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Q04660

- ERB1_YEAST

UniProt

Q04660 - ERB1_YEAST

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Protein

Ribosome biogenesis protein ERB1

Gene

ERB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.2 PublicationsUniRule annotation

GO - Molecular functioni

  1. ribonucleoprotein complex binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-HAMAP
  2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-HAMAP
  3. ribosomal large subunit biogenesis Source: SGD
  4. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32754-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein ERB1UniRule annotation
Alternative name(s):
Eukaryotic ribosome biogenesis protein 1UniRule annotation
Gene namesi
Name:ERB1UniRule annotation
Ordered Locus Names:YMR049C
ORF Names:YM9796.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR049c.
SGDiS000004652. ERB1.

Subcellular locationi

Nucleusnucleolus 1 PublicationUniRule annotation. Nucleusnucleoplasm 1 PublicationUniRule annotation

GO - Cellular componenti

  1. PeBoW complex Source: SGD
  2. preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Ribosome biogenesis protein ERB1PRO_0000050968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine3 Publications
Modified residuei72 – 721Phosphoserine1 Publication
Modified residuei76 – 761Phosphoserine1 Publication
Modified residuei146 – 1461Phosphoserine1 Publication
Modified residuei149 – 1491Phosphoserine1 Publication
Modified residuei418 – 4181Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04660.
PaxDbiQ04660.
PeptideAtlasiQ04660.

Expressioni

Gene expression databases

GenevestigatoriQ04660.

Interactioni

Subunit structurei

Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome. Also interacts with NOG1.3 PublicationsUniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
NOG1Q028922EBI-28098,EBI-12105
YTM1Q120244EBI-28098,EBI-29589

Protein-protein interaction databases

BioGridi35223. 129 interactions.
DIPiDIP-3970N.
IntActiQ04660. 61 interactions.
MINTiMINT-575265.
STRINGi4932.YMR049C.

Structurei

3D structure databases

ProteinModelPortaliQ04660.
SMRiQ04660. Positions 434-466, 592-626, 647-805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati435 – 47440WD 1Add
BLAST
Repeati483 – 52341WD 2Add
BLAST
Repeati592 – 63443WD 3Add
BLAST
Repeati637 – 67539WD 4Add
BLAST
Repeati678 – 71740WD 5Add
BLAST
Repeati721 – 76040WD 6Add
BLAST
Repeati776 – 80732WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 383119Required for interaction with NOP7Add
BLAST
Regioni383 – 41937Required for interaction with YTM1Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
InParanoidiQ04660.
KOiK14824.
OMAiWYEDFPH.
OrthoDBiEOG70PC60.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03027. BOP1.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAKNNKTTE AKMSKKRAAS EESDVEEDED KLLSVDGLID AEASESDEDD
60 70 80 90 100
DEYESAVEEK ESSSDKEAQD DSDDDSDAEL NKLLAEEEGD GEEDYDSSEF
110 120 130 140 150
SDDTTSLTDR LSGVKLQTIV DPNIYSKYAD GSDRIIKPEI NPVYDSDDSD
160 170 180 190 200
AETQNTIGNI PLSAYDEMPH IGYDINGKRI MRPAKGSALD QLLDSIELPE
210 220 230 240 250
GWTGLLDKNS GSSLNLTKEE LELISKIQRN EQTDDSINPY EPLIDWFTRH
260 270 280 290 300
EEVMPLTAVP EPKRRFVPSK NEAKRVMKIV RAIREGRIIP PKKLKEMKEK
310 320 330 340 350
EKIENYQYDL WGDSTETNDH VMHLRAPKLP PPTNEESYNP PEEYLLSPEE
360 370 380 390 400
KEAWENTEYS ERERNFIPQK YSALRKVPGY GESIRERFER SLDLYLAPRV
410 420 430 440 450
RKNKLNIDPN SLIPELPSPK DLRPFPIRCS TIYAGHKGKV RTLSIDPSGL
460 470 480 490 500
WLATGSDDGT VRVWEILTGR EVYRTTLIDD EENPDYHIEC IEWNPDANNG
510 520 530 540 550
ILAVAVGENI HLIVPPIFGY DIENNGKTKI EDGFGYDTFG TVKKSNLEVN
560 570 580 590 600
ENGDGDEDGE NESAKNAVKK QVAQWNKPSQ KQLEKDICIT ISCKKTVKKL
610 620 630 640 650
SWHRKGDYFV TVQPDSGNTS VLIHQVSKHL TQSPFKKSKG IIMDAKFHPF
660 670 680 690 700
KPQLFVCSQR YVRIYDLSQQ ILVKKLLPGA RWLSKIDIHP RGDNLIASSF
710 720 730 740 750
DKRVLWHDLD LASTPYKTLR YHEKAVRSVN FHKKLPLFSS AADDGTIHVF
760 770 780 790 800
HATVYDDMMK NPMIVPLKKL TGHKVINSLG VLDAIWHPRE AWLFSAGADN

