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Q04592

- PCSK5_MOUSE

UniProt

Q04592 - PCSK5_MOUSE

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Protein

Proprotein convertase subtilisin/kexin type 5

Gene

Pcsk5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors By similarity.By similarity

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1172Cleavage; by autolysisBy similarity
Active sitei173 – 1731Charge relay systemBy similarity
Active sitei214 – 2141Charge relay systemBy similarity
Active sitei388 – 3881Charge relay systemBy similarity

GO - Molecular functioni

  1. endopeptidase activity Source: BHF-UCL
  2. peptidase activity Source: MGI
  3. peptide binding Source: BHF-UCL
  4. serine-type endopeptidase activity Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior pattern specification Source: BHF-UCL
  2. cytokine biosynthetic process Source: BHF-UCL
  3. embryo implantation Source: BHF-UCL
  4. embryonic digestive tract development Source: BHF-UCL
  5. embryonic skeletal system development Source: BHF-UCL
  6. heart development Source: BHF-UCL
  7. kidney development Source: BHF-UCL
  8. limb morphogenesis Source: BHF-UCL
  9. peptide biosynthetic process Source: BHF-UCL
  10. peptide hormone processing Source: BHF-UCL
  11. protein processing Source: BHF-UCL
  12. renin secretion into blood stream Source: Ensembl
  13. respiratory tube development Source: BHF-UCL
  14. signal peptide processing Source: Ensembl
  15. viral life cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Pregnancy

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.

Protein family/group databases

MEROPSiS08.076.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
Alternative name(s):
Proprotein convertase 5
Short name:
PC5
Proprotein convertase 6
Short name:
PC6
Subtilisin-like proprotein convertase 6
Short name:
SPC6
Subtilisin/kexin-like protease PC5
Gene namesi
Name:Pcsk5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:97515. Pcsk5.

Subcellular locationi

Isoform PC5A : Secreted
Note: Secreted through the regulated secretory pathway.
Isoform PC5B : Endomembrane system; Single-pass type I membrane protein
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular space Source: BHF-UCL
  3. Golgi apparatus Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Propeptidei35 – 11682PRO_0000027104Add
BLAST
Chaini117 – 18771761Proprotein convertase subtilisin/kexin type 5PRO_0000027105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi667 – 6671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi854 – 8541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi951 – 9511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1016 – 10161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1220 – 12201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1317 – 13171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1523 – 15231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1711 – 17111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1733 – 17331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ04592.

PTM databases

PhosphoSiteiQ04592.

Expressioni

Tissue specificityi

PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.

Developmental stagei

Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up-regulated at discrete sites during development. At E6.5, prominent expression observed in differentiated decidua. At E7.5, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At E8.5, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between E9.5 and E11.5, abundant expression in AER (thickened ectodermal cells of limb buds). At E12.5, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At E16.5, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at E12.5.2 Publications

Gene expression databases

BgeeiQ04592.
CleanExiMM_PCSK5.
ExpressionAtlasiQ04592. baseline and differential.
GenevestigatoriQ04592.

Interactioni

Protein-protein interaction databases

IntActiQ04592. 1 interaction.
MINTiMINT-5314211.

Structurei

3D structure databases

ProteinModelPortaliQ04592.
SMRiQ04592. Positions 130-601.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini117 – 17681652ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1790 – 187788CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1769 – 178921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 455288Peptidase S8Add
BLAST
Repeati632 – 68251FU 1Add
BLAST
Repeati685 – 73248FU 2Add
BLAST
Repeati736 – 77944FU 3Add
BLAST
Repeati781 – 82646FU 4Add
BLAST
Repeati834 – 88148FU 5Add
BLAST
Repeati884 – 92946FU 6Add
BLAST
Repeati931 – 98151FU 7Add
BLAST
Repeati984 – 103047FU 8Add
BLAST
Repeati1034 – 107946FU 9Add
BLAST
Repeati1081 – 112343FU 10Add
BLAST
Repeati1127 – 116842FU 11Add
BLAST
Repeati1206 – 124843FU 12Add
BLAST
Repeati1252 – 129948FU 13Add
BLAST
Repeati1301 – 134545FU 14Add
BLAST
Repeati1347 – 139044FU 15Add
BLAST
Repeati1392 – 143847FU 16Add
BLAST
Repeati1442 – 148746FU 17Add
BLAST
Repeati1491 – 153646FU 18Add
BLAST
Repeati1540 – 158546FU 19Add
BLAST
Repeati1589 – 163648FU 20Add
BLAST
Repeati1640 – 168546FU 21Add
BLAST
Repeati1691 – 173848FU 22Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni638 – 17531116CRM (Cys-rich motif)Add
BLAST
Regioni1825 – 184420AC 1Add
BLAST
Regioni1856 – 187722AC 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi521 – 5233Cell attachment siteSequence Analysis

Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1.

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 22 FU (furin-like) repeats.Curated
Contains 1 peptidase S8 domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ04592.
KOiK08654.
OMAiLHEGRCY.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00181. EGF. 2 hits.
SM00261. FU. 22 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 8 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform PC5B (identifier: Q04592-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA
60 70 80 90 100
EADRIASKYG FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP
110 120 130 140 150
KVEWIQQQVV KKRTKRDYDL SHAQSTYFND PKWPSMWYMH CSDNTHPCQS
160 170 180 190 200
DMNIEGAWKR GYTGKNIVVT ILDDGIERTH PDLMQNYDAL ASCDVNGNDL
210 220 230 240 250
DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK IGGVRMLDGD
260 270 280 290 300
VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM
310 320 330 340 350
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL
360 370 380 390 400
EECSSTLATT YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL
410 420 430 440 450
ALEANPFLTW RDVQHVIVRT SRAGHLNAND WKTNAAGFKV SHLYGFGLMD
460 470 480 490 500
AEAMVMEAEK WTTVPQQHVC VESTDRQIKT IRPNSAVRSI YKASGCSDNP
510 520 530 540 550
NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA NRLFDHSMEG
560 570 580 590 600
FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT
610 620 630 640 650
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP
660 670 680 690 700
GPDHCSDCLH YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG
710 720 730 740 750
SHGNQCLSCK YGYFLNEETS SCVTQCPDGS YEDIKKNVCG KCSENCKACI
760 770 780 790 800
GFHNCTECKG GLSLQGSRCS VTCEDGQFFN GHDCQPCHRF CATCSGAGAD
810 820 830 840 850
GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC DNSCLTCNGP
860 870 880 890 900
GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP
910 920 930 940 950
TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS
960 970 980 990 1000
NCTSCRADKH GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP
1010 1020 1030 1040 1050
HVCSRCMSGY VIIPPNHTCQ KLECRQGEFQ DSEYEECMPC EEGCLGCTED
1060 1070 1080 1090 1100
DPGACTSCAT GYYMFERHCY KACPEKTFGV KWECRACGTN CGSCDQHECY
1110 1120 1130 1140 1150
WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC TGSGYNQCSS
1160 1170 1180 1190 1200
CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ
1210 1220 1230 1240 1250
IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV
1260 1270 1280 1290 1300
TSGSCEKCSE DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK
1310 1320 1330 1340 1350
DGVCEHCSSP CKTCEGNATS CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC
1360 1370 1380 1390 1400
KHCPERCQDC IHEKTCKECM PDFFLYNDMC HRSCPKSFYP DMRQCVPCHK
1410 1420 1430 1440 1450
NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE ENDECRDCPE
1460 1470 1480 1490 1500
SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK
1510 1520 1530 1540 1550
CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC
1560 1570 1580 1590 1600
RTCEGPHSMQ CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK
1610 1620 1630 1640 1650
SCRGPRPTDC QSCDTFFFLL RSKGQCHRAC PEHYYADQHA QTCERCHPTC
1660 1670 1680 1690 1700
DKCSGKEAWS CLSCVWSYHL LKGICIPECI VGEYREGKGE NFNCKKCHES
1710 1720 1730 1740 1750
CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS QDCCDCQSST
1760 1770 1780 1790 1800
DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG
1810 1820 1830 1840 1850
RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV
1860 1870
YRKFKYGLLD ETEDDELEYD DESYSYQ
Length:1,877
Mass (Da):209,257
Last modified:July 27, 2011 - v3
Checksum:i68F7B768E063872B
GO
Isoform PC5A (identifier: Q04592-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     878-915: GEYIDDQGHC...ISCPVTRVLD → ATEESWAEGG...LCCKTCTFQG
     916-1877: Missing.

