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Protein

Heat shock cognate protein HSP 90-beta

Gene

HSP90AB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from Hsp90 which acquires an open conformation for the next cycle.By similarity

Miscellaneous

In contrast to other HSP90 heat shock proteins, this one is not induced by heat shock or mitogenic stimuli but is strictly constitutive.

Enzyme regulationi

In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPBy similarity1
Binding sitei88ATPBy similarity1
Binding sitei107ATPBy similarity1
Binding sitei133ATP; via amide nitrogenBy similarity1
Binding sitei393ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock cognate protein HSP 90-beta
Gene namesi
Name:HSP90AB1
Synonyms:HSPCB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629231 – 725Heat shock cognate protein HSP 90-betaAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04619
PRIDEiQ04619

Interactioni

Subunit structurei

Monomer. Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676448, 6 interactors
STRINGi9031.ENSGALP00000037355

Structurei

3D structure databases

ProteinModelPortaliQ04619
SMRiQ04619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi721 – 725TPR repeat-binding5

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
KOG0020 Eukaryota
COG0326 LUCA
HOGENOMiHOG000031988
HOVERGENiHBG007374
InParanoidiQ04619
KOiK04079
PhylomeDBiQ04619

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

Q04619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQVQHGED EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDTGKD LKIDIVPNPR DPTLTLLDTG IGMTKADLVN
110 120 130 140 150
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN
160 170 180 190 200
DDEQYAWESS AGGSFTVRTD HGEPIGRGTK VILYLKEDQT EYLEERRVKE
210 220 230 240 250
VVKKHSQFIG YPITLYVEKE REKEVSDDEA EEEKVEKEEE ESKDEEKPKI
260 270 280 290 300
EDVGSDEEEE EGEKSKKKKT KKIKEKYIDQ EELNKTKPIW TRNPDDITQE
310 320 330 340 350
EYGEFYKSLT NDWEDHLAVK HFSVEGQLEF RALLFIPRRA PFDLFENKKK
360 370 380 390 400
KNNIKLYVRR VFIMDSCDEL IPEYLNFIRG VVDSEDLPLN ISREMLQQSK
410 420 430 440 450
ILKVIRKNIV KKCLELFTEL AEDKENYKKF YEAFSKNLKL GIHEDSTNRK
460 470 480 490 500
RLSELLRYHT SQSGDEMTSL SEYVSRMKES QKSIYYITGE SKEQVANSAF
510 520 530 540 550
VERVRKRGFE VVYMTEPIDE YCVQQLKEFD GKTLVSVTKE GLELPEDEEE
560 570 580 590 600
KKNMEESKAK FETLCKLMKE ILDKKVEKVT ISNRLVSSPC CIVTSTYGWT
610 620 630 640 650
ANMERIMKAQ ALRDNSTMGY MMAKKHLEIN PDHPIVETLR QKADANKNDK
660 670 680 690 700
AVKDLVVLLF ETALLSSGFS LEDPQTHSNR IYRMIKLGLG IDEDEVIAEE
710 720
SSIAPPDEIP PLEGDEDTSR MEEVD
Length:725
Mass (Da):83,427
Last modified:October 1, 1993 - v1
Checksum:iC0BF463D3219422F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70101 mRNA Translation: CAA49704.1
PIRiJC1468
RefSeqiNP_996842.1, NM_206959.1
UniGeneiGga.4332

Genome annotation databases

GeneIDi396188
KEGGigga:396188

Similar proteinsi

Entry informationi

Entry nameiHS90B_CHICK
AccessioniPrimary (citable) accession number: Q04619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health