Reviewed, UniProtKB/Swiss-Prot Q04683 (CXCR5_MOUSE)

Names and origin

Protein names

Recommended name:
    C-X-C chemokine receptor type 5
      Short name=CXC-R5
      Short name=CXCR-5
Alternative name(s):
    Burkitt lymphoma receptor 1 homolog
    CD_antigen=CD185

Gene names

Name:	Cxcr5
Synonyms:	Blr1, Gpcr6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Mainly in spleen, in resting B-cells.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	B-cell activation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW lymph node development Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	C-X-C chemokine receptor type 5		PRO_0000069361
Regions
	Topological domain	1 – 57	57	Extracellular Potential
	Transmembrane	58 – 78	21	1 Potential
	Topological domain	79 – 90	12	Cytoplasmic Potential
	Transmembrane	91 – 111	21	2 Potential
	Topological domain	112 – 126	15	Extracellular Potential
	Transmembrane	127 – 147	21	3 Potential
	Topological domain	148 – 169	22	Cytoplasmic Potential
	Transmembrane	170 – 190	21	4 Potential
	Topological domain	191 – 221	31	Extracellular Potential
	Transmembrane	222 – 242	21	5 Potential
	Topological domain	243 – 261	19	Cytoplasmic Potential
	Transmembrane	262 – 282	21	6 Potential
	Topological domain	283 – 306	24	Extracellular Potential
	Transmembrane	307 – 327	21	7 Potential
	Topological domain	328 – 374	47	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 204		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q04683-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 385258420C1EDE30	FASTA	374	42,101
	10 20 30 40 50 60 MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS FKAVFMPVAY 70 80 90 100 110 120 SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG 130 140 150 160 170 180 TFLCKTVIAL HKINFYCSSL LVACIAVDRY LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF 190 200 210 220 230 240 LFALPELLFA KVGQPHNNDS LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY 250 260 270 280 290 300 VGVVHRLLQA QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG 310 320 330 340 350 360 YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPNWRKS 370 SLSESENATS LTTF

References

[1]	"The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues." Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M. Eur. J. Immunol. 23:2532-2539(1993) [PubMed: 8405054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
[2]	"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A. Genomics 18:175-184(1993) [PubMed: 8288218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-269. Tissue: Testis.
[3]	"A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen." Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M. Cell 87:1037-1047(1996) [PubMed: 8978608] [Abstract] Cited for: CHARACTERIZATION.
[4]	"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1." Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. Nature 391:799-803(1998) [PubMed: 9486651] [Abstract] Cited for: LIGAND-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X71788 mRNA. Translation: CAA50673.1. L20332 mRNA. Translation: AAA16852.1.
IPI	IPI00108764.
PIR	S42628.
UniGene	Mm.476110 Mm.6246
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5919N.
IntAct	Q04683. 1 interaction.
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000047880. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103567. Cxcr5.
Phylogenomic databases
HOGENOM	Q04683.
HOVERGEN	Q04683.
Gene expression databases
Bgee	Q04683.
CleanEx	MM_CXCR5.
GermOnline	ENSMUSG00000047880. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001053. CXC_5_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF213. CXC_5_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00564. CXCCHMKINER5. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CXCR5_MOUSE

Accession

Primary (citable) accession number: Q04683

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)