TARLWTT
Length:807
Mass (Da):91,705
Last modified:November 1, 1997 - v1
Checksum:i6542DFE4670341CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49703 Genomic DNA. Translation: CAA89759.1.
BK006946 Genomic DNA. Translation: DAA09948.1.
PIRiS54549.
RefSeqiNP_013764.1. NM_001182546.1.

Genome annotation databases

EnsemblFungiiYMR049C; YMR049C; YMR049C.
GeneIDi855068.
KEGGisce:YMR049C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49703 Genomic DNA. Translation: CAA89759.1 .
BK006946 Genomic DNA. Translation: DAA09948.1 .
PIRi S54549.
RefSeqi NP_013764.1. NM_001182546.1.

3D structure databases

ProteinModelPortali Q04660.
SMRi Q04660. Positions 434-466, 592-626, 647-805.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35223. 129 interactions.
DIPi DIP-3970N.
IntActi Q04660. 61 interactions.
MINTi MINT-575265.
STRINGi 4932.YMR049C.

Proteomic databases

MaxQBi Q04660.
PaxDbi Q04660.
PeptideAtlasi Q04660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR049C ; YMR049C ; YMR049C .
GeneIDi 855068.
KEGGi sce:YMR049C.

Organism-specific databases

CYGDi YMR049c.
SGDi S000004652. ERB1.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00390000018422.
HOGENOMi HOG000029368.
InParanoidi Q04660.
KOi K14824.
OMAi WYEDFPH.
OrthoDBi EOG70PC60.

Enzyme and pathway databases

BioCyci YEAST:G3O-32754-MONOMER.

Miscellaneous databases

NextBioi 978335.
PROi Q04660.

Gene expression databases

Genevestigatori Q04660.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
HAMAPi MF_03027. BOP1.
InterProi IPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF08145. BOP1NT. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM01035. BOP1NT. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs."
    Pestov D.G., Stockelman M.G., Strezoska Z., Lau L.F.
    Nucleic Acids Res. 29:3621-3630(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis."
    Du Y.-C.N., Stillman B.
    Cell 109:835-848(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NOP7 COMPLEX.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes."
    Miles T.D., Jakovljevic J., Horsey E.W., Harnpicharnchai P., Tang L., Woolford J.L. Jr.
    Mol. Cell. Biol. 25:10419-10432(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NOP7 COMPLEX, ASSOCIATION OF THE NOP7 COMPLEX WITH 66S PRE-RIBOSOMES.
  7. "TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients."
    Honma Y., Kitamura A., Shioda R., Maruyama H., Ozaki K., Oda Y., Mini T., Jenoe P., Maki Y., Yonezawa K., Hurt E., Ueno M., Uritani M., Hall M.N., Ushimaru T.
    EMBO J. 25:3832-3842(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOG1.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-72 AND SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes."
    Tang L., Sahasranaman A., Jakovljevic J., Schleifman E., Woolford J.L. Jr.
    Mol. Biol. Cell 19:2844-2856(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION OF THE NOP7 COMPLEX, SUBCELLULAR LOCATION.
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-146; SER-149 AND SER-418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERB1_YEAST
AccessioniPrimary (citable) accession number: Q04660
Secondary accession number(s): D6VZM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2680 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3