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Q04690

- NF1_MOUSE

UniProt

Q04690 - NF1_MOUSE

Protein

Neurofibromin

Gene

Nf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

    GO - Molecular functioni

    1. GTPase activator activity Source: MGI
    2. phosphatidylcholine binding Source: UniProtKB
    3. phosphatidylethanolamine binding Source: UniProtKB
    4. protein binding Source: MGI
    5. Ras GTPase activator activity Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. adrenal gland development Source: MGI
    3. artery morphogenesis Source: MGI
    4. brain development Source: MGI
    5. camera-type eye morphogenesis Source: MGI
    6. cell communication Source: MGI
    7. cerebral cortex development Source: MGI
    8. collagen fibril organization Source: MGI
    9. extracellular matrix organization Source: MGI
    10. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    11. forebrain astrocyte development Source: MGI
    12. forebrain morphogenesis Source: MGI
    13. heart development Source: MGI
    14. liver development Source: MGI
    15. MAPK cascade Source: MGI
    16. metanephros development Source: MGI
    17. myelination in peripheral nervous system Source: MGI
    18. negative regulation of angiogenesis Source: MGI
    19. negative regulation of astrocyte differentiation Source: MGI
    20. negative regulation of cell-matrix adhesion Source: MGI
    21. negative regulation of cell migration Source: MGI
    22. negative regulation of cell proliferation Source: MGI
    23. negative regulation of endothelial cell proliferation Source: MGI
    24. negative regulation of fibroblast proliferation Source: BHF-UCL
    25. negative regulation of MAPK cascade Source: MGI
    26. negative regulation of MAP kinase activity Source: MGI
    27. negative regulation of neuroblast proliferation Source: MGI
    28. negative regulation of neurotransmitter secretion Source: MGI
    29. negative regulation of oligodendrocyte differentiation Source: MGI
    30. negative regulation of osteoclast differentiation Source: MGI
    31. negative regulation of protein kinase activity Source: MGI
    32. negative regulation of Rac protein signal transduction Source: MGI
    33. negative regulation of Ras protein signal transduction Source: MGI
    34. negative regulation of transcription factor import into nucleus Source: MGI
    35. neural tube development Source: MGI
    36. osteoblast differentiation Source: MGI
    37. peripheral nervous system development Source: MGI
    38. phosphatidylinositol 3-kinase signaling Source: MGI
    39. pigmentation Source: MGI
    40. positive regulation of adenylate cyclase activity Source: MGI
    41. positive regulation of apoptotic process Source: MGI
    42. positive regulation of endothelial cell proliferation Source: MGI
    43. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    44. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    45. positive regulation of neuron apoptotic process Source: MGI
    46. positive regulation of Ras GTPase activity Source: MGI
    47. Ras protein signal transduction Source: MGI
    48. regulation of angiogenesis Source: MGI
    49. regulation of blood vessel endothelial cell migration Source: Ensembl
    50. regulation of bone resorption Source: MGI
    51. regulation of cell-matrix adhesion Source: MGI
    52. regulation of cell proliferation Source: MGI
    53. regulation of glial cell differentiation Source: MGI
    54. regulation of long-term neuronal synaptic plasticity Source: MGI
    55. regulation of synaptic transmission, GABAergic Source: MGI
    56. response to hypoxia Source: MGI
    57. Schwann cell development Source: MGI
    58. skeletal muscle tissue development Source: MGI
    59. smooth muscle tissue development Source: MGI
    60. spinal cord development Source: MGI
    61. sympathetic nervous system development Source: MGI
    62. visual learning Source: MGI
    63. wound healing Source: MGI

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurofibromin
    Alternative name(s):
    Neurofibromatosis-related protein NF-1
    Gene namesi
    Name:Nf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:97306. Nf1.

    Subcellular locationi

    Nucleus By similarity. Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: MGI
    3. dendrite Source: Ensembl
    4. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
    5. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 28412840NeurofibrominPRO_0000056666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei866 – 8661PhosphoserineBy similarity
    Modified residuei878 – 8781PhosphoserineBy similarity
    Modified residuei2190 – 21901PhosphoserineBy similarity
    Modified residuei2517 – 25171PhosphoserineBy similarity
    Modified residuei2523 – 25231PhosphoserineBy similarity
    Modified residuei2545 – 25451PhosphoserineBy similarity
    Modified residuei2819 – 28191PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ04690.
    PaxDbiQ04690.
    PRIDEiQ04690.

