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Protein

ER-derived vesicles protein ERV41

Gene

ERV41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV41
Gene namesi
Name:ERV41
Ordered Locus Names:YML067C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YML067C
SGDiS000004532 ERV41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 311LumenalSequence analysisAdd BLAST267
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 352CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032511 – 352ER-derived vesicles protein ERV41Add BLAST352

Proteomic databases

MaxQBiQ04651
PaxDbiQ04651
PRIDEiQ04651

Interactioni

Subunit structurei

Interacts with ERV46.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35099, 156 interactors
DIPiDIP-6791N
IntActiQ04651, 29 interactors
MINTiQ04651
STRINGi4932.YML067C

Structurei

Secondary structure

1352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 57Combined sources6
Beta strandi63 – 75Combined sources13
Helixi77 – 79Combined sources3
Beta strandi80 – 88Combined sources9
Beta strandi98 – 102Combined sources5
Helixi134 – 136Combined sources3
Helixi157 – 159Combined sources3
Beta strandi162 – 181Combined sources20
Beta strandi184 – 187Combined sources4
Helixi194 – 196Combined sources3
Beta strandi201 – 210Combined sources10
Turni218 – 221Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi233 – 245Combined sources13
Turni246 – 248Combined sources3
Beta strandi250 – 252Combined sources3
Beta strandi254 – 264Combined sources11
Helixi266 – 269Combined sources4
Beta strandi278 – 285Combined sources8
Beta strandi287 – 293Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651
SMRiQ04651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi349 – 350Isoleucine-leucine motif2

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000185254
InParanoidiQ04651
KOiK20366
OMAiVAMKCQY
OrthoDBiEOG092C43FV

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit

Sequencei

Sequence statusi: Complete.

Q04651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY
60 70 80 90 100
IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL
110 120 130 140 150
EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD
160 170 180 190 200
PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN
210 220 230 240 250
HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA
260 270 280 290 300
EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI
310 320 330 340 350
QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL

DR
Length:352
Mass (Da):40,706
Last modified:November 1, 1997 - v1
Checksum:iA9F002FB97666501
GO

Sequence cautioni

The sequence CAA86253 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA Translation: CAA86253.1 Sequence problems.
Z38114 Genomic DNA Translation: CAA86254.1
BK006946 Genomic DNA Translation: DAA09830.1
PIRiS48331
RefSeqiNP_013644.1, NM_001182426.1

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C
GeneIDi854935
KEGGisce:YML067C

Similar proteinsi

Entry informationi

Entry nameiERV41_YEAST
AccessioniPrimary (citable) accession number: Q04651
Secondary accession number(s): D6VZA6, E9PAD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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