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Protein

Heat shock cognate protein HSP 90-beta

Gene

HSP90AB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPBy similarity
Binding sitei88 – 881ATPBy similarity
Binding sitei107 – 1071ATPBy similarity
Binding sitei133 – 1331ATP; via amide nitrogenBy similarity
Binding sitei393 – 3931ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock cognate protein HSP 90-beta
Gene namesi
Name:HSP90AB1
Synonyms:HSPCB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: AgBase
  • melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Heat shock cognate protein HSP 90-betaPRO_0000062923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei255 – 2551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04619.
PRIDEiQ04619.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi676448. 6 interactions.
STRINGi9031.ENSGALP00000037355.

Structurei

3D structure databases

ProteinModelPortaliQ04619.
SMRiQ04619. Positions 11-219, 286-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi721 – 7255TPR repeat-binding

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiQ04619.
KOiK04079.
PhylomeDBiQ04619.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQVQHGED EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDTGKD LKIDIVPNPR DPTLTLLDTG IGMTKADLVN
110 120 130 140 150
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN
160 170 180 190 200
DDEQYAWESS AGGSFTVRTD HGEPIGRGTK VILYLKEDQT EYLEERRVKE
210 220 230 240 250
VVKKHSQFIG YPITLYVEKE REKEVSDDEA EEEKVEKEEE ESKDEEKPKI
260 270 280 290 300
EDVGSDEEEE EGEKSKKKKT KKIKEKYIDQ EELNKTKPIW TRNPDDITQE
310 320 330 340 350
EYGEFYKSLT NDWEDHLAVK HFSVEGQLEF RALLFIPRRA PFDLFENKKK
360 370 380 390 400
KNNIKLYVRR VFIMDSCDEL IPEYLNFIRG VVDSEDLPLN ISREMLQQSK
410 420 430 440 450
ILKVIRKNIV KKCLELFTEL AEDKENYKKF YEAFSKNLKL GIHEDSTNRK
460 470 480 490 500
RLSELLRYHT SQSGDEMTSL SEYVSRMKES QKSIYYITGE SKEQVANSAF
510 520 530 540 550
VERVRKRGFE VVYMTEPIDE YCVQQLKEFD GKTLVSVTKE GLELPEDEEE
560 570 580 590 600
KKNMEESKAK FETLCKLMKE ILDKKVEKVT ISNRLVSSPC CIVTSTYGWT
610 620 630 640 650
ANMERIMKAQ ALRDNSTMGY MMAKKHLEIN PDHPIVETLR QKADANKNDK
660 670 680 690 700
AVKDLVVLLF ETALLSSGFS LEDPQTHSNR IYRMIKLGLG IDEDEVIAEE
710 720
SSIAPPDEIP PLEGDEDTSR MEEVD
Length:725
Mass (Da):83,427
Last modified:October 1, 1993 - v1
Checksum:iC0BF463D3219422F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70101 mRNA. Translation: CAA49704.1.
PIRiJC1468.
RefSeqiNP_996842.1. NM_206959.1.
UniGeneiGga.4332.

Genome annotation databases

GeneIDi396188.
KEGGigga:396188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70101 mRNA. Translation: CAA49704.1.
PIRiJC1468.
RefSeqiNP_996842.1. NM_206959.1.
UniGeneiGga.4332.

3D structure databases

ProteinModelPortaliQ04619.
SMRiQ04619. Positions 11-219, 286-689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676448. 6 interactions.
STRINGi9031.ENSGALP00000037355.

Proteomic databases

PaxDbiQ04619.
PRIDEiQ04619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396188.
KEGGigga:396188.

Organism-specific databases

CTDi3326.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiQ04619.
KOiK04079.
PhylomeDBiQ04619.

Miscellaneous databases

PROiQ04619.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS90B_CHICK
AccessioniPrimary (citable) accession number: Q04619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to other HSP90 heat shock proteins, this one is not induced by heat shock or mitogenic stimuli but is strictly constitutive.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.