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Protein

Sodium/potassium-transporting ATPase subunit gamma

Gene

Fxyd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled transmembrane transport Source: GOC
  • establishment or maintenance of transmembrane electrochemical gradient Source: GOC
  • potassium ion transport Source: RGD
  • regulation of cell growth Source: RGD
  • regulation of cell proliferation Source: RGD
  • regulation of sodium ion transmembrane transporter activity Source: Ensembl
  • sodium ion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.
SABIO-RKQ04679.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name:
Na(+)/K(+) ATPase subunit gamma
Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain
Gene namesi
Name:Fxyd2
Synonyms:Atp1c, Atp1g1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2173. Fxyd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4618HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • extracellular exosome Source: Ensembl
  • intracellular membrane-bounded organelle Source: RGD
  • sodium:potassium-exchanging ATPase complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Sodium/potassium-transporting ATPase subunit gammaPRO_0000148187Add
BLAST

Proteomic databases

PaxDbiQ04679.
PRIDEiQ04679.

Expressioni

Tissue specificityi

Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.

Gene expression databases

GenevisibleiQ04679. RN.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022074.

Structurei

3D structure databases

ProteinModelPortaliQ04679.
SMRiQ04679. Positions 23-51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J35I. Eukaryota.
ENOG410Z10F. LUCA.
GeneTreeiENSGT00530000064417.
HOGENOMiHOG000234468.
HOVERGENiHBG100880.
InParanoidiQ04679.
KOiK01538.
OMAiDRWYLGG.
OrthoDBiEOG786H66.
PhylomeDBiQ04679.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q04679-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTELSANHGG SAKGTENPFE YDYETVRKGG LIFAGLAFVV GLLILLSKRF
60
RCGGSKKHRQ VNEDEL
Length:66
Mass (Da):7,257
Last modified:January 23, 2002 - v2
Checksum:i95D5CB3783410C06
GO
Isoform 2 (identifier: Q04679-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MTELSANH → MDRWYL

Show »
Length:64
Mass (Da):7,238
Checksum:iF69EA9A8D504E607
GO

Sequence cautioni

The sequence CAA49666.1 differs from that shown. Reason: Frameshift at position 13. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MTELSANH → MDRWYL in isoform 2. 1 PublicationVSP_001583

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70062 mRNA. Translation: CAA49666.1. Frameshift.
AF129400 mRNA. Translation: AAD32613.1.
AF233060 mRNA. Translation: AAF36985.1.
PIRiB46435.
RefSeqiNP_059045.2. NM_017349.2. [Q04679-2]
NP_663769.1. NM_145717.1. [Q04679-1]
XP_006242973.1. XM_006242911.2. [Q04679-1]
XP_006242974.1. XM_006242912.2. [Q04679-2]
UniGeneiRn.6700.

Genome annotation databases

EnsembliENSRNOT00000022074; ENSRNOP00000022074; ENSRNOG00000016469. [Q04679-1]
ENSRNOT00000064611; ENSRNOP00000061133; ENSRNOG00000016469. [Q04679-2]
GeneIDi29639.
KEGGirno:29639.
UCSCiRGD:2173. rat. [Q04679-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70062 mRNA. Translation: CAA49666.1. Frameshift.
AF129400 mRNA. Translation: AAD32613.1.
AF233060 mRNA. Translation: AAF36985.1.
PIRiB46435.
RefSeqiNP_059045.2. NM_017349.2. [Q04679-2]
NP_663769.1. NM_145717.1. [Q04679-1]
XP_006242973.1. XM_006242911.2. [Q04679-1]
XP_006242974.1. XM_006242912.2. [Q04679-2]
UniGeneiRn.6700.

3D structure databases

ProteinModelPortaliQ04679.
SMRiQ04679. Positions 23-51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022074.

Proteomic databases

PaxDbiQ04679.
PRIDEiQ04679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022074; ENSRNOP00000022074; ENSRNOG00000016469. [Q04679-1]
ENSRNOT00000064611; ENSRNOP00000061133; ENSRNOG00000016469. [Q04679-2]
GeneIDi29639.
KEGGirno:29639.
UCSCiRGD:2173. rat. [Q04679-1]

Organism-specific databases

CTDi486.
RGDi2173. Fxyd2.

Phylogenomic databases

eggNOGiENOG410J35I. Eukaryota.
ENOG410Z10F. LUCA.
GeneTreeiENSGT00530000064417.
HOGENOMiHOG000234468.
HOVERGENiHBG100880.
InParanoidiQ04679.
KOiK01538.
OMAiDRWYLGG.
OrthoDBiEOG786H66.
PhylomeDBiQ04679.

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.
SABIO-RKQ04679.

Miscellaneous databases

NextBioi609888.
PROiQ04679.

Gene expression databases

GenevisibleiQ04679. RN.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase."
    Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III
    J. Cell Biol. 121:579-586(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Expression and functional role of the gamma subunit of the Na,K-ATPase in mammalian cells."
    Therien A.G., Karlish S.J., Blostein R.
    J. Biol. Chem. 274:12252-12256(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.
  3. "Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney."
    Arystarkhova E., Wetzel R.K., Sweadner K.J.
    Am. J. Physiol. 282:F393-F407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).

Entry informationi

Entry nameiATNG_RAT
AccessioniPrimary (citable) accession number: Q04679
Secondary accession number(s): Q9JKN3, Q9WUD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2002
Last modified: May 11, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.