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Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • chemotaxis Source: InterPro
  • immune response Source: InterPro
  • lymph node development Source: MGI
  • positive regulation of cytokinesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1, Gpcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:103567. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini79 – 9012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini112 – 12615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini191 – 22131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 26119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 37447CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-X-C chemokine receptor type 5PRO_0000069361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04683.

PTM databases

PhosphoSiteiQ04683.

Expressioni

Tissue specificityi

Mainly in spleen, in resting B-cells.

Gene expression databases

BgeeiQ04683.
CleanExiMM_CXCR5.
GenevisibleiQ04683. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-5919N.
IntActiQ04683. 1 interaction.
MINTiMINT-1672594.
STRINGi10090.ENSMUSP00000050444.

Structurei

3D structure databases

ProteinModelPortaliQ04683.
SMRiQ04683. Positions 58-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146951.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ04683.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG7R8322.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS
60 70 80 90 100
FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL
110 120 130 140 150
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY
160 170 180 190 200
LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS
210 220 230 240 250
LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA
260 270 280 290 300
QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG
310 320 330 340 350
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL
360 370
CQLFPNWRKS SLSESENATS LTTF
Length:374
Mass (Da):42,115
Last modified:July 27, 2011 - v2
Checksum:iE41E3C844C9CD610
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421L → V in CAA50673 (PubMed:8405054).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
CCDSiCCDS23115.1.
PIRiS42628.
RefSeqiNP_031577.2. NM_007551.2.
XP_011240689.1. XM_011242387.1.
UniGeneiMm.491799.
Mm.6246.

Genome annotation databases

EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneIDi12145.
KEGGimmu:12145.
UCSCiuc009pdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
CCDSiCCDS23115.1.
PIRiS42628.
RefSeqiNP_031577.2. NM_007551.2.
XP_011240689.1. XM_011242387.1.
UniGeneiMm.491799.
Mm.6246.

3D structure databases

ProteinModelPortaliQ04683.
SMRiQ04683. Positions 58-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5919N.
IntActiQ04683. 1 interaction.
MINTiMINT-1672594.
STRINGi10090.ENSMUSP00000050444.

Chemistry

GuidetoPHARMACOLOGYi72.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ04683.

Proteomic databases

PRIDEiQ04683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneIDi12145.
KEGGimmu:12145.
UCSCiuc009pdx.1. mouse.

Organism-specific databases

CTDi643.
MGIiMGI:103567. Cxcr5.

Phylogenomic databases

eggNOGiNOG146951.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ04683.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG7R8322.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi280479.
PROiQ04683.
SOURCEiSearch...

Gene expression databases

BgeeiQ04683.
CleanExiMM_CXCR5.
GenevisibleiQ04683. MM.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues."
    Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.
    Eur. J. Immunol. 23:2532-2539(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  5. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-269.
    Tissue: Testis.
  6. "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen."
    Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.
    Cell 87:1037-1047(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
    Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
    Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.

Entry informationi

Entry nameiCXCR5_MOUSE
AccessioniPrimary (citable) accession number: Q04683
Secondary accession number(s): Q6P3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.