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Protein

Transcription factor HES-3

Gene

Hes3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-3
Alternative name(s):
Hairy and enhancer of split 3
Gene namesi
Name:Hes3
Synonyms:Hes-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621339. Hes3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272101 – 175Transcription factor HES-3Add BLAST175

Proteomic databases

PaxDbiQ04667.
PRIDEiQ04667.

Expressioni

Tissue specificityi

Expressed exclusively in Purkinje cells.

Gene expression databases

GenevisibleiQ04667. RN.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014535.

Structurei

3D structure databases

ProteinModelPortaliQ04667.
SMRiQ04667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49bHLHPROSITE-ProRule annotationAdd BLAST49
Domaini65 – 98OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 175WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 167Pro-richAdd BLAST60

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410JC70. Eukaryota.
ENOG4112CPE. LUCA.
GeneTreeiENSGT00730000111482.
HOGENOMiHOG000236346.
HOVERGENiHBG005959.
InParanoidiQ04667.
KOiK09088.
OMAiCTPAVWA.
OrthoDBiEOG091G0D3I.
PhylomeDBiQ04667.
TreeFamiTF351373.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003650. Orange_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKRRARIN LSLEQLRSLL ERHYSHQIRK RKLEKADILE LSVKYVRSLQ
60 70 80 90 100
NSLQGLWLVP SGVDYPSGFR GGLPGSSQRL RPGEDDSGLR CPLLLQRRAG
110 120 130 140 150
STTDSANPQT ASVLSPCLPA IWAPGPPAGG SQSPQSPFPP LGGLLESSTG
160 170
ILAPPPASNC QAENPRPGFR VWRPW
Length:175
Mass (Da):19,137
Last modified:June 1, 1994 - v1
Checksum:iD490663869155CB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13418 mRNA. Translation: BAA02683.1.
PIRiS36749.
RefSeqiNP_073178.1. NM_022687.1.
XP_008762603.1. XM_008764381.2.
XP_008762604.1. XM_008764382.2.
XP_008762605.1. XM_008764383.1.
XP_017449101.1. XM_017593612.1.
XP_017449102.1. XM_017593613.1.
XP_017449103.1. XM_017593614.1.
UniGeneiRn.48807.

Genome annotation databases

EnsembliENSRNOT00000014536; ENSRNOP00000014535; ENSRNOG00000010893.
GeneIDi64628.
KEGGirno:64628.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHES3_RAT
AccessioniPrimary (citable) accession number: Q04667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome