Q04680 (ATNG_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name=Na(+)/K(+) ATPase subunit gamma

Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain

Gene names

Name:	FXYD2
Synonyms:	ATP1C, ATP1G1

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	53 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type III membrane protein Potential.
Tissue specificity	Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium Sodium
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 53	›53	Sodium/potassium-transporting ATPase subunit gamma		PRO_0000148188
Regions
	Transmembrane	16 – 34	19	Helical; Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q04680 [UniParc]. Last modified February 1, 1994. Version 2. Checksum: C0B52783D804AFB0	FASTA	53	6,073
	10 20 30 40 50 ENEDPFYYDY ETVRNGGLIF AALAFIVGLV IILSKRFRCG AKKKHRQIPE DGL

References

[1]	"Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase." Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III J. Cell Biol. 121:579-586(1993) [PubMed: 8387529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-53. Tissue: Kidney.
[2]	"The 'gamma subunit' of Na,K-ATPase: a small, amphiphilic protein with a unique amino acid sequence." Collins J.H., Leszyk J. Biochemistry 26:8665-8668(1987) [PubMed: 2831947] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-33. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70061 mRNA. Translation: CAA49665.1.
PIR	A46435.
UniGene	Oar.432.
3D structure databases
ProteinModelPortal	Q04680.
SMR	Q04680. Positions 10-38.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATNG_SHEEP

Accession

Primary (citable) accession number: Q04680

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	February 1, 1994
Last modified:	October 19, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program