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Protein

Protein ECM18

Gene

ECM18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell wall organization and biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-29725-MONOMER.
ReactomeiR-SCE-1483152. Hydrolysis of LPE.

Protein family/group databases

ESTHERiyeast-ECM18. CGI-58_ABHD5_ABHD4.
MEROPSiS33.A42.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ECM18 (EC:2.3.1.-)
Alternative name(s):
Extracellular mutant protein 18
Gene namesi
Name:ECM18
Ordered Locus Names:YDR125C
ORF Names:YD9727.20C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR125C.
SGDiS000002532. ECM18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Protein ECM18PRO_0000086914Add
BLAST

Proteomic databases

PRIDEiQ04623.

Interactioni

Protein-protein interaction databases

BioGridi32181. 5 interactions.
MINTiMINT-4480946.

Structurei

3D structure databases

ProteinModelPortaliQ04623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi428 – 4336HXXXXD motifBy similarity

Domaini

The HXXXXD motif is essential for acyltransferase activity.By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016277.
HOGENOMiHOG000065957.
InParanoidiQ04623.
OMAiPLGVERN.
OrthoDBiEOG793BKF.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequencei

Sequence statusi: Complete.

Q04623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIKRYLMD PESLRRQIMN VYKCYMWKRA FHSNRSLLEV KRREKSLQRK
60 70 80 90 100
ILERILRPKE ENAVKKSGFK LWSSHLNNPH KTYMRLEELQ RRIMEEVHVE
110 120 130 140 150
GIKKNDKLFN EINQWHFQNE NTSTVRTPTL LIHGYAASSM SFFRNYPGLS
160 170 180 190 200
KHIRNLYSID MPASGLSSVP SLEINTTTPL PLDIKFIGEN KFKVPYTINA
210 220 230 240 250
NHNKFVIQMY EDFYLDRIEQ WRIDNKLGKM NVVGHSFGGY LSFKYAVKYP
260 270 280 290 300
NSVNKLCLVS PLGVERNIWS VNNNFHSNTL YTIDFKNPNS KFYSKRNMIP
310 320 330 340 350
KYLFEQQFHI LRMMGPLGAK LCWNYIMAAY SRVPSLAYKE YIFELFYGKG
360 370 380 390 400
GIPEVTTDIF KALFSRCILA KDPLMDSLQY LNVKKLLIVY GQYDWMNKKA
410 420 430 440 450
GMFMVKELNN LKNCLEGASY LEIPSSGHNL FLDNPESFNQ SIVSFLSDET

KSP
Length:453
Mass (Da):53,185
Last modified:November 1, 1996 - v1
Checksum:iA927A846375B10CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA. Translation: CAA88678.1.
BK006938 Genomic DNA. Translation: DAA11971.1.
PIRiS52690.
RefSeqiNP_010410.3. NM_001180433.3.

Genome annotation databases

EnsemblFungiiYDR125C; YDR125C; YDR125C.
GeneIDi851703.
KEGGisce:YDR125C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA. Translation: CAA88678.1.
BK006938 Genomic DNA. Translation: DAA11971.1.
PIRiS52690.
RefSeqiNP_010410.3. NM_001180433.3.

3D structure databases

ProteinModelPortaliQ04623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32181. 5 interactions.
MINTiMINT-4480946.

Protein family/group databases

ESTHERiyeast-ECM18. CGI-58_ABHD5_ABHD4.
MEROPSiS33.A42.

Proteomic databases

PRIDEiQ04623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR125C; YDR125C; YDR125C.
GeneIDi851703.
KEGGisce:YDR125C.

Organism-specific databases

EuPathDBiFungiDB:YDR125C.
SGDiS000002532. ECM18.

Phylogenomic databases

GeneTreeiENSGT00390000016277.
HOGENOMiHOG000065957.
InParanoidiQ04623.
OMAiPLGVERN.
OrthoDBiEOG793BKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-29725-MONOMER.
ReactomeiR-SCE-1483152. Hydrolysis of LPE.

Miscellaneous databases

PROiQ04623.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae."
    Lussier M., White A.-M., Sheraton J., di Paolo T., Treadwell J., Southard S.B., Horenstein C.I., Chen-Weiner J., Ram A.F.J., Kapteyn J.C., Roemer T.W., Vo D.H., Bondoc D.C., Hall J., Zhong W.-W., Sdicu A.-M., Davies J., Klis F.M., Robbins P.W., Bussey H.
    Genetics 147:435-450(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiECM18_YEAST
AccessioniPrimary (citable) accession number: Q04623
Secondary accession number(s): D6VSB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 143 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.