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Protein

Sodium/potassium-transporting ATPase subunit gamma

Gene

Fxyd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: RGD
  • regulation of cell growth Source: RGD
  • regulation of cell proliferation Source: RGD
  • regulation of sodium ion transmembrane transporter activity Source: GO_Central
  • sodium ion transport Source: RGD

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-5578775 Ion homeostasis
R-RNO-936837 Ion transport by P-type ATPases
SABIO-RKQ04679

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name:
Na(+)/K(+) ATPase subunit gamma
Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain
Gene namesi
Name:Fxyd2
Synonyms:Atp1c, Atp1g1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2173 Fxyd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 46HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001481871 – 66Sodium/potassium-transporting ATPase subunit gammaAdd BLAST66

Proteomic databases

PaxDbiQ04679
PRIDEiQ04679

Expressioni

Tissue specificityi

Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.

Gene expression databases

BgeeiENSRNOG00000016469
GenevisibleiQ04679 RN

Interactioni

Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022074

Structurei

3D structure databases

ProteinModelPortaliQ04679
SMRiQ04679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J35I Eukaryota
ENOG410Z10F LUCA
GeneTreeiENSGT00530000063932
HOGENOMiHOG000234468
HOVERGENiHBG100880
InParanoidiQ04679
KOiK01538
OMAiDRWYLGG
OrthoDBiEOG091G13K5
PhylomeDBiQ04679

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q04679-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTELSANHGG SAKGTENPFE YDYETVRKGG LIFAGLAFVV GLLILLSKRF
60
RCGGSKKHRQ VNEDEL
Length:66
Mass (Da):7,257
Last modified:January 23, 2002 - v2
Checksum:i95D5CB3783410C06
GO
Isoform 2 (identifier: Q04679-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MTELSANH → MDRWYL

Show »
Length:64
Mass (Da):7,238
Checksum:iF69EA9A8D504E607
GO

Sequence cautioni

The sequence CAA49666 differs from that shown. Reason: Frameshift at position 13.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015831 – 8MTELSANH → MDRWYL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70062 mRNA Translation: CAA49666.1 Frameshift.
AF129400 mRNA Translation: AAD32613.1
AF233060 mRNA Translation: AAF36985.1
PIRiB46435
RefSeqiNP_059045.2, NM_017349.2 [Q04679-2]
NP_663769.1, NM_145717.1 [Q04679-1]
XP_006242973.1, XM_006242911.3 [Q04679-1]
XP_006242974.1, XM_006242912.3 [Q04679-2]
UniGeneiRn.6700

Genome annotation databases

EnsembliENSRNOT00000022074; ENSRNOP00000022074; ENSRNOG00000016469 [Q04679-1]
ENSRNOT00000064611; ENSRNOP00000061133; ENSRNOG00000016469 [Q04679-2]
GeneIDi29639
KEGGirno:29639
UCSCiRGD:2173 rat [Q04679-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATNG_RAT
AccessioniPrimary (citable) accession number: Q04679
Secondary accession number(s): Q9JKN3, Q9WUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2002
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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