Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q04668 (KPYK_LEIBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
OrganismLeishmania braziliensis
Taxonomic identifier5660 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex

Protein attributes

Sequence length91 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›91›91Pyruvate kinase
PRO_0000112101

Sites

Metal binding501Potassium By similarity
Metal binding521Potassium By similarity
Metal binding821Potassium By similarity
Metal binding831Potassium; via carbonyl oxygen By similarity
Binding site481Substrate By similarity

Experimental info

Non-terminal residue911

Sequences

Sequence LengthMass (Da)Tools
Q04668 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 6D5E18C18D5E759D

FASTA919,704
        10         20         30         40         50         60 
MSQLAHNLTL SIFEPLRTTG TIVCTIGPST QSVEALKGLI KSGMSVARMN FSHGSHEYHQ 

        70         80         90 
TTINNVRQAA AELGVNIAIA LDTKGPEIRT G 

« Hide

References

[1]Martinez C., Hung A., Alonso G., Ponte A., Ramirez J.L.
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08597 mRNA. Translation: AAA29260.1.

3D structure databases

ProteinModelPortalQ04668.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D3.20.20.60. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR015793. Pyrv_Knase_brl.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
[Graphical view]
SUPFAMSSF51621. SSF51621. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKPYK_LEIBR
AccessionPrimary (citable) accession number: Q04668
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways