurofibromatosis-related protein NF-1
Gene namesi
Name:Nf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97306. Nf1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: MGI
  3. dendrite Source: Ensembl
  4. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 28412840NeurofibrominPRO_0000056666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei866 – 8661Phosphoserine By similarity
Modified residuei878 – 8781Phosphoserine By similarity
Modified residuei2190 – 21901Phosphoserine By similarity
Modified residuei2517 – 25171Phosphoserine By similarity
Modified residuei2523 – 25231Phosphoserine By similarity
Modified residuei2545 – 25451Phosphoserine By similarity
Modified residuei2819 – 28191Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04690.
PaxDbiQ04690.
PRIDEiQ04690.

PTM databases

PhosphoSiteiQ04690.

Expressioni

Tissue specificityi

Isoform 1 is expressed predominantly in brain, spinal cord and testis. Isoform 2 is expressed predominantly in adrenal gland, kidney, ovary and lung. Isoform 3 is expressed predominantly in adrenal gland and isoform 4 is expressed mainly in the testis.

Gene expression databases

BgeeiQ04690.
CleanExiMM_NF1.
GenevestigatoriQ04690.

Interactioni

Protein-protein interaction databases

BioGridi201736. 8 interactions.
IntActiQ04690. 7 interactions.
MINTiMINT-4103389.

Structurei

3D structure databases

ProteinModelPortaliQ04690.
SMRiQ04690. Positions 1208-1552, 1583-1839.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1237 – 1453217Ras-GAPAdd
BLAST
Domaini1582 – 1740159CRAL-TRIOAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1582 – 1839258Lipid binding By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2557 – 257317Bipartite nuclear localization signal By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1354 – 13574Poly-Ser

Domaini

Binds phospholipids via a region that includes the CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol By similarity.

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.
Contains 1 Ras-GAP domain.

Phylogenomic databases

eggNOGiCOG5261.
GeneTreeiENSGT00550000074797.
HOGENOMiHOG000047020.
HOVERGENiHBG006486.
InParanoidiQ04690.
KOiK08052.
OMAiIDFTHTC.
OrthoDBiEOG74J96W.
PhylomeDBiQ04690.
TreeFamiTF300302.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001251. CRAL-TRIO_dom.
IPR028553. Neurofibromin.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PANTHERiPTHR10194:SF60. PTHR10194:SF60. 1 hit.
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00323. RasGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q04690-1) [UniParc]FASTAAdd to Basket

