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Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB.By similarity

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Ordered Locus Names:gbs1245
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000823 Componenti: Chromosome

Organism-specific databases

GenoListigbs1245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Tyrosine-protein kinase CpsDPRO_0000217235Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi211110.gbs1245.

Structurei

3D structure databases

ProteinModelPortaliQ04663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.Curated

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000056186.
OMAiGKYYGKY.
OrthoDBiEOG69D3H6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS
60 70 80 90 100
TTSTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA
110 120 130 140 150
DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII
160 170 180 190 200
IDTPPIGLVV DAAIIANACD GFILVTQAGR IKRNYVEKAK EQMEQSGSKF
210 220 230
LGIILNKVNE SVATYGDYGD YGNYGKRDRK RK
Length:232
Mass (Da):25,429
Last modified:January 17, 2003 - v3
Checksum:i7F81FA15A9C77C33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411T → A in AAB00363 (PubMed:8355611).Curated
Sequence conflicti218 – 2203Missing in AAB00363 (PubMed:8355611).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163833 Genomic DNA. Translation: AAB00363.1.
AL766849 Genomic DNA. Translation: CAD46904.1.
PIRiS34976.
T44642.
RefSeqiNP_735689.1. NC_004368.1.

Genome annotation databases

KEGGisan:gbs1244.
PATRICi19638373. VBIStrAga3577_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163833 Genomic DNA. Translation: AAB00363.1.
AL766849 Genomic DNA. Translation: CAD46904.1.
PIRiS34976.
T44642.
RefSeqiNP_735689.1. NC_004368.1.

3D structure databases

ProteinModelPortaliQ04663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211110.gbs1245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisan:gbs1244.
PATRICi19638373. VBIStrAga3577_1275.

Organism-specific databases

GenoListigbs1245.

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000056186.
OMAiGKYYGKY.
OrthoDBiEOG69D3H6.

Enzyme and pathway databases

UniPathwayiUPA00934.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
    Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
    Mol. Microbiol. 8:843-855(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: COH1 / Serotype III.
  2. Yim H.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
    Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
    Mol. Microbiol. 45:1499-1513(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEM316.

Entry informationi

Entry nameiCPSD_STRA3
AccessioniPrimary (citable) accession number: Q04663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 17, 2003
Last modified: April 1, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally called CpsC.1 Publication

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.