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Protein

54S ribosomal protein L1, mitochondrial

Gene

MRPL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 7000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29716-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L1, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL1m1 Publication
Gene namesi
Name:MRPL1
Ordered Locus Names:YDR116C
ORF Names:YD9727.11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR116C
SGDiS000002523 MRPL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030479? – 28554S ribosomal protein L1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ04599
PaxDbiQ04599
PRIDEiQ04599

PTM databases

iPTMnetiQ04599

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.1 Publication

Protein-protein interaction databases

BioGridi32172, 336 interactors
DIPiDIP-5223N
IntActiQ04599, 12 interactors
MINTiQ04599
STRINGi4932.YDR116C

Structurei

3D structure databases

ProteinModelPortaliQ04599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000248778
InParanoidiQ04599
OMAiQFSLCDA
OrthoDBiEOG092C4774

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR002143 Ribosomal_L1
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR023673 Ribosomal_L1_CS
IPR005879 Ribosomal_L1_mit
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
PIRSFiPIRSF002155 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
TIGRFAMsiTIGR01170 rplA_mito, 1 hit
PROSITEiView protein in PROSITE
PS01199 RIBOSOMAL_L1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVVAIPKI CVTGPARRCF FHTAKKLYAD DYKPAAMSSN APSLTKDQAK
60 70 80 90 100
KRELKRLVQR KAEAKRPATA SPLYMPVTKA LRYLRAAEVG RPQSQQTINL
110 120 130 140 150
TTLVVGERGT APLSGSVTFP KPLRYIKIAA FTNDESKLEE LREKYPNHLI
160 170 180 190 200
GGADLVAKIK SGEISVDFDK AFATPDIVPA LQSQVARILG PRGVLPSVKK
210 220 230 240 250
GTVSDDISSL LQESLGSMPF RQRGNSISIG VGKCYFTDRE ILQNIISARA
260 270 280
AFKTAVDNQK SKKPNILSKT TLSSTHGPGI VIDFA
Length:285
Mass (Da):30,996
Last modified:November 1, 1996 - v1
Checksum:i59DB6C5D10421A77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48758 Genomic DNA Translation: CAA88669.1
AY557683 Genomic DNA Translation: AAS56009.1
BK006938 Genomic DNA Translation: DAA11961.1
PIRiS52681
RefSeqiNP_010401.1, NM_001180424.1

Genome annotation databases

EnsemblFungiiYDR116C; YDR116C; YDR116C
GeneIDi851694
KEGGisce:YDR116C

Similar proteinsi

Entry informationi

Entry nameiRM01_YEAST
AccessioniPrimary (citable) accession number: Q04599
Secondary accession number(s): D6VSA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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