    PTM databases

    PhosphoSiteiQ04690.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed predominantly in brain, spinal cord and testis. Isoform 2 is expressed predominantly in adrenal gland, kidney, ovary and lung. Isoform 3 is expressed predominantly in adrenal gland and isoform 4 is expressed mainly in the testis.

    Gene expression databases

    BgeeiQ04690.
    CleanExiMM_NF1.
    GenevestigatoriQ04690.

    Interactioni

    Protein-protein interaction databases

    BioGridi201736. 8 interactions.
    IntActiQ04690. 7 interactions.
    MINTiMINT-4103389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04690.
    SMRiQ04690. Positions 1208-1552, 1583-1839.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1237 – 1453217Ras-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1582 – 1740159CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1582 – 1839258Lipid bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2557 – 257317Bipartite nuclear localization signalBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1354 – 13574Poly-Ser

    Domaini

    Binds phospholipids via a region that includes the CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol By similarity.By similarity

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5261.
    GeneTreeiENSGT00550000074797.
    HOGENOMiHOG000047020.
    HOVERGENiHBG006486.
    InParanoidiQ04690.
    KOiK08052.
    OMAiIDFTHTC.
    OrthoDBiEOG74J96W.
    PhylomeDBiQ04690.
    TreeFamiTF300302.

    Family and domain databases

    Gene3Di1.25.10.10. 5 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR001251. CRAL-TRIO_dom.
    IPR028553. Neurofibromin.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view]
    PANTHERiPTHR10194:SF60. PTHR10194:SF60. 1 hit.
    PfamiPF13716. CRAL_TRIO_2. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view]
    SMARTiSM00323. RasGAP. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF48371. SSF48371. 4 hits.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q04690-1) [UniParc]FASTAAdd to Basket

    Also known as: Type II

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK     50
    FSLVISGLTT ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD 100
    TMRLDETMLV KQLLPEICHF LHTCREGNQH AAELRNSASG VLFSLSCNNF 150
    NAVFSRISTR LQELTVCSED NVDVHDIELL QYINVDCAKL KRLLKETAFK 200
    FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT DMAECAEKLF 250
    DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ESNINKKLFL 300
    DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV 350
    VDLKNLLFNP SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ 400
    NSPSTFHYVL VNSLHRIITN SALDWWPKID AVYCHSVELR NMFGETLHKA 450
    VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK PTDLETRSYK CLLLSMVKLI 500
    HADPKLLLCN PRKQGPETQS STAELITGLV QLVPQSHMPE VAQEAMEALL 550
    VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL 600
    REILICRNKF LLKNKQADRS SCHSLYLYGV GCEMSATGNT TQMSVDHDEF 650
    LRACTPGASL RKGRGNSSMD STAGCSGTPP ICRQAQTKLE VALYMFLWNP 700
    DTEAVLVAMS CFRHLCEEAD IRCGVDEVSV HNFLPNYNTF MEFASVSNMM 750
    STGRAALQKR VMALLRRIEH PTAGNIEAWE DTHAKWEQAT KLILNYPKAK 800
    MEDGQAAESL HKTIVKRRMS HVSGGGSIDL SDTDSLQEWI NMTGFLCALG 850
    GVCLQQRSSS GLATYSPPMG AVSERKGSMI SVMSSEGNID SPVSRFMDRL 900
    LSLMVCNHEK VGLQIRTNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ 950
    GQVLLSDSNT QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY 1000
    VRVLGNMVHA IQIKTKLCQL VEVMMARRDD LSFCQEMKFR NKMVEYLTDW 1050
    VMGTSNQAAD DDIKCLTRDL DQASMEAVVS LLAGLPLQPE EGDGVELMEA 1100
    KSQLFLKYFT LFMNLLNDCS EVEDENAQTG GRKRGMSRRL ASLRHCTVLA 1150
    MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ QGTEFDTLAE 1200
    TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD 1250
    SRHLLYQLLW NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ 1300
    KLLDPLLRVI ITSSDWQHVS FEVDPTRLEP SESLEENQRN LLQMTEKFFH 1350
    AIISSSSEFP SQLRSVCHCL YQATCHSLLN KATVKERKEN KKSVVSQRFP 1400
    QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPRIERG LKLMSKVLQS 1450
    IANHVLFTKE EHMRPFNDFV KSNFDLARRF FLDIASDCPT SDAVNHSLSF 1500
    ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK MATLLAYLGP 1550
    PEHKPVADTH WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLSIFYQAGT 1600
    SKAGNPIFYY VARRFKTGQI NGDLLIYHVL LTLKPYYAKP YEIVVDLTHT 1650
    GPSNRFKTDF LSKWFVVFPG FAYDNVSAVY IYNCNSWVRE YTKYHERLLT 1700
    GLKGSKRLIF IDCPGKLAEH IEHEQQKLPA ATLALEEDLK VFHNALKLAH 1750
    KDTKVSIKVG STAVQVTSAE RTKVLGQSVF LNDIYYASEI EEICLVDENQ 1800
    FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS IPQHTKIRPK 1850
    DVPGTLLNIA LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL 1900
    CIPANNTLFI VSISKTLAAN EPHLTLEFLE ECISGFSKSS IELKHLCLEY 1950
    MTPWLSNLVR FCKHNDDAKR QRVTAILDKL ITMTINEKQM YPSIQAKIWG 2000
    SLGQITDLLD VVLDSFIKTS ATGGLGSIKA EVMADTAVAL ASGNVKLVSS 2050
    KVIGRMCKII DKTCLSPTPT LEQHLMWDDI AILARYMLML SFNNSLDVAA 2100
    HLPYLFHVVT FLVATGPLSL RASTHGLLIN IIHSLCTCSQ LHFSEETKQV 2150
    LRLSLTEFSL PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA 2200
    LTSLETVTEA LLEIMEACMR DIPTCKWLDQ WTELAQRFAF QYNPSLQPRA 2250
    LVVFGCISKR VSHGQIKQII RILSKALESC LKGPDTYNSQ VLIESTVIAL 2300
    TKLQPLLNKD SPLHKALFWV AVAVLQLDEV NLYSAGTALL EQNLHTLDSL 2350
    RIFNDKSPEE VFMAIRNPLE WHCKQMDHFV GLNFNSNFNF ALVGHLLKGY 2400
    RHPSPAIVAR TVRILHTLLT LVNKHRNCDK FEVNTQSVAY LAALLTVSEE 2450
    VRSRCSLKHR KSLLLTDISM ENVPMDTYPI HHGDPSYRTL KETQPWSSPK 2500
    GSEGYLAATY PAVGQTSPRA RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI 2550
    SDTKAPKRQE MESGITTPPK MRRVAETDYE METQRIPSSQ QHPHLRKVSV 2600
    SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI LYEYLAEASV 2650
    VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY 2700
    QTSYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE 2750
    ETSEESLLTP TSPYPPALQS QLSITANLNL SNSMTSLATS QHSPGLDKEN 2800
    VELSPTAGHC NSGRTRHGSA SQVQKQRSAG SFKRNSIKKI V 2841
    Length:2,841
    Mass (Da):319,596
    Last modified:June 1, 1994 - v1
    Checksum:i06650BDCDC531002
    GO
    Isoform 1 (identifier: Q04690-2) [UniParc]FASTAAdd to Basket

    Also known as: Type I

    The sequence of this isoform differs from the canonical sequence as follows:
         1373-1393: Missing.

    Show »
    Length:2,820
    Mass (Da):317,228
    Checksum:i5CA21CD5946C597B
    GO
    Isoform 3 (identifier: Q04690-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
         1407-2841: Missing.

    Show »
    Length:1,419
    Mass (Da):159,714
    Checksum:iEBA01C4F82A4A46C
    GO
    Isoform 4 (identifier: Q04690-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1373-1393: Missing.
         1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
         1407-2841: Missing.

    Show »
    Length:1,398
    Mass (Da):157,347
    Checksum:iAF69F30DFD7C4F9A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1373 – 139321Missing in isoform 1 and isoform 4. CuratedVSP_001633Add
    BLAST
    Alternative sequencei1394 – 140613VVSQR…NSIGA → VPKSSCFSCLNNRWLASASL RTASVP in isoform 3 and isoform 4. CuratedVSP_001634Add
    BLAST
    Alternative sequencei1407 – 28411435Missing in isoform 3 and isoform 4. CuratedVSP_001635Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10369, L10367, L10368 Genomic DNA. Translation: AAA39806.1.
    L10370 mRNA. Translation: AAA68132.1.
    X54924 mRNA. Translation: CAA38690.1.
    D30730 mRNA. Translation: BAA06395.1.
    D30731 mRNA. Translation: BAA06396.1.
    CCDSiCCDS25119.1. [Q04690-1]
    PIRiI53855.
    I54352.
    I67934.
    I68623.
    RefSeqiNP_035027.1. NM_010897.2. [Q04690-1]
    XP_006532504.1. XM_006532441.1. [Q04690-2]
    UniGeneiMm.255596.
    Mm.488324.

