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Q04683 (CXCR5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 5

Short name=CXC-R5
Short name=CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
CD_antigen=CD185
Gene names
Name:Cxcr5
Synonyms:Blr1, Gpcr6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Mainly in spleen, in resting B-cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374C-X-C chemokine receptor type 5
PRO_0000069361

Regions

Topological domain1 – 5757Extracellular Potential
Transmembrane58 – 7821Helical; Name=1; Potential
Topological domain79 – 9012Cytoplasmic Potential
Transmembrane91 – 11121Helical; Name=2; Potential
Topological domain112 – 12615Extracellular Potential
Transmembrane127 – 14721Helical; Name=3; Potential
Topological domain148 – 16922Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 22131Extracellular Potential
Transmembrane222 – 24221Helical; Name=5; Potential
Topological domain243 – 26119Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=6; Potential
Topological domain283 – 30624Extracellular Potential
Transmembrane307 – 32721Helical; Name=7; Potential
Topological domain328 – 37447Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 204 Potential

Experimental info

Sequence conflict1421L → V in CAA50673. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04683 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: E41E3C844C9CD610

FASTA37442,115
        10         20         30         40         50         60 
MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS FKAVFMPVAY 

        70         80         90        100        110        120 
SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG 

       130        140        150        160        170        180 
TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF 

       190        200        210        220        230        240 
LFALPELLFA KVGQPHNNDS LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY 

       250        260        270        280        290        300 
VGVVHRLLQA QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG 

       310        320        330        340        350        360 
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPNWRKS 

       370 
SLSESENATS LTTF 

« Hide

References

« Hide 'large scale' references
[1]"The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues."
Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.
Eur. J. Immunol. 23:2532-2539(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[5]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-269.
Tissue: Testis.
[6]"A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen."
Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.
Cell 87:1037-1047(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
PIRS42628.
RefSeqNP_031577.2. NM_007551.2.
UniGeneMm.491799.
Mm.6246.

3D structure databases

ProteinModelPortalQ04683.
SMRQ04683. Positions 28-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5919N.
IntActQ04683. 1 interaction.
MINTMINT-1672594.

Chemistry

GuidetoPHARMACOLOGY72.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ04683.

Proteomic databases

PRIDEQ04683.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneID12145.
KEGGmmu:12145.
UCSCuc009pdx.1. mouse.

Organism-specific databases

CTD643.
MGIMGI:103567. Cxcr5.

Phylogenomic databases

eggNOGNOG146951.
GeneTreeENSGT00730000110292.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ6P3C2.
KOK04190.
OMAGLAHCCL.
OrthoDBEOG7R8322.
TreeFamTF330966.

Gene expression databases

BgeeQ04683.
CleanExMM_CXCR5.
GenevestigatorQ04683.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280479.
PROQ04683.
SOURCESearch...

Entry information

Entry nameCXCR5_MOUSE
AccessionPrimary (citable) accession number: Q04683
Secondary accession number(s): Q6P3C2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries