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Protein

Conserved oligomeric Golgi complex subunit 8

Gene

COG8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.1 Publication

GO - Biological processi

  1. CVT pathway Source: SGD
  2. intra-Golgi vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene namesi
Name:COG8
Synonyms:DOR1
Ordered Locus Names:YML071C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML071c.
SGDiS000004536. COG8.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi transport complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Conserved oligomeric Golgi complex subunit 8PRO_0000213525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei410 – 4101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04632.
PaxDbiQ04632.

Expressioni

Gene expression databases

GenevestigatoriQ04632.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COG1P530796EBI-6035,EBI-4835
COG2P532714EBI-6035,EBI-16614
COG5P539513EBI-6035,EBI-4841
COG6P539595EBI-6035,EBI-4829
COG7P531952EBI-6035,EBI-4847

Protein-protein interaction databases

BioGridi35070. 255 interactions.
DIPiDIP-6749N.
IntActiQ04632. 21 interactions.
MINTiMINT-644150.

Structurei

3D structure databases

ProteinModelPortaliQ04632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG8 family.Curated

Phylogenomic databases

eggNOGiNOG237287.
HOGENOMiHOG000111884.
InParanoidiQ04632.
OMAiVYCSFRL.
OrthoDBiEOG7GJ6R5.

Family and domain databases

InterProiIPR007255. COG8.
[Graphical view]
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiPF04124. Dor1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELILNSLIS DDLTEEQKRL SLDFLQDILQ SNTKDYESYF SSRAVPGSIT
60 70 80 90 100
EDIAEIDAEL SALDRKIRKT LLDNTSQIIG NILENDDRAQ LDDIAKSLEQ
110 120 130 140 150
LWELDTNINK AADRNVTNDD INNESVSIDD FLEDDKEDND TGRIMTTESN
160 170 180 190 200
NLARKKKEDE FHKALSRLRN RISTKEDDKD DIRSDTLVTV LENLDSITDL
210 220 230 240 250
MELPFLARTC IRTGHYQEAV MLYTHTTSLR SRFPGSTIVD EVCEKVLNEI
260 270 280 290 300
STTMLSGLVK LLSTNVSVNS LKKILQYLNS IPPFDGKTNK SLLSVFLAMR
310 320 330 340 350
YKFITDEIAS YPLDVESSNE SLIEMMVKRK IEVLREHVYM SLNVFLKSFL
360 370 380 390 400
YDTNDLEIPF PEELESTVLR INGTNEEKEI EEKEKETKKE EYQKQDSVAN
410 420 430 440 450
NEEDVTENKS IEDVQEEVQG KVEGEDDGAE RKTENEIENE TVNKTEDKAE
460 470 480 490 500
KEKEEEVNTK DNKAEKEEEE INKVEVTPEE PSKSIDNKAE KEEEEINKVE
510 520 530 540 550
VTPEEPSKKI RTSKRENKIP TNAVMLQFVD KCITYVLKDL TRGLNSIKLS
560 570 580 590 600
DSVCLQLVYC SFRLCDLNRN YHHLFLKKIN DTSLFTTEQL ARAIDKRAEL

ASKYIYS
Length:607
Mass (Da):69,829
Last modified:November 1, 1997 - v1
Checksum:i57E34E2DE36664B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86249.1.
Z46373 Genomic DNA. Translation: CAA86507.1.
BK006946 Genomic DNA. Translation: DAA09826.1.
PIRiS48326.
RefSeqiNP_013640.1. NM_001182430.1.

Genome annotation databases

EnsemblFungiiYML071C; YML071C; YML071C.
GeneIDi854904.
KEGGisce:YML071C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86249.1.
Z46373 Genomic DNA. Translation: CAA86507.1.
BK006946 Genomic DNA. Translation: DAA09826.1.
PIRiS48326.
RefSeqiNP_013640.1. NM_001182430.1.

3D structure databases

ProteinModelPortaliQ04632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35070. 255 interactions.
DIPiDIP-6749N.
IntActiQ04632. 21 interactions.
MINTiMINT-644150.

Proteomic databases

MaxQBiQ04632.
PaxDbiQ04632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML071C; YML071C; YML071C.
GeneIDi854904.
KEGGisce:YML071C.

Organism-specific databases

CYGDiYML071c.
SGDiS000004536. COG8.

Phylogenomic databases

eggNOGiNOG237287.
HOGENOMiHOG000111884.
InParanoidiQ04632.
OMAiVYCSFRL.
OrthoDBiEOG7GJ6R5.

Enzyme and pathway databases

BioCyciYEAST:G3O-32665-MONOMER.

Miscellaneous databases

NextBioi977888.
PROiQ04632.

Gene expression databases

GenevestigatoriQ04632.

Family and domain databases

InterProiIPR007255. COG8.
[Graphical view]
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiPF04124. Dor1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
    Whyte J.R., Munro S.
    Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
    Loh E., Hong W.
    J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG8_YEAST
AccessioniPrimary (citable) accession number: Q04632
Secondary accession number(s): D6VZA2, Q03641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6440 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.