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Protein

Translation machinery-associated protein 64

Gene

TMA64

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: SGD
  • translation initiation factor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-29717-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 64
Gene namesi
Name:TMA64
Ordered Locus Names:YDR117C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR117C
SGDiS000002524 TMA64

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002446401 – 565Translation machinery-associated protein 64Add BLAST565

Proteomic databases

MaxQBiQ04600
PaxDbiQ04600
PRIDEiQ04600

PTM databases

iPTMnetiQ04600

Interactioni

Subunit structurei

Interacts with the 40S ribosomal subunit.1 Publication

Protein-protein interaction databases

BioGridi32173, 235 interactors
IntActiQ04600, 14 interactors
MINTiQ04600
STRINGi4932.YDR117C

Structurei

3D structure databases

ProteinModelPortaliQ04600
SMRiQ04600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 170PUAPROSITE-ProRule annotationAdd BLAST82
Domaini363 – 446SWIBAdd BLAST84
Domaini475 – 547SUI1PROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi558 – 565Poly-Lys8

Domaini

The PUA and the SUI1 domains may be involved in RNA binding.1 Publication

Sequence similaritiesi

Belongs to the eIF2D family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074865
HOGENOMiHOG000248777
InParanoidiQ04600
KOiK15027
OMAiPKEFGHR
OrthoDBiEOG092C46NJ

Family and domain databases

Gene3Di1.10.245.10, 1 hit
2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PF02201 SWIB, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF55159 SSF55159, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Q04600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKEPHIKA LSNLKNSERK KLLQTFQKQT NNEEYSFRTS TIKQTNFNGQ
60 70 80 90 100
KSVGTVYTDE NNTPILFKEK HKEQLFPTVY SCWEYPALLP IVLTHGFVIE
110 120 130 140 150
EHLFNGANLM ISGSIPPFDP RCKIGTLCGI ASKQAPETVL AIGIVELDLP
160 170 180 190 200
SFDKVIGETG VAVKIIHHFN DGLSKVFKMK LEPPFVLSTQ SKDNNISSKQ
210 220 230 240 250
IESSEQIKAV EKEQEDVKEA SVDVEEIAEV LDHFTVSDVD YFITRALYYT
260 270 280 290 300
LTQDKGLELP ISASNFISNH IMRNLPPIDH NEVNVKKTSW KKSAKFLKHF
310 320 330 340 350
EKEGFLKLKG KGDDLTIVGK NTDKDELKNF VPYKLGCSKS ATESRESTTS
360 370 380 390 400
KEKTSGMMYS LTLYKPFNLA KDLLKEVNLA SHTYYTSQDI RSAVSQYISV
410 420 430 440 450
KNLADTKDKG KVIMDDLLFD MVNKKKKVLN ASRIIARGEI LHPLLTNNFT
460 470 480 490 500
EFYQIFKSDD TLLFKAPMKG SLPHIKIITE MKIGRKVITR VSNFEVFQVD
510 520 530 540 550
PESLAADLRK ICSGSTTISE SQTFKCAEVQ VQGPHGQSII DHLNKLGIPS
560
KWIDFENKLK KKKRK
Length:565
Mass (Da):63,992
Last modified:November 1, 1996 - v1
Checksum:i2ED921EFABEF3739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA Translation: CAA88670.1
BK006938 Genomic DNA Translation: DAA11962.1
PIRiS52682
RefSeqiNP_010402.3, NM_001180425.3

Genome annotation databases

EnsemblFungiiYDR117C; YDR117C; YDR117C
GeneIDi851695
KEGGisce:YDR117C

Similar proteinsi

Entry informationi

Entry nameiTMA64_YEAST
AccessioniPrimary (citable) accession number: Q04600
Secondary accession number(s): D6VSA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health