Reviewed,
UniProtKB/Swiss-Prot Q04661 (CPSB_STRA3)
Last modified
November 3, 2009.
Version 47.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Tyrosine-protein phosphatase cpsB EC=3.1.3.48 | ||||
| Gene names |
| ||||
| Organism | Streptococcus agalactiae serotype III [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 216495 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 243 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| Cofactor | Manganese By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the cpsB/capC family. |
| Caution | Was originally (Ref.1) called cpsA. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Capsule biogenesis/degradation Exopolysaccharide synthesis |
| Ligand | Manganese |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 243 | 243 | Tyrosine-protein phosphatase cpsB | PRO_0000057889 | |||||
Experimental info | |||||||||
| Sequence conflict | 66 | 1 | A → T in AAB00361. Ref.1 | ||||||
| Sequence conflict | 142 | 1 | S → A in AAB00361. Ref.1 | ||||||
| Sequence conflict | 165 | 1 | S → F in AAB00361. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci." Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R. Mol. Microbiol. 8:843-855(1993) [PubMed: 8355611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: COH1 / Serotype III. |
| [2] | "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III. |
Cross-references
Sequence databases | |
|---|---|
| AF163833 Genomic DNA. Translation: AAB00361.1. AL766849 Genomic DNA. Translation: CAD46906.1. | |
| PIR | S34974. |
| RefSeq | NP_735691.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1030270. |
| GenomeReviews | Gene locus gbs1247 in contig AL732656_GR. |
| KEGG | san:gbs1247. |
Organism-specific databases | |
| SagaList | gbs1247. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q04661. |
| OMA | ITPVIAH. |
Enzyme and pathway databases | |
| BioCyc | SAGA211110:GBS1247-MON. |
Family and domain databases | |
| InterPro | IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view] |
| Pfam | PF02811. PHP. 1 hit. [Graphical view] |
| PIRSF | PIRSF016557. Caps_synth_CpsB. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CPSB_STRA3 | ||||||||
| Accession | Primary (citable) accession number: Q04661 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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