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Protein

ER-derived vesicles protein ERV41

Gene

ERV41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV41
Gene namesi
Name:ERV41
Ordered Locus Names:YML067C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML067C.
SGDiS000004532. ERV41.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 311LumenalSequence analysisAdd BLAST267
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 352CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle Source: SGD
  • integral component of endoplasmic reticulum membrane Source: SGD
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032511 – 352ER-derived vesicles protein ERV41Add BLAST352

Proteomic databases

MaxQBiQ04651.
PRIDEiQ04651.

Interactioni

Subunit structurei

Interacts with ERV46.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV46P397273EBI-27850,EBI-20659

Protein-protein interaction databases

BioGridi35099. 116 interactors.
DIPiDIP-6791N.
IntActiQ04651. 17 interactors.
MINTiMINT-640267.

Structurei

Secondary structure

1352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 57Combined sources6
Beta strandi63 – 75Combined sources13
Helixi77 – 79Combined sources3
Beta strandi80 – 88Combined sources9
Beta strandi98 – 102Combined sources5
Helixi134 – 136Combined sources3
Helixi157 – 159Combined sources3
Beta strandi162 – 181Combined sources20
Beta strandi184 – 187Combined sources4
Helixi194 – 196Combined sources3
Beta strandi201 – 210Combined sources10
Turni218 – 221Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi233 – 245Combined sources13
Turni246 – 248Combined sources3
Beta strandi250 – 252Combined sources3
Beta strandi254 – 264Combined sources11
Helixi266 – 269Combined sources4
Beta strandi278 – 285Combined sources8
Beta strandi287 – 293Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651.
SMRiQ04651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi349 – 350Isoleucine-leucine motif2

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000185254.
InParanoidiQ04651.
OMAiFYPFINN.
OrthoDBiEOG092C43FV.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY
60 70 80 90 100
IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL
110 120 130 140 150
EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD
160 170 180 190 200
PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN
210 220 230 240 250
HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA
260 270 280 290 300
EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI
310 320 330 340 350
QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL

DR
Length:352
Mass (Da):40,706
Last modified:November 1, 1997 - v1
Checksum:iA9F002FB97666501
GO

Sequence cautioni

The sequence CAA86253 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRiS48331.
RefSeqiNP_013644.1. NM_001182426.1.

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C.
GeneIDi854935.
KEGGisce:YML067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRiS48331.
RefSeqiNP_013644.1. NM_001182426.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651.
SMRiQ04651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35099. 116 interactors.
DIPiDIP-6791N.
IntActiQ04651. 17 interactors.
MINTiMINT-640267.

Proteomic databases

MaxQBiQ04651.
PRIDEiQ04651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C.
GeneIDi854935.
KEGGisce:YML067C.

Organism-specific databases

EuPathDBiFungiDB:YML067C.
SGDiS000004532. ERV41.

Phylogenomic databases

HOGENOMiHOG000185254.
InParanoidiQ04651.
OMAiFYPFINN.
OrthoDBiEOG092C43FV.

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER.

Miscellaneous databases

PROiQ04651.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERV41_YEAST
AccessioniPrimary (citable) accession number: Q04651
Secondary accession number(s): D6VZA6, E9PAD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.