    Genome annotation databases

    EnsembliENSMUST00000071325; ENSMUSP00000071289; ENSMUSG00000020716. [Q04690-1]
    ENSMUST00000108251; ENSMUSP00000103886; ENSMUSG00000020716. [Q04690-2]
    GeneIDi18015.
    KEGGimmu:18015.
    UCSCiuc007kkl.1. mouse. [Q04690-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10369 , L10367 , L10368 Genomic DNA. Translation: AAA39806.1 .
    L10370 mRNA. Translation: AAA68132.1 .
    X54924 mRNA. Translation: CAA38690.1 .
    D30730 mRNA. Translation: BAA06395.1 .
    D30731 mRNA. Translation: BAA06396.1 .
    CCDSi CCDS25119.1. [Q04690-1 ]
    PIRi I53855.
    I54352.
    I67934.
    I68623.
    RefSeqi NP_035027.1. NM_010897.2. [Q04690-1 ]
    XP_006532504.1. XM_006532441.1. [Q04690-2 ]
    UniGenei Mm.255596.
    Mm.488324.

    3D structure databases

    ProteinModelPortali Q04690.
    SMRi Q04690. Positions 1208-1552, 1583-1839.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201736. 8 interactions.
    IntActi Q04690. 7 interactions.
    MINTi MINT-4103389.

    Chemistry

    ChEMBLi CHEMBL2176807.

    PTM databases

    PhosphoSitei Q04690.

    Proteomic databases

    MaxQBi Q04690.
    PaxDbi Q04690.
    PRIDEi Q04690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071325 ; ENSMUSP00000071289 ; ENSMUSG00000020716 . [Q04690-1 ]
    ENSMUST00000108251 ; ENSMUSP00000103886 ; ENSMUSG00000020716 . [Q04690-2 ]
    GeneIDi 18015.
    KEGGi mmu:18015.
    UCSCi uc007kkl.1. mouse. [Q04690-1 ]

    Organism-specific databases

    CTDi 4763.
    MGIi MGI:97306. Nf1.

    Phylogenomic databases

    eggNOGi COG5261.
    GeneTreei ENSGT00550000074797.
    HOGENOMi HOG000047020.
    HOVERGENi HBG006486.
    InParanoidi Q04690.
    KOi K08052.
    OMAi IDFTHTC.
    OrthoDBi EOG74J96W.
    PhylomeDBi Q04690.
    TreeFami TF300302.

    Miscellaneous databases

    ChiTaRSi NF1. mouse.
    NextBioi 293049.
    PROi Q04690.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04690.
    CleanExi MM_NF1.
    Genevestigatori Q04690.

    Family and domain databases

    Gene3Di 1.25.10.10. 5 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR001251. CRAL-TRIO_dom.
    IPR028553. Neurofibromin.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view ]
    PANTHERi PTHR10194:SF60. PTHR10194:SF60. 1 hit.
    Pfami PF13716. CRAL_TRIO_2. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00323. RasGAP. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF48371. SSF48371. 4 hits.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments."
      Bernards A., Snijders A.J., Hannigan G.E., Murthy A.E., Gusella J.F.
      Hum. Mol. Genet. 2:645-650(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "A novel isoform of the neurofibromatosis type-1 mRNA and a switch of isoforms during murine cell differentiation and proliferation."
      Mantani A., Makasugi S., Yokota Y., Abe K., Ushio Y., Yamamura K.
      Gene 148:245-251(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1178-1555, ALTERNATIVE SPLICING.
    3. "Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway."
      Buchberg A.M., Cleveland L.S., Jenkins N.A., Copeland N.G.
      Nature 347:291-294(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1950-2568.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1973-1979, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiNF1_MOUSE
    AccessioniPrimary (citable) accession number: Q04690
    Secondary accession number(s): Q61956, Q61957
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3