Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q04690 (NF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurofibromin
Alternative name(s):
Neurofibromatosis-related protein NF-1
Gene names
Name:Nf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2841 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

Subcellular location

Nucleus By similarity. Nucleusnucleolus By similarity.

Tissue specificity

Isoform 1 is expressed predominantly in brain, spinal cord and testis. Isoform 2 is expressed predominantly in adrenal gland, kidney, ovary and lung. Isoform 3 is expressed predominantly in adrenal gland and isoform 4 is expressed mainly in the testis.

Domain

Binds phospholipids via a region that includes the CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol By similarity.

Sequence similarities

Contains 1 CRAL-TRIO domain.

Contains 1 Ras-GAP domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandLipid-binding
   Molecular functionGTPase activation
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from mutant phenotype PubMed 14724565. Source: MGI

Ras protein signal transduction

Inferred from mutant phenotype PubMed 10498620PubMed 11435472PubMed 12469121PubMed 16906226PubMed 8563750PubMed 9001241. Source: MGI

Schwann cell development

Inferred from mutant phenotype PubMed 9001241. Source: MGI

actin cytoskeleton organization

Inferred from mutant phenotype PubMed 16405917. Source: MGI

adrenal gland development

Inferred from mutant phenotype PubMed 16906226. Source: MGI

artery morphogenesis

Inferred from mutant phenotype PubMed 7926784. Source: MGI

brain development

Inferred from mutant phenotype PubMed 10419687. Source: MGI

camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 7926784. Source: MGI

cell communication

Inferred from mutant phenotype PubMed 10442636. Source: MGI

cerebral cortex development

Inferred from mutant phenotype PubMed 11297510. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 10383727. Source: MGI

extracellular matrix organization

Inferred from mutant phenotype PubMed 16835260. Source: MGI

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from genetic interaction PubMed 15039234. Source: MGI

forebrain astrocyte development

Inferred from mutant phenotype PubMed 15944386. Source: MGI

forebrain morphogenesis

Inferred from mutant phenotype PubMed 11297510. Source: MGI

heart development

Inferred from mutant phenotype PubMed 10419687PubMed 12469121PubMed 16906226PubMed 7920653PubMed 7926784. Source: MGI

liver development

Inferred from mutant phenotype PubMed 7926784. Source: MGI

metanephros development

Inferred from mutant phenotype PubMed 7926784. Source: MGI

myelination in peripheral nervous system

Inferred from mutant phenotype PubMed 10586246. Source: MGI

negative regulation of MAP kinase activity

Inferred from mutant phenotype PubMed 11297510PubMed 12409258. Source: MGI

negative regulation of MAPK cascade

Inferred from mutant phenotype PubMed 16644864. Source: MGI

negative regulation of Rac protein signal transduction

Inferred from genetic interaction PubMed 15665300. Source: MGI

negative regulation of Ras protein signal transduction

Inferred from mutant phenotype PubMed 11246230PubMed 15665300PubMed 15944386PubMed 16835260PubMed 16893911. Source: MGI

negative regulation of angiogenesis

Inferred from genetic interaction PubMed 16648142. Source: MGI

negative regulation of astrocyte differentiation

Inferred from mutant phenotype PubMed 10442636PubMed 11297510PubMed 9878702. Source: MGI

negative regulation of cell migration

Inferred from mutant phenotype PubMed 14724565. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 10383727PubMed 10442636PubMed 10498620PubMed 11246230PubMed 11401406PubMed 14982883PubMed 15944386PubMed 8563750PubMed 9001241. Source: MGI

negative regulation of cell-matrix adhesion

Inferred from genetic interaction PubMed 17053831. Source: MGI

negative regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 16288202. Source: MGI

negative regulation of fibroblast proliferation

Inferred from mutant phenotype PubMed 20154697. Source: BHF-UCL

negative regulation of neuroblast proliferation

Inferred from mutant phenotype PubMed 7926784. Source: MGI

negative regulation of neurotransmitter secretion

Inferred from mutant phenotype PubMed 16298082. Source: MGI

negative regulation of oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 15944386. Source: MGI

negative regulation of osteoclast differentiation

Inferred from genetic interaction PubMed 17053831. Source: MGI

negative regulation of protein kinase activity

Inferred from mutant phenotype PubMed 16835260. Source: MGI

negative regulation of transcription factor import into nucleus

Inferred from mutant phenotype PubMed 12469121. Source: MGI

neural tube development

Inferred from genetic interaction PubMed 10419687. Source: MGI

osteoblast differentiation

Inferred from mutant phenotype PubMed 16893911. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 10419687. Source: MGI