Also known as: Type II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK     50
FSLVISGLTT ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD 100
TMRLDETMLV KQLLPEICHF LHTCREGNQH AAELRNSASG VLFSLSCNNF 150
NAVFSRISTR LQELTVCSED NVDVHDIELL QYINVDCAKL KRLLKETAFK 200
FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT DMAECAEKLF 250
DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ESNINKKLFL 300
DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV 350
VDLKNLLFNP SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ 400
NSPSTFHYVL VNSLHRIITN SALDWWPKID AVYCHSVELR NMFGETLHKA 450
VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK PTDLETRSYK CLLLSMVKLI 500
HADPKLLLCN PRKQGPETQS STAELITGLV QLVPQSHMPE VAQEAMEALL 550
VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL 600
REILICRNKF LLKNKQADRS SCHSLYLYGV GCEMSATGNT TQMSVDHDEF 650
LRACTPGASL RKGRGNSSMD STAGCSGTPP ICRQAQTKLE VALYMFLWNP 700
DTEAVLVAMS CFRHLCEEAD IRCGVDEVSV HNFLPNYNTF MEFASVSNMM 750
STGRAALQKR VMALLRRIEH PTAGNIEAWE DTHAKWEQAT KLILNYPKAK 800
MEDGQAAESL HKTIVKRRMS HVSGGGSIDL SDTDSLQEWI NMTGFLCALG 850
GVCLQQRSSS GLATYSPPMG AVSERKGSMI SVMSSEGNID SPVSRFMDRL 900
LSLMVCNHEK VGLQIRTNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ 950
GQVLLSDSNT QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY 1000
VRVLGNMVHA IQIKTKLCQL VEVMMARRDD LSFCQEMKFR NKMVEYLTDW 1050
VMGTSNQAAD DDIKCLTRDL DQASMEAVVS LLAGLPLQPE EGDGVELMEA 1100
KSQLFLKYFT LFMNLLNDCS EVEDENAQTG GRKRGMSRRL ASLRHCTVLA 1150
MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ QGTEFDTLAE 1200
TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD 1250
SRHLLYQLLW NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ 1300
KLLDPLLRVI ITSSDWQHVS FEVDPTRLEP SESLEENQRN LLQMTEKFFH 1350
AIISSSSEFP SQLRSVCHCL YQATCHSLLN KATVKERKEN KKSVVSQRFP 1400
QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPRIERG LKLMSKVLQS 1450
IANHVLFTKE EHMRPFNDFV KSNFDLARRF FLDIASDCPT SDAVNHSLSF 1500
ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK MATLLAYLGP 1550
PEHKPVADTH WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLSIFYQAGT 1600
SKAGNPIFYY VARRFKTGQI NGDLLIYHVL LTLKPYYAKP YEIVVDLTHT 1650
GPSNRFKTDF LSKWFVVFPG FAYDNVSAVY IYNCNSWVRE YTKYHERLLT 1700
GLKGSKRLIF IDCPGKLAEH IEHEQQKLPA ATLALEEDLK VFHNALKLAH 1750
KDTKVSIKVG STAVQVTSAE RTKVLGQSVF LNDIYYASEI EEICLVDENQ 1800
FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS IPQHTKIRPK 1850
DVPGTLLNIA LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL 1900
CIPANNTLFI VSISKTLAAN EPHLTLEFLE ECISGFSKSS IELKHLCLEY 1950
MTPWLSNLVR FCKHNDDAKR QRVTAILDKL ITMTINEKQM YPSIQAKIWG 2000
SLGQITDLLD VVLDSFIKTS ATGGLGSIKA EVMADTAVAL ASGNVKLVSS 2050
KVIGRMCKII DKTCLSPTPT LEQHLMWDDI AILARYMLML SFNNSLDVAA 2100
HLPYLFHVVT FLVATGPLSL RASTHGLLIN IIHSLCTCSQ LHFSEETKQV 2150
LRLSLTEFSL PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA 2200
LTSLETVTEA LLEIMEACMR DIPTCKWLDQ WTELAQRFAF QYNPSLQPRA 2250
LVVFGCISKR VSHGQIKQII RILSKALESC LKGPDTYNSQ VLIESTVIAL 2300
TKLQPLLNKD SPLHKALFWV AVAVLQLDEV NLYSAGTALL EQNLHTLDSL 2350
RIFNDKSPEE VFMAIRNPLE WHCKQMDHFV GLNFNSNFNF ALVGHLLKGY 2400
RHPSPAIVAR TVRILHTLLT LVNKHRNCDK FEVNTQSVAY LAALLTVSEE 2450
VRSRCSLKHR KSLLLTDISM ENVPMDTYPI HHGDPSYRTL KETQPWSSPK 2500
GSEGYLAATY PAVGQTSPRA RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI 2550
SDTKAPKRQE MESGITTPPK MRRVAETDYE METQRIPSSQ QHPHLRKVSV 2600
SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI LYEYLAEASV 2650
VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY 2700
QTSYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE 2750
ETSEESLLTP TSPYPPALQS QLSITANLNL SNSMTSLATS QHSPGLDKEN 2800
VELSPTAGHC NSGRTRHGSA SQVQKQRSAG SFKRNSIKKI V 2841
Length:2,841
Mass (Da):319,596
Last modified:June 1, 1994 - v1
Checksum:i06650BDCDC531002
GO
Isoform 1 (identifier: Q04690-2) [UniParc]FASTAAdd to Basket

Also known as: Type I

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.

Show »
Length:2,820
Mass (Da):317,228
Checksum:i5CA21CD5946C597B
GO
Isoform 3 (identifier: Q04690-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.

Show »
Length:1,419
Mass (Da):159,714
Checksum:iEBA01C4F82A4A46C
GO
Isoform 4 (identifier: Q04690-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.

