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Protein

ER-derived vesicles protein ERV41

Gene

ERV41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV41
Gene namesi
Name:ERV41
Ordered Locus Names:YML067C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYML067c.
EuPathDBiFungiDB:YML067C.
SGDiS000004532. ERV41.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Topological domaini45 – 311267LumenalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 35220CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle Source: SGD
  • integral component of endoplasmic reticulum membrane Source: SGD
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352ER-derived vesicles protein ERV41PRO_0000203251Add
BLAST

Proteomic databases

MaxQBiQ04651.
PaxDbiQ04651.
PeptideAtlasiQ04651.

Interactioni

Subunit structurei

Interacts with ERV46.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV46P397273EBI-27850,EBI-20659

Protein-protein interaction databases

BioGridi35099. 115 interactions.
DIPiDIP-6791N.
IntActiQ04651. 17 interactions.
MINTiMINT-640267.

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 576Combined sources
Beta strandi63 – 7513Combined sources
Helixi77 – 793Combined sources
Beta strandi80 – 889Combined sources
Beta strandi98 – 1025Combined sources
Helixi134 – 1363Combined sources
Helixi157 – 1593Combined sources
Beta strandi162 – 18120Combined sources
Beta strandi184 – 1874Combined sources
Helixi194 – 1963Combined sources
Beta strandi201 – 21010Combined sources
Turni218 – 2214Combined sources
Beta strandi222 – 2243Combined sources
Beta strandi233 – 24513Combined sources
Turni246 – 2483Combined sources
Beta strandi250 – 2523Combined sources
Beta strandi254 – 26411Combined sources
Helixi266 – 2694Combined sources
Beta strandi278 – 2858Combined sources
Beta strandi287 – 2937Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651.
SMRiQ04651. Positions 51-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi349 – 3502Isoleucine-leucine motif

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285181.
HOGENOMiHOG000185254.
InParanoidiQ04651.
OMAiFYPFINN.
OrthoDBiEOG7ZD251.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY
60 70 80 90 100
IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL
110 120 130 140 150
EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD
160 170 180 190 200
PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN
210 220 230 240 250
HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA
260 270 280 290 300
EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI
310 320 330 340 350
QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL

DR
Length:352
Mass (Da):40,706
Last modified:November 1, 1997 - v1
Checksum:iA9F002FB97666501
GO

Sequence cautioni

The sequence CAA86253.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRiS48331.
RefSeqiNP_013644.1. NM_001182426.1.

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C.
GeneIDi854935.
KEGGisce:YML067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRiS48331.
RefSeqiNP_013644.1. NM_001182426.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651.
SMRiQ04651. Positions 51-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35099. 115 interactions.
DIPiDIP-6791N.
IntActiQ04651. 17 interactions.
MINTiMINT-640267.

Proteomic databases

MaxQBiQ04651.
PaxDbiQ04651.
PeptideAtlasiQ04651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C.
GeneIDi854935.
KEGGisce:YML067C.

Organism-specific databases

CYGDiYML067c.
EuPathDBiFungiDB:YML067C.
SGDiS000004532. ERV41.

Phylogenomic databases

eggNOGiNOG285181.
HOGENOMiHOG000185254.
InParanoidiQ04651.
OMAiFYPFINN.
OrthoDBiEOG7ZD251.

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER.

Miscellaneous databases

NextBioi977974.
PROiQ04651.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
    Cho J.-H., Noda Y., Yoda K.
    FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 4-10, SUBCELLULAR LOCATION.
  4. "A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
    Cho J.-H., Noda Y., Adachi H., Yoda K.
    Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
  5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
    Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
    J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
  6. "The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
    Otte S., Barlowe C.
    EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiERV41_YEAST
AccessioniPrimary (citable) accession number: Q04651
Secondary accession number(s): D6VZA6, E9PAD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.