phosphatidylinositol 3-kinase signaling

Inferred from mutant phenotype PubMed 14724565. Source: MGI

pigmentation

Inferred from mutant phenotype PubMed 10594763PubMed 10844550. Source: MGI

positive regulation of Ras GTPase activity

Inferred from mutant phenotype PubMed 11435472PubMed 8563750. Source: MGI

positive regulation of adenylate cyclase activity

Inferred from mutant phenotype PubMed 11788835. Source: MGI

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 15944386PubMed 17053831. Source: MGI

positive regulation of endothelial cell proliferation

Inferred from genetic interaction PubMed 16644864. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 15039234. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from mutant phenotype PubMed 15039234. Source: MGI

positive regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 11297510PubMed 7671302. Source: MGI

regulation of angiogenesis

Inferred from mutant phenotype PubMed 16288202. Source: MGI

regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

regulation of bone resorption

Inferred from mutant phenotype PubMed 17053831. Source: MGI

regulation of cell proliferation

Inferred from genetic interaction PubMed 10678181. Source: MGI

regulation of cell-matrix adhesion

Inferred from mutant phenotype PubMed 16405917. Source: MGI

regulation of glial cell differentiation

Inferred from mutant phenotype PubMed 12904481. Source: MGI

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 11793011. Source: MGI

regulation of synaptic transmission, GABAergic

Inferred from genetic interaction PubMed 11793011. Source: MGI

response to hypoxia

Inferred from mutant phenotype PubMed 16288202. Source: MGI

skeletal muscle tissue development

Inferred from mutant phenotype PubMed 7926784. Source: MGI

smooth muscle tissue development

Inferred from mutant phenotype PubMed 7926784. Source: MGI

spinal cord development

Inferred from mutant phenotype PubMed 16906226. Source: MGI

sympathetic nervous system development

Inferred from mutant phenotype PubMed 16906226PubMed 7926784. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 11279521PubMed 11793011. Source: MGI

wound healing

Inferred from mutant phenotype PubMed 10383727. Source: MGI

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 15133494. Source: MGI

dendrite

Inferred from electronic annotation. Source: Ensembl

intrinsic component of the cytoplasmic side of the plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from mutant phenotype PubMed 11435472PubMed 17053831PubMed 8563750. Source: MGI

Ras GTPase activator activity

Inferred from genetic interaction PubMed 15665300. Source: MGI

phosphatidylcholine binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylethanolamine binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 16405917. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q04690-1)

Also known as: Type II;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q04690-2)

Also known as: Type I;

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.
Isoform 3 (identifier: Q04690-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.
Isoform 4 (identifier: Q04690-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 28412840Neurofibromin
PRO_0000056666

Regions

Domain1237 – 1453217Ras-GAP
Domain1582 – 1740159CRAL-TRIO
Region1582 – 1839258Lipid binding By similarity
Motif2557 – 257317Bipartite nuclear localization signal By similarity
Compositional bias1354 – 13574Poly-Ser

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue8661Phosphoserine By similarity
Modified residue8781Phosphoserine By similarity
Modified residue21901Phosphoserine By similarity
Modified residue25171Phosphoserine By similarity
Modified residue25231Phosphoserine By similarity
Modified residue25451Phosphoserine By similarity
Modified residue28191Phosphoserine By similarity

Natural variations

Alternative sequence1373 – 139321Missing in isoform 1 and isoform 4.
VSP_001633
Alternative sequence1394 – 140613VVSQR…NSIGA → VPKSSCFSCLNNRWLASASL RTASVP in isoform 3 and isoform 4.
VSP_001634
Alternative sequence1407 – 28411435Missing in isoform 3 and isoform 4.
VSP_001635

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (Type II) [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 06650BDCDC531002

FASTA2,841319,596
        10         20         30         40         50         60 
MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTT 

        70         80         90        100        110        120 
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF 

       130        140        150        160        170        180 
LHTCREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NVDVHDIELL 

       190        200        210        220        230        240 
QYINVDCAKL KRLLKETAFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT 

       250        260        270        280        290        300 
DMAECAEKLF DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ESNINKKLFL 

       310        320        330        340        350        360 
DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP 

       370        380        390        400        410        420 
SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN 

       430        440        450        460        470        480 
SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK 

       490        500        510        520        530        540 
PTDLETRSYK CLLLSMVKLI HADPKLLLCN PRKQGPETQS STAELITGLV QLVPQSHMPE 

       550        560        570        580        590        600 
VAQEAMEALL VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL 

       610        620        630        640        650        660 
REILICRNKF LLKNKQADRS SCHSLYLYGV GCEMSATGNT TQMSVDHDEF LRACTPGASL 

