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Q04651

- ERV41_YEAST

UniProt

Q04651 - ERV41_YEAST

Protein

ER-derived vesicles protein ERV41

Gene

ERV41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32662-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER-derived vesicles protein ERV41
    Gene namesi
    Name:ERV41
    Ordered Locus Names:YML067C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML067c.
    SGDiS000004532. ERV41.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein
    Note: Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    2. ER to Golgi transport vesicle Source: SGD
    3. integral component of endoplasmic reticulum membrane Source: SGD
    4. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352ER-derived vesicles protein ERV41PRO_0000203251Add
    BLAST

    Proteomic databases

    MaxQBiQ04651.
    PaxDbiQ04651.
    PeptideAtlasiQ04651.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04651.

    Interactioni

    Subunit structurei

    Interacts with ERV46.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERV46P397273EBI-27850,EBI-20659

    Protein-protein interaction databases

    BioGridi35099. 111 interactions.
    DIPiDIP-6791N.
    IntActiQ04651. 17 interactions.
    MINTiMINT-640267.

    Structurei

    Secondary structure

    1
    352
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi52 – 576
    Beta strandi63 – 7513
    Helixi77 – 793
    Beta strandi80 – 889
    Beta strandi98 – 1025
    Helixi134 – 1363
    Helixi157 – 1593
    Beta strandi162 – 18120
    Helixi194 – 1963
    Beta strandi201 – 21010
    Turni218 – 2214
    Beta strandi222 – 2243
    Beta strandi233 – 24513
    Turni246 – 2483
    Beta strandi250 – 2523
    Beta strandi254 – 26411
    Helixi266 – 2694
    Beta strandi278 – 2858
    Beta strandi287 – 2937

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZLCX-ray2.00A/B49-297[»]
    ProteinModelPortaliQ04651.
    SMRiQ04651. Positions 51-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 311267LumenalSequence AnalysisAdd
    BLAST
    Topological domaini333 – 35220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi349 – 3502Isoleucine-leucine motif

    Sequence similaritiesi

    Belongs to the ERGIC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285181.
    HOGENOMiHOG000185254.
    OMAiDAFPKVN.
    OrthoDBiEOG7ZD251.

    Family and domain databases

    InterProiIPR012936. Erv_C.
    [Graphical view]
    PfamiPF07970. COPIIcoated_ERV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY    50
    IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL 100
    EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD 150
    PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN 200
    HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA 250
    EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI 300
    QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL 350
    DR 352
    Length:352
    Mass (Da):40,706
    Last modified:November 1, 1997 - v1
    Checksum:iA9F002FB97666501
    GO

    Sequence cautioni

    The sequence CAA86253.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
    Z38114 Genomic DNA. Translation: CAA86254.1.
    BK006946 Genomic DNA. Translation: DAA09830.1.
    PIRiS48331.
    RefSeqiNP_013644.1. NM_001182426.1.

    Genome annotation databases

    EnsemblFungiiYML067C; YML067C; YML067C.
    GeneIDi854935.
    KEGGisce:YML067C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38114 Genomic DNA. Translation: CAA86253.1 . Sequence problems.
    Z38114 Genomic DNA. Translation: CAA86254.1 .
    BK006946 Genomic DNA. Translation: DAA09830.1 .
    PIRi S48331.
    RefSeqi NP_013644.1. NM_001182426.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZLC X-ray 2.00 A/B 49-297 [» ]
    ProteinModelPortali Q04651.
    SMRi Q04651. Positions 51-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35099. 111 interactions.
    DIPi DIP-6791N.
    IntActi Q04651. 17 interactions.
    MINTi MINT-640267.

    Proteomic databases

    MaxQBi Q04651.
    PaxDbi Q04651.
    PeptideAtlasi Q04651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML067C ; YML067C ; YML067C .
    GeneIDi 854935.
    KEGGi sce:YML067C.

    Organism-specific databases

    CYGDi YML067c.
    SGDi S000004532. ERV41.

    Phylogenomic databases

    eggNOGi NOG285181.
    HOGENOMi HOG000185254.
    OMAi DAFPKVN.
    OrthoDBi EOG7ZD251.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32662-MONOMER.

    Miscellaneous databases

    NextBioi 977974.
    PROi Q04651.

    Gene expression databases

    Genevestigatori Q04651.

    Family and domain databases

    InterProi IPR012936. Erv_C.
    [Graphical view ]
    Pfami PF07970. COPIIcoated_ERV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
      Cho J.-H., Noda Y., Yoda K.
      FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 4-10, SUBCELLULAR LOCATION.
    4. "A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
      Cho J.-H., Noda Y., Adachi H., Yoda K.
      Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
    5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
      Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
      J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
    6. "The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
      Otte S., Barlowe C.
      EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiERV41_YEAST
    AccessioniPrimary (citable) accession number: Q04651
    Secondary accession number(s): D6VZA6, E9PAD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3