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Q04651

- ERV41_YEAST

UniProt

Q04651 - ERV41_YEAST

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Protein

ER-derived vesicles protein ERV41

Gene

ERV41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV41
Gene namesi
Name:ERV41
Ordered Locus Names:YML067C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML067c.
SGDiS000004532. ERV41.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein
Note: Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

GO - Cellular componenti

  1. ER to Golgi transport vesicle Source: SGD
  2. integral component of endoplasmic reticulum membrane Source: SGD
  3. integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352ER-derived vesicles protein ERV41PRO_0000203251Add
BLAST

Proteomic databases

MaxQBiQ04651.
PaxDbiQ04651.
PeptideAtlasiQ04651.

Expressioni

Gene expression databases

GenevestigatoriQ04651.

Interactioni

Subunit structurei

Interacts with ERV46.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV46P397273EBI-27850,EBI-20659

Protein-protein interaction databases

BioGridi35099. 111 interactions.
DIPiDIP-6791N.
IntActiQ04651. 17 interactions.
MINTiMINT-640267.

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 576
Beta strandi63 – 7513
Helixi77 – 793
Beta strandi80 – 889
Beta strandi98 – 1025
Helixi134 – 1363
Helixi157 – 1593
Beta strandi162 – 18120
Helixi194 – 1963
Beta strandi201 – 21010
Turni218 – 2214
Beta strandi222 – 2243
Beta strandi233 – 24513
Turni246 – 2483
Beta strandi250 – 2523
Beta strandi254 – 26411
Helixi266 – 2694
Beta strandi278 – 2858
Beta strandi287 – 2937

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZLCX-ray2.00A/B49-297[»]
ProteinModelPortaliQ04651.
SMRiQ04651. Positions 51-293.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini45 – 311267LumenalSequence AnalysisAdd
BLAST
Topological domaini333 – 35220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi349 – 3502Isoleucine-leucine motif

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285181.
HOGENOMiHOG000185254.
InParanoidiQ04651.
OMAiDAFPKVN.
OrthoDBiEOG7ZD251.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04651-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLKTFDAF PKTEEQYKKK STKGGLTSLL TYLFLLFIAW TEFGEYFGGY
60 70 80 90 100
IDQQYVVDSQ VRDTVQINMD IYVNTKCDWL QINVRDQTMD RKLVLEELQL
110 120 130 140 150
EEMPFFIPYD TKVNDINEII TPELDEILGE AIPAEFREKL DTRSFFDESD
160 170 180 190 200
PNKAHLPEFN GCHVFGSIPV NRVSGELQIT AKSLGYVASR KAPLEELKFN
210 220 230 240 250
HVINEFSFGD FYPYIDNPLD NTAQFNQDEP LTTYVYYTSV VPTLFKKLGA
260 270 280 290 300
EVDTNQYSVN DYRYLYKDVA AKGDKMPGIF FKYNFEPLSI VVSDVRLSFI
310 320 330 340 350
QFLVRLVAIC SFLVYCASWI FTLLDMALIT IMGPKWSLRY QPDDKTKGIL

DR
Length:352
Mass (Da):40,706
Last modified:November 1, 1997 - v1
Checksum:iA9F002FB97666501
GO

Sequence cautioni

The sequence CAA86253.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1. Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1.
BK006946 Genomic DNA. Translation: DAA09830.1.
PIRiS48331.
RefSeqiNP_013644.1. NM_001182426.1.

Genome annotation databases

EnsemblFungiiYML067C; YML067C; YML067C.
GeneIDi854935.
KEGGisce:YML067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38114 Genomic DNA. Translation: CAA86253.1 . Sequence problems.
Z38114 Genomic DNA. Translation: CAA86254.1 .
BK006946 Genomic DNA. Translation: DAA09830.1 .
PIRi S48331.
RefSeqi NP_013644.1. NM_001182426.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZLC X-ray 2.00 A/B 49-297 [» ]
ProteinModelPortali Q04651.
SMRi Q04651. Positions 51-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35099. 111 interactions.
DIPi DIP-6791N.
IntActi Q04651. 17 interactions.
MINTi MINT-640267.

Proteomic databases

MaxQBi Q04651.
PaxDbi Q04651.
PeptideAtlasi Q04651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML067C ; YML067C ; YML067C .
GeneIDi 854935.
KEGGi sce:YML067C.

Organism-specific databases

CYGDi YML067c.
SGDi S000004532. ERV41.

Phylogenomic databases

eggNOGi NOG285181.
HOGENOMi HOG000185254.
InParanoidi Q04651.
OMAi DAFPKVN.
OrthoDBi EOG7ZD251.

Enzyme and pathway databases

BioCyci YEAST:G3O-32662-MONOMER.

Miscellaneous databases

NextBioi 977974.
PROi Q04651.

Gene expression databases

Genevestigatori Q04651.

Family and domain databases

InterProi IPR012936. Erv_C.
[Graphical view ]
Pfami PF07970. COPIIcoated_ERV. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Proteins in the early Golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p."
    Cho J.-H., Noda Y., Yoda K.
    FEBS Lett. 469:151-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 4-10, SUBCELLULAR LOCATION.
  4. "A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
    Cho J.-H., Noda Y., Adachi H., Yoda K.
    Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
  5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
    Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
    J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ERV46, SUBCELLULAR LOCATION.
  6. "The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
    Otte S., Barlowe C.
    EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiERV41_YEAST
AccessioniPrimary (citable) accession number: Q04651
Secondary accession number(s): D6VZA6, E9PAD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3