Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar basic amino acid transporter 4

Gene

VBA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter required for vacuolar uptake of basic amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29719-MONOMER

Protein family/group databases

TCDBi2.A.1.48.5 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar basic amino acid transporter 4
Gene namesi
Name:VBA4
Ordered Locus Names:YDR119W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR119W
SGDiS000002526 VBA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 252CytoplasmicSequence analysisAdd BLAST252
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 282VacuolarSequence analysis9
Transmembranei283 – 305HelicalSequence analysisAdd BLAST23
Topological domaini306 – 311CytoplasmicSequence analysis6
Transmembranei312 – 331HelicalSequence analysisAdd BLAST20
Topological domaini332 – 334VacuolarSequence analysis3
Transmembranei335 – 357HelicalSequence analysisAdd BLAST23
Topological domaini358 – 375CytoplasmicSequence analysisAdd BLAST18
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 406VacuolarSequence analysis10
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 447CytoplasmicSequence analysisAdd BLAST20
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 481VacuolarSequence analysisAdd BLAST13
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 522CytoplasmicSequence analysisAdd BLAST20
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 562VacuolarSequence analysisAdd BLAST19
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 587CytoplasmicSequence analysis4
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Topological domaini609 – 617VacuolarSequence analysis9
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Topological domaini639 – 653CytoplasmicSequence analysisAdd BLAST15
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 734VacuolarSequence analysisAdd BLAST60
Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 768CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522721 – 768Vacuolar basic amino acid transporter 4Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ04602
PaxDbiQ04602
PRIDEiQ04602

PTM databases

iPTMnetiQ04602

Interactioni

Protein-protein interaction databases

BioGridi32175, 71 interactors
DIPiDIP-8662N
STRINGi4932.YDR119W

Structurei

3D structure databases

ProteinModelPortaliQ04602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 40Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ04602
OrthoDBiEOG092C0OX1

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q04602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKDRQRKK LREFAKLKNR QRNLRKSVQT LKNEVQREAK VPRTSNQIAL
60 70 80 90 100
GNDKIEEINE NSPLLSAPSK QEEVSIPKAV DIDTIDAQPL HEGPKIDDSP
110 120 130 140 150
QDEVNSIKGK PADKANEDDL KPPSQHEACG NSALQSSITD FSDRSVSPLQ
160 170 180 190 200
SITSCNTPMS EHELPVSSSN SFERADDMPV VQADNQTSSS KSLHIVAPSP
210 220 230 240 250
EVPVSGDEIT SYGYGSIPQS IGDVENGLNP PYVENTSSDE LVHDLTRRRI
260 270 280 290 300
FSSCMCTYLF FIAMDSSIIL VIASKIASEF HELWRLSLVI SAYLLSNAIG
310 320 330 340 350
QLVFLKLSLI SSVKLLLCIA QFSFILGGYL SWSSAHFWTF IFARCVTGFG
360 370 380 390 400
GGSLIALKST IMNRFSQKND SRYSLSASMI TFAMGVVIGP FMMNLFDSSH
410 420 430 440 450
GSGWRNAFLI PVPFCLVNAS IMLADMYSVK STLYGRPTPT LWKRFKNTLL
460 470 480 490 500
SPDLYEILTL TLFLLCFVQV TSLDLTGLKN NTMIQALLFS VIIVCGILFF
510 520 530 540 550
LIETSDTYMN SVISMSLQGD KRLIWTMIGI SFCFAALMCI IPFGTTYFII
560 570 580 590 600
VLNLSTLQLA ERLSPFFFSI VLGYFSVSYF WKSKGQNFLL KFVLSGATLL
610 620 630 640 650
LYVALMGVSL NLPVWKQYIC LSLPFLGSSM ILTLLSNLYH EYHEQRKSPI
660 670 680 690 700
SGSIVYCFGA VGGTVGISLG GYVFHKTLIK LMHEKVMPFS KQGYLKKDLL
710 720 730 740 750
KIIKHATESS DWVHESAPKF VFQTLIECYL QACRNVFKLS TLFFTITVVA
760
IFIFNRIHCR SQNCLSLS
Length:768
Mass (Da):85,683
Last modified:November 1, 1996 - v1
Checksum:i08495E43E011C099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA Translation: CAA88672.1
BK006938 Genomic DNA Translation: DAA11964.1
PIRiS52684
RefSeqiNP_010404.1, NM_001180427.1

Genome annotation databases

EnsemblFungiiYDR119W; YDR119W; YDR119W
GeneIDi851697
KEGGisce:YDR119W

Similar proteinsi

Entry informationi

Entry nameiVBA4_YEAST
AccessioniPrimary (citable) accession number: Q04602
Secondary accession number(s): D6VSA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health