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Q04661

- CPSB_STRA3

UniProt

Q04661 - CPSB_STRA3

Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. manganese ion binding Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
    Gene namesi
    Name:cpsB
    Ordered Locus Names:gbs1247
    OrganismiStreptococcus agalactiae serotype III (strain NEM316)
    Taxonomic identifieri211110 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000823: Chromosome

    Organism-specific databases

    GenoListigbs1247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057889Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211110.gbs1247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04661.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsB/CapC family.Curated

    Phylogenomic databases

    eggNOGiCOG4464.
    HOGENOMiHOG000244648.
    KOiK01104.
    OMAiTPHTLNG.
    OrthoDBiEOG6PKFDD.

    Family and domain databases

    InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view]
    PfamiPF02811. PHP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET    50
    PEDIIFKNFS IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN 100
    NTKFALIEFS MQTSWKDIHT ALSNVLMLGI TPVVAHIERY NSLENQKERV 150
    KEIINMGCYT QINSSHILKQ KLFNDKHKRF KKRARYFLEE NLVHFVASDM 200
    HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI 243
    Length:243
    Mass (Da):28,616
    Last modified:January 17, 2003 - v2
    Checksum:iB747C92DB128FF5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661A → T in AAB00361. (PubMed:8355611)Curated
    Sequence conflicti142 – 1421S → A in AAB00361. (PubMed:8355611)Curated
    Sequence conflicti165 – 1651S → F in AAB00361. (PubMed:8355611)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163833 Genomic DNA. Translation: AAB00361.1.
    AL766849 Genomic DNA. Translation: CAD46906.1.
    PIRiS34974.
    RefSeqiNP_735691.1. NC_004368.1.

    Genome annotation databases

    EnsemblBacteriaiCAD46906; CAD46906; CAD46906.
    GeneIDi1030270.
    KEGGisan:gbs1246.
    PATRICi19638377. VBIStrAga3577_1277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163833 Genomic DNA. Translation: AAB00361.1 .
    AL766849 Genomic DNA. Translation: CAD46906.1 .
    PIRi S34974.
    RefSeqi NP_735691.1. NC_004368.1.

    3D structure databases

    ProteinModelPortali Q04661.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211110.gbs1247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD46906 ; CAD46906 ; CAD46906 .
    GeneIDi 1030270.
    KEGGi san:gbs1246.
    PATRICi 19638377. VBIStrAga3577_1277.

    Organism-specific databases

    GenoListi gbs1247.

    Phylogenomic databases

    eggNOGi COG4464.
    HOGENOMi HOG000244648.
    KOi K01104.
    OMAi TPHTLNG.
    OrthoDBi EOG6PKFDD.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .

    Family and domain databases

    InterProi IPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view ]
    Pfami PF02811. PHP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016557. Caps_synth_CpsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci."
      Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.
      Mol. Microbiol. 8:843-855(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: COH1 / Serotype III.
    2. "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
      Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
      Mol. Microbiol. 45:1499-1513(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NEM316.

    Entry informationi

    Entry nameiCPSB_STRA3
    AccessioniPrimary (citable) accession number: Q04661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally called CpsA.1 Publication

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3