Reviewed, UniProtKB/Swiss-Prot Q04661 (CPSB_STRA3)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase cpsB
    EC=3.1.3.48

Gene names

Name:	cpsB
Ordered Locus Names:	gbs1247

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the cpsB/capC family.
Caution	Was originally (Ref.1) called cpsA.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Tyrosine-protein phosphatase cpsB		PRO_0000057889
Experimental info
	Sequence conflict	66	1	A → T in AAB00361. Ref.1
	Sequence conflict	142	1	S → A in AAB00361. Ref.1
	Sequence conflict	165	1	S → F in AAB00361. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q04661-1 [UniParc]. Last modified January 17, 2003. Version 2. Checksum: B747C92DB128FF5A	FASTA	243	28,616
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS 70 80 90 100 110 120 IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT 130 140 150 160 170 180 ALSNVLMLGI TPVVAHIERY NSLENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF 190 200 210 220 230 240 KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of cpsD, a gene essential for type III capsule expression in group B streptococci." Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R. Mol. Microbiol. 8:843-855(1993) [PubMed: 8355611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: COH1 / Serotype III.
[2]	"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF163833 Genomic DNA. Translation: AAB00361.1. AL766849 Genomic DNA. Translation: CAD46906.1.
PIR	S34974.
RefSeq	NP_735691.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1030270.
GenomeReviews	Gene locus gbs1247 in contig AL732656_GR.
KEGG	san:gbs1247.
Organism-specific databases
SagaList	gbs1247.
CMR	Search...
Phylogenomic databases
HOGENOM	Q04661.
OMA	ITPVIAH.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS1247-MON.
Family and domain databases
InterPro	IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view]
Pfam	PF02811. PHP. 1 hit. [Graphical view]
PIRSF	PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSB_STRA3

Accession

Primary (citable) accession number: Q04661

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 17, 2003
Last modified:	November 3, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)