Q04645 (ATNG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name=Na(+)/K(+) ATPase subunit gamma

Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain

Gene names

Name:	FXYD2
Synonyms:	ATP1C, ATP1G1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	58 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type III membrane protein Potential.
Tissue specificity	Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 58	58	Sodium/potassium-transporting ATPase subunit gamma		PRO_0000148184
Regions
	Transmembrane	20 – 39	20	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q04645 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 54B590B816731183	FASTA	58	6,545
	10 20 30 40 50 MVAVQGTEDP FYYDYETVRN GGLIFAALAF IVGLVIILSK RFRCGAKRQH RQIPEDGL

References

[1]

"Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase." Mercer R.W., Biemesderfer D., Bliss D.P. Jr., Collins J.H., Forbush B. III J. Cell Biol. 121:579-586(1993) [PubMed: 8387529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70059 mRNA. Translation: CAA49663.1.
IPI	IPI00717985.
PIR	D46435.
UniGene	Bt.182.
3D structure databases
ProteinModelPortal	Q04645.
SMR	Q04645. Positions 15-43.
ModBase	Search...
Protein-protein interaction databases
STRING	Q04645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	maNOG21430.
HOVERGEN	HBG100880.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATNG_BOVIN

Accession

Primary (citable) accession number: Q04645

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	October 19, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program