Show »
Length:915
Mass (Da):101,489
Checksum:iEE13FF8F7AFC78EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti704 – 7041N → D in BAA04507. (PubMed:8335106)Curated
Sequence conflicti704 – 7041N → D in BAA02143. (PubMed:8468318)Curated
Sequence conflicti704 – 7041N → D in AAA74636. (PubMed:8341687)Curated
Sequence conflicti986 – 9861A → T in BAA04507. (PubMed:8335106)Curated
Sequence conflicti1002 – 10021V → I in BAA04507. (PubMed:8335106)Curated
Sequence conflicti1139 – 11391N → T in BAA04507. (PubMed:8335106)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei878 – 91538GEYID…TRVLD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC5A. 2 PublicationsVSP_005438Add
BLAST
Alternative sequencei916 – 1877962Missing in isoform PC5A. 2 PublicationsVSP_005439Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17583 mRNA. Translation: BAA04507.1.
D12619 mRNA. Translation: BAA02143.1.
L14932 mRNA. Translation: AAA74636.1.
AC125203 Genomic DNA. No translation available.
AC126940 Genomic DNA. No translation available.
AC133509 Genomic DNA. No translation available.
AC147369 Genomic DNA. No translation available.
CCDSiCCDS50401.1. [Q04592-1]
CCDS50402.1. [Q04592-2]
PIRiA48225.
S34583.
RefSeqiNP_001177412.1. NM_001190483.1. [Q04592-1]
UniGeneiMm.3401.

Genome annotation databases

EnsembliENSMUST00000025618; ENSMUSP00000025618; ENSMUSG00000024713. [Q04592-1]
ENSMUST00000050715; ENSMUSP00000050272; ENSMUSG00000024713. [Q04592-2]
GeneIDi18552.
KEGGimmu:18552.
UCSCiuc008gxp.2. mouse. [Q04592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17583 mRNA. Translation: BAA04507.1 .
D12619 mRNA. Translation: BAA02143.1 .
L14932 mRNA. Translation: AAA74636.1 .
AC125203 Genomic DNA. No translation available.
AC126940 Genomic DNA. No translation available.
AC133509 Genomic DNA. No translation available.
AC147369 Genomic DNA. No translation available.
CCDSi CCDS50401.1. [Q04592-1 ]
CCDS50402.1. [Q04592-2 ]
PIRi A48225.
S34583.
RefSeqi NP_001177412.1. NM_001190483.1. [Q04592-1 ]
UniGenei Mm.3401.

3D structure databases

ProteinModelPortali Q04592.
SMRi Q04592. Positions 130-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q04592. 1 interaction.
MINTi MINT-5314211.

Protein family/group databases

MEROPSi S08.076.

PTM databases

PhosphoSitei Q04592.

Proteomic databases

PRIDEi Q04592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025618 ; ENSMUSP00000025618 ; ENSMUSG00000024713 . [Q04592-1 ]
ENSMUST00000050715 ; ENSMUSP00000050272 ; ENSMUSG00000024713 . [Q04592-2 ]
GeneIDi 18552.
KEGGi mmu:18552.
UCSCi uc008gxp.2. mouse. [Q04592-1 ]

Organism-specific databases

CTDi 5125.
MGIi MGI:97515. Pcsk5.

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117358.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
InParanoidi Q04592.
KOi K08654.
OMAi LHEGRCY.
OrthoDBi EOG7BW0JD.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.

Miscellaneous databases

NextBioi 294356.
PROi Q04592.
SOURCEi Search...

Gene expression databases

Bgeei Q04592.
CleanExi MM_PCSK5.
ExpressionAtlasi Q04592. baseline and differential.
Genevestigatori Q04592.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SMARTi SM00181. EGF. 2 hits.
SM00261. FU. 22 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 8 hits.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease."
    Nakagawa T., Murakami K., Nakayama K.
    FEBS Lett. 327:165-171(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-1877 (ISOFORM PC5B).
    Strain: ICR.
    Tissue: Intestine.
  2. "Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4."
    Nakagawa T., Hosaka M., Torii S., Watanabe T., Murakami K., Nakayama K.
    J. Biochem. 113:132-135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
    Tissue: Brain and Intestine.
  3. "cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells."
    Lusson J., Vieau D., Hamelin J., Day R., Chretien M., Seidah N.G.
    Proc. Natl. Acad. Sci. U.S.A. 90:6691-6695(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
    Tissue: Adrenal cortex.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments."
    De Bie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., Seidah N.G.
    J. Cell Biol. 135:1261-1275(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION.
  6. "SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis."
    Constam D.B., Calfon M., Robertson E.J.
    J. Cell Biol. 134:181-191(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  7. "Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation."
    Rancourt S.L., Rancourt D.E.
    Dev. Genet. 21:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPCSK5_MOUSE
AccessioniPrimary (citable) accession number: Q04592
Secondary accession number(s): E9QPB7, Q62040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3