       670        680        690        700        710        720 
RKGRGNSSMD STAGCSGTPP ICRQAQTKLE VALYMFLWNP DTEAVLVAMS CFRHLCEEAD 

       730        740        750        760        770        780 
IRCGVDEVSV HNFLPNYNTF MEFASVSNMM STGRAALQKR VMALLRRIEH PTAGNIEAWE 

       790        800        810        820        830        840 
DTHAKWEQAT KLILNYPKAK MEDGQAAESL HKTIVKRRMS HVSGGGSIDL SDTDSLQEWI 

       850        860        870        880        890        900 
NMTGFLCALG GVCLQQRSSS GLATYSPPMG AVSERKGSMI SVMSSEGNID SPVSRFMDRL 

       910        920        930        940        950        960 
LSLMVCNHEK VGLQIRTNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ GQVLLSDSNT 

       970        980        990       1000       1010       1020 
QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY VRVLGNMVHA IQIKTKLCQL 

      1030       1040       1050       1060       1070       1080 
VEVMMARRDD LSFCQEMKFR NKMVEYLTDW VMGTSNQAAD DDIKCLTRDL DQASMEAVVS 

      1090       1100       1110       1120       1130       1140 
LLAGLPLQPE EGDGVELMEA KSQLFLKYFT LFMNLLNDCS EVEDENAQTG GRKRGMSRRL 

      1150       1160       1170       1180       1190       1200 
ASLRHCTVLA MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ QGTEFDTLAE 

      1210       1220       1230       1240       1250       1260 
TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD SRHLLYQLLW 

      1270       1280       1290       1300       1310       1320 
NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ KLLDPLLRVI ITSSDWQHVS 

      1330       1340       1350       1360       1370       1380 
FEVDPTRLEP SESLEENQRN LLQMTEKFFH AIISSSSEFP SQLRSVCHCL YQATCHSLLN 

      1390       1400       1410       1420       1430       1440 
KATVKERKEN KKSVVSQRFP QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPRIERG 

      1450       1460       1470       1480       1490       1500 
LKLMSKVLQS IANHVLFTKE EHMRPFNDFV KSNFDLARRF FLDIASDCPT SDAVNHSLSF 

      1510       1520       1530       1540       1550       1560 
ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK MATLLAYLGP PEHKPVADTH 

      1570       1580       1590       1600       1610       1620 
WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLSIFYQAGT SKAGNPIFYY VARRFKTGQI 

      1630       1640       1650       1660       1670       1680 
NGDLLIYHVL LTLKPYYAKP YEIVVDLTHT GPSNRFKTDF LSKWFVVFPG FAYDNVSAVY 

      1690       1700       1710       1720       1730       1740 
IYNCNSWVRE YTKYHERLLT GLKGSKRLIF IDCPGKLAEH IEHEQQKLPA ATLALEEDLK 

      1750       1760       1770       1780       1790       1800 
VFHNALKLAH KDTKVSIKVG STAVQVTSAE RTKVLGQSVF LNDIYYASEI EEICLVDENQ 

      1810       1820       1830       1840       1850       1860 
FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS IPQHTKIRPK DVPGTLLNIA 

      1870       1880       1890       1900       1910       1920 
LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL CIPANNTLFI VSISKTLAAN 

      1930       1940       1950       1960       1970       1980 
EPHLTLEFLE ECISGFSKSS IELKHLCLEY MTPWLSNLVR FCKHNDDAKR QRVTAILDKL 

      1990       2000       2010       2020       2030       2040 
ITMTINEKQM YPSIQAKIWG SLGQITDLLD VVLDSFIKTS ATGGLGSIKA EVMADTAVAL 

      2050       2060       2070       2080       2090       2100 
ASGNVKLVSS KVIGRMCKII DKTCLSPTPT LEQHLMWDDI AILARYMLML SFNNSLDVAA 

      2110       2120       2130       2140       2150       2160 
HLPYLFHVVT FLVATGPLSL RASTHGLLIN IIHSLCTCSQ LHFSEETKQV LRLSLTEFSL 

      2170       2180       2190       2200       2210       2220 
PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA LTSLETVTEA LLEIMEACMR 

      2230       2240       2250       2260       2270       2280 
DIPTCKWLDQ WTELAQRFAF QYNPSLQPRA LVVFGCISKR VSHGQIKQII RILSKALESC 

      2290       2300       2310       2320       2330       2340 
LKGPDTYNSQ VLIESTVIAL TKLQPLLNKD SPLHKALFWV AVAVLQLDEV NLYSAGTALL 

      2350       2360       2370       2380       2390       2400 
EQNLHTLDSL RIFNDKSPEE VFMAIRNPLE WHCKQMDHFV GLNFNSNFNF ALVGHLLKGY 

      2410       2420       2430       2440       2450       2460 
RHPSPAIVAR TVRILHTLLT LVNKHRNCDK FEVNTQSVAY LAALLTVSEE VRSRCSLKHR 

      2470       2480       2490       2500       2510       2520 
KSLLLTDISM ENVPMDTYPI HHGDPSYRTL KETQPWSSPK GSEGYLAATY PAVGQTSPRA 

      2530       2540       2550       2560       2570       2580 
RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI SDTKAPKRQE MESGITTPPK MRRVAETDYE 

      2590       2600       2610       2620       2630       2640 
METQRIPSSQ QHPHLRKVSV SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI 

      2650       2660       2670       2680       2690       2700 
LYEYLAEASV VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY 

      2710       2720       2730       2740       2750       2760 
QTSYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE ETSEESLLTP 

      2770       2780       2790       2800       2810       2820 
TSPYPPALQS QLSITANLNL SNSMTSLATS QHSPGLDKEN VELSPTAGHC NSGRTRHGSA 

      2830       2840 
SQVQKQRSAG SFKRNSIKKI V 

« Hide

Isoform 1 (Type I) [UniParc].

Checksum: 5CA21CD5946C597B
Show »

FASTA2,820317,228
Isoform 3 [UniParc].

Checksum: EBA01C4F82A4A46C
Show »

FASTA1,419159,714
Isoform 4 [UniParc].

Checksum: AF69F30DFD7C4F9A
Show »

FASTA1,398157,347

References

[1]"Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments."
Bernards A., Snijders A.J., Hannigan G.E., Murthy A.E., Gusella J.F.
Hum. Mol. Genet. 2:645-650(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"A novel isoform of the neurofibromatosis type-1 mRNA and a switch of isoforms during murine cell differentiation and proliferation."
Mantani A., Makasugi S., Yokota Y., Abe K., Ushio Y., Yamamura K.
Gene 148:245-251(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1178-1555, ALTERNATIVE SPLICING.
[3]"Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway."
Buchberg A.M., Cleveland L.S., Jenkins N.A., Copeland N.G.
Nature 347:291-294(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1950-2568.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1973-1979, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10369, L10367, L10368 Genomic DNA. Translation: AAA39806.1.
L10370 mRNA. Translation: AAA68132.1.
X54924 mRNA. Translation: CAA38690.1.
D30730 mRNA. Translation: BAA06395.1.
D30731 mRNA. Translation: BAA06396.1.
CCDSCCDS25119.1. [Q04690-1]
PIRI53855.
I54352.
I67934.
I68623.
RefSeqNP_035027.1. NM_010897.2. [Q04690-1]
XP_006532504.1. XM_006532441.1. [Q04690-2]
UniGeneMm.255596.
Mm.488324.

3D structure databases

ProteinModelPortalQ04690.
SMRQ04690. Positions 1208-1552, 1583-1839.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201736. 8 interactions.
IntActQ04690. 7 interactions.
MINTMINT-4103389.

Chemistry

ChEMBLCHEMBL2176807.

PTM databases

PhosphoSiteQ04690.

Proteomic databases

MaxQBQ04690.
PaxDbQ04690.
PRIDEQ04690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000071325; ENSMUSP00000071289; ENSMUSG00000020716. [Q04690-1]
ENSMUST00000108251; ENSMUSP00000103886; ENSMUSG00000020716. [Q04690-2]
GeneID18015.
KEGGmmu:18015.
UCSCuc007kkl.1. mouse. [Q04690-1]

Organism-specific databases

CTD4763.
MGIMGI:97306. Nf1.

Phylogenomic databases

eggNOGCOG5261.
GeneTreeENSGT00550000074797.
HOGENOMHOG000047020.
HOVERGENHBG006486.
InParanoidQ04690.
KOK08052.
OMAIDFTHTC.
OrthoDBEOG74J96W.
PhylomeDBQ04690.
TreeFamTF300302.

Gene expression databases

BgeeQ04690.
CleanExMM_NF1.
GenevestigatorQ04690.

Family and domain databases

Gene3D1.25.10.10. 5 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001251. CRAL-TRIO_dom.
IPR028553. Neurofibromin.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PANTHERPTHR10194:SF60. PTHR10194:SF60. 1 hit.
PfamPF13716. CRAL_TRIO_2. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTSM00323. RasGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEPS50191. CRAL_TRIO. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNF1. mouse.
NextBio293049.
PROQ04690.
SOURCESearch...

Entry information

Entry nameNF1_MOUSE
AccessionPrimary (citable) accession number: Q04690
Secondary accession number(s): Q61956, Q61957
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot