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Q04592

- PCSK5_MOUSE

UniProt

Q04592 - PCSK5_MOUSE

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Protein
Proprotein convertase subtilisin/kexin type 5
Gene
Pcsk5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors By similarity.

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1172Cleavage; by autolysis By similarity
Active sitei173 – 1731Charge relay system By similarity
Active sitei214 – 2141Charge relay system By similarity
Active sitei388 – 3881Charge relay system By similarity

GO - Molecular functioni

  1. endopeptidase activity Source: BHF-UCL
  2. peptidase activity Source: MGI
  3. peptide binding Source: BHF-UCL
  4. serine-type endopeptidase activity Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior pattern specification Source: BHF-UCL
  2. cytokine biosynthetic process Source: BHF-UCL
  3. embryo implantation Source: BHF-UCL
  4. embryonic digestive tract development Source: BHF-UCL
  5. embryonic skeletal system development Source: BHF-UCL
  6. heart development Source: BHF-UCL
  7. kidney development Source: BHF-UCL
  8. limb morphogenesis Source: BHF-UCL
  9. peptide biosynthetic process Source: BHF-UCL
  10. peptide hormone processing Source: BHF-UCL
  11. protein processing Source: BHF-UCL
  12. renin secretion into blood stream Source: Ensembl
  13. respiratory tube development Source: BHF-UCL
  14. signal peptide processing Source: Ensembl
  15. viral life cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Pregnancy

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.

Protein family/group databases

MEROPSiS08.076.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
Alternative name(s):
Proprotein convertase 5
Short name:
PC5
Proprotein convertase 6
Short name:
PC6
Subtilisin-like proprotein convertase 6
Short name:
SPC6
Subtilisin/kexin-like protease PC5
Gene namesi
Name:Pcsk5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:97515. Pcsk5.

Subcellular locationi

Isoform PC5A : Secreted
Note: Secreted through the regulated secretory pathway.1 Publication
Isoform PC5B : Endomembrane system; Single-pass type I membrane protein
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini117 – 17681652Extracellular Reviewed prediction
Add
BLAST
Transmembranei1769 – 178921Helical; Reviewed prediction
Add
BLAST
Topological domaini1790 – 187788Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular space Source: BHF-UCL
  4. integral component of membrane Source: UniProtKB-KW
  5. secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434
Add
BLAST
Propeptidei35 – 11682
PRO_0000027104Add
BLAST
Chaini117 – 18771761Proprotein convertase subtilisin/kexin type 5
PRO_0000027105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi383 – 3831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi667 – 6671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi754 – 7541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi804 – 8041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi854 – 8541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi951 – 9511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1016 – 10161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1220 – 12201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1317 – 13171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1523 – 15231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1711 – 17111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1733 – 17331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ04592.

PTM databases

PhosphoSiteiQ04592.

Expressioni

Tissue specificityi

PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.

Developmental stagei

Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up-regulated at discrete sites during development. At E6.5, prominent expression observed in differentiated decidua. At E7.5, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At E8.5, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between E9.5 and E11.5, abundant expression in AER (thickened ectodermal cells of limb buds). At E12.5, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At E16.5, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at E12.5.2 Publications

Gene expression databases

ArrayExpressiQ04592.
BgeeiQ04592.
CleanExiMM_PCSK5.
GenevestigatoriQ04592.

Interactioni

Protein-protein interaction databases

IntActiQ04592. 1 interaction.
MINTiMINT-5314211.

Structurei

3D structure databases

ProteinModelPortaliQ04592.
SMRiQ04592. Positions 130-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini464 – 602139Homo B/P
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 452336Catalytic
Add
BLAST
Regioni638 – 17531116CRM (Cys-rich motif)
Add
BLAST
Regioni1825 – 184420AC 1
Add
BLAST
Regioni1856 – 187722AC 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi521 – 5233Cell attachment site Reviewed prediction

Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1.

Sequence similaritiesi

Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ04592.
KOiK08654.
OMAiLHEGRCY.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00181. EGF. 2 hits.
SM00261. FU. 22 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 8 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform PC5B (identifier: Q04592-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA     50
EADRIASKYG FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP 100
KVEWIQQQVV KKRTKRDYDL SHAQSTYFND PKWPSMWYMH CSDNTHPCQS 150
DMNIEGAWKR GYTGKNIVVT ILDDGIERTH PDLMQNYDAL ASCDVNGNDL 200
DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK IGGVRMLDGD 250
VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM 300
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL 350
EECSSTLATT YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL 400
ALEANPFLTW RDVQHVIVRT SRAGHLNAND WKTNAAGFKV SHLYGFGLMD 450
AEAMVMEAEK WTTVPQQHVC VESTDRQIKT IRPNSAVRSI YKASGCSDNP 500
NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA NRLFDHSMEG 550
FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT 600
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP 650
GPDHCSDCLH YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG 700
SHGNQCLSCK YGYFLNEETS SCVTQCPDGS YEDIKKNVCG KCSENCKACI 750
GFHNCTECKG GLSLQGSRCS VTCEDGQFFN GHDCQPCHRF CATCSGAGAD 800
GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC DNSCLTCNGP 850
GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP 900
TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS 950
NCTSCRADKH GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP 1000
HVCSRCMSGY VIIPPNHTCQ KLECRQGEFQ DSEYEECMPC EEGCLGCTED 1050
DPGACTSCAT GYYMFERHCY KACPEKTFGV KWECRACGTN CGSCDQHECY 1100
WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC TGSGYNQCSS 1150
CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ 1200
IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV 1250
TSGSCEKCSE DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK 1300
DGVCEHCSSP CKTCEGNATS CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC 1350
KHCPERCQDC IHEKTCKECM PDFFLYNDMC HRSCPKSFYP DMRQCVPCHK 1400
NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE ENDECRDCPE 1450
SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK 1500
CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC 1550
RTCEGPHSMQ CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK 1600
SCRGPRPTDC QSCDTFFFLL RSKGQCHRAC PEHYYADQHA QTCERCHPTC 1650
DKCSGKEAWS CLSCVWSYHL LKGICIPECI VGEYREGKGE NFNCKKCHES 1700
CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS QDCCDCQSST 1750
DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG 1800
RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV 1850
YRKFKYGLLD ETEDDELEYD DESYSYQ 1877
Length:1,877
Mass (Da):209,257
Last modified:July 27, 2011 - v3
Checksum:i68F7B768E063872B
GO
Isoform PC5A (identifier: Q04592-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     878-915: GEYIDDQGHC...ISCPVTRVLD → ATEESWAEGG...LCCKTCTFQG
     916-1877: Missing.

Show »
Length:915
Mass (Da):101,489
Checksum:iEE13FF8F7AFC78EE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei878 – 91538GEYID…TRVLD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC5A.
VSP_005438Add
BLAST
Alternative sequencei916 – 1877962Missing in isoform PC5A.
VSP_005439Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti704 – 7041N → D in BAA04507. 1 Publication
Sequence conflicti704 – 7041N → D in BAA02143. 1 Publication
Sequence conflicti704 – 7041N → D in AAA74636. 1 Publication
Sequence conflicti986 – 9861A → T in BAA04507. 1 Publication
Sequence conflicti1002 – 10021V → I in BAA04507. 1 Publication
Sequence conflicti1139 – 11391N → T in BAA04507. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17583 mRNA. Translation: BAA04507.1.
D12619 mRNA. Translation: BAA02143.1.
L14932 mRNA. Translation: AAA74636.1.
AC125203 Genomic DNA. No translation available.
AC126940 Genomic DNA. No translation available.
AC133509 Genomic DNA. No translation available.
AC147369 Genomic DNA. No translation available.
CCDSiCCDS50401.1. [Q04592-1]
CCDS50402.1. [Q04592-2]
PIRiA48225.
S34583.
RefSeqiNP_001177412.1. NM_001190483.1. [Q04592-1]
UniGeneiMm.3401.

Genome annotation databases

EnsembliENSMUST00000025618; ENSMUSP00000025618; ENSMUSG00000024713. [Q04592-1]
ENSMUST00000050715; ENSMUSP00000050272; ENSMUSG00000024713. [Q04592-2]
GeneIDi18552.
KEGGimmu:18552.
UCSCiuc008gxp.2. mouse. [Q04592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17583 mRNA. Translation: BAA04507.1 .
D12619 mRNA. Translation: BAA02143.1 .
L14932 mRNA. Translation: AAA74636.1 .
AC125203 Genomic DNA. No translation available.
AC126940 Genomic DNA. No translation available.
AC133509 Genomic DNA. No translation available.
AC147369 Genomic DNA. No translation available.
CCDSi CCDS50401.1. [Q04592-1 ]
CCDS50402.1. [Q04592-2 ]
PIRi A48225.
S34583.
RefSeqi NP_001177412.1. NM_001190483.1. [Q04592-1 ]
UniGenei Mm.3401.

3D structure databases

ProteinModelPortali Q04592.
SMRi Q04592. Positions 130-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q04592. 1 interaction.
MINTi MINT-5314211.

Protein family/group databases

MEROPSi S08.076.

PTM databases

PhosphoSitei Q04592.

Proteomic databases

PRIDEi Q04592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025618 ; ENSMUSP00000025618 ; ENSMUSG00000024713 . [Q04592-1 ]
ENSMUST00000050715 ; ENSMUSP00000050272 ; ENSMUSG00000024713 . [Q04592-2 ]
GeneIDi 18552.
KEGGi mmu:18552.
UCSCi uc008gxp.2. mouse. [Q04592-1 ]

Organism-specific databases

CTDi 5125.
MGIi MGI:97515. Pcsk5.

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117358.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
InParanoidi Q04592.
KOi K08654.
OMAi LHEGRCY.
OrthoDBi EOG7BW0JD.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.

Miscellaneous databases

NextBioi 294356.
PROi Q04592.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q04592.
Bgeei Q04592.
CleanExi MM_PCSK5.
Genevestigatori Q04592.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SMARTi SM00181. EGF. 2 hits.
SM00261. FU. 22 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 8 hits.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease."
    Nakagawa T., Murakami K., Nakayama K.
    FEBS Lett. 327:165-171(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-1877 (ISOFORM PC5B).
    Strain: ICR.
    Tissue: Intestine.
  2. "Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4."
    Nakagawa T., Hosaka M., Torii S., Watanabe T., Murakami K., Nakayama K.
    J. Biochem. 113:132-135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
    Tissue: Brain and Intestine.
  3. "cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells."
    Lusson J., Vieau D., Hamelin J., Day R., Chretien M., Seidah N.G.
    Proc. Natl. Acad. Sci. U.S.A. 90:6691-6695(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
    Tissue: Adrenal cortex.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments."
    De Bie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., Seidah N.G.
    J. Cell Biol. 135:1261-1275(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION.
  6. "SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis."
    Constam D.B., Calfon M., Robertson E.J.
    J. Cell Biol. 134:181-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  7. "Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation."
    Rancourt S.L., Rancourt D.E.
    Dev. Genet. 21:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPCSK5_MOUSE
AccessioniPrimary (citable) accession number: Q04592
Secondary accession number(s): E9QPB7, Q62040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi