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Q04683

- CXCR5_MOUSE

UniProt

Q04683 - CXCR5_MOUSE

Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW
    2. chemotaxis Source: InterPro
    3. immune response Source: InterPro
    4. lymph node development Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    B-cell activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 5
    Short name:
    CXC-R5
    Short name:
    CXCR-5
    Alternative name(s):
    Burkitt lymphoma receptor 1 homolog
    CD_antigen: CD185
    Gene namesi
    Name:Cxcr5
    Synonyms:Blr1, Gpcr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:103567. Cxcr5.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374C-X-C chemokine receptor type 5PRO_0000069361Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ04683.

    PTM databases

    PhosphoSiteiQ04683.

    Expressioni

    Tissue specificityi

    Mainly in spleen, in resting B-cells.

    Gene expression databases

    BgeeiQ04683.
    CleanExiMM_CXCR5.
    GenevestigatoriQ04683.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5919N.
    IntActiQ04683. 1 interaction.
    MINTiMINT-1672594.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04683.
    SMRiQ04683. Positions 58-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 12615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 26119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 37447CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146951.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ6P3C2.
    KOiK04190.
    OMAiGLAHCCL.
    OrthoDBiEOG7R8322.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04683-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS    50
    FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL 100
    LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY 150
    LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS 200
    LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA 250
    QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG 300
    YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL 350
    CQLFPNWRKS SLSESENATS LTTF 374
    Length:374
    Mass (Da):42,115
    Last modified:July 27, 2011 - v2
    Checksum:iE41E3C844C9CD610
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421L → V in CAA50673. (PubMed:8405054)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71788 mRNA. Translation: CAA50673.1.
    AK155954 mRNA. Translation: BAE33519.1.
    AK156087 mRNA. Translation: BAE33583.1.
    AK157016 mRNA. Translation: BAE33932.1.
    CH466522 Genomic DNA. Translation: EDL25602.1.
    BC064059 mRNA. Translation: AAH64059.1.
    L20332 mRNA. Translation: AAA16852.1.
    CCDSiCCDS23115.1.
    PIRiS42628.
    RefSeqiNP_031577.2. NM_007551.2.
    UniGeneiMm.491799.
    Mm.6246.

    Genome annotation databases

    EnsembliENSMUST00000062215; ENSMUSP00000050444; ENSMUSG00000047880.
    ENSMUST00000179828; ENSMUSP00000137518; ENSMUSG00000047880.
    GeneIDi12145.
    KEGGimmu:12145.
    UCSCiuc009pdx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71788 mRNA. Translation: CAA50673.1 .
    AK155954 mRNA. Translation: BAE33519.1 .
    AK156087 mRNA. Translation: BAE33583.1 .
    AK157016 mRNA. Translation: BAE33932.1 .
    CH466522 Genomic DNA. Translation: EDL25602.1 .
    BC064059 mRNA. Translation: AAH64059.1 .
    L20332 mRNA. Translation: AAA16852.1 .
    CCDSi CCDS23115.1.
    PIRi S42628.
    RefSeqi NP_031577.2. NM_007551.2.
    UniGenei Mm.491799.
    Mm.6246.

    3D structure databases

    ProteinModelPortali Q04683.
    SMRi Q04683. Positions 58-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5919N.
    IntActi Q04683. 1 interaction.
    MINTi MINT-1672594.

    Chemistry

    GuidetoPHARMACOLOGYi 72.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q04683.

    Proteomic databases

    PRIDEi Q04683.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062215 ; ENSMUSP00000050444 ; ENSMUSG00000047880 .
    ENSMUST00000179828 ; ENSMUSP00000137518 ; ENSMUSG00000047880 .
    GeneIDi 12145.
    KEGGi mmu:12145.
    UCSCi uc009pdx.1. mouse.

    Organism-specific databases

    CTDi 643.
    MGIi MGI:103567. Cxcr5.

    Phylogenomic databases

    eggNOGi NOG146951.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q6P3C2.
    KOi K04190.
    OMAi GLAHCCL.
    OrthoDBi EOG7R8322.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 280479.
    PROi Q04683.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04683.
    CleanExi MM_CXCR5.
    Genevestigatori Q04683.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues."
      Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.
      Eur. J. Immunol. 23:2532-2539(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    5. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
      Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
      Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-269.
      Tissue: Testis.
    6. "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen."
      Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.
      Cell 87:1037-1047(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
      Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
      Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.

    Entry informationi

    Entry nameiCXCR5_MOUSE
    AccessioniPrimary (citable) accession number: Q04683
    Secondary accession number(s): Q6P3C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3