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Q04661

- CPSB_STRA3

UniProt

Q04661 - CPSB_STRA3

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Protein
Tyrosine-protein phosphatase CpsB
Gene
cpsB, gbs1247
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. manganese ion binding Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Ordered Locus Names:gbs1247
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000823: Chromosome

Organism-specific databases

GenoListigbs1247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Tyrosine-protein phosphatase CpsB
PRO_0000057889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211110.gbs1247.

Structurei

3D structure databases

ProteinModelPortaliQ04661.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.

Phylogenomic databases

eggNOGiCOG4464.
HOGENOMiHOG000244648.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04661-1 [UniParc]FASTAAdd to Basket

« Hide

MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET    50
PEDIIFKNFS IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN 100
NTKFALIEFS MQTSWKDIHT ALSNVLMLGI TPVVAHIERY NSLENQKERV 150
KEIINMGCYT QINSSHILKQ KLFNDKHKRF KKRARYFLEE NLVHFVASDM 200
HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI 243
Length:243
Mass (Da):28,616
Last modified:January 17, 2003 - v2
Checksum:iB747C92DB128FF5A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661A → T in AAB00361. 1 Publication
Sequence conflicti142 – 1421S → A in AAB00361. 1 Publication
Sequence conflicti165 – 1651S → F in AAB00361. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163833 Genomic DNA. Translation: AAB00361.1.
AL766849 Genomic DNA. Translation: CAD46906.1.
PIRiS34974.
RefSeqiNP_735691.1. NC_004368.1.

Genome annotation databases

EnsemblBacteriaiCAD46906; CAD46906; CAD46906.
GeneIDi1030270.
KEGGisan:gbs1246.
PATRICi19638377. VBIStrAga3577_1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163833 Genomic DNA. Translation: AAB00361.1 .
AL766849 Genomic DNA. Translation: CAD46906.1 .
PIRi S34974.
RefSeqi NP_735691.1. NC_004368.1.

3D structure databases

ProteinModelPortali Q04661.
ModBasei Search...

Protein-protein interaction databases

STRINGi 211110.gbs1247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD46906 ; CAD46906 ; CAD46906 .
GeneIDi 1030270.
KEGGi san:gbs1246.
PATRICi 19638377. VBIStrAga3577_1277.

Organism-specific databases

GenoListi gbs1247.

Phylogenomic databases

eggNOGi COG4464.
HOGENOMi HOG000244648.
KOi K01104.
OMAi TPHTLNG.
OrthoDBi EOG6PKFDD.

Enzyme and pathway databases

UniPathwayi UPA00934 .

Family and domain databases

InterProi IPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view ]
Pfami PF02811. PHP. 1 hit.
[Graphical view ]
PIRSFi PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
    Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
    Mol. Microbiol. 8:843-855(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: COH1 / Serotype III.
  2. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
    Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
    Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEM316.

Entry informationi

Entry nameiCPSB_STRA3
AccessioniPrimary (citable) accession number: Q04661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 17, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) called CpsA.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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