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Protein

Sodium/potassium-transporting ATPase subunit gamma

Gene

FXYD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name:
Na(+)/K(+) ATPase subunit gamma
Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain
Gene namesi
Name:FXYD2
Synonyms:ATP1C, ATP1G1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001481841 – 58Sodium/potassium-transporting ATPase subunit gammaAdd BLAST58

Proteomic databases

PaxDbiQ04645.
PRIDEiQ04645.

Expressioni

Tissue specificityi

Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.

Interactioni

Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012957.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XE5X-ray3.90G1-58[»]
ProteinModelPortaliQ04645.
SMRiQ04645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J35I. Eukaryota.
ENOG410Z10F. LUCA.
HOVERGENiHBG100880.
InParanoidiQ04645.

Family and domain databases

InterProiView protein in InterPro
IPR000272. Ion-transport_regulator_FXYD.
PfamiView protein in Pfam
PF02038. ATP1G1_PLM_MAT8. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989. PD005989. 1 hit.
PROSITEiView protein in PROSITE
PS01310. FXYD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVQGTEDP FYYDYETVRN GGLIFAALAF IVGLVIILSK RFRCGAKRQH

RQIPEDGL
Length:58
Mass (Da):6,545
Last modified:October 1, 1993 - v1
Checksum:i54B590B816731183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70059 mRNA. Translation: CAA49663.1.
PIRiD46435.
UniGeneiBt.182.

Entry informationi

Entry nameiATNG_BOVIN
AccessioniPrimary (citable) accession number: Q04645
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families