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Protein

Protein ECM18

Gene

ECM18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell wall organization and biogenesis.

Miscellaneous

Present with 143 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-29725-MONOMER
ReactomeiR-SCE-1482839 Acyl chain remodelling of PE

Protein family/group databases

ESTHERiyeast-ECM18 CGI-58_ABHD5_ABHD4
MEROPSiS33.A42

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ECM18 (EC:2.3.1.-)
Alternative name(s):
Extracellular mutant protein 18
Gene namesi
Name:ECM18
Ordered Locus Names:YDR125C
ORF Names:YD9727.20C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR125C
SGDiS000002532 ECM18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869141 – 453Protein ECM18Add BLAST453

Proteomic databases

PaxDbiQ04623
PRIDEiQ04623

Interactioni

Protein-protein interaction databases

BioGridi32181, 28 interactors
STRINGi4932.YDR125C

Structurei

3D structure databases

ProteinModelPortaliQ04623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 435AB hydrolase-1Sequence analysisAdd BLAST306

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi428 – 433HXXXXD motifBy similarity6

Domaini

The HXXXXD motif is essential for acyltransferase activity.By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016277
HOGENOMiHOG000065957
InParanoidiQ04623
OMAiYDFMNSE
OrthoDBiEOG092C49VO

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits

Sequencei

Sequence statusi: Complete.

Q04623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIKRYLMD PESLRRQIMN VYKCYMWKRA FHSNRSLLEV KRREKSLQRK
60 70 80 90 100
ILERILRPKE ENAVKKSGFK LWSSHLNNPH KTYMRLEELQ RRIMEEVHVE
110 120 130 140 150
GIKKNDKLFN EINQWHFQNE NTSTVRTPTL LIHGYAASSM SFFRNYPGLS
160 170 180 190 200
KHIRNLYSID MPASGLSSVP SLEINTTTPL PLDIKFIGEN KFKVPYTINA
210 220 230 240 250
NHNKFVIQMY EDFYLDRIEQ WRIDNKLGKM NVVGHSFGGY LSFKYAVKYP
260 270 280 290 300
NSVNKLCLVS PLGVERNIWS VNNNFHSNTL YTIDFKNPNS KFYSKRNMIP
310 320 330 340 350
KYLFEQQFHI LRMMGPLGAK LCWNYIMAAY SRVPSLAYKE YIFELFYGKG
360 370 380 390 400
GIPEVTTDIF KALFSRCILA KDPLMDSLQY LNVKKLLIVY GQYDWMNKKA
410 420 430 440 450
GMFMVKELNN LKNCLEGASY LEIPSSGHNL FLDNPESFNQ SIVSFLSDET

KSP
Length:453
Mass (Da):53,185
Last modified:November 1, 1996 - v1
Checksum:iA927A846375B10CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA Translation: CAA88678.1
BK006938 Genomic DNA Translation: DAA11971.1
PIRiS52690
RefSeqiNP_010410.3, NM_001180433.3

Genome annotation databases

EnsemblFungiiYDR125C; YDR125C; YDR125C
GeneIDi851703
KEGGisce:YDR125C

Similar proteinsi

Entry informationi

Entry nameiECM18_YEAST
AccessioniPrimary (citable) accession number: Q04623
Secondary accession number(s): D6VSB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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