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Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • immune response Source: InterPro
  • leukocyte chemotaxis Source: MGI
  • lymph node development Source: MGI
  • positive regulation of cytokinesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1, Gpcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:103567. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 90CytoplasmicSequence analysisAdd BLAST12
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 126ExtracellularSequence analysisAdd BLAST15
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 169CytoplasmicSequence analysisAdd BLAST22
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 221ExtracellularSequence analysisAdd BLAST31
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini243 – 261CytoplasmicSequence analysisAdd BLAST19
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 306ExtracellularSequence analysisAdd BLAST24
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 374CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693611 – 374C-X-C chemokine receptor type 5Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ04683.
PRIDEiQ04683.

PTM databases

iPTMnetiQ04683.
PhosphoSitePlusiQ04683.

Expressioni

Tissue specificityi

Mainly in spleen, in resting B-cells.

Gene expression databases

BgeeiENSMUSG00000047880.
CleanExiMM_CXCR5.
GenevisibleiQ04683. MM.

Interactioni

Protein-protein interaction databases

IntActiQ04683. 1 interactor.
MINTiMINT-1672594.
STRINGi10090.ENSMUSP00000050444.

Structurei

3D structure databases

ProteinModelPortaliQ04683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ04683.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG091G0EDT.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS
60 70 80 90 100
FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL
110 120 130 140 150
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY
160 170 180 190 200
LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS
210 220 230 240 250
LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA
260 270 280 290 300
QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG
310 320 330 340 350
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL
360 370
CQLFPNWRKS SLSESENATS LTTF
Length:374
Mass (Da):42,115
Last modified:July 27, 2011 - v2
Checksum:iE41E3C844C9CD610
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142L → V in CAA50673 (PubMed:8405054).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
CCDSiCCDS23115.1.
PIRiS42628.
RefSeqiNP_031577.2. NM_007551.2.
UniGeneiMm.491799.
Mm.6246.

Genome annotation databases

EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneIDi12145.
KEGGimmu:12145.
UCSCiuc009pdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
CCDSiCCDS23115.1.
PIRiS42628.
RefSeqiNP_031577.2. NM_007551.2.
UniGeneiMm.491799.
Mm.6246.

3D structure databases

ProteinModelPortaliQ04683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ04683. 1 interactor.
MINTiMINT-1672594.
STRINGi10090.ENSMUSP00000050444.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ04683.
PhosphoSitePlusiQ04683.

Proteomic databases

PaxDbiQ04683.
PRIDEiQ04683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneIDi12145.
KEGGimmu:12145.
UCSCiuc009pdx.1. mouse.

Organism-specific databases

CTDi643.
MGIiMGI:103567. Cxcr5.

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ04683.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG091G0EDT.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ04683.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047880.
CleanExiMM_CXCR5.
GenevisibleiQ04683. MM.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR5_MOUSE
AccessioniPrimary (citable) accession number: Q04683
Secondary accession number(s): Q6P3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.