Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q04690

- NF1_MOUSE

UniProt

Q04690 - NF1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Neurofibromin

Gene

Nf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

GO - Molecular functioni

  1. GTPase activator activity Source: MGI
  2. phosphatidylcholine binding Source: UniProtKB
  3. phosphatidylethanolamine binding Source: UniProtKB
  4. Ras GTPase activator activity Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. adrenal gland development Source: MGI
  3. artery morphogenesis Source: MGI
  4. brain development Source: MGI
  5. camera-type eye morphogenesis Source: MGI
  6. cell communication Source: MGI
  7. cerebral cortex development Source: MGI
  8. collagen fibril organization Source: MGI
  9. extracellular matrix organization Source: MGI
  10. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  11. forebrain astrocyte development Source: MGI
  12. forebrain morphogenesis Source: MGI
  13. heart development Source: MGI
  14. liver development Source: MGI
  15. MAPK cascade Source: MGI
  16. metanephros development Source: MGI
  17. myelination in peripheral nervous system Source: MGI
  18. negative regulation of angiogenesis Source: MGI
  19. negative regulation of astrocyte differentiation Source: MGI
  20. negative regulation of cell-matrix adhesion Source: MGI
  21. negative regulation of cell migration Source: MGI
  22. negative regulation of cell proliferation Source: MGI
  23. negative regulation of endothelial cell proliferation Source: MGI
  24. negative regulation of fibroblast proliferation Source: BHF-UCL
  25. negative regulation of MAPK cascade Source: MGI
  26. negative regulation of MAP kinase activity Source: MGI
  27. negative regulation of neuroblast proliferation Source: MGI
  28. negative regulation of neurotransmitter secretion Source: MGI
  29. negative regulation of oligodendrocyte differentiation Source: MGI
  30. negative regulation of osteoclast differentiation Source: MGI
  31. negative regulation of protein kinase activity Source: MGI
  32. negative regulation of Rac protein signal transduction Source: MGI
  33. negative regulation of Ras protein signal transduction Source: MGI
  34. negative regulation of transcription factor import into nucleus Source: MGI
  35. neural tube development Source: MGI
  36. osteoblast differentiation Source: MGI
  37. peripheral nervous system development Source: MGI
  38. phosphatidylinositol 3-kinase signaling Source: MGI
  39. pigmentation Source: MGI
  40. positive regulation of adenylate cyclase activity Source: MGI
  41. positive regulation of apoptotic process Source: MGI
  42. positive regulation of endothelial cell proliferation Source: MGI
  43. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  44. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  45. positive regulation of neuron apoptotic process Source: MGI
  46. positive regulation of Ras GTPase activity Source: MGI
  47. Ras protein signal transduction Source: MGI
  48. regulation of angiogenesis Source: MGI
  49. regulation of blood vessel endothelial cell migration Source: Ensembl
  50. regulation of bone resorption Source: MGI
  51. regulation of cell-matrix adhesion Source: MGI
  52. regulation of cell proliferation Source: MGI
  53. regulation of glial cell differentiation Source: MGI
  54. regulation of long-term neuronal synaptic plasticity Source: MGI
  55. regulation of synaptic transmission, GABAergic Source: MGI
  56. response to hypoxia Source: MGI
  57. Schwann cell development Source: MGI
  58. skeletal muscle tissue development Source: MGI
  59. smooth muscle tissue development Source: MGI
  60. spinal cord development Source: MGI
  61. sympathetic nervous system development Source: MGI
  62. visual learning Source: MGI
  63. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofibromin
Alternative name(s):
Neurofibromatosis-related protein NF-1
Gene namesi
Name:Nf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97306. Nf1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: MGI
  3. dendrite Source: Ensembl
  4. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
  5. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 28412840NeurofibrominPRO_0000056666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei866 – 8661PhosphoserineBy similarity
Modified residuei878 – 8781PhosphoserineBy similarity
Modified residuei2190 – 21901PhosphoserineBy similarity
Modified residuei2517 – 25171PhosphoserineBy similarity
Modified residuei2523 – 25231PhosphoserineBy similarity
Modified residuei2545 – 25451PhosphoserineBy similarity
Modified residuei2819 – 28191PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04690.
PaxDbiQ04690.
PRIDEiQ04690.

PTM databases

PhosphoSiteiQ04690.

Expressioni

Tissue specificityi

Isoform 1 is expressed predominantly in brain, spinal cord and testis. Isoform 2 is expressed predominantly in adrenal gland, kidney, ovary and lung. Isoform 3 is expressed predominantly in adrenal gland and isoform 4 is expressed mainly in the testis.

Gene expression databases

BgeeiQ04690.
CleanExiMM_NF1.
ExpressionAtlasiQ04690. baseline and differential.
GenevestigatoriQ04690.

Interactioni

Protein-protein interaction databases

BioGridi201736. 8 interactions.
IntActiQ04690. 7 interactions.
MINTiMINT-4103389.

Structurei

3D structure databases

ProteinModelPortaliQ04690.
SMRiQ04690. Positions 1208-1552, 1583-1839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1237 – 1453217Ras-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini1582 – 1740159CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1582 – 1839258Lipid bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2557 – 257317Bipartite nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1354 – 13574Poly-Ser

Domaini

Binds phospholipids via a region that includes the CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol (By similarity).By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5261.
GeneTreeiENSGT00550000074797.
HOGENOMiHOG000047020.
HOVERGENiHBG006486.
InParanoidiQ04690.
KOiK08052.
OMAiIDFTHTC.
OrthoDBiEOG74J96W.
PhylomeDBiQ04690.
TreeFamiTF300302.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001251. CRAL-TRIO_dom.
IPR028553. Neurofibromin.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PANTHERiPTHR10194:SF60. PTHR10194:SF60. 1 hit.
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00323. RasGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q04690-1) [UniParc]FASTAAdd to Basket

Also known as: Type II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK
60 70 80 90 100
FSLVISGLTT ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD
110 120 130 140 150
TMRLDETMLV KQLLPEICHF LHTCREGNQH AAELRNSASG VLFSLSCNNF
160 170 180 190 200
NAVFSRISTR LQELTVCSED NVDVHDIELL QYINVDCAKL KRLLKETAFK
210 220 230 240 250
FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT DMAECAEKLF
260 270 280 290 300
DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ESNINKKLFL
310 320 330 340 350
DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV
360 370 380 390 400
VDLKNLLFNP SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ
410 420 430 440 450
NSPSTFHYVL VNSLHRIITN SALDWWPKID AVYCHSVELR NMFGETLHKA
460 470 480 490 500
VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK PTDLETRSYK CLLLSMVKLI
510 520 530 540 550
HADPKLLLCN PRKQGPETQS STAELITGLV QLVPQSHMPE VAQEAMEALL
560 570 580 590 600
VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL
610 620 630 640 650
REILICRNKF LLKNKQADRS SCHSLYLYGV GCEMSATGNT TQMSVDHDEF
660 670 680 690 700
LRACTPGASL RKGRGNSSMD STAGCSGTPP ICRQAQTKLE VALYMFLWNP
710 720 730 740 750
DTEAVLVAMS CFRHLCEEAD IRCGVDEVSV HNFLPNYNTF MEFASVSNMM
760 770 780 790 800
STGRAALQKR VMALLRRIEH PTAGNIEAWE DTHAKWEQAT KLILNYPKAK
810 820 830 840 850
MEDGQAAESL HKTIVKRRMS HVSGGGSIDL SDTDSLQEWI NMTGFLCALG
860 870 880 890 900
GVCLQQRSSS GLATYSPPMG AVSERKGSMI SVMSSEGNID SPVSRFMDRL
910 920 930 940 950
LSLMVCNHEK VGLQIRTNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ
960 970 980 990 1000
GQVLLSDSNT QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY
1010 1020 1030 1040 1050
VRVLGNMVHA IQIKTKLCQL VEVMMARRDD LSFCQEMKFR NKMVEYLTDW
1060 1070 1080 1090 1100
VMGTSNQAAD DDIKCLTRDL DQASMEAVVS LLAGLPLQPE EGDGVELMEA
1110 1120 1130 1140 1150
KSQLFLKYFT LFMNLLNDCS EVEDENAQTG GRKRGMSRRL ASLRHCTVLA
1160 1170 1180 1190 1200
MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ QGTEFDTLAE
1210 1220 1230 1240 1250
TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD
1260 1270 1280 1290 1300
SRHLLYQLLW NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ
1310 1320 1330 1340 1350
KLLDPLLRVI ITSSDWQHVS FEVDPTRLEP SESLEENQRN LLQMTEKFFH
1360 1370 1380 1390 1400
AIISSSSEFP SQLRSVCHCL YQATCHSLLN KATVKERKEN KKSVVSQRFP
1410 1420 1430 1440 1450
QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPRIERG LKLMSKVLQS
1460 1470 1480 1490 1500
IANHVLFTKE EHMRPFNDFV KSNFDLARRF FLDIASDCPT SDAVNHSLSF
1510 1520 1530 1540 1550
ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK MATLLAYLGP
1560 1570 1580 1590 1600
PEHKPVADTH WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLSIFYQAGT
1610 1620 1630 1640 1650
SKAGNPIFYY VARRFKTGQI NGDLLIYHVL LTLKPYYAKP YEIVVDLTHT
1660 1670 1680 1690 1700
GPSNRFKTDF LSKWFVVFPG FAYDNVSAVY IYNCNSWVRE YTKYHERLLT
1710 1720 1730 1740 1750
GLKGSKRLIF IDCPGKLAEH IEHEQQKLPA ATLALEEDLK VFHNALKLAH
1760 1770 1780 1790 1800
KDTKVSIKVG STAVQVTSAE RTKVLGQSVF LNDIYYASEI EEICLVDENQ
1810 1820 1830 1840 1850
FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS IPQHTKIRPK
1860 1870 1880 1890 1900
DVPGTLLNIA LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL
1910 1920 1930 1940 1950
CIPANNTLFI VSISKTLAAN EPHLTLEFLE ECISGFSKSS IELKHLCLEY
1960 1970 1980 1990 2000
MTPWLSNLVR FCKHNDDAKR QRVTAILDKL ITMTINEKQM YPSIQAKIWG
2010 2020 2030 2040 2050
SLGQITDLLD VVLDSFIKTS ATGGLGSIKA EVMADTAVAL ASGNVKLVSS
2060 2070 2080 2090 2100
KVIGRMCKII DKTCLSPTPT LEQHLMWDDI AILARYMLML SFNNSLDVAA
2110 2120 2130 2140 2150
HLPYLFHVVT FLVATGPLSL RASTHGLLIN IIHSLCTCSQ LHFSEETKQV
2160 2170 2180 2190 2200
LRLSLTEFSL PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA
2210 2220 2230 2240 2250
LTSLETVTEA LLEIMEACMR DIPTCKWLDQ WTELAQRFAF QYNPSLQPRA
2260 2270 2280 2290 2300
LVVFGCISKR VSHGQIKQII RILSKALESC LKGPDTYNSQ VLIESTVIAL
2310 2320 2330 2340 2350
TKLQPLLNKD SPLHKALFWV AVAVLQLDEV NLYSAGTALL EQNLHTLDSL
2360 2370 2380 2390 2400
RIFNDKSPEE VFMAIRNPLE WHCKQMDHFV GLNFNSNFNF ALVGHLLKGY
2410 2420 2430 2440 2450
RHPSPAIVAR TVRILHTLLT LVNKHRNCDK FEVNTQSVAY LAALLTVSEE
2460 2470 2480 2490 2500
VRSRCSLKHR KSLLLTDISM ENVPMDTYPI HHGDPSYRTL KETQPWSSPK
2510 2520 2530 2540 2550
GSEGYLAATY PAVGQTSPRA RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI
2560 2570 2580 2590 2600
SDTKAPKRQE MESGITTPPK MRRVAETDYE METQRIPSSQ QHPHLRKVSV
2610 2620 2630 2640 2650
SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI LYEYLAEASV
2660 2670 2680 2690 2700
VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY
2710 2720 2730 2740 2750
QTSYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE
2760 2770 2780 2790 2800
ETSEESLLTP TSPYPPALQS QLSITANLNL SNSMTSLATS QHSPGLDKEN
2810 2820 2830 2840
VELSPTAGHC NSGRTRHGSA SQVQKQRSAG SFKRNSIKKI V
Length:2,841
Mass (Da):319,596
Last modified:June 1, 1994 - v1
Checksum:i06650BDCDC531002
GO
Isoform 1 (identifier: Q04690-2) [UniParc]FASTAAdd to Basket

Also known as: Type I

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.

Show »
Length:2,820
Mass (Da):317,228
Checksum:i5CA21CD5946C597B
GO
Isoform 3 (identifier: Q04690-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.

Show »
Length:1,419
Mass (Da):159,714
Checksum:iEBA01C4F82A4A46C
GO
Isoform 4 (identifier: Q04690-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1393: Missing.
     1394-1406: VVSQRFPQNSIGA → VPKSSCFSCLNNRWLASASLRTASVP
     1407-2841: Missing.

