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Protein

Transcription factor HES-3

Gene

Hes3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-3
Alternative name(s):
Hairy and enhancer of split 3
Gene namesi
Name:Hes3
Synonyms:Hes-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621339 Hes3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272101 – 175Transcription factor HES-3Add BLAST175

Proteomic databases

PaxDbiQ04667
PRIDEiQ04667

Expressioni

Tissue specificityi

Expressed exclusively in Purkinje cells.

Gene expression databases

BgeeiENSRNOG00000010893
GenevisibleiQ04667 RN

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiQ04667
STRINGi10116.ENSRNOP00000014535

Structurei

3D structure databases

ProteinModelPortaliQ04667
SMRiQ04667
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49bHLHPROSITE-ProRule annotationAdd BLAST49
Domaini65 – 98OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 175WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 167Pro-richAdd BLAST60

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410JC70 Eukaryota
ENOG4112CPE LUCA
GeneTreeiENSGT00730000111482
HOGENOMiHOG000236346
HOVERGENiHBG005959
InParanoidiQ04667
KOiK09088
OMAiCTPAVWA
OrthoDBiEOG091G0D3I
PhylomeDBiQ04667
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q04667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKRRARIN LSLEQLRSLL ERHYSHQIRK RKLEKADILE LSVKYVRSLQ
60 70 80 90 100
NSLQGLWLVP SGVDYPSGFR GGLPGSSQRL RPGEDDSGLR CPLLLQRRAG
110 120 130 140 150
STTDSANPQT ASVLSPCLPA IWAPGPPAGG SQSPQSPFPP LGGLLESSTG
160 170
ILAPPPASNC QAENPRPGFR VWRPW
Length:175
Mass (Da):19,137
Last modified:June 1, 1994 - v1
Checksum:iD490663869155CB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13418 mRNA Translation: BAA02683.1
PIRiS36749
RefSeqiNP_073178.1, NM_022687.1
XP_008762603.1, XM_008764381.2
XP_008762604.1, XM_008764382.2
XP_008762605.1, XM_008764383.1
XP_017449101.1, XM_017593612.1
XP_017449102.1, XM_017593613.1
XP_017449103.1, XM_017593614.1
UniGeneiRn.48807

Genome annotation databases

EnsembliENSRNOT00000014536; ENSRNOP00000014535; ENSRNOG00000010893
GeneIDi64628
KEGGirno:64628

Similar proteinsi

Entry informationi

Entry nameiHES3_RAT
AccessioniPrimary (citable) accession number: Q04667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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