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Q04651 (ERV41_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER-derived vesicles protein ERV41
Gene names
Name:ERV41
Ordered Locus Names:YML067C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum. Ref.5 Ref.6

Subunit structure

Interacts with ERV46. Ref.4 Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note: Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles. Ref.3 Ref.4 Ref.5 Ref.6 Ref.8

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ERGIC family.

Sequence caution

The sequence CAA86253.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ERV46P397273EBI-27850,EBI-20659

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352ER-derived vesicles protein ERV41
PRO_0000203251

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4421Helical; Potential
Topological domain45 – 311267Lumenal Potential
Transmembrane312 – 33221Helical; Potential
Topological domain333 – 35220Cytoplasmic Potential
Motif349 – 3502Isoleucine-leucine motif

Secondary structure

.................................... 352
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q04651 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A9F002FB97666501

FASTA35240,706
        10         20         30         40         50         60 
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY IDQQYVVDSQ 

        70         80         90        100        110        120 
VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL EEMPFFIPYD TKVNDINEII 

       130        140        150        160        170        180 
TPELDEILGE AIPAEFREKL DTRSFFDESD PNKAHLPEFN GCHVFGSIPV NRVSGELQIT 

       190        200        210        220        230        240 
AKSLGYVASR KAPLEELKFN HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV 

       250        260        270        280        290        300 
VPTLFKKLGA EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI 

       310        320        330        340        350 
QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL DR 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
Cho J.-H., Noda Y., Yoda K.
FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 4-10, SUBCELLULAR LOCATION.
[4]"A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
Cho J.-H., Noda Y., Adachi H., Yoda K.
Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
[5]"Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
[6]"The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
Otte S., Barlowe C.
EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRS48331.
RefSeqNP_013644.1. NM_001182426.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortalQ04651.
SMRQ04651. Positions 51-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35099. 111 interactions.
DIPDIP-6791N.
IntActQ04651. 17 interactions.
MINTMINT-640267.

Proteomic databases

MaxQBQ04651.
PaxDbQ04651.
PeptideAtlasQ04651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML067C; YML067C; YML067C.
GeneID854935.
KEGGsce:YML067C.

Organism-specific databases

CYGDYML067c.
SGDS000004532. ERV41.

Phylogenomic databases

eggNOGNOG285181.
HOGENOMHOG000185254.
OMADAFPKVN.
OrthoDBEOG7ZD251.

Enzyme and pathway databases

BioCycYEAST:G3O-32662-MONOMER.

Gene expression databases

GenevestigatorQ04651.

Family and domain databases

InterProIPR012936. Erv_C.
[Graphical view]
PfamPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977974.
PROQ04651.

Entry information

Entry nameERV41_YEAST
AccessionPrimary (citable) accession number: Q04651
Secondary accession number(s): D6VZA6, E9PAD9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references