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Protein

Homeobox protein CDX-2

Gene

CDX2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 244HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
Caudal-type homeobox protein 2
Gene namesi
Name:CDX2
Synonyms:CDX-3, CDX3
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488501 – 313Homeobox protein CDX-2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ04649
SMRiQ04649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Poly-Ala8
Compositional biasi113 – 124His-richAdd BLAST12
Compositional biasi249 – 259Poly-GlnAdd BLAST11

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG005302
OrthoDBiEOG091G0LXJ

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA
60 70 80 90 100
AAANLDSAQS PGPSWSTAYG APLREDWNGY PPGGAAAANA VAHGLNGGSP
110 120 130 140 150
AAAMGYSSPA DYHAHHHPHH HPHHPAAAPS CASGLLQTLN PGPPGPAATG
160 170 180 190 200
AAEQLSPSGQ RRNLCEWMRK PAQPSLGSQV KTRTKDKYRV VYTDHQRLEL
210 220 230 240 250
EKEFHYSRYI TIRRKAELAA TLGLSERQVK IWFQNRRAKE RKINKKKLQQ
260 270 280 290 300
QQQQQQQQQL ASPPPQPSQP QPGSLRSVPE PLSPVSSLQG SVPGSVPGVL
310
GPAGGVLNPT VTQ
Length:313
Mass (Da):33,560
Last modified:June 1, 1994 - v1
Checksum:i63C98A9C0DEFD05C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81404 mRNA Translation: CAA57162.1
PIRiA46233
RefSeqiNP_001268630.1, NM_001281701.1

Genome annotation databases

EnsembliENSMAUT00000027774; ENSMAUP00000023761; ENSMAUG00000020822
GeneIDi101841392

Similar proteinsi

Entry informationi

Entry nameiCDX2_MESAU
AccessioniPrimary (citable) accession number: Q04649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health