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Q04661 (CPSB_STRA3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase CpsB

EC=3.1.3.48
Gene names
Name:cpsB
Ordered Locus Names:gbs1247
OrganismStreptococcus agalactiae serotype III (strain NEM316) [Complete proteome] [HAMAP]
Taxonomic identifier211110 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactor

Manganese By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Sequence similarities

Belongs to the CpsB/CapC family.

Caution

Was originally (Ref.1) called CpsA.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Tyrosine-protein phosphatase CpsB
PRO_0000057889

Experimental info

Sequence conflict661A → T in AAB00361. Ref.1
Sequence conflict1421S → A in AAB00361. Ref.1
Sequence conflict1651S → F in AAB00361. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04661 [UniParc].

Last modified January 17, 2003. Version 2.
Checksum: B747C92DB128FF5A

FASTA24328,616
        10         20         30         40         50         60 
MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS 

        70         80         90        100        110        120 
IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT 

       130        140        150        160        170        180 
ALSNVLMLGI TPVVAHIERY NSLENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF 

       190        200        210        220        230        240 
KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN 


HYI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
Mol. Microbiol. 8:843-855(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: COH1 / Serotype III.
[2]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF163833 Genomic DNA. Translation: AAB00361.1.
AL766849 Genomic DNA. Translation: CAD46906.1.
PIRS34974.
RefSeqNP_735691.1. NC_004368.1.

3D structure databases

ProteinModelPortalQ04661.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211110.gbs1247.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD46906; CAD46906; CAD46906.
GeneID1030270.
KEGGsan:gbs1246.
PATRIC19638377. VBIStrAga3577_1277.

Organism-specific databases

GenoListgbs1247.
CMRSearch...

Phylogenomic databases

eggNOGCOG4464.
HOGENOMHOG000244648.
KOK01104.
OMATPHTLNG.
OrthoDBEOG6PKFDD.
ProtClustDBCLSK883942.

Enzyme and pathway databases

UniPathwayUPA00934.

Family and domain databases

InterProIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamPF02811. PHP. 1 hit.
[Graphical view]
PIRSFPIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSB_STRA3
AccessionPrimary (citable) accession number: Q04661
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 17, 2003
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways