Q04679 (ATNG_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name=Na(+)/K(+) ATPase subunit gamma

Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain

Gene names

Name:	Fxyd2
Synonyms:	Atp1c, Atp1g1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	66 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type III membrane protein Potential.
Tissue specificity	Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.
Sequence similarities	Belongs to the FXYD family.
Sequence caution	The sequence CAA49666.1 differs from that shown. Reason: Frameshift at position 13.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Inferred from mutant phenotype. Source: RGD regulation of cell proliferation Inferred from mutant phenotype. Source: RGD
Cellular component	basolateral plasma membrane Inferred from direct assay. Source: RGD microsome Inferred from direct assay Ref.3. Source: RGD sodium:potassium-exchanging ATPase complex Inferred from direct assay. Source: RGD
Molecular function	ion channel activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: RGD sodium:potassium-exchanging ATPase activity Inferred from mutant phenotype. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q04679-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q04679-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MTELSANH → MDRWYL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 66	66	Sodium/potassium-transporting ATPase subunit gamma		PRO_0000148187
Regions
	Transmembrane	29 – 46	18	Helical; Potential
Natural variations
	Alternative sequence	1 – 8	8	MTELSANH → MDRWYL in isoform 2.		VSP_001583

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 95D5CB3783410C06	FASTA	66	7,257
	10 20 30 40 50 60 MTELSANHGG SAKGTENPFE YDYETVRKGG LIFAGLAFVV GLLILLSKRF RCGGSKKHRQ VNEDEL
	Isoform 2 (B) [UniParc]. Checksum: F69EA9A8D504E607	FASTA	64	7,238
	10 20 30 40 50 60 MDRWYLGGSA KGTENPFEYD YETVRKGGLI FAGLAFVVGL LILLSKRFRC GGSKKHRQVN EDEL

References

[1]	"Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase." Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III J. Cell Biol. 121:579-586(1993) [PubMed: 8387529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[2]	"Expression and functional role of the gamma subunit of the Na,K-ATPase in mammalian cells." Therien A.G., Karlish S.J., Blostein R. J. Biol. Chem. 274:12252-12256(1999) [PubMed: 10212192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Sprague-Dawley.
[3]	"Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney." Arystarkhova E., Wetzel R.K., Sweadner K.J. Am. J. Physiol. 282:F393-F407(2002) [PubMed: 11832419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70062 mRNA. Translation: CAA49666.1. Frameshift. AF129400 mRNA. Translation: AAD32613.1. AF233060 mRNA. Translation: AAF36985.1.
IPI	IPI00188134. IPI00231198.
PIR	B46435.
RefSeq	NP_059045.2. NM_017349.2. NP_663769.1. NM_145717.1.
UniGene	Rn.6700.
3D structure databases
ProteinModelPortal	Q04679.
SMR	Q04679. Positions 23-51.
ModBase	Search...
Protein-protein interaction databases
STRING	Q04679.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000064611; ENSRNOP00000061133; ENSRNOG00000016469.
GeneID	29639.
KEGG	rno:29639.
Organism-specific databases
CTD	486.
RGD	2173. Fxyd2.
Phylogenomic databases
eggNOG	maNOG21430.
GeneTree	ENSGT00530000064417.
HOVERGEN	HBG100880.
OrthoDB	EOG45HS03.
Gene expression databases
Genevestigator	Q04679.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K01538.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	609888.

Entry information

Entry name

ATNG_RAT

Accession

Primary (citable) accession number: Q04679
Secondary accession number(s): Q9JKN3, Q9WUD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2002
Last modified:	November 16, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program