Q04646 (ATNG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name=Na(+)/K(+) ATPase subunit gamma

Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain

Gene names

Name:	Fxyd2
Synonyms:	Atp1c, Atp1g1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type III membrane protein Potential.
Tissue specificity	Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.
Sequence similarities	Belongs to the FXYD family.
Sequence caution	The sequence CAA49664.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q04646-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q04646-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MAGEISDLSANS → MDRWYL

Isoform 3 (identifier: Q04646-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAGEISDLSAN → MQINTKRRKRCWSLKFDALDSGWKPHKALGCWAAESCCRKTG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 70	70	Sodium/potassium-transporting ATPase subunit gamma		PRO_0000148186
Regions
	Transmembrane	33 – 50	18	Helical; Potential
Natural variations
	Alternative sequence	1 – 12	12	MAGEI…LSANS → MDRWYL in isoform 2.		VSP_001581
	Alternative sequence	1 – 11	11	MAGEISDLSAN → MQINTKRRKRCWSLKFDALD SGWKPHKALGCWAAESCCRK TG in isoform 3.		VSP_001582

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 7114553B004A3422	FASTA	70	7,520
	10 20 30 40 50 60 MAGEISDLSA NSGGSAKGTE NPFEYDYETV RKGGLIFAGL AFVVGLLIIL SKRFRCGGGK 70 KHRQVNEDEL
	Isoform 2 (B) [UniParc]. Checksum: F69EA9B9910250B7	FASTA	64	7,208
	10 20 30 40 50 60 MDRWYLGGSA KGTENPFEYD YETVRKGGLI FAGLAFVVGL LIILSKRFRC GGGKKHRQVN EDEL
	Isoform 3 (C) [UniParc]. Checksum: 090346D9FC2658A6	FASTA	101	11,281
	10 20 30 40 50 60 MQINTKRRKR CWSLKFDALD SGWKPHKALG CWAAESCCRK TGSGGSAKGT ENPFEYDYET 70 80 90 100 VRKGGLIFAG LAFVVGLLII LSKRFRCGGG KKHRQVNEDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse Na+-K+-ATPase gamma-subunit gene (Fxyd2) encodes three developmentally regulated transcripts." Jones D.H., Golding M.C., Barr K.J., Fong G.-H., Kidder G.M. Physiol. Genomics 6:129-135(2001) [PubMed: 11526196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3). Strain: 129/Sv.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: FVB/N. Tissue: Kidney.
[4]	"Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase." Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III J. Cell Biol. 121:579-586(1993) [PubMed: 8387529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-70. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY035583 Genomic DNA. Translation: AAK62036.1. AY035583 Genomic DNA. Translation: AAK62037.1. AY035583 Genomic DNA. Translation: AAK62038.1. AK002215 mRNA. Translation: BAC24981.1. BC024614 mRNA. Translation: AAH24614.1. X70060 mRNA. Translation: CAA49664.1. Different initiation.
IPI	IPI00108584. IPI00227916. IPI00227917.
PIR	C46435.
RefSeq	NP_031529.2. NM_007503.3. NP_439888.1. NM_052823.2.
UniGene	Mm.22742.
3D structure databases
ProteinModelPortal	Q04646.
SMR	Q04646. Positions 27-55.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000041005; ENSMUSP00000035429; ENSMUSG00000059412.
GeneID	11936.
KEGG	mmu:11936.
Organism-specific databases
CTD	486.
MGI	MGI:1195260. Fxyd2.
Phylogenomic databases
GeneTree	ENSGT00530000064417.
HOVERGEN	HBG100880.
OrthoDB	EOG45HS03.
Gene expression databases
Bgee	Q04646.
CleanEx	MM_FXYD2.
Genevestigator	Q04646.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K01538.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280029.
SOURCE	Search...

Entry information

Entry name

ATNG_MOUSE

Accession

Primary (citable) accession number: Q04646
Secondary accession number(s): Q923I2, Q923I3, Q923I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2002
Last modified:	November 16, 2011
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program