Show »
Length:1,398
Mass (Da):157,347
Checksum:iAF69F30DFD7C4F9A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1373 – 139321Missing in isoform 1 and isoform 4. CuratedVSP_001633Add
BLAST
Alternative sequencei1394 – 140613VVSQR…NSIGA → VPKSSCFSCLNNRWLASASL RTASVP in isoform 3 and isoform 4. CuratedVSP_001634Add
BLAST
Alternative sequencei1407 – 28411435Missing in isoform 3 and isoform 4. CuratedVSP_001635Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10369, L10367, L10368 Genomic DNA. Translation: AAA39806.1.
L10370 mRNA. Translation: AAA68132.1.
X54924 mRNA. Translation: CAA38690.1.
D30730 mRNA. Translation: BAA06395.1.
D30731 mRNA. Translation: BAA06396.1.
CCDSiCCDS25119.1. [Q04690-1]
PIRiI53855.
I54352.
I67934.
I68623.
RefSeqiNP_035027.1. NM_010897.2. [Q04690-1]
XP_006532504.1. XM_006532441.1. [Q04690-2]
UniGeneiMm.255596.
Mm.488324.

Genome annotation databases

EnsembliENSMUST00000071325; ENSMUSP00000071289; ENSMUSG00000020716. [Q04690-1]
ENSMUST00000108251; ENSMUSP00000103886; ENSMUSG00000020716. [Q04690-2]
GeneIDi18015.
KEGGimmu:18015.
UCSCiuc007kkl.1. mouse. [Q04690-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10369 , L10367 , L10368 Genomic DNA. Translation: AAA39806.1 .
L10370 mRNA. Translation: AAA68132.1 .
X54924 mRNA. Translation: CAA38690.1 .
D30730 mRNA. Translation: BAA06395.1 .
D30731 mRNA. Translation: BAA06396.1 .
CCDSi CCDS25119.1. [Q04690-1 ]
PIRi I53855.
I54352.
I67934.
I68623.
RefSeqi NP_035027.1. NM_010897.2. [Q04690-1 ]
XP_006532504.1. XM_006532441.1. [Q04690-2 ]
UniGenei Mm.255596.
Mm.488324.

3D structure databases

ProteinModelPortali Q04690.
SMRi Q04690. Positions 1208-1552, 1583-1839.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201736. 8 interactions.
IntActi Q04690. 7 interactions.
MINTi MINT-4103389.

Chemistry

ChEMBLi CHEMBL2176807.

PTM databases

PhosphoSitei Q04690.

Proteomic databases

MaxQBi Q04690.
PaxDbi Q04690.
PRIDEi Q04690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071325 ; ENSMUSP00000071289 ; ENSMUSG00000020716 . [Q04690-1 ]
ENSMUST00000108251 ; ENSMUSP00000103886 ; ENSMUSG00000020716 . [Q04690-2 ]
GeneIDi 18015.
KEGGi mmu:18015.
UCSCi uc007kkl.1. mouse. [Q04690-1 ]

Organism-specific databases

CTDi 4763.
MGIi MGI:97306. Nf1.

Phylogenomic databases

eggNOGi COG5261.
GeneTreei ENSGT00550000074797.
HOGENOMi HOG000047020.
HOVERGENi HBG006486.
InParanoidi Q04690.
KOi K08052.
OMAi IDFTHTC.
OrthoDBi EOG74J96W.
PhylomeDBi Q04690.
TreeFami TF300302.

Miscellaneous databases

ChiTaRSi NF1. mouse.
NextBioi 293049.
PROi Q04690.
SOURCEi Search...

Gene expression databases

Bgeei Q04690.
CleanExi MM_NF1.
ExpressionAtlasi Q04690. baseline and differential.
Genevestigatori Q04690.

Family and domain databases

Gene3Di 1.25.10.10. 5 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001251. CRAL-TRIO_dom.
IPR028553. Neurofibromin.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
PANTHERi PTHR10194:SF60. PTHR10194:SF60. 1 hit.
Pfami PF13716. CRAL_TRIO_2. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00323. RasGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments."
    Bernards A., Snijders A.J., Hannigan G.E., Murthy A.E., Gusella J.F.
    Hum. Mol. Genet. 2:645-650(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "A novel isoform of the neurofibromatosis type-1 mRNA and a switch of isoforms during murine cell differentiation and proliferation."
    Mantani A., Makasugi S., Yokota Y., Abe K., Ushio Y., Yamamura K.
    Gene 148:245-251(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1178-1555, ALTERNATIVE SPLICING.
  3. "Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway."
    Buchberg A.M., Cleveland L.S., Jenkins N.A., Copeland N.G.
    Nature 347:291-294(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1950-2568.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1973-1979, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiNF1_MOUSE
AccessioniPrimary (citable) accession number: Q04690
Secondary accession number(s): Q61956, Q61957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3