Show »
Length:1,398
Mass (Da):157,347
Checksum:iAF69F30DFD7C4F9A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1373 – 139321Missing in isoform 1 and isoform 4. VSP_001633Add
BLAST
Alternative sequencei1394 – 140613VVSQR…NSIGA → VPKSSCFSCLNNRWLASASL RTASVP in isoform 3 and isoform 4. VSP_001634Add
BLAST
Alternative sequencei1407 – 28411435Missing in isoform 3 and isoform 4. VSP_001635Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10369, L10367, L10368 Genomic DNA. Translation: AAA39806.1.
L10370 mRNA. Translation: AAA68132.1.
X54924 mRNA. Translation: CAA38690.1.
D30730 mRNA. Translation: BAA06395.1.
D30731 mRNA. Translation: BAA06396.1.
CCDSiCCDS25119.1. [Q04690-1]
PIRiI53855.
I54352.
I67934.
I68623.
RefSeqiNP_035027.1. NM_010897.2. [Q04690-1]
XP_006532504.1. XM_006532441.1. [Q04690-2]
UniGeneiMm.255596.
Mm.488324.

Genome annotation databases

EnsembliENSMUST00000071325; ENSMUSP00000071289; ENSMUSG00000020716. [Q04690-1]
ENSMUST00000108251; ENSMUSP00000103886; ENSMUSG00000020716. [Q04690-2]
GeneIDi18015.
KEGGimmu:18015.
UCSCiuc007kkl.1. mouse. [Q04690-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10369 , L10367 , L10368 Genomic DNA. Translation: AAA39806.1 .
L10370 mRNA. Translation: AAA68132.1 .
X54924 mRNA. Translation: CAA38690.1 .
D30730 mRNA. Translation: BAA06395.1 .
D30731 mRNA. Translation: BAA06396.1 .
CCDSi CCDS25119.1. [Q04690-1 ]
PIRi I53855.
I54352.
I67934.
I68623.
RefSeqi NP_035027.1. NM_010897.2. [Q04690-1 ]
XP_006532504.1. XM_006532441.1. [Q04690-2 ]
UniGenei Mm.255596.
Mm.488324.

3D structure databases

ProteinModelPortali Q04690.
SMRi Q04690. Positions 1208-1552, 1583-1839.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201736. 8 interactions.
IntActi Q04690. 7 interactions.
MINTi MINT-4103389.

Chemistry

ChEMBLi CHEMBL2176807.

PTM databases

PhosphoSitei Q04690.

Proteomic databases

MaxQBi Q04690.
PaxDbi Q04690.
PRIDEi Q04690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071325 ; ENSMUSP00000071289 ; ENSMUSG00000020716 . [Q04690-1 ]
ENSMUST00000108251 ; ENSMUSP00000103886 ; ENSMUSG00000020716 . [Q04690-2 ]
GeneIDi 18015.
KEGGi mmu:18015.
UCSCi uc007kkl.1. mouse. [Q04690-1 ]

Organism-specific databases

CTDi 4763.
MGIi MGI:97306. Nf1.

Phylogenomic databases

eggNOGi COG5261.
GeneTreei ENSGT00550000074797.
HOGENOMi HOG000047020.
HOVERGENi HBG006486.
InParanoidi Q04690.
KOi K08052.
OMAi IDFTHTC.
OrthoDBi EOG74J96W.
PhylomeDBi Q04690.
TreeFami TF300302.

Miscellaneous databases

ChiTaRSi NF1. mouse.
NextBioi 293049.
PROi Q04690.
SOURCEi Search...

Gene expression databases

Bgeei Q04690.
CleanExi MM_NF1.
Genevestigatori Q04690.

Family and domain databases

Gene3Di 1.25.10.10. 5 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001251. CRAL-TRIO_dom.
IPR028553. Neurofibromin.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
PANTHERi PTHR10194:SF60. PTHR10194:SF60. 1 hit.
Pfami PF13716. CRAL_TRIO_2. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00323. RasGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments."
    Bernards A., Snijders A.J., Hannigan G.E., Murthy A.E., Gusella J.F.
    Hum. Mol. Genet. 2:645-650(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "A novel isoform of the neurofibromatosis type-1 mRNA and a switch of isoforms during murine cell differentiation and proliferation."
    Mantani A., Makasugi S., Yokota Y., Abe K., Ushio Y., Yamamura K.
    Gene 148:245-251(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1178-1555, ALTERNATIVE SPLICING.
  3. "Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway."
    Buchberg A.M., Cleveland L.S., Jenkins N.A., Copeland N.G.
    Nature 347:291-294(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1950-2568.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1973-1979, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiNF1_MOUSE
AccessioniPrimary (citable) accession number: Q04690
Secondary accession number(s): Q61956, Q61957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi