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Q04632

- COG8_YEAST

UniProt

Q04632 - COG8_YEAST

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Protein

Conserved oligomeric Golgi complex subunit 8

Gene
COG8, DOR1, YML071C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. CVT pathway Source: SGD
  2. intra-Golgi vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene namesi
Name:COG8
Synonyms:DOR1
Ordered Locus Names:YML071C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML071c.
SGDiS000004536. COG8.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi transport complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Conserved oligomeric Golgi complex subunit 8PRO_0000213525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei410 – 4101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04632.
PaxDbiQ04632.

Expressioni

Gene expression databases

GenevestigatoriQ04632.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COG1P530796EBI-6035,EBI-4835
COG2P532714EBI-6035,EBI-16614
COG5P539513EBI-6035,EBI-4841
COG6P539595EBI-6035,EBI-4829
COG7P531952EBI-6035,EBI-4847

Protein-protein interaction databases

BioGridi35070. 254 interactions.
DIPiDIP-6749N.
IntActiQ04632. 21 interactions.
MINTiMINT-644150.

Structurei

3D structure databases

ProteinModelPortaliQ04632.

Family & Domainsi

Sequence similaritiesi

Belongs to the COG8 family.

Phylogenomic databases

eggNOGiNOG237287.
HOGENOMiHOG000111884.
OMAiVYCSFRL.
OrthoDBiEOG7GJ6R5.

Family and domain databases

InterProiIPR007255. COG8.
[Graphical view]
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiPF04124. Dor1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04632-1 [UniParc]FASTAAdd to Basket

« Hide

MELILNSLIS DDLTEEQKRL SLDFLQDILQ SNTKDYESYF SSRAVPGSIT    50
EDIAEIDAEL SALDRKIRKT LLDNTSQIIG NILENDDRAQ LDDIAKSLEQ 100
LWELDTNINK AADRNVTNDD INNESVSIDD FLEDDKEDND TGRIMTTESN 150
NLARKKKEDE FHKALSRLRN RISTKEDDKD DIRSDTLVTV LENLDSITDL 200
MELPFLARTC IRTGHYQEAV MLYTHTTSLR SRFPGSTIVD EVCEKVLNEI 250
STTMLSGLVK LLSTNVSVNS LKKILQYLNS IPPFDGKTNK SLLSVFLAMR 300
YKFITDEIAS YPLDVESSNE SLIEMMVKRK IEVLREHVYM SLNVFLKSFL 350
YDTNDLEIPF PEELESTVLR INGTNEEKEI EEKEKETKKE EYQKQDSVAN 400
NEEDVTENKS IEDVQEEVQG KVEGEDDGAE RKTENEIENE TVNKTEDKAE 450
KEKEEEVNTK DNKAEKEEEE INKVEVTPEE PSKSIDNKAE KEEEEINKVE 500
VTPEEPSKKI RTSKRENKIP TNAVMLQFVD KCITYVLKDL TRGLNSIKLS 550
DSVCLQLVYC SFRLCDLNRN YHHLFLKKIN DTSLFTTEQL ARAIDKRAEL 600
ASKYIYS 607
Length:607
Mass (Da):69,829
Last modified:November 1, 1997 - v1
Checksum:i57E34E2DE36664B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38114 Genomic DNA. Translation: CAA86249.1.
Z46373 Genomic DNA. Translation: CAA86507.1.
BK006946 Genomic DNA. Translation: DAA09826.1.
PIRiS48326.
RefSeqiNP_013640.1. NM_001182430.1.

Genome annotation databases

EnsemblFungiiYML071C; YML071C; YML071C.
GeneIDi854904.
KEGGisce:YML071C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38114 Genomic DNA. Translation: CAA86249.1 .
Z46373 Genomic DNA. Translation: CAA86507.1 .
BK006946 Genomic DNA. Translation: DAA09826.1 .
PIRi S48326.
RefSeqi NP_013640.1. NM_001182430.1.

3D structure databases

ProteinModelPortali Q04632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35070. 254 interactions.
DIPi DIP-6749N.
IntActi Q04632. 21 interactions.
MINTi MINT-644150.

Proteomic databases

MaxQBi Q04632.
PaxDbi Q04632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML071C ; YML071C ; YML071C .
GeneIDi 854904.
KEGGi sce:YML071C.

Organism-specific databases

CYGDi YML071c.
SGDi S000004536. COG8.

Phylogenomic databases

eggNOGi NOG237287.
HOGENOMi HOG000111884.
OMAi VYCSFRL.
OrthoDBi EOG7GJ6R5.

Enzyme and pathway databases

BioCyci YEAST:G3O-32665-MONOMER.

Miscellaneous databases

NextBioi 977888.
PROi Q04632.

Gene expression databases

Genevestigatori Q04632.

Family and domain databases

InterProi IPR007255. COG8.
[Graphical view ]
PANTHERi PTHR21311. PTHR21311. 1 hit.
Pfami PF04124. Dor1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
    Whyte J.R., Munro S.
    Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
    Loh E., Hong W.
    J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG8_YEAST
AccessioniPrimary (citable) accession number: Q04632
Secondary accession number(s): D6VZA2, Q03641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6440 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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