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Protein

Conserved oligomeric Golgi complex subunit 8

Gene

COG8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.1 Publication

Miscellaneous

Present with 6440 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • CVT pathway Source: SGD
  • intra-Golgi vesicle-mediated transport Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene namesi
Name:COG8
Synonyms:DOR1
Ordered Locus Names:YML071C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML071C.
SGDiS000004536. COG8.

Subcellular locationi

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • Golgi transport complex Source: SGD

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135251 – 607Conserved oligomeric Golgi complex subunit 8Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei410PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04632.
PRIDEiQ04632.

PTM databases

iPTMnetiQ04632.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35070. 376 interactors.
DIPiDIP-6749N.
IntActiQ04632. 21 interactors.
MINTiMINT-644150.
STRINGi4932.YML071C.

Structurei

3D structure databases

ProteinModelPortaliQ04632.
SMRiQ04632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG8 family.Curated

Phylogenomic databases

HOGENOMiHOG000111884.
InParanoidiQ04632.
KOiK20295.
OMAiLVYCSFR.
OrthoDBiEOG092C2XUZ.

Family and domain databases

InterProiView protein in InterPro
IPR007255. COG8.
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiView protein in Pfam
PF04124. Dor1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELILNSLIS DDLTEEQKRL SLDFLQDILQ SNTKDYESYF SSRAVPGSIT
60 70 80 90 100
EDIAEIDAEL SALDRKIRKT LLDNTSQIIG NILENDDRAQ LDDIAKSLEQ
110 120 130 140 150
LWELDTNINK AADRNVTNDD INNESVSIDD FLEDDKEDND TGRIMTTESN
160 170 180 190 200
NLARKKKEDE FHKALSRLRN RISTKEDDKD DIRSDTLVTV LENLDSITDL
210 220 230 240 250
MELPFLARTC IRTGHYQEAV MLYTHTTSLR SRFPGSTIVD EVCEKVLNEI
260 270 280 290 300
STTMLSGLVK LLSTNVSVNS LKKILQYLNS IPPFDGKTNK SLLSVFLAMR
310 320 330 340 350
YKFITDEIAS YPLDVESSNE SLIEMMVKRK IEVLREHVYM SLNVFLKSFL
360 370 380 390 400
YDTNDLEIPF PEELESTVLR INGTNEEKEI EEKEKETKKE EYQKQDSVAN
410 420 430 440 450
NEEDVTENKS IEDVQEEVQG KVEGEDDGAE RKTENEIENE TVNKTEDKAE
460 470 480 490 500
KEKEEEVNTK DNKAEKEEEE INKVEVTPEE PSKSIDNKAE KEEEEINKVE
510 520 530 540 550
VTPEEPSKKI RTSKRENKIP TNAVMLQFVD KCITYVLKDL TRGLNSIKLS
560 570 580 590 600
DSVCLQLVYC SFRLCDLNRN YHHLFLKKIN DTSLFTTEQL ARAIDKRAEL

ASKYIYS
Length:607
Mass (Da):69,829
Last modified:November 1, 1997 - v1
Checksum:i57E34E2DE36664B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38114 Genomic DNA. Translation: CAA86249.1.
Z46373 Genomic DNA. Translation: CAA86507.1.
BK006946 Genomic DNA. Translation: DAA09826.1.
PIRiS48326.
RefSeqiNP_013640.1. NM_001182430.1.

Genome annotation databases

EnsemblFungiiYML071C; YML071C; YML071C.
GeneIDi854904.
KEGGisce:YML071C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOG8_YEAST
AccessioniPrimary (citable) accession number: Q04632
Secondary accession number(s): D6VZA2, Q03641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names