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Q04592

- PCSK5_MOUSE

UniProt

Q04592 - PCSK5_MOUSE

Protein

Proprotein convertase subtilisin/kexin type 5

Gene

Pcsk5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors By similarity.By similarity

    Catalytic activityi

    Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei116 – 1172Cleavage; by autolysisBy similarity
    Active sitei173 – 1731Charge relay systemBy similarity
    Active sitei214 – 2141Charge relay systemBy similarity
    Active sitei388 – 3881Charge relay systemBy similarity

    GO - Molecular functioni

    1. endopeptidase activity Source: BHF-UCL
    2. peptidase activity Source: MGI
    3. peptide binding Source: BHF-UCL
    4. serine-type endopeptidase activity Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior pattern specification Source: BHF-UCL
    2. cytokine biosynthetic process Source: BHF-UCL
    3. embryo implantation Source: BHF-UCL
    4. embryonic digestive tract development Source: BHF-UCL
    5. embryonic skeletal system development Source: BHF-UCL
    6. heart development Source: BHF-UCL
    7. kidney development Source: BHF-UCL
    8. limb morphogenesis Source: BHF-UCL
    9. peptide biosynthetic process Source: BHF-UCL
    10. peptide hormone processing Source: BHF-UCL
    11. protein processing Source: BHF-UCL
    12. renin secretion into blood stream Source: Ensembl
    13. respiratory tube development Source: BHF-UCL
    14. signal peptide processing Source: Ensembl
    15. viral life cycle Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Pregnancy

    Enzyme and pathway databases

    ReactomeiREACT_206713. NGF processing.

    Protein family/group databases

    MEROPSiS08.076.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
    Alternative name(s):
    Proprotein convertase 5
    Short name:
    PC5
    Proprotein convertase 6
    Short name:
    PC6
    Subtilisin-like proprotein convertase 6
    Short name:
    SPC6
    Subtilisin/kexin-like protease PC5
    Gene namesi
    Name:Pcsk5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:97515. Pcsk5.

    Subcellular locationi

    Isoform PC5A : Secreted
    Note: Secreted through the regulated secretory pathway.
    Isoform PC5B : Endomembrane system; Single-pass type I membrane protein
    Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular space Source: BHF-UCL
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: UniProtKB-KW
    5. secretory granule Source: MGI

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Propeptidei35 – 11682PRO_0000027104Add
    BLAST
    Chaini117 – 18771761Proprotein convertase subtilisin/kexin type 5PRO_0000027105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi667 – 6671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi854 – 8541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi951 – 9511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1016 – 10161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1220 – 12201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1317 – 13171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1523 – 15231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1711 – 17111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1733 – 17331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ04592.

    PTM databases

    PhosphoSiteiQ04592.

    Expressioni

    Tissue specificityi

    PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.

    Developmental stagei

    Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up-regulated at discrete sites during development. At E6.5, prominent expression observed in differentiated decidua. At E7.5, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At E8.5, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between E9.5 and E11.5, abundant expression in AER (thickened ectodermal cells of limb buds). At E12.5, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At E16.5, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at E12.5.2 Publications

    Gene expression databases

    ArrayExpressiQ04592.
    BgeeiQ04592.
    CleanExiMM_PCSK5.
    GenevestigatoriQ04592.

    Interactioni

    Protein-protein interaction databases

    IntActiQ04592. 1 interaction.
    MINTiMINT-5314211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04592.
    SMRiQ04592. Positions 130-601.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini117 – 17681652ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1790 – 187788CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1769 – 178921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 455288Peptidase S8Add
    BLAST
    Repeati632 – 68251FU 1Add
    BLAST
    Repeati685 – 73248FU 2Add
    BLAST
    Repeati736 – 77944FU 3Add
    BLAST
    Repeati781 – 82646FU 4Add
    BLAST
    Repeati834 – 88148FU 5Add
    BLAST
    Repeati884 – 92946FU 6Add
    BLAST
    Repeati931 – 98151FU 7Add
    BLAST
    Repeati984 – 103047FU 8Add
    BLAST
    Repeati1034 – 107946FU 9Add
    BLAST
    Repeati1081 – 112343FU 10Add
    BLAST
    Repeati1127 – 116842FU 11Add
    BLAST
    Repeati1206 – 124843FU 12Add
    BLAST
    Repeati1252 – 129948FU 13Add
    BLAST
    Repeati1301 – 134545FU 14Add
    BLAST
    Repeati1347 – 139044FU 15Add
    BLAST
    Repeati1392 – 143847FU 16Add
    BLAST
    Repeati1442 – 148746FU 17Add
    BLAST
    Repeati1491 – 153646FU 18Add
    BLAST
    Repeati1540 – 158546FU 19Add
    BLAST
    Repeati1589 – 163648FU 20Add
    BLAST
    Repeati1640 – 168546FU 21Add
    BLAST
    Repeati1691 – 173848FU 22Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni638 – 17531116CRM (Cys-rich motif)Add
    BLAST
    Regioni1825 – 184420AC 1Add
    BLAST
    Regioni1856 – 187722AC 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi521 – 5233Cell attachment siteSequence Analysis

    Domaini

    The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
    AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1.

    Sequence similaritiesi

    Belongs to the peptidase S8 family.Curated
    Contains 22 FU (furin-like) repeats.Curated
    Contains 1 peptidase S8 domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4935.
    GeneTreeiENSGT00750000117358.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    InParanoidiQ04592.
    KOiK08654.
    OMAiLHEGRCY.
    OrthoDBiEOG7BW0JD.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR000742. EG-like_dom.
    IPR006212. Furin_repeat.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SMARTiSM00181. EGF. 2 hits.
    SM00261. FU. 22 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    SSF57184. SSF57184. 8 hits.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform PC5B (identifier: Q04592-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA     50
    EADRIASKYG FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP 100
    KVEWIQQQVV KKRTKRDYDL SHAQSTYFND PKWPSMWYMH CSDNTHPCQS 150
    DMNIEGAWKR GYTGKNIVVT ILDDGIERTH PDLMQNYDAL ASCDVNGNDL 200
    DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK IGGVRMLDGD 250
    VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM 300
    GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL 350
    EECSSTLATT YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL 400
    ALEANPFLTW RDVQHVIVRT SRAGHLNAND WKTNAAGFKV SHLYGFGLMD 450
    AEAMVMEAEK WTTVPQQHVC VESTDRQIKT IRPNSAVRSI YKASGCSDNP 500
    NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA NRLFDHSMEG 550
    FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT 600
    SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP 650
    GPDHCSDCLH YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG 700
    SHGNQCLSCK YGYFLNEETS SCVTQCPDGS YEDIKKNVCG KCSENCKACI 750
    GFHNCTECKG GLSLQGSRCS VTCEDGQFFN GHDCQPCHRF CATCSGAGAD 800
    GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC DNSCLTCNGP 850
    GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP 900
    TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS 950
    NCTSCRADKH GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP 1000
    HVCSRCMSGY VIIPPNHTCQ KLECRQGEFQ DSEYEECMPC EEGCLGCTED 1050
    DPGACTSCAT GYYMFERHCY KACPEKTFGV KWECRACGTN CGSCDQHECY 1100
    WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC TGSGYNQCSS 1150
    CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ 1200
    IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV 1250
    TSGSCEKCSE DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK 1300
    DGVCEHCSSP CKTCEGNATS CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC 1350
    KHCPERCQDC IHEKTCKECM PDFFLYNDMC HRSCPKSFYP DMRQCVPCHK 1400
    NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE ENDECRDCPE 1450
    SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK 1500
    CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC 1550
    RTCEGPHSMQ CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK 1600
    SCRGPRPTDC QSCDTFFFLL RSKGQCHRAC PEHYYADQHA QTCERCHPTC 1650
    DKCSGKEAWS CLSCVWSYHL LKGICIPECI VGEYREGKGE NFNCKKCHES 1700
    CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS QDCCDCQSST 1750
    DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG 1800
    RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV 1850
    YRKFKYGLLD ETEDDELEYD DESYSYQ 1877
    Length:1,877
    Mass (Da):209,257
    Last modified:July 27, 2011 - v3
    Checksum:i68F7B768E063872B
    GO
    Isoform PC5A (identifier: Q04592-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         878-915: GEYIDDQGHC...ISCPVTRVLD → ATEESWAEGG...LCCKTCTFQG
         916-1877: Missing.

