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Q04663

- CPSD_STRA3

UniProt

Q04663 - CPSD_STRA3

Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Dephosphorylated and activated by CpsB.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme regulator activity Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase CpsD (EC:2.7.10.2)
    Gene namesi
    Name:cpsD
    Ordered Locus Names:gbs1245
    OrganismiStreptococcus agalactiae serotype III (strain NEM316)
    Taxonomic identifieri211110 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000823: Chromosome

    Organism-specific databases

    GenoListigbs1245.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Tyrosine-protein kinase CpsDPRO_0000217235Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi211110.gbs1245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsD/CapB family.Curated

    Phylogenomic databases

    eggNOGiCOG0489.
    HOGENOMiHOG000056186.
    OMAiISTNAFR.
    OrthoDBiEOG69D3H6.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13614. AAA_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01007. eps_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04663-1 [UniParc]FASTAAdd to Basket

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    MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS    50
    TTSTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA 100
    DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII 150
    IDTPPIGLVV DAAIIANACD GFILVTQAGR IKRNYVEKAK EQMEQSGSKF 200
    LGIILNKVNE SVATYGDYGD YGNYGKRDRK RK 232
    Length:232
    Mass (Da):25,429
    Last modified:January 17, 2003 - v3
    Checksum:i7F81FA15A9C77C33
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411T → A in AAB00363. (PubMed:8355611)Curated
    Sequence conflicti218 – 2203Missing in AAB00363. (PubMed:8355611)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163833 Genomic DNA. Translation: AAB00363.1.
    AL766849 Genomic DNA. Translation: CAD46904.1.
    PIRiS34976.
    T44642.
    RefSeqiNP_735689.1. NC_004368.1.

    Genome annotation databases

    EnsemblBacteriaiCAD46904; CAD46904; CAD46904.
    GeneIDi1030264.
    KEGGisan:gbs1244.
    PATRICi19638373. VBIStrAga3577_1275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163833 Genomic DNA. Translation: AAB00363.1 .
    AL766849 Genomic DNA. Translation: CAD46904.1 .
    PIRi S34976.
    T44642.
    RefSeqi NP_735689.1. NC_004368.1.

    3D structure databases

    ProteinModelPortali Q04663.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211110.gbs1245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD46904 ; CAD46904 ; CAD46904 .
    GeneIDi 1030264.
    KEGGi san:gbs1244.
    PATRICi 19638373. VBIStrAga3577_1275.

    Organism-specific databases

    GenoListi gbs1245.

    Phylogenomic databases

    eggNOGi COG0489.
    HOGENOMi HOG000056186.
    OMAi ISTNAFR.
    OrthoDBi EOG69D3H6.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13614. AAA_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01007. eps_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
      Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
      Mol. Microbiol. 8:843-855(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: COH1 / Serotype III.
    2. Yim H.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
      Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
      Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NEM316.

    Entry informationi

    Entry nameiCPSD_STRA3
    AccessioniPrimary (citable) accession number: Q04663
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally called CpsC.1 Publication

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3