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Q04663 (CPSD_STRA3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase CpsD

EC=2.7.10.2
Gene names
Name:cpsD
Ordered Locus Names:gbs1245
OrganismStreptococcus agalactiae serotype III (strain NEM316) [Complete proteome] [HAMAP]
Taxonomic identifier211110 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation

Dephosphorylated and activated by CpsB By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the CpsD/CapB family.

Caution

Was originally (Ref.1) called CpsC.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Tyrosine-protein kinase CpsD
PRO_0000217235

Experimental info

Sequence conflict411T → A in AAB00363. Ref.1
Sequence conflict218 – 2203Missing in AAB00363. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04663 [UniParc].

Last modified January 17, 2003. Version 3.
Checksum: 7F81FA15A9C77C33

FASTA23225,429
        10         20         30         40         50         60 
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS TTSTSLALSL 

        70         80         90        100        110        120 
AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA DLGDIICETN VPRLMVVPSG 

       130        140        150        160        170        180 
KVPPNPTALL QNAYFNKMIE AIKNIFDYII IDTPPIGLVV DAAIIANACD GFILVTQAGR 

       190        200        210        220        230 
IKRNYVEKAK EQMEQSGSKF LGIILNKVNE SVATYGDYGD YGNYGKRDRK RK 

« Hide

References

« Hide 'large scale' references
[1]"Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
Mol. Microbiol. 8:843-855(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: COH1 / Serotype III.
[2]Yim H.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF163833 Genomic DNA. Translation: AAB00363.1.
AL766849 Genomic DNA. Translation: CAD46904.1.
PIRS34976.
T44642.
RefSeqNP_735689.1. NC_004368.1.

3D structure databases

ProteinModelPortalQ04663.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211110.gbs1245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD46904; CAD46904; CAD46904.
GeneID1030264.
KEGGsan:gbs1244.
PATRIC19638373. VBIStrAga3577_1275.

Organism-specific databases

GenoListgbs1245.
CMRSearch...

Phylogenomic databases

eggNOGCOG0489.
HOGENOMHOG000056186.
OMAGKYYGKY.
OrthoDBEOG69D3H6.
ProtClustDBCLSK883944.

Enzyme and pathway databases

UniPathwayUPA00934.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01007. eps_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSD_STRA3
AccessionPrimary (citable) accession number: Q04663
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 17, 2003
Last modified: April 16, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways