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Q04683

- CXCR5_MOUSE

UniProt

Q04683 - CXCR5_MOUSE

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Protein
C-X-C chemokine receptor type 5
Gene
Cxcr5, Blr1, Gpcr6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. chemotaxis Source: InterPro
  3. immune response Source: InterPro
  4. lymph node development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1, Gpcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:103567. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757Extracellular Reviewed prediction
Add
BLAST
Transmembranei58 – 7821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini79 – 9012Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini112 – 12615Extracellular Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini148 – 16922Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini191 – 22131Extracellular Reviewed prediction
Add
BLAST
Transmembranei222 – 24221Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini243 – 26119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini283 – 30624Extracellular Reviewed prediction
Add
BLAST
Transmembranei307 – 32721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini328 – 37447Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-X-C chemokine receptor type 5
PRO_0000069361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 204 Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04683.

PTM databases

PhosphoSiteiQ04683.

Expressioni

Tissue specificityi

Mainly in spleen, in resting B-cells.

Gene expression databases

BgeeiQ04683.
CleanExiMM_CXCR5.
GenevestigatoriQ04683.

Interactioni

Protein-protein interaction databases

DIPiDIP-5919N.
IntActiQ04683. 1 interaction.
MINTiMINT-1672594.

Structurei

3D structure databases

ProteinModelPortaliQ04683.
SMRiQ04683. Positions 58-343.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146951.
GeneTreeiENSGT00730000110292.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ6P3C2.
KOiK04190.
OMAiGLAHCCL.
OrthoDBiEOG7R8322.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04683-1 [UniParc]FASTAAdd to Basket

« Hide

MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS    50
FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL 100
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY 150
LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS 200
LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA 250
QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG 300
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL 350
CQLFPNWRKS SLSESENATS LTTF 374
Length:374
Mass (Da):42,115
Last modified:July 27, 2011 - v2
Checksum:iE41E3C844C9CD610
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421L → V in CAA50673. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71788 mRNA. Translation: CAA50673.1.
AK155954 mRNA. Translation: BAE33519.1.
AK156087 mRNA. Translation: BAE33583.1.
AK157016 mRNA. Translation: BAE33932.1.
CH466522 Genomic DNA. Translation: EDL25602.1.
BC064059 mRNA. Translation: AAH64059.1.
L20332 mRNA. Translation: AAA16852.1.
CCDSiCCDS23115.1.
PIRiS42628.
RefSeqiNP_031577.2. NM_007551.2.
UniGeneiMm.491799.
Mm.6246.

Genome annotation databases

EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
GeneIDi12145.
KEGGimmu:12145.
UCSCiuc009pdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71788 mRNA. Translation: CAA50673.1 .
AK155954 mRNA. Translation: BAE33519.1 .
AK156087 mRNA. Translation: BAE33583.1 .
AK157016 mRNA. Translation: BAE33932.1 .
CH466522 Genomic DNA. Translation: EDL25602.1 .
BC064059 mRNA. Translation: AAH64059.1 .
L20332 mRNA. Translation: AAA16852.1 .
CCDSi CCDS23115.1.
PIRi S42628.
RefSeqi NP_031577.2. NM_007551.2.
UniGenei Mm.491799.
Mm.6246.

3D structure databases

ProteinModelPortali Q04683.
SMRi Q04683. Positions 58-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5919N.
IntActi Q04683. 1 interaction.
MINTi MINT-1672594.

Chemistry

GuidetoPHARMACOLOGYi 72.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q04683.

Proteomic databases

PRIDEi Q04683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062215 ; ENSMUSP00000050444 ; ENSMUSG00000047880 .
ENSMUST00000179828 ; ENSMUSP00000137518 ; ENSMUSG00000047880 .
GeneIDi 12145.
KEGGi mmu:12145.
UCSCi uc009pdx.1. mouse.

Organism-specific databases

CTDi 643.
MGIi MGI:103567. Cxcr5.

Phylogenomic databases

eggNOGi NOG146951.
GeneTreei ENSGT00730000110292.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi Q6P3C2.
KOi K04190.
OMAi GLAHCCL.
OrthoDBi EOG7R8322.
TreeFami TF330966.

Miscellaneous databases

NextBioi 280479.
PROi Q04683.
SOURCEi Search...

Gene expression databases

Bgeei Q04683.
CleanExi MM_CXCR5.
Genevestigatori Q04683.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues."
    Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.
    Eur. J. Immunol. 23:2532-2539(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  5. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-269.
    Tissue: Testis.
  6. "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen."
    Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.
    Cell 87:1037-1047(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
    Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
    Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.

Entry informationi

Entry nameiCXCR5_MOUSE
AccessioniPrimary (citable) accession number: Q04683
Secondary accession number(s): Q6P3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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