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Q04632 (COG8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conserved oligomeric Golgi complex subunit 8

Short name=COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene names
Name:COG8
Synonyms:DOR1
Ordered Locus Names:YML071C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Ref.3

Subunit structure

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. Ref.3

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein By similarity.

Miscellaneous

Present with 6440 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the COG8 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 607607Conserved oligomeric Golgi complex subunit 8
PRO_0000213525

Amino acid modifications

Modified residue4101Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q04632 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 57E34E2DE36664B6

FASTA60769,829
        10         20         30         40         50         60 
MELILNSLIS DDLTEEQKRL SLDFLQDILQ SNTKDYESYF SSRAVPGSIT EDIAEIDAEL 

        70         80         90        100        110        120 
SALDRKIRKT LLDNTSQIIG NILENDDRAQ LDDIAKSLEQ LWELDTNINK AADRNVTNDD 

       130        140        150        160        170        180 
INNESVSIDD FLEDDKEDND TGRIMTTESN NLARKKKEDE FHKALSRLRN RISTKEDDKD 

       190        200        210        220        230        240 
DIRSDTLVTV LENLDSITDL MELPFLARTC IRTGHYQEAV MLYTHTTSLR SRFPGSTIVD 

       250        260        270        280        290        300 
EVCEKVLNEI STTMLSGLVK LLSTNVSVNS LKKILQYLNS IPPFDGKTNK SLLSVFLAMR 

       310        320        330        340        350        360 
YKFITDEIAS YPLDVESSNE SLIEMMVKRK IEVLREHVYM SLNVFLKSFL YDTNDLEIPF 

       370        380        390        400        410        420 
PEELESTVLR INGTNEEKEI EEKEKETKKE EYQKQDSVAN NEEDVTENKS IEDVQEEVQG 

       430        440        450        460        470        480 
KVEGEDDGAE RKTENEIENE TVNKTEDKAE KEKEEEVNTK DNKAEKEEEE INKVEVTPEE 

       490        500        510        520        530        540 
PSKSIDNKAE KEEEEINKVE VTPEEPSKKI RTSKRENKIP TNAVMLQFVD KCITYVLKDL 

       550        560        570        580        590        600 
TRGLNSIKLS DSVCLQLVYC SFRLCDLNRN YHHLFLKKIN DTSLFTTEQL ARAIDKRAEL 


ASKYIYS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
Whyte J.R., Munro S.
Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"The binary interacting network of the conserved oligomeric Golgi tethering complex."
Loh E., Hong W.
J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38114 Genomic DNA. Translation: CAA86249.1.
Z46373 Genomic DNA. Translation: CAA86507.1.
BK006946 Genomic DNA. Translation: DAA09826.1.
PIRS48326.
RefSeqNP_013640.1. NM_001182430.1.

3D structure databases

ProteinModelPortalQ04632.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35070. 254 interactions.
DIPDIP-6749N.
IntActQ04632. 21 interactions.
MINTMINT-644150.

Proteomic databases

PaxDbQ04632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML071C; YML071C; YML071C.
GeneID854904.
KEGGsce:YML071C.

Organism-specific databases

CYGDYML071c.
SGDS000004536. COG8.

Phylogenomic databases

eggNOGNOG237287.
HOGENOMHOG000111884.
OMAVYCSFRL.
OrthoDBEOG7GJ6R5.

Enzyme and pathway databases

BioCycYEAST:G3O-32665-MONOMER.

Gene expression databases

GenevestigatorQ04632.

Family and domain databases

InterProIPR007255. COG8.
[Graphical view]
PANTHERPTHR21311. PTHR21311. 1 hit.
PfamPF04124. Dor1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977888.
PROQ04632.

Entry information

Entry nameCOG8_YEAST
AccessionPrimary (citable) accession number: Q04632
Secondary accession number(s): D6VZA2, Q03641
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families