    Show »
    Length:915
    Mass (Da):101,489
    Checksum:iEE13FF8F7AFC78EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti704 – 7041N → D in BAA04507. (PubMed:8335106)Curated
    Sequence conflicti704 – 7041N → D in BAA02143. (PubMed:8468318)Curated
    Sequence conflicti704 – 7041N → D in AAA74636. (PubMed:8341687)Curated
    Sequence conflicti986 – 9861A → T in BAA04507. (PubMed:8335106)Curated
    Sequence conflicti1002 – 10021V → I in BAA04507. (PubMed:8335106)Curated
    Sequence conflicti1139 – 11391N → T in BAA04507. (PubMed:8335106)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei878 – 91538GEYID…TRVLD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC5A. 2 PublicationsVSP_005438Add
    BLAST
    Alternative sequencei916 – 1877962Missing in isoform PC5A. 2 PublicationsVSP_005439Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17583 mRNA. Translation: BAA04507.1.
    D12619 mRNA. Translation: BAA02143.1.
    L14932 mRNA. Translation: AAA74636.1.
    AC125203 Genomic DNA. No translation available.
    AC126940 Genomic DNA. No translation available.
    AC133509 Genomic DNA. No translation available.
    AC147369 Genomic DNA. No translation available.
    CCDSiCCDS50401.1. [Q04592-1]
    CCDS50402.1. [Q04592-2]
    PIRiA48225.
    S34583.
    RefSeqiNP_001177412.1. NM_001190483.1. [Q04592-1]
    UniGeneiMm.3401.

    Genome annotation databases

    EnsembliENSMUST00000025618; ENSMUSP00000025618; ENSMUSG00000024713. [Q04592-1]
    ENSMUST00000050715; ENSMUSP00000050272; ENSMUSG00000024713. [Q04592-2]
    GeneIDi18552.
    KEGGimmu:18552.
    UCSCiuc008gxp.2. mouse. [Q04592-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17583 mRNA. Translation: BAA04507.1 .
    D12619 mRNA. Translation: BAA02143.1 .
    L14932 mRNA. Translation: AAA74636.1 .
    AC125203 Genomic DNA. No translation available.
    AC126940 Genomic DNA. No translation available.
    AC133509 Genomic DNA. No translation available.
    AC147369 Genomic DNA. No translation available.
    CCDSi CCDS50401.1. [Q04592-1 ]
    CCDS50402.1. [Q04592-2 ]
    PIRi A48225.
    S34583.
    RefSeqi NP_001177412.1. NM_001190483.1. [Q04592-1 ]
    UniGenei Mm.3401.

    3D structure databases

    ProteinModelPortali Q04592.
    SMRi Q04592. Positions 130-601.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q04592. 1 interaction.
    MINTi MINT-5314211.

    Protein family/group databases

    MEROPSi S08.076.

    PTM databases

    PhosphoSitei Q04592.

    Proteomic databases

    PRIDEi Q04592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025618 ; ENSMUSP00000025618 ; ENSMUSG00000024713 . [Q04592-1 ]
    ENSMUST00000050715 ; ENSMUSP00000050272 ; ENSMUSG00000024713 . [Q04592-2 ]
    GeneIDi 18552.
    KEGGi mmu:18552.
    UCSCi uc008gxp.2. mouse. [Q04592-1 ]

    Organism-specific databases

    CTDi 5125.
    MGIi MGI:97515. Pcsk5.

    Phylogenomic databases

    eggNOGi COG4935.
    GeneTreei ENSGT00750000117358.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    InParanoidi Q04592.
    KOi K08654.
    OMAi LHEGRCY.
    OrthoDBi EOG7BW0JD.
    TreeFami TF314277.

    Enzyme and pathway databases

    Reactomei REACT_206713. NGF processing.

    Miscellaneous databases

    NextBioi 294356.
    PROi Q04592.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04592.
    Bgeei Q04592.
    CleanExi MM_PCSK5.
    Genevestigatori Q04592.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR000742. EG-like_dom.
    IPR006212. Furin_repeat.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SMARTi SM00181. EGF. 2 hits.
    SM00261. FU. 22 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    SSF57184. SSF57184. 8 hits.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease."
      Nakagawa T., Murakami K., Nakayama K.
      FEBS Lett. 327:165-171(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-1877 (ISOFORM PC5B).
      Strain: ICR.
      Tissue: Intestine.
    2. "Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4."
      Nakagawa T., Hosaka M., Torii S., Watanabe T., Murakami K., Nakayama K.
      J. Biochem. 113:132-135(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
      Tissue: Brain and Intestine.
    3. "cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells."
      Lusson J., Vieau D., Hamelin J., Day R., Chretien M., Seidah N.G.
      Proc. Natl. Acad. Sci. U.S.A. 90:6691-6695(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC5A).
      Tissue: Adrenal cortex.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments."
      De Bie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., Seidah N.G.
      J. Cell Biol. 135:1261-1275(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION.
    6. "SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis."
      Constam D.B., Calfon M., Robertson E.J.
      J. Cell Biol. 134:181-191(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    7. "Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation."
      Rancourt S.L., Rancourt D.E.
      Dev. Genet. 21:75-81(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPCSK5_MOUSE
    AccessioniPrimary (citable) accession number: Q04592
    Secondary accession number(s): E9QPB7, Q62040
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3