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Protein

Palmitoyltransferase SWF1

Gene

SWF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • cortical actin cytoskeleton organization Source: SGD
  • establishment of cell polarity Source: SGD
  • protein palmitoylation Source: UniProtKB
  • regulation of exocytosis Source: SGD
  • vacuole fusion, non-autophagic Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-29726-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase SWF1 (EC:2.3.1.225)
Alternative name(s):
Spore wall formation protein 1
Gene namesi
Name:SWF1
Synonyms:PSL10
Ordered Locus Names:YDR126W
ORF Names:YD9302.01, YD9727.21
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR126W
SGDiS000002533 SWF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 50CytoplasmicSequence analysisAdd BLAST27
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 86LumenalSequence analysisAdd BLAST15
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 179CytoplasmicSequence analysisAdd BLAST72
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 216LumenalSequence analysisAdd BLAST16
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 336CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164C → A: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129941 – 336Palmitoyltransferase SWF1Add BLAST336

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ04629
PaxDbiQ04629
PRIDEiQ04629

Interactioni

Protein-protein interaction databases

BioGridi32182, 458 interactors
DIPiDIP-8105N
IntActiQ04629, 2 interactors
MINTiQ04629
STRINGi4932.YDR126W

Structurei

3D structure databases

ProteinModelPortaliQ04629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 184DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000154460
InParanoidiQ04629
KOiK20003
OMAiNEQDKWY
OrthoDBiEOG092C41AH

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q04629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWNLLFVLL IGFVVLILLS PVFKSTWPFS TFYRNVFQPF LVDDQKYRWK
60 70 80 90 100
LHLVPLFYTS IYLYLVYTYH MRVESTIKNE LFLLERILIV PIIILPPVAL
110 120 130 140 150
GILAMVSRAE DSKDHKSGST EEYPYDYLLY YPAIKCSTCR IVKPARSKHC
160 170 180 190 200
SICNRCVLVA DHHCIWINNC IGKGNYLQFY LFLISNIFSM CYAFLRLWYI
210 220 230 240 250
SLNSTSTLPR AVLTLTILCG CFTIICAIFT YLQLAIVKEG MTTNEQDKWY
260 270 280 290 300
TIQEYMREGK LVRSLDDDCP SWFFKCTEQK DDAAEPLQDQ HVTFYSTNAY
310 320 330
DHKHYNLTHY ITIKDASEIP NIYDKGTFLA NLTDLI
Length:336
Mass (Da):39,312
Last modified:March 1, 2001 - v2
Checksum:i1F61B9809383A94C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA Translation: CAA88679.1
Z48179 Genomic DNA Translation: CAA88207.1
AY557692 Genomic DNA Translation: AAS56018.1
BK006938 Genomic DNA Translation: DAA11972.1
PIRiS52691
RefSeqiNP_010411.1, NM_001180434.1

Genome annotation databases

EnsemblFungiiYDR126W; YDR126W; YDR126W
GeneIDi851704
KEGGisce:YDR126W

Similar proteinsi

Entry informationi

Entry nameiSWF1_YEAST
AccessioniPrimary (citable) accession number: Q04629
Secondary accession number(s): D6VSB2, Q03889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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